List of works by Jacques Epelbaum

A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice

scientific article

AMPA-sst2 somatostatin receptor interaction in rat hypothalamus requires activation of NMDA and/or metabotropic glutamate receptors and depends on intracellular calcium

scientific article

Actions of Agonists and Antagonists of the ghrelin/GHS-R Pathway on GH Secretion, Appetite, and cFos Activity.

scientific article published on 18 March 2013

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice.

scientific article published on 31 October 2014

Altered morphology of rod bipolar cell axonal terminals in the retinas of mice carrying genetic deletion of somatostatin subtype receptor 1 or 2.

scientific article published in January 2004

An Early Reduction in GH Peak Amplitude in Preproghrelin-Deficient Male Mice Has a Minor Impact on Linear Growth

scientific article published on 20 June 2014

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women

scientific article

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism

scientific article

Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates

scientific article published on 05 April 2018

Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus

scientific article

Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release

scientific journal article

Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain

scientific article published on 21 May 2003

Characterization of MCH-gene-overprinted-polypeptide-immunoreactive material in hypothalamus reveals an inhibitory role of pro-somatostatin1-64 on somatostatin secretion.

scientific article published in February 2004

Combination of Selective Immunoassays and Mass Spectrometry to Characterize Preproghrelin-Derived Peptides in Mouse Tissues

scientific article

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Comparative inhibition of the GH/IGF-I axis obtained with either the targeted secretion inhibitor SXN101959 or the somatostatin analog octreotide in growing male rats

scientific article

Cooperation between hippocampal somatostatin receptor subtypes 4 and 2: functional relevance in interactive memory systems.

scientific article published in June 2010

Correction: IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice

scientific article published on 21 February 2017

Corrigendum: Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aß, and Tau Proteins in Elderly Patients With Mild Cognitive Impairment

scientific article published on 19 February 2019

Daily rhythms of core temperature and locomotor activity indicate different adaptive strategies to cold exposure in adult and aged mouse lemurs acclimated to a summer-like photoperiod

scientific article published on 01 July 2009

Delayed age-associated decrease in growth hormone pulsatile secretion and increased orexigenic peptide expression in the Lou C/JaLL rat.

scientific article

Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus

scientific article (publication date: 2012)

Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite

scientific article

Expression, localization, and functional coupling of the somatostatin receptor subtype 2 in a mouse model of oxygen-induced retinopathy

scientific article published on 3 December 2009

Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset

scientific article published on 2 January 2007

Genetic deletion of somatostatin receptor 1 alters somatostatinergic transmission in the mouse retina

scientific article published in December 2003

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Ghrelin and obestatin circadian levels differentiate bingeing-purging from restrictive anorexia nervosa

scientific article published on 25 March 2010

Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons.

scientific article

Ghrelin-Derived Peptides: A Link between Appetite/Reward, GH Axis, and Psychiatric Disorders?

scientific article

Ghrelin/obestatin ratio in two populations with low bodyweight: constitutional thinness and anorexia nervosa.

scientific article

Ghrelin: a striking example of neuroendocrine peptide pleiotropy

scientific article

Hippocampal SSTR4 somatostatin receptors control the selection of memory strategies.

scientific article

IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice

scientific article published on 11 January 2017

IGF-I in early-stage Alzheimer's diesease: a potential therapeutic target?

scientific article published on 01 March 2013

Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates.

scientific article

Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis

article

Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst(2) but not sst(1) receptors are coupled to inhibition of single-cell intracellular free calcium concentrations

scientific article published in August 2002

Insulin-Like Growth Factor-I, Insulin-Like Growth factor Binding Protein-3 and Blood Hemoglobin Concentration in an Elderly Population.

scientific article

Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly.

scientific article

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Alzheimer's disease.

scientific article published on 26 September 2012

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

scientific article

Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer's Disease.

scientific article published on 29 March 2016

Medial septal GABAergic neurons express the somatostatin sst2A receptor: functional consequences on unit firing and hippocampal theta.

