Search filters

List of works by Peter J. Ratcliffe

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

scientific article published in August 2003

31P nuclear magnetic resonance in the investigation of renal ischemia during hypotension

scientific article published on 01 January 1987

31P nuclear magnetic resonance study of steady-state adenosine 5'-triphosphate levels during graded hypoxia in the isolated perfused rat kidney

scientific article published on April 1988

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

scientific article published on August 2013

87-rubidium NMR: a novel method of measuring cation flux in intact kidney

scientific article

A Large Duplicated Area in the Polycystic Kidney Disease 1 (PKD1) Region of Chromosome 16 Is Prone to Rearrangement

scientific article published on 01 September 1994

A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism ⬇️

scientific article

A competitive radioimmunoassay using a monoclonal antibody to detect the factor X activator of Russell's viper venom

scientific article

A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease

scientific article published on 6 July 2015

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

scientific article

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia

scientific article published on 2 May 2013

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

scientific article

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

scientific journal article

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

scientific article published in Journal of Biological Chemistry

Activation of the HIF pathway in cancer

scientific article

Acute renal failure in hemorrhagic hypotension: Cellular energetics and renal function

article

Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.

scientific article

Adult hematopoietic stem cells lacking Hif-1α self-renew normally.

scientific article published on 8 April 2016

Age-dependent expression of the erythropoietin gene in rat liver and kidneys

scientific article published on March 1992

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

scientific article published in April 2003

Analysis of cis-acting sequences required for operation of the erythropoietin 3' enhancer in different cell lines.

scientific article published on April 1994

Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing.

scientific article published in January 2004

Angiogenesis: escape from hypoxia

scientific article published in May 2009

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor

scientific article

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold

scientific article

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

scientific article

Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice

scientific article published in January 2015

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

scientific article published in 2015

Beyond erythropoietin: the oxygen sensor

scientific article published on September 1997

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

scientific article

Cancer. Puzzling patterns of predisposition

scientific article

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters

scientific article published on 8 August 2016

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density.

scientific article published on July 2001

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation

scientific article

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

scientific article published on 20 May 2013

Cellular oxygen sensing in health and disease

scientific article published on 23 October 2007

Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines

scientific article published on April 1994

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

scientific article published on July 2006

Clinical importance of acquired cystic disease of the kidney in patients undergoing dialysis

scientific article

Clinical iron deficiency disturbs normal human responses to hypoxia

scientific article published on 03 May 2016

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

scientific article published on 10 December 2019

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

scientific article

Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions

scientific article published in December 1993

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

scientific article published on 24 March 2006

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

scientific article published on 01 July 2019

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

scientific article

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

scientific article

Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

scientific article

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

scientific article

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia

article

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia.

scientific article published in October 2002

Determination and comparison of specific activity of the HIF-prolyl hydroxylases

scientific article

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

scientific article

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

scientific article

Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing

scientific article

Direct nephrotoxicity of Russell's viper venom demonstrated in the isolated perfused rat kidney

scientific article published in March 1989

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

scientific journal article

Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia

scientific article published on 01 April 1993

Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites

scientific article published on June 1996

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

scientific article

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

scientific article

Dynamic regulatory network controlling TH17 cell differentiation

scientific article published on 6 March 2013

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

scientific article published on 21 July 2010

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells

scientific article (publication date: 15 April 2003)

Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys

Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function

scientific article published on 01 January 1991

Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials

scientific article published on October 2009

Electrocardiographic measures of left ventricular hypertrophy show greater heritability than echocardiographic left ventricular mass

scientific article

Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner

scientific article published on 01 February 1998

Endothelial Oxygen Sensing in Alveolar Maintenance

scientific article published on 15 July 2020

Endothelin: an important factor in acute renal failure?

scientific article published on November 1988

Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

scientific article published in Nature

Erythrocytes alter the pattern of renal hypoxic injury: predominance of proximal tubular injury with moderate hypoxia

Erythrocytosis associated with a novel missense mutation in the BPGM gene

scientific article published on 11 July 2014

Erythropoietin-producing cells in transgenic mice expressing SV40 large T antigen directed by erythropoietin control sequences

scientific article published on 01 April 1994

Erythropoietin: An Historical Overview of Physiology, Molecular Biology and Gene Regulation

article

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases

scientific article

Evidence for abnormal Na+/H+ antiport activity detected by phosphorus nuclear magnetic resonance spectroscopy in exercising skeletal muscle of patients with essential hypertension

article

ExCITED about HIF

Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis

scientific article published on 21 September 2016

Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells

article

Expression of endothelins 1 and 3 in the rat kidney

article

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

scientific article published on July 2002

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

scientific article published in May 2002

Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast

scientific article

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.

scientific article published on 21 December 2013

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

scientific article published on October 2009

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

scientific article

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

scientific article

Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia

scientific article published in September 1992

First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease

scientific article (publication date: March 2005)

From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway

scientific article

Fumarate Hydratase Deficiency and Cancer: Activation of Hypoxia Signaling?

