Search filters

List of works by Rolf Gebhardt

"Artificial micro organs"--a microfluidic device for dielectrophoretic assembly of liver sinusoids

scientific article published in June 2011

4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin

scientific article published on 3 October 2009

A Silencer Element in the First Intron of the Glutamine Synthetase Gene Represses Induction by Glucocorticoids ⬇️

scientific article published on October 16, 2003

A method for patterned in situ biofunctionalization in injection-molded microfluidic devices

scientific article

A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation

scientific article

Aldosterone and D-glucose stimulate the proliferation of human cardiac myofibroblasts in vitro

scientific article

Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling

scientific article

An intronic silencer element is responsible for specific zonal expression of glutamine synthetase in the rat liver

scientific article published in June 2005

Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver

scientific article published on 17 February 2020

Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.

scientific article

Carnosine inhibits ATP production in cells from malignant glioma.

scientific article

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model

scientific article

Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load

scientific article published on 01 July 2012

Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system

scientific article published on 10 March 2016

Citric acid as the last therapeutic approach in an acute life-threatening metabolic decompensation of propionic acidaemia ⬇️

scientific article published on January 1, 2013

Colocalization of glial fibrillary acidic protein, metallothionein, and MHC II in human, rat, NOD/SCID, and nude mouse skin keratinocytes and fibroblasts

scientific article published on 28 September 2006

Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.

scientific article published on 21 March 2009

Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility

scientific article published on 30 May 2017

Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis ⬇️

scientific article published on May 1, 2003

Correction: Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity.

scientific article

Correction: Keratinocytes as Depository of Ammonium-Inducible Glutamine Synthetase: Age- and Anatomy-Dependent Distribution in Human and Rat Skin.

scientific article published on 16 March 2009

Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma.

scientific article published on 18 February 2008

Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.

scientific article

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver

scientific article published on 31 July 2020

Differential and stereoselective in vitro cytotoxicity of eremophilane sesquiterpenes of Petasites hybridus rhizomes in rat hepatocytes.

scientific article published on 22 July 2010

Differential inhibition of matrix metalloproteinases-2, -9, and -13 activities by selected anthraquinones

scientific article published on 16 January 2009

Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling

scientific article published on 18 January 2017

Dual Luciferase Assay for Secreted Luciferases Based onGaussiaand NanoLuc ⬇️

scientific article published on May 1, 2013

Dual origin, development, and fate of bovine pancreatic islets.

scientific article published on 21 November 2012

E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells

scientific article published on 29 June 2007

FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells

scientific article

From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age.

scientific article published on 28 July 2009

Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes

scientific article

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

scientific article published on 23 June 2016

Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors.

scientific article published on 30 September 2014

Glucocorticoid induced expression of glutamine synthetase in hepatoma cells.

scientific article published on August 2002

Hedgehog signaling in glioblastoma multiforme.

scientific article

Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis.

scientific article published on 17 May 2016

Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism

scientific article

Hedgehog signalling pathway in adult liver: a major new player in hepatocyte metabolism and zonation?

scientific article

HepaChip-MP - a twenty-four chamber microplate for a continuously perfused liver coculture model

scientific article published on 14 July 2020

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

scientific journal article

Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors

scientific article published on 01 October 2006

Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver

scientific article published on 8 February 2007

Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage

scientific journal article

Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS-2) in liver tissue.

scientific article published on 14 May 2009

Identification of Factors Involved in the Anti-Tumor Activity of Carnosine on Glioblastomas Using a Proteomics Approach ⬇️

scientific article published on February 23, 2011

Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects

scientific article published in July 2005

Influence of Liver Fibrosis on Lobular Zonation

scientific article published on 02 December 2019

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

scientific article published on 12 May 2014

Keratinocytes as depository of ammonium-inducible glutamine synthetase: age- and anatomy-dependent distribution in human and rat skin

scientific article

Lessons from hepatocyte-specific Cyp51 knockout mice: impaired cholesterol synthesis leads to oval cell-driven liver injury.

scientific article

Liposomes as carriers: not as innocent as one would like

scientific article published on 06 August 2015

Liver-restricted Repin1 deficiency improves whole-body insulin sensitivity, alters lipid metabolism, and causes secondary changes in adipose tissue in mice.

scientific article

Mathematical modelling of liver regeneration after intoxication with CCl(4).

scientific article published on 2 February 2007

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

scientific article

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

scientific article published on 01 December 2019

Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action

scientific article

Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells

scientific article published on 3 October 2017

Optimality in the zonation of ammonia detoxification in rodent liver.

scientific article published on 5 October 2015

Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli.

scientific article published on 05 December 2007

Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.

scientific article published in October 2002

Phosphatidylcholine dimers can be easily misinterpreted as cardiolipins in complex lipid mixtures: a matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric study of lipids from hepatocytes ⬇️

scientific article published on September 30, 2011

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

scientific article

Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes

scientific article (publication date: October 2007)

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis

scientific article published on 19 April 2014

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

scientific article published on 23 August 2013

Reduction and expansion of the glutamine synthetase expressing zone in livers from tetracycline controlled TGF-beta1 transgenic mice and multiple starved mice

scientific article published in July 2004

Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet ⬇️

scientific article published on October 13, 2010

Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes

scientific article

Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes.

scientific article published on 28 May 2014

Serum IGF-I Is Not a Reliable Pharmacodynamic Marker of Exogenous Growth Hormone Activity in Mice

The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism - A Systems Biology Analysis Using Self-Organizing Maps

article

The RL-ET-14 cell line mediates expression of glutamine synthetase through the upstream enhancer/promoter region.

scientific article

The Wnt/β-catenin pathway determines the predisposition- and the efficiency of liver to pancreas reprogramming.

scientific article published on 2 February 2018

The extended TILAR approach: a novel tool for dynamic modeling of the transcription factor network regulating the adaption to in vitro cultivation of murine hepatocytes

scientific article

The many faces of Hedgehog signalling in the liver: recent progress reveals striking cellular diversity and the importance of microenvironments

scientific article published on 23 August 2014

The virtual liver: state of the art and future perspectives

scientific article

Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis

scientific article published on 01 February 2019

Tissue proteomics by one-dimensional gel electrophoresis combined with label-free protein quantification

scientific article

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.

scientific article published on 26 October 2010

Zonal gene expression in murine liver: Are tumors helping us to solve the mystery?

scientific article published on 01 August 2006

β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis

scientific article published on 19 February 2019

Paulina is supported by:

About Paulina

Help