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List of works by Renger Witkamp

17α-Ethyl-5β-estrane-3α,17β-diol, a biological marker for the abuse of norethandrolone and ethylestrenol in slaughter cattle

scientific article published on 01 May 1999

26th Hohenheim Consensus Conference, September 11, 2010 Scientific substantiation of health claims: evidence-based nutrition

scientific article

A 2 Week Cross-over Intervention with a Low Carbohydrate, High Fat Diet Compared to a High Carbohydrate Diet Attenuates Exercise-Induced Cortisol Response, but Not the Reduction of Exercise Capacity, in Recreational Athletes

scientific article published on 06 January 2021

A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice

scientific article published on 09 October 2019

A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line.

scientific article published in April 2004

A standardised approach towards PROving the efficacy of foods and food constituents for health CLAIMs (PROCLAIM): providing guidance

article

Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice

scientific article published on 4 January 2010

Adaptation of exercise-induced stress in well-trained healthy young men.

scientific article published on 3 November 2016

Alterations in total and high-molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women

scientific article published on 24 February 2011

Analysis of Omega-3 Fatty Acid Derived N-Acylethanolamines in Biological Matrices.

scientific article published on January 2016

Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model

scientific article published on 15 July 2019

Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study

scientific article

Associations of hyperosmolar medications administered via nasogastric or nasoduodenal tubes and feeding adequacy, food intolerance and gastrointestinal complications amongst critically ill patients: A retrospective study

scientific article published on 17 April 2018

Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice

scientific article

Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages.

scientific article

Beta-blocker use and fall risk in older individuals: Original results from two studies with meta-analysis

scientific article published on 07 June 2017

Bovine colostrum supplementation's lack of effect on immune variables during short-term intense exercise in well-trained athletes

scientific article published on 01 April 2011

CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis.

scientific article published on 23 November 2016

Calcium Imaging of GPCR Activation Using Arrays of Reverse Transfected HEK293 Cells in a Microfluidic System.

scientific article published on 16 February 2018

Capsaicin Analogues Derived from n-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro.

scientific article published on 24 April 2019

Characterization of anti-inflammatory compounds using transcriptomics, proteomics, and metabolomics in combination with multivariate data analysis.

scientific article published in November 2004

Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes

scientific article published in December 1998

Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy.

scientific article published on 15 November 2014

Cocultures of porcine hepatocytes and kupffer cells as an improvedin vitromodel for the study of hepatotoxic compounds

scientific article published on 01 January 2000

Commentary: "A systems view on the future of medicine: inspiration from Chinese medicine?".

scientific article

Comparative analyses of seeds of wild fruits of Rubus and Sambucus species from Southern Italy: fatty acid composition of the oil, total phenolic content, antioxidant and anti-inflammatory properties of the methanolic extracts

scientific article published on 15 November 2012

Comparative aspects and sex differentiation of plasma sulfamethazine elimination and metabolite formation in rats, rabbits, dwarf goats, and cattle

scientific article published on October 1, 1992

Comparison of conventional immunoassays and the oestrogen radioreceptor assay for screening for the presence of oestrogenic anabolic compounds in urine samples†

scientific article published on 01 December 1998

Congener specific PCB and polychlorinated camphene (toxaphene) levels in Svalbard ringed seals (Phoca hispida) in relation to sex, age, condition and cytochrome P450 enzyme activity

scientific article published in May 1998

Cross-species comparison of genes related to nutrient sensing mechanisms expressed along the intestine

scientific article

Current and Future Drug Targets in Weight Management ⬇️

scientific article published on December 23, 2010

Cytochrome P4502E in vivo and in vitro in the dwarf goat: effects of enzyme induction and the applicability of chlorzoxazone as marker substrate

scientific article published on 01 June 1996

Cytochromes and cytokines: changes in drug disposition in animals during an acute phase response: a mini-review

scientific article

DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial

scientific article published in 2022

Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores within Hours-Potential Consequences for Monitoring and Supplementation

scientific article published on 20 December 2016

Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins.

