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List of works by David M. Sabatini

A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

scientific article

A CRISPR screen identifies a pathway required for paraquat-induced cell death

scientific article published on 23 October 2017

A Central role for mTOR in lipid homeostasis

scientific article published on 22 August 2013

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion

scientific article published on 01 May 2020

A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells

scientific article published on 28 April 2020

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

scientific article

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

scientific article

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

scientific article

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.

scientific article

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

scientific article

A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

scientific article published on 20 January 2020

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

scientific article (publication date: 24 March 2006)

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

scientific article

A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.

scientific article published on 20 December 2017

A radical role for TOR in longevity.

scientific article published on June 2011

A unifying model for mTORC1-mediated regulation of mRNA translation.

scientific article

AMPK and p53 help cells through lean times.

scientific article

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

scientific article published on 01 May 2020

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

scientific article

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

scientific article published on August 2016

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib

scientific article

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program

scientific article published on 09 May 2019

Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells

scientific article published on 20 March 2017

Amino acids and mTORC1: from lysosomes to disease

scientific article

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

scientific article published in July 2015

An emerging role of mTOR in lipid biosynthesis.

scientific article published on December 2009

An expanding role for mTOR in cancer

scientific article

An interview with David Sabatini ⬇️

scientific article published on June 11, 2013

Applications of transfected cell microarrays in high-throughput drug discovery.

scientific article

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

scientific article published on 01 October 2019

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes

scientific article published on 28 March 2018

Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases

scientific article published on 16 January 2019

Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

scientific article published on 01 February 2020

Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells

scientific article published on 21 July 2020

Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

scientific article published in Nature

Author Correction: Tumours with PI3K activation are resistant to dietary restriction

scientific article published on 01 May 2020

Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease

scientific article published on 01 April 2020

Building mammalian signalling pathways with RNAi screens

scientific article

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

scientific article published on 28 July 2019

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

scientific article published on 05 June 2013

Cancer cell metabolism: Warburg and beyond

scientific article

Cancer cell metabolism: one hallmark, many faces.

scientific article published on 25 September 2012

Cell biology. The TASCC of secretion

scientific article published on May 2011

Cell biology: The TORC1 pathway to protein destruction.

scientific article published on 27 July 2016

Cell microarrays and RNA interference chip away at gene function

scientific article

Cell-biological applications of transfected-cell microarrays

scientific article

CellProfiler Analyst: data exploration and analysis software for complex image-based screens

scientific article

CellProfiler: free, versatile software for automated biological image analysis

scientific article published in January 2007

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

scientific article

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

scientific article published on 22 February 2013

Cooperative nutrient accumulation sustains growth of mammalian cells.

scientific article

Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

scientific article published on 08 April 2020

Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

scientific article published on 28 February 2020

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

scientific article

Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex

scientific article published on 06 November 2019

DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

scientific article

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

scientific article

DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation

scientific article published on 17 August 2018

Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.

scientific article published on May 2011

Defining the role of mTOR in cancer

scientific article (publication date: July 2007)

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

scientific article (publication date: October 2014)

Development of ATP-competitive mTOR inhibitors

scientific article published on January 2012

Dietary and metabolic control of stem cell function in physiology and cancer

scientific article published on March 2014

Dietary modifications for enhanced cancer therapy

scientific article published on 25 March 2020

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition

scientific article

Dihydroxyacetone phosphate signals glucose availability to mTORC1

scientific article published on 27 July 2020

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

scientific article published on 27 February 2018

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability.

scientific article published on 7 May 2011

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

scientific article

Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

scientific article published on 15 February 2011

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.

scientific article published on 19 August 2015

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

scientific article published on 20 October 2016

Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

scientific article

Erratum: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

scholarly article published in Nature Genetics

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse ⬇️

scientific article published on November 13, 2001

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

scientific article published on 01 May 2018

Fumarate is a terminal electron acceptor in the mammalian electron transport chain

scientific article published on 3 December 2021

Functional genomics identifies TOR-regulated genes that control growth and division

scientific article published on May 2006

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

scientific article

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

scientific article

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

scientific journal article

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

scientific article published on February 2017

Genetic screens in human cells using the CRISPR-Cas9 system

scientific article (publication date: 3 January 2014)

Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines

scientific article published on 01 January 2019

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling

scientific article

Genome-scale loss-of-function screening with a lentiviral RNAi library

scientific article published in September 2006

Genome-wide CRISPR screen for Zika virus resistance in human neural cells

scientific article published on 24 April 2019

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

scientific article published on 26 January 2021

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.

scientific article published in June 2017

Growth control and metabolism.

scientific article published in June 2012

Growth signaling at the nexus of stem cell life and death

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

scientific article

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

scientific article published on March 2016

High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target

scientific article

Highly parallel identification of essential genes in cancer cells

scholarly article

Histidine catabolism is a major determinant of methotrexate sensitivity

scientific article published in Nature

Huntingtin aggregates ask to be eaten.

scientific article

Identification and characterization of essential genes in the human genome.

scientific article

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.

scientific article

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.

scientific article

Identification of an oncogenic RAB protein

scientific article published on 3 September 2015

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux

scientific journal article

Immunophilins and nervous system ⬇️

scientific article published on January 1, 1995

Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition

scientific article published on 17 June 2020

Increased mTORC1 signaling UPRegulates stress

scientific article published on 01 March 2008

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

scientific article

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

scientific article (publication date: 14 May 1999)

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

scientific article published in November 2017

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

scientific article

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

scientific journal article

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

scientific article published on 5 January 2012

Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens

scientific article

Lentivirus-delivered stable gene silencing by RNAi in primary cells

scientific article published on April 2003

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

scientific article published on 22 June 2020

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

scientific article published on 16 June 2021

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

scientific article published on 16 June 2016

Loss of hepatic DEPTOR alters the metabolic transition to fasting

scientific article

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes.

scientific article published on 26 October 2017

MCART1/SLC25A51 is required for mitochondrial NAD transport

scientific article published on 21 October 2020

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

scientific article

MERAV: a tool for comparing gene expression across human tissues and cell types

scientific article

MFSD12 mediates the import of cysteine into melanosomes and lysosomes

scientific article published on 18 November 2020

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo

scientific article published on 12 December 2018

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

scientific article

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

scientific article published on 8 December 2015

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

scientific article

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

scientific article published on 04 November 2020

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

scientific article

MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma

scientific article

Microarrays of lentiviruses for gene function screens in immortalized and primary cells

scientific article published on February 2006

Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens.

scholarly article

Minimizing the risk of reporting false positives in large-scale RNAi screens

article

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

scientific article published on 11 May 2016

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

scientific journal article

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

scientific article published on 22 November 2017

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

scientific article published on 26 April 2018

Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes

scientific article

Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton

scientific article

Neural actions of immunophilin ligands.

scientific article published on January 1998

Neural roles of immunophilins and their ligands ⬇️

scientific article published on October 1, 1997

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

scientific article published on 10 July 2019

Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance

scientific article published on 01 January 2020

Nutrient regulation of mTORC1 at a glance

scientific article published on 13 November 2019

Nutrient-sensing mechanisms across evolution

scientific article

Nutrient-sensing mechanisms and pathways.

scientific article

Nutrients and growth factors in mTORC1 activation ⬇️

scientific article published on August 1, 2013

Off-target effects associated with long dsRNAs in Drosophila RNAi screens

scientific article published on 9 March 2007

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

scientific article published on 10 April 2017

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

scientific article

Pharmacologic Means of Extending Lifespan.

scientific article

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

scientific article

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

scientific article

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c

scientific article

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

scientific article

Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.

scientific article published on 29 May 2013

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

scientific article published on 21 November 2018

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

scientific article

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

scientific article

RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells.

scientific article

Rag proteins regulate amino-acid-induced mTORC1 signalling.

