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List of works by Victoria Ploplis

A central role for plasminogen in the inflammatory response to biomaterials

scientific article published in October 2004

A coagulation factor VII deficiency protects against acute inflammatory responses in mice

scientific article published on 01 December 2006

A deficiency of uPAR alters endothelial angiogenic function and cell morphology ⬇️

scientific article

A fibrin specific monoclonal antibody which interferes with the fibrinolytic effect of tissue plasminogen activator

scientific article published on 01 June 1988

A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

scientific article published on 24 January 2006

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection

scientific article

A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen

scientific article published on 09 April 2020

A monoclonal antibody which recognises an epitopic region unique to the intact fibrin polymeric structure

scholarly article

A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes

scientific article published on 13 January 2013

A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells

scientific article published on 19 June 2006

A role of plasminogen in atherosclerosis and restenosis models in mice

scientific article published on 01 September 1999

A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice

scientific article published on 13 March 2009

A total fibrinogen deficiency is compatible with the development of bleomycininduced pulmonary fibrosis in mice

scholarly article

A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice

scientific article published in September 2000

A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice

scientific journal article

Abnormal whole blood thrombi in humans with inherited platelet receptor defects

scientific article

Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia ⬇️

scientific article published on 23 March 2015

Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice

scientific article published on November 2001

Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis

scientific article published on 18 January 2016

An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

scientific article

Attenuation of neointima formation following arterial injury in PAI-1 deficient mice.

scientific article published in January 2001

Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination

scientific article

Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography ⬇️

scientific article published on September 1, 2011

Calorimetric evaluation of the existence of separate domains in bovine prothrombin

scientific article published on 01 January 1981

Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia.

scientific article

Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase

scientific article

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

scientific article published on 19 April 2019

Coagulation factor Xa modulates airway remodeling in a murine model of asthma

scientific article published on 2 November 2006

Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice

scientific article published on April 2000

Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers

scientific article

Comparative studies of the physical state of the lipid phase of normal and hypercholesterolemic very low density lipoprotein ⬇️

scientific article published on January 1, 1979

Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system

scientific article published on 08 August 2013

Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen.

scientific article published on 19 July 2017

Conservation of critical functional domains in murine plasminogen activator inhibitor-1.

scientific article published on 12 February 2004

Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization

scientific article published on 30 July 2018

CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants

scientific article

Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice

scientific article published on November 2006

Development of pulmonary fibrosis in fibrinogen-deficient mice

scientific article

Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.

scientific article

Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein

scientific article published on 12 June 2015

Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes.

scientific article

Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury.

scientific article published on 17 May 2016

Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans

scientific article

Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.

scientific article

Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29.

scientific article

Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in Mice ⬇️

scientific article published on November 1, 1995

Effects of altered plasminogen activator inhibitor-1 expression on cardiovascular disease ⬇️

scientific article published on November 1, 2011

Endoluminal arterial injury in plasminogen-deficient mice

scientific article published in June 2000

Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice.

scientific article published on 18 November 2003

Expression of foreign epitopes on recombinant occlusion bodies of baculoviruses

scientific article published on January 1, 1992

Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system

scientific article published in June 1989

Factor VII deficiency impairs cutaneous wound healing in mice

scientific article published on 11 February 2010

Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden.

scientific article

Fibrinogen facilitates the anti-tumor effect of nonnative endostatin

scientific article published on 22 January 2009

Fibrinogen has chaperone-like activity

scientific article published on 04 December 2008

Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse

scientific article published on March 2002

Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between".

scientific article published on 20 February 2017

Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene

scientific article published on 01 December 2006

Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains

scientific article published on 07 March 2013

Gene targeting in hemostasis. plasminogen

scientific article

Gene targeting of components of the fibrinolytic system

scientific article published on 01 January 2002

Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity

scientific article published on 04 April 2016

Glomerulonephritis in mice with genetic deficiencies of the plasminogen system

scholarly article

Growth and behavioral development in plasminogen gene-targeted mice.

scientific article published in March 1999

Host Pathways of Hemostasis that Regulate Group A Streptococcus pyogenes Pathogenicity

scientific article published on 01 January 2020

Humoral immune response to 2,4-dinitrophenyl--keyhole limpet hemocyanin in antigen-free, germ-free and conventional BALB/c mice

scientific article published on 01 January 1994

Immunochemical evidence for intramolecular interaction of the carboxy terminal A??-appendages of plasma fibrinogen ⬇️

scientific article published on 01 October 1990

Impaired arterial neointima formation in mice with disruption of the plasminogen gene ⬇️

scientific article

Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.