scientific article published on 11 November 2016

Development and validation of a quantitative method for the determination of 12 endocannabinoids and related compounds in human plasma using liquid chromatography–tandem mass spectrometry

article

Development of an Androgen Reporter Gene Assay (AR-LUX) Utilizing a Human Cell Line with an Endogenously Regulated Androgen Receptor ⬇️

scientific article published on November 1, 2001

Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling

scientific article

Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome p450

scientific article published on 01 October 1996

Differential effects of pentoxifylline on the hepatic inflammatory response in porcine liver cell cultures. Increase in inducible nitric oxide synthase expression

scientific article published in May 2001

Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activityin vitro, and correlation with som e m olecular descriptors in the dwarf goat (Caprus hircus aegagrus)

Direct cell-to-cell contact between Kupffer cells and hepatocytes augments endotoxin-induced hepatic injury

scientific article published on 01 April 2001

Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties.

scientific article published on 27 June 2010

Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue.

scientific article published on 16 May 2017

Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages

scientific article published on 20 September 2016

Dose-dependent pharmacokinetic interaction between antipyrine and paracetamol in vivo and in vitro when administered as a cocktail in pig

scientific article published on 01 April 1994

Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyrine in the dwarf goat

scientific article published on 01 June 1993

Effects of Ehrlichia phagocytophila infection on serum thyroid hormone concentrations and on antipyrine clearance and metabolite formation in dwarf goats

scientific article published on 01 August 1992

Effects of long- and short-chain fatty acids on the release of gastrointestinal hormones using an ex vivo porcine intestinal tissue model

article

Effects of mood inductions by meal ambiance and moderate alcohol consumption on endocannabinoids and N-acylethanolamines in humans: a randomized crossover trial

scientific article published on 11 May 2015

Effects of triiodothyronine treatment on pharmacokinetic properties and metabolite formation of antipyrine in dwarf goats

scientific article published on 01 August 1992

Endotoxin-induced liver damage in rats is minimized by beta 2-adrenoceptor stimulation

scientific article published on 16 February 2004

Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans

scientific article published on 21 January 2017

Explorative Placebo-Controlled Double-Blind Intervention Study with Low Doses of Inhaled Δ9-Tetrahydrocannabinol and Cannabidiol Reveals No Effect on Sweet Taste Intensity Perception and Liking in Humans

scientific article published on June 2017

Fatty acids, endocannabinoids and inflammation.

scientific article

Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence

scientific article published on 31 August 2018

Fish oil LC-PUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition.

scientific article published on 29 March 2017

Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues

scientific article

Genomics and systems biology--how relevant are the developments to veterinary pharmacology, toxicology and therapeutics?

scientific article

High-performance liquid chromatographic method for the routine determination of sulphadimidine, its hydroxy metabolites and N4-acetylsulphadimidine in body fluids and cell culture media ⬇️

scientific article published on November 15, 1991

Hormonal regulation of oxidative drug metabolism in the dwarf goat. The effect of sex and hormonal treatment on plasma disposition and metabolite formation of sulphadimidine.

scientific article published in March 1993

Hypothalamic food intake regulation in a cancer-cachectic mouse model.

scientific article published on 13 November 2013

Hypothalamic inflammation and food intake regulation during chronic illness

scientific article published on 06 July 2015

Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products

scientific article published on 06 December 2018

Identification of some important metabolites of boldenone in urine and feces of cattle by gas chromatography-mass spectrometry†

scientific article published on 01 December 1998

In Vitro Anti-Inflammatory and Radical Scavenging Properties of Chinotto (Citrus myrtifolia Raf.) Essential Oils.

scientific article published on 18 June 2018

In search of secreted protein biomarkers for the anti-inflammatory effect of beta2-adrenergic receptor agonists: application of DIGE technology in combination with multivariate and univariate data analysis tools.

scientific article

In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): Substrate activities and effects of inducers

scientific article published on 01 November 1996

In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle

scientific article published on February 1999

In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle†

scientific article published on 01 December 1998

Increased hypothalamic serotonin turnover in inflammation-induced anorexia

scientific article

Increasing quality of life in pulmonary arterial hypertension: is there a role for nutrition?

