List of works - Veit Hornung

A mammalian microRNA expression atlas based on small RNA library sequencing

scientific article

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

scientific article

5'-Triphosphate RNA is the ligand for RIG-I

scientific article (publication date: 10 November 2006)

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

scientific article (publication date: 29 April 2010)

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

scientific article

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

scientific article (publication date: August 2008)

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

scientific article

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

scientific article (publication date: 15 July 2009)

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

scientific article (publication date: May 2010)

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

scientific article

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

scientific article

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

scientific article

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

scientific article

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

scientific article published on 01 October 2001

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

scientific article

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

scientific article

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

scientific article

Intracellular DNA recognition

scientific article published on February 2010

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

scientific article

Structural mechanism of cytosolic DNA sensing by cGAS

scientific article

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

scientific article

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

scientific article

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

scientific article

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

scientific article published on 2 June 2015

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions

scientific article

Human Monocytes Engage an Alternative Inflammasome Pathway

scientific article published on 28 March 2016

Inflammasomes: current understanding and open questions

scientific article published on 31 October 2010

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

scientific article published on June 2010

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

scientific article

Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus

scientific article published on May 2005

Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling

scientific article

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help

scientific article

NLRP3 inflammasome activity is negatively controlled by miR-223.

scientific article

Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus

scientific article published on November 2004

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

scientific article

Critical functions of priming and lysosomal damage for NLRP3 activation

scientific article published on March 2010

Recognition of Endogenous Nucleic Acids by the Innate Immune System

scientific article published on April 2016

siRNA and isRNA: two edges of one sword

scientific article published on 31 July 2006

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

scientific article published on 9 November 2015

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

scientific article published on 18 July 2014

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

scientific article published on 12 June 2014

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

scientific article published on 9 May 2014

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

scientific article

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

scientific article

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

article

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

scientific article published on 14 July 2015

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

scientific article

Spontaneous Formation of Nucleic Acid-based Nanoparticles Is Responsible for High Interferon-α Induction by CpG-A in Plasmacytoid Dendritic Cells

scientific article published in Journal of Biological Chemistry

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

scientific article

Of inflammasomes and pathogens--sensing of microbes by the inflammasome

scientific article

List of works by Veit Hornung

A mammalian microRNA expression atlas based on small RNA library sequencing

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

5'-Triphosphate RNA is the ligand for RIG-I

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Intracellular DNA recognition

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

Structural mechanism of cytosolic DNA sensing by cGAS

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions

Human Monocytes Engage an Alternative Inflammasome Pathway

Inflammasomes: current understanding and open questions

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus

Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help

NLRP3 inflammasome activity is negatively controlled by miR-223.

Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

Critical functions of priming and lysosomal damage for NLRP3 activation

Recognition of Endogenous Nucleic Acids by the Innate Immune System

siRNA and isRNA: two edges of one sword

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Spontaneous Formation of Nucleic Acid-based Nanoparticles Is Responsible for High Interferon-α Induction by CpG-A in Plasmacytoid Dendritic Cells

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

Of inflammasomes and pathogens--sensing of microbes by the inflammasome