List of works - Peter J. Ratcliffe

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

scientific article

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

scientific article

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

scientific article

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

scientific article

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

scientific article (publication date: 23 May 2008)

Regulation of angiogenesis by hypoxia: role of the HIF system

scientific article (publication date: June 2003)

Oxygen sensing by HIF hydroxylases

scientific article (publication date: May 2004)

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

scientific article (publication date: August 2000)

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

scientific article

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

scientific article

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

scientific article

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

scientific article (publication date: August 2005)

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

scientific article

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

scientific article (publication date: 18 August 2000)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

scientific article

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

scientific journal article

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

scientific article

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

scientific journal article

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

scientific article

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

scientific article published on 17 December 2002

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

scientific article

Dynamic regulatory network controlling TH17 cell differentiation

scientific article published on 6 March 2013

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

scientific article published on July 1994

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

scientific article

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

scientific article published on 21 April 2009

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

scientific article published on 24 March 2006

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

scientific article published on July 2002

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

scientific article

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

scientific article

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

scientific article published in Journal of Biological Chemistry

Hypoxic Regulation of Lactate Dehydrogenase A

scientific article published in Journal of Biological Chemistry

Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences

scientific article published on December 1995

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

scientific article

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

scientific article

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

scientific article published on September 2001

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

scientific article

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

scientific article

Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma

scientific article published on 01 August 2001

Activation of the HIF pathway in cancer

scientific article

Signalling hypoxia by HIF hydroxylases

scientific article

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

scientific article

Identification of the renal erythropoietin-producing cells using transgenic mice

scientific article published on 01 November 1993

Targeting gene expression to hypoxic tumor cells

article

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha

scientific article published on October 1998

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

scientific article

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

scientific article published on October 2003

Oxygen sensors and angiogenesis

scientific article

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

scientific article published on December 2000

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

scientific article

List of works by Peter J. Ratcliffe

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

Regulation of angiogenesis by hypoxia: role of the HIF system

Oxygen sensing by HIF hydroxylases

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

Dynamic regulatory network controlling TH17 cell differentiation

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

Hypoxic Regulation of Lactate Dehydrogenase A

Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma

Activation of the HIF pathway in cancer

Signalling hypoxia by HIF hydroxylases

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

Identification of the renal erythropoietin-producing cells using transgenic mice

Targeting gene expression to hypoxic tumor cells

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

Oxygen sensors and angiogenesis

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor