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List of works by Howard I. Scher

(11)C-acetate PET imaging in prostate cancer

scientific article published on 01 February 2007

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts

scientific article

2-[18F]fluoro-2-deoxyglucose positron emission tomography for the detection of disease in patients with prostate-specific antigen relapse after radical prostatectomy

scientific article published in July 2005

265: A Constitutively Activated Mutant form of Propsa that Manifests Catalytic Action Increases Cell Invasion in Vitro and Frequency of Pulmonary Metastases in vivo in a Subcutaneous Mouse Xenograft Model

scientific article published on 28 March 2018

A DREAM Challenge to Build Prediction Models for Short-Term Discontinuation of Docetaxel in Metastatic Castration-Resistant Prostate Cancer

scientific article published on 01 November 2017

A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle

scientific article published on 01 February 1999

A Phase I Trial of IGF-1R Inhibitor Cixutumumab and mTOR Inhibitor Temsirolimus in Metastatic Castration-resistant Prostate Cancer

scientific article published on 11 January 2020

A Phase I/II Study for Analytic Validation of 89Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer

scientific article

A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers

scientific article published on 19 September 2018

A Pilot Study of a Multimodal Treatment Paradigm to Accelerate Drug Evaluations in Early-stage Metastatic Prostate Cancer.

scientific article published on 22 November 2016

A bivalent conjugate vaccine in the treatment of biochemically relapsed prostate cancer: a study of glycosylated MUC-2-KLH and Globo H-KLH conjugate vaccines given with the new semi-synthetic saponin immunological adjuvant GPI-0100 OR QS-21

scientific article published on 01 May 2005

A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease

scientific article published on 24 January 2012

A novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin

scientific article published on 12 March 2009

A novel automated platform for quantifying the extent of skeletal tumour involvement in prostate cancer patients using the Bone Scan Index.

scientific article

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

scientific article

A phase 2 study of intravenous panobinostat in patients with castration-resistant prostate cancer

scientific article

A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostate-specific membrane antigen (PSMA) in subjects with prostate cancer ⬇️

scientific article published on December 13, 2012

A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer.

scientific article published on 9 March 2010

A phase I trial of docetaxel and pulse-dose 17-allylamino-17-demethoxygeldanamycin in adult patients with solid tumors.

scientific article

A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer

scientific article

A phase II trial of bortezomib and prednisone for castration resistant metastatic prostate cancer

scientific article published on 22 October 2007

A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM).

scientific article published on 19 November 2008

A polyvalent vaccine for high-risk prostate patients: "are more antigens better?"

scientific article published on 10 July 2007

A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study

scientific article published on 9 October 2012

A window into new drug development for urologic oncology. Part I: How bench-to-bedside research can result in approval

scientific article published on 22 January 2015

A window into new drug development for urologic oncology. Part II: Bench-to-bedside research improves survival in urologic cancer, and the discovery of better biomarkers can help predict patient response, toxicity, and resistance to therapy

scientific article published on 26 March 2015

ARN-509: a novel antiandrogen for prostate cancer treatment

scientific article

Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance

scientific article published on 3 November 2017

Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study ⬇️

scientific article published on September 18, 2012

Abiraterone and increased survival in metastatic prostate cancer

scientific article (publication date: 26 May 2011)

Abiraterone in metastatic prostate cancer without previous chemotherapy

scientific article published on 10 January 2013

Adaptive Clinical Trial Designs for Simultaneous Testing of Matched Diagnostics and Therapeutics ⬇️

scientific article published on November 1, 2011

Advances in imaging in the postoperative patient with a rising prostate-specific antigen level ⬇️

scientific article published on October 1, 2003

Alteration of p53 pathway in squamous cell carcinoma of the head and neck: impact on treatment outcome in patients treated with larynx preservation intent

scientific article published on 01 July 2002

American Society of Clinical Oncology endorsement of the Cancer Care Ontario Practice Guideline on nonhormonal therapy for men with metastatic hormone-refractory (castration-resistant) prostate cancer

scientific article published on 09 October 2007

American Society of Clinical Oncology recommendations for the initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer

scientific article

Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade

scientific article published on 01 April 2019

Analytic and clinical validation of a prostate cancer-enhanced messenger RNA detection assay in whole blood as a prognostic biomarker for survival

scientific article published on 26 July 2013

Androgen deprivation for minimal metastatic disease: threshold for achieving undetectable prostate-specific antigen

scientific article published on 01 May 2005

Androgen receptor antagonists in castration-resistant prostate cancer.

