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List of works by Luigi Fontana

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial

scientific article published on 11 July 2019

8-Iso-PGF2 alpha induces beta 2-integrin-mediated rapid adhesion of human polymorphonuclear neutrophils: a link between oxidative stress and ischemia/reperfusion injury.

scientific article

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

scientific article published on 17 July 2015

A Comparison of Objective Physical Performance Tests and Future Mortality in the Elderly People.

scientific article published on 28 July 2016

A word of caution against excessive protein intake

scientific article published on 14 November 2019

Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease

scientific article

Aging, adiposity, and calorie restriction

scientific article

Aging, lifestyle and dementia

scientific article published on 25 May 2019

Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia.

scientific article published on 23 August 2005

Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being.

scientific article published on 14 May 2016

Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.

scientific article

Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial.

scientific article published in December 2006

Caloric restriction and cellular senescence

scientific article published on 03 November 2018

Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial

scientific article published on June 2008

Caloric restriction in humans

scientific article

Caloric restriction may reverse age-related autonomic decline in humans

scientific article published on 21 May 2012

Caloric restriction: powerful protection for the aging heart and vasculature.

scientific article

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

scientific article

Calorie restriction and cardiometabolic health.

scientific article published on February 2008

Calorie restriction and prevention of age-associated chronic disease.

scientific article

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

scientific article published on 05 June 2013

Calorie restriction in humans: An update.

scientific article

Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution

scientific article published on 26 May 2018

Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial

scientific article published on 27 March 2007

Calorie restriction, endothelial function and blood pressure homeostasis

scientific article published on 01 February 2015

Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: prospective cohort study

scientific article

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

scientific article

Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans

scientific article

Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness

scientific article

Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone

scientific article published on 25 March 2009

Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans

scientific article (publication date: 20 May 2011)

Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy

scientific article published on 06 September 2018

Dietary fiber and health outcomes: an umbrella review of systematic reviews and meta-analyses

scientific article published in March 2018

Dietary protein restriction inhibits tumor growth in human xenograft models

scientific article published on December 2013

Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms

scientific article published on 02 November 2018

Dietary protein, aging and nutritional geometry

scientific article published on 5 March 2017

Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial

scientific article published on 31 August 2015

Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults

scientific article published on 01 December 2006

Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones.

scientific article

Effect of obesity, serum lipoproteins, and apolipoprotein E genotypes on mortality in hospitalized elderly patients.

scientific article

Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial

scientific article

Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial

scientific article published on 9 February 2018

Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength

scientific article published on November 2017

Effects of dietary restriction on gut microbiota and CNS autoimmunity

scientific article published on 18 August 2020

Effects of dietary restriction on neuroinflammation in neurodegenerative diseases

scientific article published on 01 February 2021

Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production

scientific article

Energy efficiency as a unifying principle for human, environmental, and global health

scientific article (publication date: 2013)

Energy requirements in nonobese men and women: results from CALERIE.

scientific article

Excess body weight increases the burden of age-associated chronic diseases and their associated health care expenditures.

scientific article

Excessive adiposity, calorie restriction, and aging

scientific article published on 01 April 2006

Extending healthy life span--from yeast to humans

scientific article

Fasting and cancer treatment in humans: A case series report.

scientific article

Fasting and differential chemotherapy protection in patients

scientific article

Food Poisoning Following Consumption of Clenbuterol-Treated Veal in Italy ⬇️

scientific article published on August 27, 1997

Forkhead-box-O1 locus and metabolic markers in the elderly: an association study

scientific article published on 8 October 2012

Frailty Is Associated with an Increased Risk of Incident Type 2 Diabetes in the Elderly.

scientific article published on 7 June 2016

Fried potato consumption is associated with elevated mortality: an 8-y longitudinal cohort study.

scientific article published on 7 June 2017

Glucose-targeted therapy for subjects with type 2 diabetes mellitus: primum non nocere

scientific article published on 26 July 2017

Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients

Immune-metabolic profiling of anorexic patients reveals an anti-oxidant and anti-inflammatory phenotype

scientific article published on 29 October 2014

Impaired mononuclear cell immune function in extreme obesity is corrected by weight loss.

scientific article

Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

scientific article published in November 2006

In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles

scientific article published on 17 September 2017

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota.

scientific article published in June 2018

Intermittent supplementation with rapamycin as a dietary restriction mimetic.

scientific article published in November 2011

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Interventions to promote cardiometabolic health and slow cardiovascular ageing

scientific article published on 01 September 2018

Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis.

scientific article published on 22 June 2011

LC-N2G: a local consistency approach for nutrigenomics data analysis

scientific article published on 17 November 2020

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

scientific article

Long-term caloric restriction ameliorates the decline in diastolic function in humans.

scientific article

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

scientific article

Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans

scientific article

Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans

scientific article published on August 2008

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

scientific article

Long-term effects of calorie restriction on serum sex-hormone concentrations in men

scientific article

Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk

scientific article published on 01 June 2007

Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk

scientific article

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

scientific article published on 13 July 2016

Low bone mass in subjects on a long-term raw vegetarian diet

scientific article

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

scientific article

Low-protein diet in cancer: ready for prime time?

scientific article published on 01 July 2018

Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss.

scientific article

Meal frequency and timing in health and disease

scientific article

Medical research: treat ageing.

scientific article

Modulating human aging and age-associated diseases.

scientific article

Molecular mechanisms of dietary restriction promoting health and longevity

scientific article published in 2021

Multiple dietary supplements do not affect metabolic and cardio-vascular health

scientific article published on February 2014

Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction

scientific article published on 12 April 2008

One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue

scientific article

Optimal body weight for health and longevity: bridging basic, clinical, and population research

scientific article

Perspective: Improving Nutritional Guidelines for Sustainable Health Policies: Current Status and Perspectives

scientific article

Physical activity, diet quality and all-cause cardiovascular disease and cancer mortality: a prospective study of 346 627 UK Biobank participants

Postprandial plasma incretin hormones in exercise-trained versus untrained subjects.

scientific article

Pre-frailty and risk of cardiovascular disease in elderly men and women: the Pro.V.A. study.

scientific article published on March 2015

Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction

scientific article published on 20 October 2011

Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society

scientific article published on 29 September 2015

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions

scientific article published on 22 December 2016

Promoting health and longevity through diet: from model organisms to humans

scientific article

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.

scientific article

Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition.

scientific article published on 15 November 2010

Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel

scientific article published on September 2015

Renal and Systemic Effects of Calorie Restriction in Patients With Type 2 Diabetes With Abdominal Obesity: A Randomized Controlled Trial.

scientific article published on 15 September 2016

Reply to KA Beals and to C Parks

scientific article published on 01 May 2018

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

scientific article published on 3 September 2015

Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance

scientific article

Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis.

scientific article

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

scientific article published on 01 October 2018

Serum from humans on long-term calorie restriction enhances stress resistance in cell culture

scientific article published on August 2013

Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice.

scientific article published on 7 December 2017

Systemic acid load from the diet affects maximal-exercise RER.

scientific article published on April 2012

The Mediterranean diet: metabolic and molecular mechanisms

scientific article published on 13 December 2017

The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function.

scientific article published on 27 December 2007

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

scientific article published on 25 March 2018

The historical context and scientific legacy of John O. Holloszy

scientific article published on 07 February 2019

The science of nutritional modulation of aging

scientific article published in October 2017

The scientific basis of caloric restriction leading to longer life.

scientific article published on March 2009

Transdisciplinary research and clinical priorities for better health

scientific article published in 2021

Translational approaches to addressing complex genetic pathways in colorectal cancer.

scientific article

Trends in age-related disease burden and healthcare utilization

scientific article published on 29 November 2018

Vascular adhesion molecule-1 and markers of platelet function before and after a treatment with iloprost or a supervised physical exercise program in patients with peripheral arterial disease.

scientific article published in June 2001

Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease

scientific article published on 25 July 2023

Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans

scientific article published on 07 February 2007

Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis.

scientific article published on 24 November 2016

What are the roles of calorie restriction and diet quality in promoting healthy longevity?

scientific article

Will calorie restriction work in humans?

scientific article

[Nutrition, adiposity and health]

scientific article published on 01 September 2007

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