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene

scientific article published on December 1991

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

scientific article published on March 2004

Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations

scientific article

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

scientific article

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

scientific article published on 9 August 2004

Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

scientific article published on 21 January 2020

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

scientific article published on 4 November 2014

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

scientific article published on 24 October 2016

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

scientific article published on 21 April 2009

Genome-wide mapping of human loci for essential hypertension

scientific article

Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein

scientific article

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

scientific article

HIF hydroxylase pathways in cardiovascular physiology and medicine

scientific article

HIF hydroxylation and cellular oxygen sensing

scientific article

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

scientific article (publication date: August 2005)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

scientific article

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

scientific article published in July 2006

HIF-1 and HIF-2: working alone or together in hypoxia?

scientific article published on April 2007

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

scientific article published on September 2001

HLA has strongest association with IgA nephropathy in genome-wide analysis

scientific article

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

scientific article published in 2015

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

scientific article

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

scientific article published on 7 December 2015

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance

scientific article published on 26 July 2013

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

scientific article

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

scientific article

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

scientific article

Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice

scientific article published on 12 April 2016

Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice

scientific article published on January 2012

Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences

scientific article published on December 1995

Hypoxia and the regulation of gene expression ⬇️

scientific article published on March 1, 1998

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

scientific article published on 05 November 2019

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

scientific article (publication date: 18 August 2000)

Hypoxia response elements

article

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

scientific article published on 27 May 2022

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

scientific article published on 04 February 2014

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

scientific article published on 19 August 2015

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

scientific journal article

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

scientific journal article

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

scientific article published in January 2007

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

scientific article

Hypoxic Regulation of Lactate Dehydrogenase A

scientific article published in Journal of Biological Chemistry

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

scientific article

Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1.

scientific article published in October 1996

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

scientific article published on December 2000

Identification of the renal erythropoietin-producing cells using transgenic mice

scientific article published on 01 November 1993

Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice

scientific article published on 12 December 2011

Increased plasma viscosity as a reason for inappropriate erythropoietin formation

scientific article published in January 1993

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

scientific article

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

scientific article

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha

scientific article published on October 1998

Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase.

scientific article published on January 1997

Influence of hypoxia on hepatic and renal endothelin gene expression

Influence of hypoxia on hepatic and renal endothelin gene expression

article

Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin

scientific article published on 14 November 2018

Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation

article

Insulin-like growth factors decrease oxygen-regulated erythropoietin production by human hepatoma cells (Hep G2)

scientific article published on August 1, 1992

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

scientific article

Iron metabolism in transgenic mice with hypoplastic anaemia due to incomplete deficiency of erythropoietin

scientific article published on 01 February 1997

Ischaemic acute renal failure: why does it occur?

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

scientific article published on February 1996

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

scientific article published on 10 September 2019

Late onset post-traumatic hypothalamic hypothermia

scientific article

Late referral for maintenance dialysis.

scientific article

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation

scientific article published on 14 April 2004

Long-term survival following left ventricular aneurysmectomy.

scientific article published on September 1983

Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury

scientific article published on 8 October 2009

MASSIVE THROMBOSIS AROUND SUBCLAVIAN CANNULAS USED FOR HAEMODIALYSIS

scientific article published in The Lancet

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

scientific article

Mammalian oxygen sensing and hypoxia inducible factor-1.

scientific article published on December 1997

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

scientific article published on 23 March 2020

Measured Haplotype Analysis of the Angiotensin-I Converting Enzyme Gene

article

Mechanisms of hypoxia signalling: new implications for nephrology

scientific article published on 05 September 2019

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

scientific article published on 11 September 2017

Molecular biology of erythropoietin

scientific article published on 01 October 1993

Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia

scientific article published on June 2008

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

scientific article

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

scientific article

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma

article

Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.

scientific article

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

scientific article (publication date: July 2006)

New horizons in hypoxia signaling pathways

scientific article published on 14 March 2017

New insights into an enigmatic tumour suppressor

Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

scientific article

Novel insights into FH-associated disease are KEAPing the lid on oncogenic HIF signalling

scientific article published on November 2011

Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively

scientific article published on 19 November 2018

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

scientific article

On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

scientific article published on 21 April 2016

Oncogenic switching of hypoxia signalling pathways

scientific article published on 28 May 2014

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

scientific article published on 30 January 2014

Organ distribution of erythropoietin messenger RNA in normal and uremic rats

scientific article published on 01 July 1991

Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression.

scientific article published in September 1992

Oxygen regulated gene expression: erythropoietin as a model system

scientific article published on February 1997

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

scientific article published on 11 February 2013

Oxygen sensing and hypoxia-induced responses

scientific article published on January 2007

Oxygen sensing by HIF hydroxylases

scientific article (publication date: May 2004)

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

scientific article (publication date: 23 May 2008)

Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.

scientific article published on April 1998

Oxygen sensors and angiogenesis

scientific article

Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro

article

Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection

scientific article

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

scientific article published on January 1999

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

scientific article published on July 1994

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

scientific article

PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies

scientific article published on 19 June 2018

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

scientific article

Pan-genomic binding of hypoxia-inducible transcription factors

scientific article published on April 2013

Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award

scientific article

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

scientific article

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development

scientific article

Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).