scientific article

Androgen receptor expression is associated with prostate cancer-specific survival in castrate patients with metastatic disease

scientific article published on 14 July 2009

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

scientific article published on October 2009

Anti-epidermal growth factor receptor monoclonal antibody cetuximab plus Doxorubicin in the treatment of metastatic castration-resistant prostate cancer

scientific article published on 01 October 2009

Antibody mass escalation study in patients with castration-resistant prostate cancer using 111In-J591: lesion detectability and dosimetric projections for 90Y radioimmunotherapy

scientific article published on 13 June 2008

Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer

scientific article published in October 2002

Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study

scientific article

Apalutamide for the treatment of prostate cancer

scientific article published on 01 September 2018

Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building

scientific article

Assessing anxiety in men with prostate cancer: further data on the reliability and validity of the Memorial Anxiety Scale for Prostate Cancer (MAX-PC).

scientific article

Assessing outcomes in prostate cancer clinical trials: a twenty-first century tower of Babel

scientific article published on September 2008

Assessment of Adverse Events From the Patient Perspective in a Phase 3 Metastatic Castration-Resistant Prostate Cancer Clinical Trial

scientific article published on 26 September 2019

Assessment of the Validity of Nuclear-Localized Androgen Receptor Splice Variant 7 in Circulating Tumor Cells as a Predictive Biomarker for Castration-Resistant Prostate Cancer

scholarly article by Howard I Scher et al published 1 September 2018 in JAMA Oncology

Association Between New Unconfirmed Bone Lesions and Outcomes in Men With Metastatic Castration-Resistant Prostate Cancer Treated With Enzalutamide: Secondary Analysis of the PREVAIL and AFFIRM Randomized Clinical Trials

scientific article published on 12 December 2019

Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer

scientific article published on 04 June 2016

Author Correction: Tumour lineage shapes BRCA-mediated phenotypes

scientific article published on 01 January 2020

Author Reply

scientific article published on 6 March 2017

Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis

scientific article

Biomarker development in the context of urologic cancers

scientific article published on 5 March 2015

Biomarkers in the management and treatment of men with metastatic castration-resistant prostate cancer

scientific article

Bladder cancer "adjuvant-lite": tastes great (works as well) and less filling (less toxic)?

scientific article published on 6 June 2005

Bone marrow aspiration for disseminated tumor cell detection: a must-have test or is the jury still out?

scientific article published on 23 February 2009

Bone metastases in castration-resistant prostate cancer: associations between morphologic CT patterns, glycolytic activity, and androgen receptor expression on PET and overall survival

scientific article

Bone scan index: a quantitative treatment response biomarker for castration-resistant metastatic prostate cancer.

scientific article published on 9 January 2012

CHAARTED/GETUG 12--docetaxel in non-castrate prostate cancers

scientific article published on 10 November 2015

CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems

scientific article published on April 2004

Cabozantinib Versus Mitoxantrone-prednisone in Symptomatic Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 3 Trial with a Primary Pain Endpoint

scientific article published on 04 December 2018

Cabozantinib for Progressive Metastatic Castration-resistant Prostate Cancer Following Docetaxel: Combined Analysis of Two Phase 3 Trials

scientific article published on 30 November 2018

Cabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: results of a phase II nonrandomized expansion study.

scientific article

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

scientific article published on 26 October 2020

Chemotherapeutic response with single agent gemcitabine in metastatic Bellini duct tumor

scientific article published in January 2004

Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer

scientific article published on 01 April 2007

Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer

scientific article published on 01 December 2007

Circulating Tumor Cell Number as a Response Measure of Prolonged Survival for Metastatic Castration-Resistant Prostate Cancer: A Comparison With Prostate-Specific Antigen Across Five Randomized Phase III Clinical Trials

scientific article published on 22 December 2017

Circulating Tumor Cells as Biomarkers in Prostate Cancer ⬇️

scientific article published on June 15, 2011

Circulating Tumor Cells in Prostate Cancer: From Discovery to Clinical Utility

scientific article published on 01 January 2019

Circulating cancer cells and their clinical applications

scientific article published on 17 May 2011

Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival

scientific article published on 20 February 2009

Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer

scientific article published on 23 March 2015

Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer

scientific article published in October 2008

Circulating tumors cells as biomarkers: progress toward biomarker qualification

scientific article

Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data

scientific article

Clinical Utility of the Nuclear-localized AR-V7 Biomarker in Circulating Tumor Cells in Improving Physician Treatment Choice in Castration-resistant Prostate Cancer

scientific article published on 21 October 2019

Clinical Validity of Detecting Circulating Tumor Cells by AdnaTest Assay Compared With Direct Detection of Tumor mRNA in Stabilized Whole Blood, as a Biomarker Predicting Overall Survival for Metastatic Castration-Resistant Prostate Cancer Patients

scientific article published on September 2016

Clinical annotations for prostate cancer research: Defining data elements, creating a reproducible analytical pipeline, and assessing data quality

scientific article published in 2022

Clinical approaches to osseous metastases in prostate cancer.

