List of works - Keisuke Hino

A Series of microRNA in the Chromosome 14q32.2 Maternally Imprinted Region Related to Progression of Non-Alcoholic Fatty Liver Disease in a Mouse Model

scientific article

A case of ovulatory cycle-dependent symptoms in woman with previous interferon beta therapy

scientific article

A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice

scientific article

Assessment of clinical and magnetic resonance imaging features of de novo hypervascular hepatocellular carcinoma using gadoxetic acid-enhanced magnetic resonance imaging

scientific article published on 10 May 2016

Assessment of hepatic fibrosis with superb microvascular imaging in hepatitis C virus-associated chronic liver diseases

scientific article published on 19 July 2016

Branched-chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein-expressing mice

scientific article published on 18 September 2014

Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease

scientific article

Combinational use of hepatitis B viral antigens predicts responses to nucleos(t)ide analogue/peg-interferon sequential therapy.

scientific article published on 20 June 2017

Current strategies for chemoprevention of hepatocellular carcinoma

scientific article

Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice

scientific article published on 11 September 2018

Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes

scientific article published on 29 October 2008

Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A.

scientific article published on 18 March 2009

Fibroblast activation protein-α-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma

scientific article published on 2 September 2015

Focal nodular hyperplasia-like nodule with reduced expression of organic anion transporter 1B3 in alcoholic liver cirrhosis

scientific article published on 01 June 2011

Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C.

scientific article

Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean

scientific article

Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C

scientific journal article

Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

scientific article

Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C

scientific article

Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein

scientific article published in June 2006

Hepatic oxidative stress in ovariectomized transgenic mice expressing the hepatitis C virus polyprotein is augmented through suppression of adenosine monophosphate-activated protein kinase/proliferator-activated receptor gamma co-activator 1 alpha s

scientific article published on 14 November 2013

Hepatitis B virus genotype G is an extremely rare genotype in Japan

scientific article published in December 2004

Hepatitis C virus core protein inhibits deoxycholic acid-mediated apoptosis despite generating mitochondrial reactive oxygen species

scientific article published on March 2006

Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization

scientific article

Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice

scientific article published in March 2010

Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription

scientific article published on 9 October 2007

Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection

scientific article published in August 2006

Interferon therapy as chemoprevention of hepatocarcinogenesis in patients with chronic hepatitis C.

scientific article published on 4 December 2003

Iron loss triggers mitophagy through induction of mitochondrial ferritin

scientific article published on 25 September 2020

Iron metabolic disorder in chronic hepatitis C: insights from recent evidence

scientific article published on 31 July 2012

Iron metabolic disorder in chronic hepatitis C: mechanisms and relevance to hepatocarcinogenesis

scientific article published on December 2013

Japan Society of Hepatology guidelines for sarcopenia in liver disease (1st edition): Recommendation from the working group for creation of sarcopenia assessment criteria

scientific article published on 2 August 2016

Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine.

scientific article

Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication

scientific article

Mitochondrial reactive oxygen species as a mystery voice in hepatitis C.

scientific article published on 08 January 2014

Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice

scientific article published on 24 October 2020

New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia

scientific article

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.

scientific article

Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010.

scientific article

Recommendation of lamivudine-to-entecavir switching treatment in chronic hepatitis B responders: Randomized controlled trial

scientific article published on 18 May 2011

Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis

scientific article published on 15 July 2013

Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan

scientific article published on 7 September 2006

Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein

scientific article published in August 2007

The rs8099917 polymorphism, when determined by a suitable genotyping method, is a better predictor for response to pegylated alpha interferon/ribavirin therapy in Japanese patients than other single nucleotide polymorphisms associated with interleuk

scientific article

Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study

scientific article published on 04 March 2013

Type 1 interferon receptor in peripheral blood mononuclear cells may predict response to intra-arterial 5-fluorouracil + interferon therapy for advanced hepatocellular carcinoma

scientific article published on 26 April 2011

Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis

scientific article published on 19 April 2016

Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease

scientific article published on 7 January 2018

[HCV and oxidative stress]

scientific article published on 01 May 2011

[Hepatocarcinogenesis and iron metabolic disorder]

scientific article published on 01 April 2012

List of works by Keisuke Hino

A Series of microRNA in the Chromosome 14q32.2 Maternally Imprinted Region Related to Progression of Non-Alcoholic Fatty Liver Disease in a Mouse Model

A case of ovulatory cycle-dependent symptoms in woman with previous interferon beta therapy

A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice

Assessment of clinical and magnetic resonance imaging features of de novo hypervascular hepatocellular carcinoma using gadoxetic acid-enhanced magnetic resonance imaging

Assessment of hepatic fibrosis with superb microvascular imaging in hepatitis C virus-associated chronic liver diseases

Branched-chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein-expressing mice

Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease

Combinational use of hepatitis B viral antigens predicts responses to nucleos(t)ide analogue/peg-interferon sequential therapy.

Current strategies for chemoprevention of hepatocellular carcinoma

Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice

Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes

Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A.

Fibroblast activation protein-α-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma

Focal nodular hyperplasia-like nodule with reduced expression of organic anion transporter 1B3 in alcoholic liver cirrhosis

Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C.

Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean

Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C

Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C

Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein

Hepatic oxidative stress in ovariectomized transgenic mice expressing the hepatitis C virus polyprotein is augmented through suppression of adenosine monophosphate-activated protein kinase/proliferator-activated receptor gamma co-activator 1 alpha s

Hepatitis B virus genotype G is an extremely rare genotype in Japan

Hepatitis C virus core protein inhibits deoxycholic acid-mediated apoptosis despite generating mitochondrial reactive oxygen species

Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization

Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice

Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription

Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection

Interferon therapy as chemoprevention of hepatocarcinogenesis in patients with chronic hepatitis C.

Iron loss triggers mitophagy through induction of mitochondrial ferritin

Iron metabolic disorder in chronic hepatitis C: insights from recent evidence

Iron metabolic disorder in chronic hepatitis C: mechanisms and relevance to hepatocarcinogenesis

Japan Society of Hepatology guidelines for sarcopenia in liver disease (1st edition): Recommendation from the working group for creation of sarcopenia assessment criteria

Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine.

Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication

Mitochondrial reactive oxygen species as a mystery voice in hepatitis C.

Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice

New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.

Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010.

Recommendation of lamivudine-to-entecavir switching treatment in chronic hepatitis B responders: Randomized controlled trial

Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis

Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan

Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein

The rs8099917 polymorphism, when determined by a suitable genotyping method, is a better predictor for response to pegylated alpha interferon/ribavirin therapy in Japanese patients than other single nucleotide polymorphisms associated with interleuk

Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study

Type 1 interferon receptor in peripheral blood mononuclear cells may predict response to intra-arterial 5-fluorouracil + interferon therapy for advanced hepatocellular carcinoma

Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis

Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease

[HCV and oxidative stress]

[Hepatocarcinogenesis and iron metabolic disorder]

[Molecular mechanisms underlying iron metabolic disorder in hepatitis C]