scientific article

RagA, but not RagB, is essential for embryonic development and adult mice

scientific article

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

scientific article published on 04 September 2018

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

scientific article

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

scientific article

Rapalogs and mTOR inhibitors as anti-aging therapeutics

scientific article

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

scientific article published on 19 December 2006

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance ⬇️

scientific article published on July 1, 2013

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

scientific article

Rapamycin inhibits mTORC1, but not completely.

scientific article published on 22 July 2009

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

scientific article

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

scientific article published on 29 September 2017

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

scientific article published on 21 December 2015

Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex

scientific article

Regulation of growth and metabolism.

scientific article published on 28 May 2014

Regulation of mTORC1 and its impact on gene expression at a glance

scientific article

Regulation of mTORC1 by amino acids

scientific article

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

scientific article published on 23 December 2012

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress ⬇️

scientific article (publication date: 22 October 2010)

Response and acquired resistance to everolimus in anaplastic thyroid cancer

scientific article

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

scientific article

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

scientific article

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.

scientific article

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

scientific article

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

scientific article

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

scientific article

Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae.

scientific article

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

scientific article published in February 2018

Sestrin2 is a leucine sensor for the mTORC1 pathway

scientific article

Single Guide RNA Library Design and Construction

scientific article

SnapShot: mTORC1 signaling at the lysosomal surface

scientific article published on 01 December 2012

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

scientific article published on 13 February 2019

Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

scientific article

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

scientific article

Structural basis for the docking of mTORC1 on the lysosomal surface

scientific article

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site

scientific article (publication date: 20 May 2005)

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

scientific article published on June 2010

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

scientific article (publication date: 5 November 2009)

Systematic genome-wide screens of gene function

scientific article (publication date: 2004)

Systematic identification of signaling pathways with potential to confer anticancer drug resistance.

scientific article

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

scientific article

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

scientific article (publication date: 13 May 2003)

The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility

scientific article published on August 1998

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

scientific journal article

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

scientific article published in August 2017

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

scientific article

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity ⬇️

scientific article published in Journal of Biological Chemistry

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

scientific journal article

The TSC-mTOR pathway regulates macrophage polarization

scientific article published on January 2013

The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism

scientific article

The apo-structure of the leucine sensor Sestrin2 is still elusive

scientific article

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

scientific article

The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations.

scientific article published on March 2015

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

scientific article published on 03 October 2013

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

scientific article

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

scientific article

The next decade of metabolism

scientific article published on 01 January 2019

The pharmacology of mTOR inhibition

scientific article published on 21 April 2009

The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.

scientific article published on 29 April 2014

Tumours with PI3K activation are resistant to dietary restriction

scientific article

Twenty-five years of mTOR: Uncovering the link from nutrients to growth.

scientific article published on 25 October 2017

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson ⬇️

scientific article published on July 6, 2012

Viral Packaging and Cell Culture for CRISPR-Based Screens

scientific article

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

scientific article published on 07 June 2013

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state

scientific journal article

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine

scientific article published in 2022

eIF3: a connecTOR of S6K1 to the translation preinitiation complex.

scientific article

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

scientific article

mTOR Mediated Anti-Cancer Drug Discovery

scientific article published on January 2009

mTOR Signaling

scientific article published on February 2012

mTOR Signaling in Growth, Metabolism, and Disease.

scientific article published on March 2017

mTOR Signaling in Growth, Metabolism, and Disease.

scientific article

mTOR and cancer: insights into a complex relationship

scientific article (publication date: September 2006)

mTOR and cancer: many loops in one pathway.

scientific article

mTOR at the nexus of nutrition, growth, ageing and disease

scientific article published on 14 January 2020

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

scientific article

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

scientific article

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

scientific article

mTOR signaling in growth control and disease

scientific article

mTOR: from growth signal integration to cancer, diabetes and ageing

scientific article

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

scientific article

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

scientific article

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

scientific article published on December 2010

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

scientific article

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

scientific article

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

scientific article

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