scientific article

Clinical experience with intravenous estramustine phosphate, paclitaxel, and carboplatin in patients with castrate, metastatic prostate adenocarcinoma

scientific article published in November 2003

Clinical implications of PTEN loss in prostate cancer

scientific article published on 20 February 2018

Clinical outcomes and survival surrogacy studies of prostate-specific antigen declines following enzalutamide in men with metastatic castration-resistant prostate cancer previously treated with docetaxel

scientific article published on 7 February 2017

Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids.

scientific article published on December 2003

Combined 18F-FDG and 11C-methionine PET scans in patients with newly progressive metastatic prostate cancer.

scientific article published in January 2002

Combined Whole Body and Multiparametric Prostate Magnetic Resonance Imaging as a 1-Step Approach to the Simultaneous Assessment of Local Recurrence and Metastatic Disease after Radical Prostatectomy

scientific article published on 16 February 2017

Comparison of Magnetic Resonance Imaging-stratified Clinical Pathways and Systematic Transrectal Ultrasound-guided Biopsy Pathway for the Detection of Clinically Significant Prostate Cancer: A Systematic Review and Meta-analysis of Randomized Contro

scientific article published on 14 June 2019

Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease

article

Computer-aided quantitative bone scan assessment of prostate cancer treatment response.

scientific article published on April 2012

Consensus Statement on Circulating Biomarkers for Advanced Prostate Cancer

scientific article published on 15 May 2018

Consensus on molecular imaging and theranostics in prostate cancer

scientific article published on 01 December 2018

Considerations in the development of circulating tumor cell technology for clinical use ⬇️

scientific article published on July 2, 2012

Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha

scientific article

Critical function for ADAM9 in mouse prostate cancer

scientific article published on 01 October 2005

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

scientific article

Cytotoxic treatment of aggressive prostate tumors with or without neuroendocrine elements

scientific article

DNA vaccines: an active immunization strategy for prostate cancer

scientific article published on October 2003

Decline in Circulating Tumor Cell Count and Treatment Outcome in Advanced Prostate Cancer

scientific article published on 8 June 2016

Decreased retinoid X receptor-alpha protein expression in basal cells occurs in the early stage of human prostate cancer development.

scientific article published on March 2004

Department of Defense prostate cancer clinical trials consortium: a new instrument for prostate cancer clinical research.

scientific article

Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group

scientific article

Detection of Androgen Receptor Mutations in Circulating Tumor Cells: Highlights of the Long Road to Clinical Qualification ⬇️

scientific article published on July 30, 2010

Developing imaging strategies for castration resistant prostate cancer

scientific article

Development of a second-generation antiandrogen for treatment of advanced prostate cancer

scientific article

Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer

scientific article published on 29 September 2020

Differential Metabolism and Pharmacokinetics of ?-[1-11C]-Methionine and 2-[18F] Fluoro-2-deoxy-?-glucose (FDG) in Androgen Independent Prostate Cancer ⬇️

scientific article published on 01 May 1999

Differential exoprotease activities confer tumor-specific serum peptidome patterns

scientific article published in January 2006

Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors

scientific article published on 12 September 2012

Do Patients With AR-V7-Positive Prostate Cancer Benefit from Novel Hormonal Therapies? It All Depends on Definitions

scientific article published on 31 August 2016

Dose escalation study of intravenous estramustine phosphate in combination with Paclitaxel and Carboplatin in patients with advanced prostate cancer.

scientific article published on June 2003

Drug development for noncastrate prostate cancer in a changed therapeutic landscape

scientific article published on 17 October 2017

Drug development for noncastrate prostate cancer in a changed therapeutic landscape

scientific article published on 8 November 2017

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss

scientific article published on 30 June 2013

Editorial: States and state transitions are all that really matter

scientific article published in December 2002

Effect of Preanalytic Variables on an Automated PTEN Immunohistochemistry Assay for Prostate Cancer

scientific article published on 08 October 2018

Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomis

scientific article published on November 9, 2012

Effect of abiraterone acetate treatment on the quality of life of patients with metastatic castration-resistant prostate cancer after failure of docetaxel chemotherapy

scientific article published on 22 August 2013

Effect of enzalutamide on time to first skeletal-related event, pain, and quality of life in men with castration-resistant prostate cancer: results from the randomised, phase 3 AFFIRM trial

scientific article published on 4 August 2014

Effective Prostate-Specific Membrane Antigen-Based 18F-DCFPyL-Guided Cryoablation of a Single Positive Site in a Patient Believed to Be More Metastatic on 11C-Choline PET/CT.

