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List of works by Johan H. van Es

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

scientific article published in December 2017

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal

scientific article

A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta

scientific article

A20 controls intestinal homeostasis through cell-specific activities

scientific article published on 30 September 2014

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth

scientific article

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

scientific article

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

scientific article published on June 2015

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells

scientific article published on 20 February 2020

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

scientific article published on 27 May 2020

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.

scientific article

CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo ⬇️

scientific article published on July 21, 2011

Canonical Wnt signaling negatively modulates regulatory T cell function.

scientific article published on 15 August 2013

Controlled gene expression in primary Lgr5 organoid cultures

scientific article

Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition

scientific article

Crypt stem cells as the cells-of-origin of intestinal cancer

scientific article

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

scientific article

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

scientific article

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine

scientific article published in March 2004

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand

scientific journal article

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium

scientific article

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. ⬇️

scientific article

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

scientific article published on 23 September 2012

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

scientific article published on 9 March 2016

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

scientific article published on 16 December 2019

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

scientific article published on 23 July 2018

Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice

scientific article published on 28 September 2018

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations

scientific article

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

scientific article published on 05 October 2016

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction

scientific journal article

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

scientific article published on 31 January 2019

Identification of stem cells in small intestine and colon by marker gene Lgr5

scientific article (publication date: 25 October 2007)

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. ⬇️

scientific article published on 27 January 2013

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition

scientific article

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

scientific article (publication date: October 2010)

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.

scientific article published on 17 May 2010

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

scientific article published on 12 October 2008

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

scientific article

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

scientific article published on 01 March 2010

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

scientific article

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

scientific article published on 01 November 2018

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

scientific article published on 02 September 2011

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

scientific article published on 15 February 2008

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele

scientific article

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

scientific article published on 11 May 2016

NOTCH1 Signaling as a Therapeutic Target in Sézary Syndrome ⬇️

scientific article published on June 21, 2012

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

scientific article published on December 2013

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

scientific article published on 17 May 2018

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

scientific article published on 03 May 2019

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

scientific article published on 09 December 2019

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

scientific article published on 01 August 2018

Paneth cells

scientific article

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

scientific article

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia

scientific article published on 28 May 2015

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

scientific article published on 23 May 2019

Profiling proliferative cells and their progeny in damaged murine hearts

article published in the Proceedings of the National Academy of Sciences of the United States of America

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine

scientific article published on 24 March 2009

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells

scientific article published on 23 August 2012

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon

scientific article published on 29 August 2016

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

scientific article published on 27 January 2016

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium

scientific article

Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus

scientific article published on 26 June 2014

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium

scientific journal article

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

scientific article (publication date: 14 May 2009)

Single-molecule transcript counting of stem-cell markers in the mouse intestine

scientific article published on 27 November 2011

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine

scientific article

TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling

scientific article

Targeting development of incretin-producing cells increases insulin secretion

scientific article published on 15 December 2014

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis

scientific article published in 2011

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

scientific article published on 12 June 2012

Transcription factor achaete scute-like 2 controls intestinal stem cell fate

scientific journal article

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

scientific article

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

scientific article published on 30 August 2012

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

scientific article

Wnt signalling induces maturation of Paneth cells in intestinal crypts

scientific journal article

You Wnt some, you lose some: oncogenes in the Wnt signaling pathway

scientific article

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