scientific article published on 01 September 2018

Infection (Actinobacillus pleuropneumoniae)-mediated suppression of oxidative hepatic drug metabolism and cytochrome P4503A mRNA levels in pigs

scientific article published on 01 January 1995

Inflammation Is a Mediating Factor in the Association between Lifestyle and Fatigue in Colorectal Cancer Patients

scientific article published on 09 December 2020

Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages

scientific article published on 23 September 2014

Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.

scientific article published on December 1996

Inhibitory effects of the beta-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-alpha in vitro and in vivo

scientific article

Intraileal casein infusion increases plasma concentrations of amino acids in humans: A randomized cross over trial

scientific article published on 29 January 2016

Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells

scientific article

Let thy food be thy medicine….when possible

scientific article published on 21 June 2018

Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice

scientific article (publication date: 2012)

Liquid chromatography-tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells

scientific article published on 29 November 2012

Macronutrient Intakes in 553 Dutch Elite and Sub-Elite Endurance, Team, and Strength Athletes: Does Intake Differ between Sport Disciplines?

scientific article published on 10 February 2017

Measurement of palmitoylethanolamide and other N-acylethanolamines during physiological and pathological conditions.

scientific article published on February 2013

Medication-related fall incidents in an older, ambulant population: the B-PROOF study

scientific article published on December 2014

Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme-inducing agents phenobarbital, troleandomycin and rifampicin

scientific article

Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology

scientific article

Micronutrient Intakes in 553 Dutch Elite and Sub-Elite Athletes: Prevalence of Low and High Intakes in Users and Non-Users of Nutritional Supplements

scientific article published on 15 February 2017

Moderate alcohol consumption after a mental stressor attenuates the endocrine stress response

scientific article published on 11 October 2016

Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolism in men

article

Moderate alcohol consumption stimulates food intake and food reward of savoury foods

scientific article published on 28 January 2015

Modulating Tumor-Associated Macrophage Polarization by Synthetic and Natural PPARγ Ligands as a Potential Target in Breast Cancer

scientific article published on 10 January 2020

Multi-detector computed tomography and 3-dimensional imaging in a multi-vendor picture archiving and communications systems (PACS) environment1

scientific article published on 01 June 2004

N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads

scientific article

N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2.

scientific article published on 6 December 2016

N-Eicosapentaenoyl Dopamine, A Conjugate of Dopamine and Eicosapentaenoic Acid (EPA), Exerts Anti-inflammatory Properties in Mouse and Human Macrophages

scientific article published on 18 September 2019

Novel COX-2 products of n-3 polyunsaturated fatty acid-ethanolamine-conjugates identified in RAW264.7 macrophages

scientific article published on 27 August 2019

Nutrient Intake by Ultramarathon Runners: Can They Meet Recommendations?

scientific article published on 26 March 2015

Nutrient-induced glucagon like peptide-1 release is modulated by serotonin

scientific article published on 29 March 2016

Nutrition to Optimise Human Health—How to Obtain Physiological Substantiation?

scientific article published in 2021

Nutritional Supplement Use by Dutch Elite and Sub-Elite Athletes: Does Receiving Dietary Counseling Make a Difference?

scientific article published on 6 September 2016

Optimal nutrition and the ever-changing dietary landscape: a conference report

scientific article

Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats

scientific article published on 01 May 1995

Oral bioavailability of sulphamethoxydiazine, sulphathiazole and sulphamoxole in dwarf goats

scientific article published on 01 March 1994

Oral bioavailability of sulphonamides in ruminants: A comparison between sulphamethoxazole, sulphatroxazole, and sulphamerazine, using the dwarf goat as animal model

article

Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold

scientific article

Participation of β-Adrenergic Receptors on Macrophages in Modulation of LPS-Induced Cytokine Release

scientific article published on 01 January 1999

Pharma-nutrition interface: the gap is narrowing

scientific article

Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women

scientific article

Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men

scientific article published on 28 September 2018

Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract.

scientific article

Public health relevance of drug-nutrition interactions.

scientific article

Regioselective O-demethylation of scoparone (6,7-dimethoxycoumarin) to assess cytochrome P450 activities in vitro in rat. Effects of gonadal steroids and the involvement of constitutive P450 enzymes

scientific article published on 01 April 1993

Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions-Ara h2 and Ara h6 Are Readily Bio-Accessible

scientific article published on 11 September 2018

Review article: the role of gastrointestinal hormones in the treatment of delayed gastric emptying in critically ill patients

scientific article published on 23 July 2013

Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig

scientific article published on 01 May 1995

Self-Reported Use and Reasons among the General Population for Using Sports Nutrition Products and Dietary Supplements.

scientific article

Short-term oral exposure to white wine transiently lowers serum free fatty acids

scientific article published on 11 May 2010

Signal transduction in inflammatory processes, current and future therapeutic targets: a mini review.

scientific article

Species- and sex-related differences in the plasma clearance and metabolite formation of antipyrine. A comparative study in four animal species: Cattle, goat, rat and rabbit

article

Stereoselectivity at the β 2 -adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of β 2 -agonists

scientific article published on 01 August 2000

Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model

article

Sulfamethazine as a model compound to assess sex hormone-dependent cytochrome P-450 activity in rats

scientific article published on 01 May 1993

Suppression of Cytochrome P450- and UDP Glucuronosyl Transferase-Dependent Enzyme Activities by Proinflammatory Cytokines and Possible Role of Nitric Oxide in Primary Cultures of Pig Hepatocytes

article

Suppression of the acute inflammatory response of porcine alveolar‐ and liver macrophages

article

The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine

scientific article published on 26 October 2016

The Pig as a Model for Studying AH Receptor and Other PAH-Binding Proteins In Man

article

The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Studies in primary hepatocyte cultures and liver microsomes of the pig ⬇️

scientific article published on May 1, 1995

The association between drugs frequently used by the elderly and vitamin D blood levels: a review of observational and experimental studies

scientific article published on February 2014

The beta-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-alpha and IL-6 in vitro and in vivo

scientific article published on September 1999

The biphasic effects of moderate alcohol consumption with a meal on ambiance-induced mood and autonomic nervous system balance: a randomized crossover trial

scientific article published on 21 January 2014

The effect of endurance exercise on intestinal integrity in well-trained healthy men.

scientific article

The effect of sulfaphenazole and sulfadoxine on tolbutamide disposition in dwarf goats (Caprus hircus aegagrus)

scientific article published on 01 November 1997

The endocannabinoid system and appetite: relevance for food reward

scientific article

The endocannabinoid system: an emerging key player in inflammation

scientific article published on March 2014

The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation

scientific article published on 4 February 2011

The preparation, solubilisation and binding characteristics of a beta 2-adrenoceptor isolated from transfected Chinese hamster cells

scientific article published on April 2001

The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol

scientific article

The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite

scientific article published on 8 January 2018

The role of hypothalamic inflammation, the hypothalamic-pituitary-adrenal axis and serotonin in the cancer anorexia-cachexia syndrome.

scientific article

The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation

scientific article published on 28 June 2019

Tiamulin inhibits human CYP3A4 activity in an NIH/3T3 cell line stably expressing CYP3A4 cDNA.

scientific article

Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig

scientific article published on 01 August 1994

Time-dependent effect of in vivo inflammation on eicosanoid and endocannabinoid levels in plasma, liver, ileum and adipose tissue in C57BL/6 mice fed a fish-oil diet

scientific article published on 09 April 2012

Tolerability and safety of Souvenaid in patients with mild Alzheimer's disease: results of multi-center, 24-week, open-label extension study

scientific article published on January 2015

Transfer of polychlorinated biphenyls and chlorinated pesticides from mother to pup in relation to cytochrome P450 enzyme activities in harp seals (Phoca groenlandica) from the gulf of St. Lawrence, Canada

scientific article published in January 2002

Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways.

scientific article

Validation of web-based, multiple 24-h recalls combined with nutritional supplement intake questionnaires against nitrogen excretions to determine protein intake in Dutch elite athletes

scientific article published on 05 October 2015

Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients.

scientific article published on 12 February 2016

Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies

scientific article published on 22 September 2015

Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe.

scientific article published on 11 December 2012

Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes

scientific article

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