scientific article published in December 2017

Effects of cabozantinib on pain and narcotic use in patients with castration-resistant prostate cancer: results from a phase 2 nonrandomized expansion cohort

scientific article published on 20 February 2014

Efficacy and safety of single-agent pertuzumab (rhuMAb 2C4), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapy

scientific article

Efficacy outcomes by baseline prostate-specific antigen quartile in the AFFIRM trial

scientific article published on 27 August 2014

Eligibility and outcomes reporting guidelines for clinical trials for patients in the state of a rising prostate-specific antigen: recommendations from the Prostate-Specific Antigen Working Group

scientific article

End points and outcomes in castration-resistant prostate cancer: from clinical trials to clinical practice

scientific article published on 22 August 2011

Enzalutamide in European and North American men participating in the AFFIRM trial

scientific article published on 23 October 2014

Enzalutamide in castration-resistant prostate cancer patients with visceral disease in the liver and/or lung: Outcomes from the randomized controlled phase 3 AFFIRM trial

scientific article published on 20 September 2016

Enzalutamide in metastatic prostate cancer before chemotherapy

scientific article published in June 2014

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

scientific article published on 01 August 2017

Estimating survival benefit in castrate metastatic prostate cancer: decision making in proceeding to a definitive phase III trial

scientific article

Estimation of tumour regression and growth rates during treatment in patients with advanced prostate cancer: a retrospective analysis

scientific article published on 12 December 2016

Evaluation of Castration-Resistant Prostate Cancer with Androgen Receptor-Axis Imaging.

scientific article

Evaluation of Plasma Insulin-like Growth Factor Binding Protein 2 and Her-2 Extracellular Domain as Biomarkers for 17-Allylamino-17-Demethoxygeldanamycin Treatment of Adult Patients with Advanced Solid Tumors

scientific article published in April 2007

Evaluation of a multimodal strategy to accelerate drug evaluations in early-stage metastatic prostate cancer

Evaluation of an online platform for cancer patient self-reporting of chemotherapy toxicities

scientific article

Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy

scientific article published on February 2009

Everolimus combined with gefitinib in patients with metastatic castration-resistant prostate cancer: Phase 1/2 results and signaling pathway implications.

scientific article

Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate

scientific article

Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors

scientific article

Expanding androgen- and androgen receptor signaling-directed therapies for castration-resistant prostate cancer

scientific article

Expression of prostate-specific membrane antigen in renal cortical tumors.

scientific article published on 14 March 2008

Fatal respiratory failure associated with treatment of prostate cancer using docetaxel and estramustine

scientific article

Feasibility of Long-Term Patient Self-Reporting of Toxicities From Home via the Internet During Routine Chemotherapy ⬇️

scientific article published on 03 June 2013

Feasibility of radical prostatectomy after neoadjuvant chemohormonal therapy for patients with high risk or locally advanced prostate cancer: results of a phase I/II study

scientific article

Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer

scientific article published on 24 April 2018

Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.

scientific article

Final Analysis of the Ipilimumab Versus Placebo Following Radiotherapy Phase III Trial in Postdocetaxel Metastatic Castration-resistant Prostate Cancer Identifies an Excess of Long-term Survivors

scientific article published on 15 August 2020

Finding the place of histone deacetylase inhibitors in prostate cancer therapy.

scientific article

First-in-Human Imaging with 89Zr-Df-IAB2M Anti-PSMA Minibody in Patients with Metastatic Prostate Cancer: Pharmacokinetics, Biodistribution, Dosimetry, and Lesion Uptake.

scientific article published on 11 August 2016

Five-year outcomes after neoadjuvant chemotherapy and conformal radiotherapy in patients with high-risk localized prostate cancer

scientific article published in July 2004

Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer

scientific article published on 10 March 2009

Fluorinated deoxyglucose positron emission tomography imaging in progressive metastatic prostate cancer

scientific article published in June 2002

Fluorodeoxyglucose positron emission tomography as an outcome measure for castrate metastatic prostate cancer treated with antimicrotubule chemotherapy.

scientific article

Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine

scientific article

Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance

scientific article

Genomic correlates of clinical outcome in advanced prostate cancer.

scientific article

Germline BRCA mutations denote a clinicopathologic subset of prostate cancer

scientific article published on 09 March 2010

Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development

scientific article

Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer

scientific article

HER-2 profiling and targeting in prostate carcinoma

scientific article published on 01 February 2002

Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer

scientific article

High-dose calcitriol, zoledronate, and dexamethasone for the treatment of progressive prostate carcinoma

scientific article published in May 2004

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

scientific article published on 25 November 2019

High-risk prostate cancer-classification and therapy

scientific article published on 20 May 2014

Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer

scientific article published on 27 January 2009

Hsp90 as a therapeutic target in prostate cancer ⬇️

scientific article published on October 1, 2003

Identification of novel androgen receptor target genes in prostate cancer

scientific article published on 6 June 2007

Imaging Patients with Metastatic Castration-Resistant Prostate Cancer Using 89Zr-DFO-MSTP2109A Anti-STEAP1 Antibody

scientific article published on 03 May 2019

Imaging therapeutic response in human bone marrow using rapid whole-body MRI

scientific article

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

scientific article published on 01 November 2018

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

scientific article published on 04 September 2018

Immunohistochemistry-based assessment of androgen receptor status and the AR-null phenotype in metastatic castrate resistant prostate cancer

scientific article published on 24 February 2020

Impact of baseline corticosteroids on survival and steroid androgens in metastatic castration-resistant prostate cancer: exploratory analysis from COU-AA-301.

