List of works - Lynn A. Hyde

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients

scientific article published on November 2016

Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway

scientific journal article

Water version of the radial-arm maze: Learning in three inbred strains of mice

scientific article published on March 2, 1998

In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm maze

scientific article published in August 2000

Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function

scientific article

MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.

scientific article published on 25 September 2015

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

scientific article

Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease

scientific article published on December 1, 2001

Increased seizure threshold and severity in young transgenic CRND8 mice

scientific article

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

scientific article published in February 2005

Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment

scientific article published in July 1996

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

scientific article

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

scientific article published on February 16, 2012

Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse

scientific article published on 31 August 2006

Motor learning in Ts65Dn mice, a model for Down syndrome

scientific article

Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice

scientific article published in April 2005

Effects of neocortical ectopias upon the acquisition and retention of a non-spatial reference memory task in BXSB mice

scientific article published in December 1998

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

scientific article

Differential learning strategies in spatial and nonspatial versions of the Morris water maze in the C57BL/6J inbred mouse strain

scientific article published in July 2002

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease

scientific article published on 18 November 2016

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

scientific article

Non-spatial water radial-arm maze learning in mice

scientific article published in April 2000

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

scientific article

Working memory deficits in BXSB mice with neocortical ectopias

scientific article published on 01 July 2000

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.

scientific article published on 28 February 2017

Spatial ability of XY sex-reversed female mice

scientific article published in July 2000

Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex

scientific article published in July 2002

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

scientific article published on November 8, 2012

Absence of postnatal testosterone fails to demasculinize the male rat's corpus callosum

scientific article published in September 1996

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo

scientific article published on 08 December 2011

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species

scientific article published on 28 April 2011

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

scientific article published in December 2003

Iminoheterocycles as gamma-secretase modulators.

scientific article published in August 2010

Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination

scientific article

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

scientific article published on 08 August 2017

Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease

scientific article published in July 2002

The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

scientific article published on May 24, 2010

Learning in Year-Old Female Autoimmune BXSB Mice

scientific article published on April 1, 1998

Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease

scientific article published on 10 October 2006

Effects of neocortical ectopias and environmental enrichment on Hebb-Williams maze learning in BXSB mice

scientific article published on 01 July 2001

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors

scientific article published on 30 October 2007

Effects of ectopias and their cortical location on several measures of learning in BXSB mice

scientific article published on December 1, 2001

Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

scientific article published on March 29, 2011

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

scientific article published on March 22, 2016

Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators

scientific article published on December 13, 2010

Lack of activational influence of ovarian hormones on the size of the female rat's corpus callosum

scientific article published in August 1996

Effects of the non-pseudoautosomal region of the Y-chromosome on behavior in female offspring of two congenic strains of mice

scientific article published in January 2000

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

scientific article

Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

scientific article published in March 2007

MitoPark mice, an animal model of Parkinson's disease, show enhanced prepulse inhibition of acoustic startle and no loss of gating in response to the adenosine A(2A) antagonist SCH 412348

scientific article published on 23 October 2013

List of works by Lynn A. Hyde

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients

Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway

Water version of the radial-arm maze: Learning in three inbred strains of mice

In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm maze

Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function

MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease

Increased seizure threshold and severity in young transgenic CRND8 mice

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse

Motor learning in Ts65Dn mice, a model for Down syndrome

Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice

Effects of neocortical ectopias upon the acquisition and retention of a non-spatial reference memory task in BXSB mice

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Differential learning strategies in spatial and nonspatial versions of the Morris water maze in the C57BL/6J inbred mouse strain

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Non-spatial water radial-arm maze learning in mice

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

Working memory deficits in BXSB mice with neocortical ectopias

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.

Spatial ability of XY sex-reversed female mice

Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Absence of postnatal testosterone fails to demasculinize the male rat's corpus callosum

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

Iminoheterocycles as gamma-secretase modulators.

Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease

The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

Learning in Year-Old Female Autoimmune BXSB Mice

Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease

Effects of neocortical ectopias and environmental enrichment on Hebb-Williams maze learning in BXSB mice

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors

Effects of ectopias and their cortical location on several measures of learning in BXSB mice

Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators

Lack of activational influence of ovarian hormones on the size of the female rat's corpus callosum

Effects of the non-pseudoautosomal region of the Y-chromosome on behavior in female offspring of two congenic strains of mice

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

MitoPark mice, an animal model of Parkinson's disease, show enhanced prepulse inhibition of acoustic startle and no loss of gating in response to the adenosine A(2A) antagonist SCH 412348