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List of works by Veit Hornung

5'-Triphosphate RNA is the ligand for RIG-I

scientific article (publication date: 10 November 2006)

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

scientific article

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

scientific article

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

scientific article published on 9 November 2015

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

scientific article

A mammalian microRNA expression atlas based on small RNA library sequencing

scientific article

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

scientific article published on 26 June 2015

AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice

scientific article published on 22 July 2019

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

scientific article

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

scientific article published on 26 November 2015

ATP-dependent effector-like functions of RIG-I-like receptors

scientific article

Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum

scholarly article by Frank Surup et al published 5 September 2018 in ACS Chemical Biology

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

article

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

scientific article

Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference

scientific article

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances.

scientific article published on 26 August 2016

Alternative inflammasome activation enables IL-1β release from living cells

scientific article published on 11 November 2016

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.

scientific article published on 2 June 2016

An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?

scientific article published on 27 July 2021

An unexpected role for RNA in the recognition of DNA by the innate immune system

scientific article published on 28 March 2010

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

scientific article published on 12 June 2014

Author Correction: AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice

scientific article published on 21 February 2020

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages

scientific article published on 01 November 2018

Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids

scientific article published on January 2007

BrowserGenome.org: web-based RNA-seq data analysis and visualization

scientific article published on October 2015

C-tag TNF: a reporter system to study TNF shedding

scientific article published on 20 October 2020

CARD8 inflammasome activation triggers pyroptosis in human T cells

scientific article published on 25 August 2020

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

scientific article published on 28 July 2016

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

scientific article published on 14 July 2015

Cell cycle effects of radiation on human bronchial epithelium and lung carcinoma cells in monolayer cultures and a three-dimensional co-culture system.

scientific article published on October 2005

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

scientific article

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

scientific article published on 20 October 2014

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.

scientific article published on 05 January 2016

Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons

scientific article

Correction: AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

scientific article published in PLoS ONE

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

scientific article published on 2 March 2016

Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

article

CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells

scientific article published in August 2005

CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro

article

Cre-dependent DNA recombination activates a STING-dependent innate immune response

scientific article published on 10 May 2016

Critical functions of priming and lysosomal damage for NLRP3 activation

scientific article published on March 2010

Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair

scientific article published on 13 July 2011

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

scientific article (publication date: 15 July 2009)

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

scientific article

Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms

scientific article published on 3 September 2014

Cyclic Dinucleotides in the Scope of the Mammalian Immune System

scientific article published on 9 February 2017

Cytoplasmic RNA Sensor Pathways and Nitazoxanide Broadly Inhibit Intracellular Mycobacterium tuberculosis Growth

scientific article published on 06 November 2019

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions

scientific article

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

scientific article published on 23 December 2019

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

scientific article

DNA sensing unchained

scientific article published on 19 February 2013

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

scientific article published on 01 March 2019

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

scientific article published on 26 June 2015

Designer Nuclease-Mediated Generation of Knockout THP1 Cells.

scientific article published on January 2016

Enzymatic synthesis and purification of a defined RIG-I ligand

scientific article published on January 2014

Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

scientific article published in Nature

Evidence for increased SARS-CoV-2 susceptibility and COVID-19 severity related to pre-existing immunity to seasonal coronaviruses

publication published on 07 December 2021

Extracorporeal photopheresis promotes IL-1β production

scientific article published on 13 February 2015

Fourth defence molecule completes antiviral line-up

scientific article published on 13 May 2020

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.

scientific article published on 4 December 2017

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

scientific article

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.

scientific article

Genome Replication Is Associated With Release of Immunogenic DNA Waste

scientific article published on 11 May 2022

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

scientific article published on July 2016

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

scientific article published on 15 March 2016

Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes

scientific article published on 29 May 2020

Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis

scientific article published on 03 June 2019

Human Monocytes Engage an Alternative Inflammasome Pathway

scientific article published on 28 March 2016

Human NLRP1 is a sensor for double-stranded RNA

scientific article published on 26 November 2020

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

scientific article published on 27 December 2018

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA.

scientific article

Human plasmacytoid dentritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway.

scientific article

ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.

scientific article published in November 2017

IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network

scientific article published in 2022

IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

scientific article published on 25 June 2019

Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3

scientific article published on 24 May 2019

Immunoblotting for active caspase-1.

scientific article published in January 2013

Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation

scientific article

Immunostimulatory RNA Blocks Suppression by Regulatory T Cells

scientific article published on 04 December 2009

Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7.

scientific article

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response

scientific article published in April 2007

Induction of type I IFNs by intracellular DNA-sensing pathways

scientific article published on 27 March 2012

Inflammasome-Dependent Induction of Adaptive NK Cell Memory

scientific article published on 6 June 2016

Inflammasomes: current understanding and open questions

scientific article published on 31 October 2010

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

scientific article published on 19 February 2016

Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.

scientific article

Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus

scientific article published on May 2005

Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells

scientific article published on 26 November 2019

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

scientific article published on 26 September 2018

Intracellular DNA recognition

scientific article published on February 2010

Irgm2 and Gate-16 put a break on non-canonical inflammasome activation

scientific article published on 01 November 2020

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

scientific article published on 06 May 2019

Ligation-independent cloning (LIC) assembly of TALEN genes.