scientific article

Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer's disease at various cognitive stages

scientific article published on 17 January 2018

Multiple co-localizations in arcuate GHRH-eGFP neurons in the mouse hypothalamus

scientific article published on 29 November 2006

Neuroendocrine Regulation of Growth Hormone Secretion.

scientific article

New Insights in Anorexia Nervosa

scientific article

Novel analogs of ghrelin: physiological and clinical implications

scientific article published on 01 August 2004

Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents

scientific article

Physiological roles of preproghrelin-derived peptides in GH secretion and feeding

scientific article published on 16 April 2011

Promoting healthspan and lifespan with caloric restriction in primates

scientific article published on 15 March 2019

QTLs influencing IGF-1 levels in a LOU/CxFischer 344F2 rat population. Tracks towards the metabolic theory of Ageing

scientific article published on 19 August 2013

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

Rational and design of an overfeeding protocol in constitutional thinness: Understanding the physiology, metabolism and genetic background of resistance to weight gain.

scientific article published on 13 July 2016

Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor

scientific article published on 29 September 2009

Relationships Between Lower Olfaction and Brain White Matter Lesions in Elderly Subjects with Mild Cognitive Impairment.

scientific article published in January 2018

Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment.

scientific article

Resistance to lean mass gain in constitutional thinness in free-living conditions is not overpassed by overfeeding

scientific article published on 10 April 2020

Resveratrol metabolism in a non-human primate, the grey mouse lemur (Microcebus murinus), using ultra-high-performance liquid chromatography-quadrupole time of flight

scientific article

Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis

scientific article published on 04 September 2009

Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality

scientific article published on 16 December 2016

Selective alteration at the growth-hormone- releasing-hormone nerve terminals during aging in GHRH-green fluorescent protein mice.

scientific article

Sexually dimorphic distribution of sst2A somatostatin receptors on growth hormone-releasing hormone neurons in mice

scientific article published on 23 February 2006

Somatostatin

Somatostatin

Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence

Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aβ and Tau Proteins in Elderly Patients With Mild Cognitive Impairment

scientific article published on 01 October 2018

Somatostatin binds to murine macrophages through two distinct subsets of receptors ⬇️

scientific article published on May 1, 2003

Somatostatin contributes to in vivo gamma oscillation modulation and odor discrimination in the olfactory bulb.

scientific article published in January 2010

Somatostatin decreases voltage-gated Ca2+ currents in GH3 cells through activation of somatostatin receptor 2.

scientific article published on 27 February 2007

Somatostatin receptor type 2 undergoes plastic changes in the human epileptic dentate gyrus

scientific article published in November 2005

Somatostatin, Alzheimer's disease and cognition: an old story coming of age?

scientific article published on 10 July 2009

Somatostatin-IRES-Cre Mice: Between Knockout and Wild-Type?

scientific article

Somatostatinergic systems in brain: networks and functions

scientific article published on 22 September 2007

Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia

scientific article published on 30 October 2019

Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association Study

article

Targeting sst2A receptor-expressing cells in the rat hypothalamus through in vivo agonist stimulation: neuroanatomical evidence for a major role of this subtype in mediating somatostatin functions

scientific article published in April 2003

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

scientific article

The neurotrophins NT3 and BDNF induce selective specification of neuropeptide coexpression and neuronal connectivity in arcuate and periventricular hypothalamic neurons in vitro

scientific article published in January 2002

The somatostatin sst1 receptor: an autoreceptor for somatostatin in brain and retina?

scientific article

Ultradian Rhythmicity of Ghrelin Secretion in Relation with GH, Feeding Behavior, and Sleep-Wake Patterns in Rats

article published in 2002

Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats

scientific article

Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa

scientific article published on 28 August 2020

sst2-receptor gene deletion exacerbates chronic stress-induced deficits: Consequences for emotional and cognitive ageing

scientific article published on 31 January 2018

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