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List of works by Victoria Ploplis

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The generation and characterization of mice expressing a plasmin-inactivating active site mutation

scientific article
Humoral immune response to 2,4-dinitrophenyl--keyhole limpet hemocyanin in antigen-free, germ-free and conventional BALB/c mice

scientific article published on 01 January 1994
Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans

scientific article
Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β‐domains

scientific article published on 07 March 2013
The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

scientific article published on 26 November 2007
A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice

scientific article published on 13 March 2009
The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation

scientific article published on 21 May 2014
Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4.

scientific article published on 14 June 2016
A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection

scientific article
Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein

scientific article published on June 12, 2015
CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants

scientific article published on July 27, 2015
Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity

scientific article published on 04 April 2016
Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between".

scientific article published on 20 February 2017
The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors

scientific article published on January 31, 2014
A deficiency of uPAR alters endothelial angiogenic function and cell morphology

scientific article
Calorimetric evaluation of the existence of separate domains in bovine prothrombin

scientific article published on 01 January 1981
Targeting plasminogen activator inhibitor-1: role in cell signaling and the biology of domain-specific knock-in mice

scientific article published on September 2007
Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system

scientific article published in June 1989
Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury.

scientific article published on 17 May 2016
Fibrinogen has chaperone-like activity

scientific article published on 04 December 2008
Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography

scientific article published on September 1, 2011
The existence of independent domain structures in human Lys77-plasminogen

scientific article published on May 25, 1981
Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.

scientific article
Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury

scientific article published on 21 May 2014
Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice

scientific article
Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen

scientific article published on 01 August 1996
Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria

scientific article published on March 4, 2016
Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion

scientific article published on 9 March 2017
Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps

scientific article published on 8 November 2016
Abrogation of Plasminogen Activator Inhibitor-1-Vitronectin Interaction Ameliorates Acute Kidney Injury in Murine Endotoxemia

scientific article published on March 23, 2015
Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

scientific article published on 03 July 2018
Spleen cells from antigen-minimized mice are superior to spleen cells from germ-free and conventional mice in the stimulation of primary in vitro proliferative responses to nominal antigens

scientific article published on 01 January 1995
Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis

scientific article published on 18 January 2016
Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.

scientific article
Growth and behavioral development in plasminogen gene-targeted mice.

scientific article published in March 1999
Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene

scientific article published on 01 December 2006
Monoclonal antibodies to discrete regions of human Glu1-plasminogen

scientific article published on 01 November 1982
Attenuation of neointima formation following arterial injury in PAI-1 deficient mice.

scientific article published in January 2001
The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine

scientific article published on 10 July 2012
Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy

scientific article published on 10 March 2016
A fibrin specific monoclonal antibody which interferes with the fibrinolytic effect of tissue plasminogen activator

scientific article published on 01 June 1988
An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

scientific article
Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice

scientific article published on April 2000
Endoluminal arterial injury in plasminogen-deficient mice

scientific article published in June 2000
Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen.

scientific article published on 19 July 2017
The vitronectin‐binding domain of plasminogen activator inhibitor‐1 plays an important functional role in lipopolysaccharide‐induced lethality in mice

scientific article published on December 1, 2012
Abnormal whole blood thrombi in humans with inherited platelet receptor defects

scientific article
Gene targeting in hemostasis. plasminogen

scientific article
gamma-Glutamate and beta-hydroxyaspartate in proteins

scientific article
Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.

scientific article published on 23 March 2017

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