scientific article published in January 2015

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

scientific article published on June 2010

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment

scientific article

MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction

scientific article published on 25 March 2016

Measuring IL-1β Processing by Bioluminescence Sensors II: The iGLuc System

scientific article

Mitochondrial dsRNA: A New DAMP for MDA5

scientific article published on 01 September 2018

Modeling Primary Human Monocytes with the Trans-Differentiation Cell Line BLaER1.

scientific article

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

scientific article

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1

scientific article published on 10 April 2022

Molecular mechanisms and cellular functions of cGAS-STING signalling

scientific article published on 18 May 2020

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

scientific article published on 2 June 2015

NLRP3 inflammasome activity is negatively controlled by miR-223.

scientific article

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

scientific article (publication date: 29 April 2010)

NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR

scientific article published on 27 April 2016

New Approaches for Absolute Quantification of Stable-Isotope-Labeled Peptide Standards for Targeted Proteomics based on a UV Active Tag

scientific article published on 08 April 2020

No indication for a defect in toll-like receptor signaling in patients with hyper-IgE syndrome

scientific article published in July 2005

Nucleic acid driven sterile inflammation

scientific article published on 19 January 2013

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

scientific article published on 18 July 2014

Of inflammasomes and pathogens--sensing of microbes by the inflammasome

scientific article

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines

scientific article published on 3 September 2014

Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling

scientific article published on 18 October 2021

Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation

scientific article published in September 2022

Phosphorylation of murine SAMHD1 regulates its antiretroviral activity

scientific article

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

scientific article

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help

scientific article

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

scientific article

Pore formation by GSDMD is the effector mechanism of pyroptosis

scientific article published on 29 August 2016

Postoperative ileus involves interleukin-1 receptor signaling in enteric glia

scientific article published on 22 September 2013

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

scientific article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.

scientific article published in October 2017

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

scientific article

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation

scientific article

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells

scientific article

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

scientific article

RNA recognition via TLR7 and TLR8.

scientific article published on January 2008

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4<sup>+</sup> T cells allows complex functional analyses

scientific article published on 23 December 2021

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

scientific article

Recognition of Endogenous Nucleic Acids by the Innate Immune System

scientific article published on April 2016

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

scientific article

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes

scientific article published on 26 June 2020

Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus

scientific article published on November 2004

Retroviral danger from within: TLR7 is in control

scientific article published on 01 November 2012

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

scientific article

STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.

scientific article published on 14 October 2016

STING Signaling the enERGIC Way

scientific article published on 01 August 2015

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

scientific article

Self-priming determines high type I IFN production by plasmacytoid dendritic cells

scientific article published on 16 January 2014

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

scientific article

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

scientific article

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

scientific article

SnapShot: Nucleic acid immune sensors, part 2.

scientific article published on December 2014

SnapShot: nucleic acid immune sensors, part 1.

scientific article published on 20 November 2014

Sox2 as a servant of two masters

scientific article published on 01 April 2015

Species-specific detection of the antiviral small-molecule compound CMA by STING

scientific article

Spontaneous Formation of Nucleic Acid-based Nanoparticles Is Responsible for High Interferon-α Induction by CpG-A in Plasmacytoid Dendritic Cells

scientific article published in Journal of Biological Chemistry

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling

scientific article published on 29 April 2015

Structural basis for sequestration and autoinhibition of cGAS by chromatin

scientific article published on 10 September 2020

Structural mechanism of cytosolic DNA sensing by cGAS

scientific article

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

scientific article

Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling.

scientific article

Suppression of intratumoral CCL22 by type i interferon inhibits migration of regulatory T cells and blocks cancer progression.

scientific article published on 2 October 2015

Synthesis of an arrayed sgRNA library targeting the human genome.

scientific article published on 8 October 2015

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes

scientific article published on June 2006

TLR2 joins the interferon gang

scientific article published on 01 November 2009

TLR8 Is a Sensor of RNase T2 Degradation Products

scientific article published on 01 November 2019

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.

scientific article

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

scientific article published on 9 May 2014

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

scientific article (publication date: May 2010)

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

scientific article

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

scientific article (publication date: August 2008)

The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory

scientific article published in December 2017

The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation

scientific article published on 26 March 2020

The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils.

scientific article published on 19 January 2012

The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.

scientific article published on 20 September 2017

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.

scientific article

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists

scientific article published on 19 December 2018

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

scientific article published on 01 October 2001

Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif

scientific article published on 21 January 2009

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.

scientific article

VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites

scientific article published on 01 March 2018

Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses

scientific article published on 01 December 2008

Warfarin and vitamin K compete for binding to Phe55 in human VKOR.

scientific article published on 12 December 2016

Where, in antiviral defense, does IFIT1 fit?

scientific article published on 20 June 2011

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome

scientific article published on 15 July 2022

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

scientific article

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

scientific article

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

scientific article published on 13 September 2017

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites

scientific article published on October 2016

iGLuc: a luciferase-based inflammasome and protease activity reporter

scientific article

siRNA and isRNA: two edges of one sword

scientific article published on 31 July 2006

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