scientific article

Initiation of the extrinsic pathway of coagulation. Association of factor VIIa with a cell line expressing tissue factor

scientific article published in July 1987

Interaction between group A streptococci and the plasmin(ogen) system promotes virulence in a mouse skin infection model

scientific article published in April 1999

Interspecies cross-reactivity of monoclonal antibodies to various epitopes of human plasminogen ⬇️

scientific article published on April 1, 1984

Microviscosity of the lipid domains of normal and hypercholesterolemic very low density lipoprotein ⬇️

scientific article published on April 25, 1977

Monoclonal antibodies to discrete regions of human Glu1-plasminogen ⬇️

scientific article published on 01 November 1982

Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence

scientific article

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

scientific article published on 03 July 2018

Nonfibrinolytic functions of plasminogen

scientific article published in June 2000

Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence

scientific article published on 21 June 2016

Ovulation in plasminogen-deficient mice

scientific article published on 01 November 1999

Past and Present Behçet's Disease Animal Models

scientific article published on 18 July 2020

Pathological consequences associated with altered expression of components of the plasminogen system in bleomycin induced pulmonary fibrosis

scholarly article

Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps

scientific article published on 8 November 2016

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.

scientific article published on 23 March 2017

Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

scientific article

Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway.

scientific article

Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4.

scientific article published on 14 June 2016

Plasminogen activator inhibitor-1: the double-edged sword in apoptosis

scientific article published on 01 December 2008

Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites

scientific article published in November 1998

Plasminogen and cell migration in vivo

scholarly article

Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis

scientific article

Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice ⬇️

scientific article published on March 15, 1998

Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy.

scientific article published in April 2013

Rapid selection of Drosophila S2 cells with the puromycin resistance gene ⬇️

scientific article published on September 1, 2003

Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48.

scientific article published on 20 February 2018

Receptor-independent plasminogen activation by urokinase-type plasminogen activator promotes, and adenoviral pai-1 gene transfer inhibits arterial neointima formation in mice

scholarly article

Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1

scientific article

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen

scientific article published on 01 August 1996

Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice

scientific article

Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes

scientific article published on 10 July 2019

Spleen cells from antigen-minimized mice are superior to spleen cells from germ-free and conventional mice in the stimulation of primary in vitro proliferative responses to nominal antigens

scientific article published on 01 January 1995

Stable genetic integration of a red fluorescent protein in a virulent Group A Streptococcus strain

scientific article published on 25 September 2019

Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence

scientific article published on 18 November 2020

Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria

scientific article published on 4 March 2016

Structure and function of the plasminogen/plasmin system

scientific article published on 01 April 2005

Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice

scientific article

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

scientific article published on 21 February 2020

Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury

scientific article published on 21 May 2014

Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy

scientific article published on 10 March 2016

Targeting plasminogen activator inhibitor-1: role in cell signaling and the biology of domain-specific knock-in mice

scientific article published on September 2007

The M-protein of Streptococcus pyogenes strain AP53 retains cell surface functional plasminogen binding after inactivation of the sortase A gene

scientific article published on 02 March 2020

The Streptococcal protease SpeB antagonizes the biofilms of the human pathogen Staphylococcus aureus USA300 through cleavage of the Staphylococcal SdrC protein

scientific article published on 23 March 2020

The characterization of mice with a targeted combined deficiency of protein c and factor XI.

scientific article published on February 2001

The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system

scientific article published on July 2000

The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine

scientific article published on 10 July 2012

The existence of independent domain structures in human Lys77-plasminogen ⬇️

scientific article published on May 25, 1981

The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection

scientific article published on August 2003

The generation and characterization of mice expressing a plasmin-inactivating active site mutation

scientific article

The hemostasis system in murine atherosclerosis

scientific article published on March 2008

The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

scientific article published on 26 November 2007

The plasminogen system and cell migration during an inflammatory response

scholarly article

The plasminogen system in pulmonary fibrosis

scholarly article

The protein C pathway and pathologic processes

scientific article published on July 2009

The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation

scientific article published on 21 May 2014

The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice

scientific article published on December 2012

The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors

scientific article published on 31 January 2014

Thromboelastography in Orthopaedic Trauma Acute Pelvic Fracture Resuscitation: A Descriptive Pilot Study.

scientific article published on 21 January 2016

Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.

scientific article published in February 2003

Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse

scientific article

Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats.

scientific article

Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1.

scientific article published in October 2000

Two novel vascular injury models demonstrate a role for urokinase in early vascular repair events

scholarly article

Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation

scientific article published on 22 November 2011

Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence

scientific article

Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review

scientific article published on 20 May 2019

Using technetium-99m MH-1 monoclonal antibody to image thrombi in a rabbit jugular vein

scholarly article

Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion

scientific article published on 9 March 2017

Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen

scientific article published on 14 March 2019

gamma-Glutamate and beta-hydroxyaspartate in proteins

scientific article

gamma-glutamate and beta-hydroxyaspartate in proteins

scientific article published on 01 January 2002

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