scientific article published on May 1992

Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions

scientific article published on 13 December 2010

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

scientific article

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

scientific article

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

scientific article

Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes

article

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

scientific article published on October 2003

Production of erythropoietin by liver cells in vivo and in vitro.

scientific article published on April 1994

Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma

scientific article published on 01 August 2001

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

scientific article published on 14 August 2017

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

scientific article published on 7 February 2011

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

scientific article published on 20 October 2008

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

scientific article published on 01 October 2018

Quantification of 32P-labeled samples in gel fragments using the flat-bed liquid scintillation counter

scientific article published on 01 August 1991

Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.

scientific article

Randomised controlled trial of steroid withdrawal in renal transplant recipients receiving triple immunosuppression

scientific article published in The Lancet

Randomized controlled trial of complete steroid withdrawal in renal transplant patients receiving triple immunosuppression

scientific article published on 01 February 1993

Rapid genetic analysis of families with polycystic kidney disease 1 by means of a microsatellite marker

scientific article published in The Lancet

Rapid oxygen-dependent changes in erythropoietin mRNA in perfused rat kidneys: Evidence against mediation by cAMP

article

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

scientific article

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

scientific article

Regulation of HIF: prolyl hydroxylases.

scientific article

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

scientific article

Regulation of angiogenesis by hypoxia: role of the HIF system

scientific article (publication date: June 2003)

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

scientific article published on June 1995

Regulation of expression of the erythropoietin gene

scientific article

Regulation of gene expression by oxygen levels in mammalian cells

scientific article

Regulation of growth differentiation factor 15 expression by intracellular iron.

scientific article

Regulation of human metabolism by hypoxia-inducible factor

scientific article

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

scientific article published in July 2001

Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha

scientific article

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex

scientific article

Regulation of the erythropoietin gene

article

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis

scientific article published on 21 October 2010

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway

scientific article published on 04 September 2015

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

scientific article

Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels

scientific article published on November 1992

Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima

scientific article published on 23 September 2005

Rhabdomyolysis in elderly people after collapse

scientific article

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

scientific article

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

scientific article

Screening for the GRA mutation in Jamaica

scientific article published on 01 February 2000

Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci.

scientific article published on December 1995

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

scientific article published on April 1998

Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor

scientific article published on 12 September 2001

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

scientific article

Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives

scientific article published on 05 December 2014

Signalling cross talk of the HIF system: involvement of the FIH protein.

scientific article published on January 2009

Signalling hypoxia by HIF hydroxylases

scientific article

Sites of erythropoietin production

scientific article published on February 1997

Sodium sulfite is a potential hypoxia inducer that mimics hypoxic stress in Caenorhabditis elegans

Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells

scientific article

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

scientific article

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

scientific article

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

scientific article

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

scientific article published on 03 December 2019

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

scientific article

Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth.

scientific article published on 18 February 2014

Systemic silencing of PHD2 causes reversible immune regulatory dysfunction

scientific article published on 04 June 2019

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

scientific article published on April 2009

Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

scientific article published on 27 March 2007

Targeting gene expression to hypoxic tumor cells

article

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

scientific article

Targeting tumors through the HIF system.

scientific article published in December 2000

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

scientific article (publication date: August 2000)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

scientific article published in March 2012

The HIF pathway: implications for patterns of gene expression in cancer.

scientific article

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin

scientific article

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

article

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

scientific article

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia

scientific article published on 20 October 2017

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia

The erythropoietin-producing cells

scientific article published on 01 November 1996

The human side of hypoxia-inducible factor

scientific article

The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer

scientific article

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

scientific article (publication date: 2011)

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

scientific article published on 27 October 2008

The interstitial response to renal injury: Fibroblast–like cells show phenotypic changes and have reduced potential for erythropoietin gene expression

article

The macrophage - a novel system to deliver gene therapy to pathological hypoxia

scientific article published in February 2000

The mini-driver model of polygenic cancer evolution

scientific article published on 12 October 2015

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

scientific article

The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma

scientific article published in August 2001

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

scientific article

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha

scientific article

The quality of function of renal allografts is associated with donor age

scientific article published on 01 January 1995

The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)

scientific article

The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells

scientific article

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

scientific article

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

scientific article

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

scientific article

Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia

scientific article published on 12 September 2013

Timing of the onset of changes in renal energetics in relation to blood pressure and glomerular filtration in haemorrhagic hypotension in the rat

Total parathyroidectomy alone or with autograft for renal hyperparathyroidism?

scientific article

Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE).

scientific article published on May 2001

Triple therapy immunosuppression in cadaveric renal transplantation

scientific article published on 01 May 1990

Tubular reabsorption rates for myoglobin in the isolated perfused rat kidney

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

scientific article published in August 2015

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

scientific article published on 24 November 2014

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

scientific article published on 8 August 2016

U.K. Prospective Diabetes Study XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM

article

UK prospective diabetes study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM.

scientific article published in August 1995

Understanding hypoxia signalling in cells--a new therapeutic opportunity?

scientific article published on November 2006

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

scientific article published on 15 March 2017

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

scientific article published on 17 December 2002

Paulina is supported by:

About Paulina

Help