scientific article published on 10 July 2014

Impact of bone-targeted therapies in chemotherapy-naïve metastatic castration-resistant prostate cancer patients treated with abiraterone acetate: post hoc analysis of study COU-AA-302.

scientific article published on 15 May 2015

Impact of clinical versus radiographic progression on clinical outcomes in metastatic castration-resistant prostate cancer

scientific article published on 01 November 2020

Improved prediction of prostate cancer recurrence through systems pathology

scientific article published on July 2007

Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Abiraterone Acetate

scientific article published on 15 January 2015

Improving the Nuclear-Localized Androgen Receptor Splice Variant 7 Test-In Reply

scientific article published on 01 March 2019

Improving the decision to pursue a phase 3 clinical trial by adjusting for patient-specific factors in evaluating phase 2 treatment efficacy data

scientific article

In Reply

article published in 2008

Indium 111-labeled J591 anti-PSMA antibody for vascular targeted imaging in progressive solid tumors.

scientific article published on 29 April 2015

Induction of autoantibodies to syngeneic prostate-specific membrane antigen by xenogeneic vaccination

scientific article

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

scientific article published on 06 July 2016

Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer

scientific article

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol ⬇️

scientific article published on May 1, 2003

Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline

scientific article published on 2 April 2007

Insights from AR Gene Mutations

article

Integrative Clinical Genomics of Advanced Prostate Cancer

scientific article

Integrative clinical genomics of advanced prostate cancer

scientific article

Integrative genomic profiling of human prostate cancer

scientific article (publication date: 13 July 2010)

Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

scientific article published on November 2016

Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial

scientific article published on 13 May 2014

Locally advanced prostate cancer: a population‐based study of treatment patterns ⬇️

scientific article published on November 15, 2011

Long-term Safety and Antitumor Activity in the Phase 1-2 Study of Enzalutamide in Pre- and Post-docetaxel Castration-Resistant Prostate Cancer

scientific article published on 16 February 2015

Long-term toxicity monitoring via electronic patient-reported outcomes in patients receiving chemotherapy

scientific article published in December 2007

Low Incidence of Corticosteroid-associated Adverse Events on Long-term Exposure to Low-dose Prednisone Given with Abiraterone Acetate to Patients with Metastatic Castration-resistant Prostate Cancer

scientific article published on 7 March 2016

Maintaining Bone Health During Hormonal Therapy for Prostate Cancer.

scientific article published on 8 August 2017

Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019

scientific article published on 27 January 2020

Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.

scientific article

Management of biochemical recurrence after primary treatment of prostate cancer: a systematic review of the literature

scientific article published on 16 May 2013

Meeting report from the Prostate Cancer Foundation PSMA theranostics state of the science meeting

scientific article published on 31 August 2020

Methylphenidate for fatigue in ambulatory men with prostate cancer

scientific article

Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events

scientific article published in November 2004

Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases

scientific article published on 04 February 2020

Monitoring the Clinical Outcomes in Advanced Prostate Cancer: What Imaging Modalities and Other Markers Are Reliable? ⬇️

scientific article published on June 1, 2013

Morphology-predicted large scale transition number in circulating tumor cells identifies a chromosomal instability biomarker associated with poor outcome in castration-resistant prostate cancer

scientific article published on 19 August 2020

Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer.

scientific article published in March 2005

Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.

scientific article published in September 2017

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

scientific article published on 8 May 2017

NF-kappaB regulates androgen receptor expression and prostate cancer growth

scientific article published on 23 July 2009

Nomogram for overall survival of patients with progressive metastatic prostate cancer after castration

scientific article published in October 2002

Novel mutations of epidermal growth factor receptor in localized prostate cancer

scientific article published in September 2006

Novel therapies for the treatment of prostate cancer: current clinical trials and development strategies

scientific article

Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in Metastatic Castration-resistant Prostate Cancer

scientific article

Oncogenic genomic alterations, clinical phenotypes, and outcomes in metastatic castration-sensitive prostate cancer

scientific article published on 27 March 2020

Optimizing targeted therapy and developing novel outcome measures for patients with advanced prostate cancer at Memorial Sloan-Kettering Cancer Center.

