List of works - Lynn A. Hyde

BXSB mice can learn complex visual pattern discriminations

scientific article

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease

scientific article published on 29 November 2012

A computer-aided procedure for measuring Hebb-Williams maze performance

scientific article published in October 1996

Lack of shuttlebox avoidance learning in autoimmune bxsb mice: A test of learned helplessness

scientific article published on August 1, 1997

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity

scientific article published on 23 February 2010

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

scientific article published on November 24, 2012

Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

scientific article published on 13 August 2016

Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

scientific article

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

scientific article

Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors

scientific article published on 15 August 2007

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

scientific article published on September 19, 2017

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

scientific article published on 14 March 2013

Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability

scientific article published on 19 September 2009

Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors

scientific article

MK-8719, a novel and selective O-GlcNAcase inhibitor that reduces the formation of pathological tau and ameliorates neurodegeneration in a mouse model of tauopathy

scientific article published on 03 June 2020

Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

scientific article published on 7 May 2016

fMRI study of olfactory processing in mice under three anesthesia protocols: Insight into the effect of ketamine on olfactory processing

scientific article published on 12 March 2020

Avoidance learning in autoimmune mice

scientific article published in December 2000

The effects of neocortical ectopias on Lashley III water maze learning in New Zealand Black mice

scientific article published in December 2000

Generation of Leads for γ-Secretase Modulation

scientific article published on 04 August 2020

Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions

scientific article published on 05 April 2011

Overcoming Time Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

scientific article published on 15 November 2018

Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models

scientific article published on 31 March 2020

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies

scientific article published on 28 April 2010

List of works by Lynn A. Hyde

BXSB mice can learn complex visual pattern discriminations

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease

A computer-aided procedure for measuring Hebb-Williams maze performance

Lack of shuttlebox avoidance learning in autoimmune bxsb mice: A test of learned helplessness

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability

Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors

MK-8719, a novel and selective O-GlcNAcase inhibitor that reduces the formation of pathological tau and ameliorates neurodegeneration in a mouse model of tauopathy

Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

fMRI study of olfactory processing in mice under three anesthesia protocols: Insight into the effect of ketamine on olfactory processing

Avoidance learning in autoimmune mice

The effects of neocortical ectopias on Lashley III water maze learning in New Zealand Black mice

Generation of Leads for γ-Secretase Modulation

Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions

Overcoming Time Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies