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List of works by Peter J. Ratcliffe

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The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells

scientific article
Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

scientific article
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

scientific article (publication date: 2011)
Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene

scientific article published on December 1991
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

scientific article published on 04 February 2014
Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

scientific article published on January 1999
Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast

scientific article
HIF-1 and HIF-2: working alone or together in hypoxia?

scientific article published on April 2007
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

scientific article published on 11 February 2013
Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein

scientific article
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

scientific article
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

scientific article (publication date: July 2006)
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

scientific article
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

scientific journal article
Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells

scientific article (publication date: 15 April 2003)
HLA has strongest association with IgA nephropathy in genome-wide analysis

scientific article
Measured Haplotype Analysis of the Angiotensin-I Converting Enzyme Gene

article
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

scientific article published on April 1998
Genome-wide mapping of human loci for essential hypertension

scientific article
Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

scientific article published on 9 August 2004
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

scientific article
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

scientific article published in July 2001
The human side of hypoxia-inducible factor

scientific article
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

scientific article
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

scientific article published on 24 November 2014
Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.

scientific article published on April 1998
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

scientific article published on 7 February 2011
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

scientific article
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

scientific article
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

scientific article
Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

scientific article published on June 1995
Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

scientific article
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

scientific article
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

scientific article
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury

scientific article published on 8 October 2009
Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

scientific article published on 20 October 2008
HIF hydroxylation and cellular oxygen sensing

scientific article
Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

scientific article published in May 2002
Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression.

scientific article published in September 1992
The macrophage - a novel system to deliver gene therapy to pathological hypoxia

scientific article published in February 2000
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

scientific article published in August 2003
Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

scientific article published on February 1996
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

scientific article
The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma

scientific article published in August 2001
First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease

scientific article (publication date: March 2005)
Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

scientific article published on 27 March 2007
Randomised controlled trial of steroid withdrawal in renal transplant recipients receiving triple immunosuppression

scientific article published in The Lancet
Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.

scientific article published on 21 December 2013
Endothelin: an important factor in acute renal failure?

scientific article published on November 1988
Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials

scientific article published on October 2009

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