scientific article

Organoid cultures derived from patients with advanced prostate cancer

scientific article

Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial

scientific article published on 18 February 2015

Outcome predictions for patients with metastatic prostate cancer.

scientific article

Outcome predictors for the increasing PSA state after definitive external-beam radiotherapy for prostate cancer

scientific article published on 01 February 2005

Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment

scientific article published on 4 June 2017

PET-based radiation dosimetry in man of 18F-fluorodihydrotestosterone, a new radiotracer for imaging prostate cancer

scientific article published in November 2004

PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

scientific article published on 13 January 2021

PTEN Loss with ERG Negative Status is Associated with Lethal Disease after Radical Prostatectomy

scientific article published on 10 September 2019

Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics

scientific article published on 19 April 2020

Pathogenic ATM Mutations in Cancer and a Genetic Basis for Radiotherapeutic Efficacy

scientific article published on 29 July 2020

Patient versus clinician symptom reporting using the National Cancer Institute Common Terminology Criteria for Adverse Events: results of a questionnaire-based study

scientific article published on November 2006

Pattern of prostate-specific antigen (PSA) failure dictates the probability of a positive bone scan in patients with an increasing PSA after radical prostatectomy

scientific article published on March 2005

Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: An early predictor of relapse or incomplete androgen suppression

article

Pharmacokinetic assessment of the uptake of 16beta-18F-fluoro-5alpha-dihydrotestosterone (FDHT) in prostate tumors as measured by PET.

scientific article

Pharmacokinetics and Biodistribution of a [89Zr]Zr-DFO-MSTP2109A Anti-STEAP1 Antibody in Metastatic Castration-Resistant Prostate Cancer Patients

scientific article published on 31 May 2019

Pharmacokinetics and toxicity of weekly docetaxel in older patients

scientific article published on October 2006

Phase 1 trial of high-dose exogenous testosterone in patients with castration-resistant metastatic prostate cancer

scientific article published on 03 April 2009

Phase 1/2 multiple ascending dose trial of the prostate-specific membrane antigen-targeted antibody drug conjugate MLN2704 in metastatic castration-resistant prostate cancer.

scientific article

Phase I Study of DSTP3086S, an Antibody-Drug Conjugate Targeting Six-Transmembrane Epithelial Antigen of Prostate 1, in Metastatic Castration-Resistant Prostate Cancer

scientific article published on 05 November 2019

Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.

scientific article

Phase I dose-escalation study of the novel antiandrogen BMS-641988 in patients with castration-resistant prostate cancer

scientific article

Phase I evaluation of J591 as a vascular targeting agent in progressive solid tumors.

scientific article published on May 2007

Phase I pharmacokinetic and biodistribution study with escalating doses of ²²³Ra-dichloride in men with castration-resistant metastatic prostate cancer.

scientific article

Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial

scientific article published on 22 October 2011

Phase I study of ARN-509, a novel antiandrogen, in the treatment of castration-resistant prostate cancer

scientific article

Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

scientific article published on 16 May 2005

Phase I study of samarium-153 lexidronam with docetaxel in castration-resistant metastatic prostate cancer

scientific article published on 13 April 2009

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

scientific article

Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer

article

Phase I trial of the prostate-specific membrane antigen-directed immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer

scientific article

Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer

scientific article

Phase II study of Lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for metastatic castration-resistant prostate cancer

scientific article

Phase II trial of SM-88, a cancer metabolism based therapy, in non-metastatic biochemical recurrent prostate cancer

scientific article published on 13 September 2020

Phase II trial of docetaxel with rapid androgen cycling for progressive noncastrate prostate cancer

scientific article

Phase Ib Study of Enzalutamide in Combination with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer.

scientific article

Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer

scientific article

Picking the winners in a sea of plenty

scientific article published on 01 February 2002

Pilot trial of unlabeled and indium-111-labeled anti-prostate-specific membrane antigen antibody J591 for castrate metastatic prostate cancer.

scientific article published on October 2005

Platinum-Based Chemotherapy in Metastatic Prostate Cancer With DNA Repair Gene Alterations

scientific article published on 16 April 2020

Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors.

scientific article

Portable Filter-Based Microdevice for Detection and Characterization of Circulating Tumor Cells ⬇️

scientific article published on September 28, 2010

Positron Emission Tomography/Computed Tomography-Based Assessments of Androgen Receptor Expression and Glycolytic Activity as a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer

scientific article published on 9 November 2017

Post-therapy changes in PSA as an outcome measure in prostate cancer clinical trials.

scientific article published on December 2006

Practical approach for comparative analysis of multilesion molecular imaging using a semiautomated program for PET/CT

scientific article

Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer.

scientific article

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data

scientific article

Prevalence of Prostate Cancer Clinical States and Mortality in the United States: Estimates Using a Dynamic Progression Model

scientific article

Prevalence of pain and analgesic use in men with metastatic prostate cancer using a patient-reported outcome measure.

scientific article published on 25 June 2013

Prior Endocrine Therapy Impact on Abiraterone Acetate Clinical Efficacy in Metastatic Castration-resistant Prostate Cancer: Post-hoc Analysis of Randomised Phase 3 Studies

scientific article published on 24 October 2015

Prognostic and Predictive Value of a Breast Cancer Expression Signature in Localized Prostate Cancer

scientific article published in December 2017

Prognostic significance of baseline reverse transcriptase-PCR for prostate-specific antigen in men with hormone-refractory prostate cancer treated with chemotherapy

scientific article published in July 2005

Prognostic value of baseline [18F] fluorodeoxyglucose positron emission tomography and 99mTc-MDP bone scan in progressing metastatic prostate cancer

scientific article

Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study

scientific article published on 09 October 2012

Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development

scientific article (publication date: 15 April 2005)

Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making

scientific article published on 31 May 2017

Prospective Multicenter Study of Circulating Tumor Cell AR-V7 and Taxane Versus Hormonal Treatment Outcomes in Metastatic Castration-Resistant Prostate Cancer

scientific article published on 28 October 2020

Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study

scientific article published on 13 March 2019

Prostate Cancer Foundation Hormone-Sensitive Prostate Cancer Biomarker Working Group Meeting Summary

scientific article published on 26 December 2020

Prostate Cancer Topography and Patterns of Lymph Node Metastasis ⬇️

scientific article published on December 1, 2010

Prostate cancer clinical trial end points: "RECIST"ing a step backwards.

scientific article published on July 2005

Prostate cancer in 2011: Hitting old targets better and identifying new targets

scientific article published on 10 January 2012

Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein

scientific article published on 30 September 2013

Prostate cancer: a dynamic illness with shifting targets

scientific article

Prostate-specific antigen as a marker of disease activity in prostate cancer

scientific article published on 01 September 2002

Prostate-specific antigen as a marker of disease activity in prostate cancer.

scientific article

Prostate-specific antigen nadir and cancer-specific mortality following hormonal therapy for prostate-specific antigen failure

scientific article published on 01 September 2005

Publisher Correction: The long tail of oncogenic drivers in prostate cancer

scientific article published on 01 July 2019

Pulsatile administration of the epidermal growth factor receptor inhibitor gefitinib is significantly more effective than continuous dosing for sensitizing tumors to paclitaxel

scientific article

QUANTIFICATION OF METASTATIC PROSTATE CANCER WHOLE-BODY TUMOR BURDEN WITH FDG PET PARAMETERS AND ASSOCIATIONS WITH OVERALL SURVIVAL AFTER FIRST LINE ABIRATERONE OR ENZALUTAMIDE: A SINGLE- CENTER RETROSPECTIVE COHORT STUDY

scientific article published on 08 January 2021

Quantifying the amount of variation in survival explained by prostate-specific antigen

scientific article published on 01 August 2002

Radiographic Progression-Free Survival as a Clinically Meaningful End Point in Metastatic Castration-Resistant Prostate Cancer: The PREVAIL Randomized Clinical Trial

scientific article published on 8 March 2018

Radiographic progression-free survival as a response biomarker in metastatic castration-resistant prostate cancer: COU-AA-302 results

scientific article

Randomized, Open-Label Phase III Trial of Docetaxel Plus High-Dose Calcitriol Versus Docetaxel Plus Prednisone for Patients With Castration-Resistant Prostate Cancer ⬇️

scientific article published on April 11, 2011

Rapid androgen cycling as treatment for patients with prostate cancer.

scientific article

Rapid elimination kinetics of free PSA or human kallikrein-related peptidase 2 after initiation of gonadotropin-releasing hormone-antagonist treatment of prostate cancer: potential for rapid monitoring of treatment responses

scientific article

Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer

scientific article published on May 2011

Repetitively dosed docetaxel and ¹⁵³samarium-EDTMP as an antitumor strategy for metastatic castration-resistant prostate cancer.

scientific article

Reply to A. Addeo and A. Bahl

scientific article

Reply to C. Ren et al

article

Reply to L. Dirix, B. De Laere et al, and A. Sharp et al

scientific article published on 02 July 2019

Reproducibility and repeatability of semi-quantitative 18F-fluorodihydrotestosterone (FDHT) uptake metrics in castration-resistant prostate cancer metastases: a prospective multi-center study.

scientific article published on 6 April 2018

Response

Safety and Antitumor Activity of Apalutamide (ARN-509) in Metastatic Castration-Resistant Prostate Cancer with and without Prior Abiraterone Acetate and Prednisone

scientific article published on 17 February 2017

Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer: A Phase 2 Clinical Trial

Safety and biologic activity of intravenous BCL-2 antisense oligonucleotide (G3139) and taxane chemotherapy in patients with advanced cancer

scientific article

Second-line chemotherapy for prostate cancer: patient characteristics and survival

scientific article

Serum Androgens As Prognostic Biomarkers in Castration-Resistant Prostate Cancer: Results From an Analysis of a Randomized Phase III Trial ⬇️

scientific article published on August 1, 2013

Setting the bar in phase II trials: the use of historical data for determining "go/no go" decision for definitive phase III testing

scientific article

Severe Hypocalcemia Associated With Denosumab in Metastatic Castration-Resistant Prostate Cancer: Risk Factors and Precautions for Treating Physicians.

scientific article published on 22 November 2014

Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate

scientific article

Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice

scientific article published on 30 June 2016

Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer

scientific article published on 28 July 2009

Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation.

scientific article published on 11 January 2007

Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse.

scientific article

Susceptibility loci associated with prostate cancer progression and mortality

scientific article published on 11 May 2010

Suspected local recurrence after radical prostatectomy: endorectal coil MR imaging

scientific article published on 02 April 2004

Symptom Monitoring With Patient-Reported Outcomes During Routine Cancer Treatment: A Randomized Controlled Trial

scientific article published on 7 December 2015

TMPRSS2-ERG Status in Circulating Tumor Cells as a Predictive Biomarker of Sensitivity in Castration-Resistant Prostate Cancer Patients Treated With Abiraterone Acetate ⬇️

scientific article published on July 14, 2011

TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomy

scientific article published on 3 February 2009

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

scientific article published in August 2002

Targeting osseous metastases: rationale and development of radio-immunotherapy for prostate cancer

scientific article published on May 2004

Targeting osseous metastases: rationale and development of radio-immunotherapy for prostate cancer

scientific article published on 01 May 2005

Targeting the androgen receptor pathway in prostate cancer

scientific article published on 12 August 2008

Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer

scientific article published in September 2004

The Added Value of Circulating Tumor Cell Enumeration to Standard Markers in Assessing Prognosis in a Metastatic Castration-Resistant Prostate Cancer Population

scientific article published on 27 September 2016

The Brief Pain Inventory and its "pain at its worst in the last 24 hours" item: clinical trial endpoint considerations

scientific article published on 15 January 2010

The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer

scientific article published on 15 December 2015

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

scientific article published on 18 July 2019

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance

scientific article published on 30 July 2019

The association between measures of progression and survival in castrate-metastatic prostate cancer

scientific article published on 01 March 2007

The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

scientific article

The long tail of oncogenic drivers in prostate cancer.

scientific article published on 2 April 2018

The memorial anxiety scale for prostate cancer: validation of a new scale to measure anxiety in men with with prostate cancer

scientific article published in June 2003

The natural history of noncastrate metastatic prostate cancer after radical prostatectomy

scientific article published on 30 October 2006

The progress and promise of molecular imaging probes in oncologic drug development

scientific article published in November 2005

Therapeutic Strategies for Bone Metastases and Their Clinical Sequelae in Prostate Cancer ⬇️

scientific article published on June 1, 2012

Thomsen-Friedenreich (TF) antigen as a target for prostate cancer vaccine: clinical trial results with TF cluster (c)-KLH plus QS21 conjugate vaccine in patients with biochemically relapsed prostate cancer

scientific article published on 22 February 2005

Time to detectable metastatic disease in patients with rising prostate-specific antigen values following surgery or radiation therapy

scientific article published on 01 December 2005

Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma

scientific article

Toward Standardization of Preanalytical Procedures for Cell-Free DNA Profiling

scientific article published on 31 October 2019

Trial Design and Objectives for Castration-Resistant Prostate Cancer: Updated Recommendations From the Prostate Cancer Clinical Trials Working Group 3

scientific article

Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

scientific article published on 04 September 2018

Tumor localization of 16beta-18F-fluoro-5alpha-dihydrotestosterone versus 18F-FDG in patients with progressive, metastatic prostate cancer

scientific article published in March 2004

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

scientific article published on 14 January 2019

Tumour lineage shapes BRCA-mediated phenotypes

scientific article published on 10 July 2019

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling ⬇️

scientific article

Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302).

scientific article published on 6 March 2014

Using confirmatory factor analysis to evaluate construct validity of the Brief Pain Inventory (BPI).

scientific article

Validation and clinical utility of prostate cancer biomarkers.

scientific article published on 05 March 2013

Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium [...]

scientific article

p27 as a target for cancer therapeutics

scientific article

β4 Integrin signaling induces expansion of prostate tumor progenitors

scientific article published on 25 January 2013

⁸⁹Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer

scientific article

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