List of works - Coen A C Ottenheijm

A bright light on myosin to study skeletal muscle relaxation

scientific article published on 21 September 2020

A two-faced cysteine residue modulates skeletal muscle contraction. Focus on "S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers

scientific article published on 01 February 2017

Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease

scientific article published on 17 August 2006

Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice

scientific article published on 01 June 2021

Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathy

scientific article

Altered contractility of skeletal muscle in mice deficient in titin's M-band region

scientific article

Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2).

scientific article

Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy.

scientific article

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

scientific article published on 01 July 2014

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

scientific article published on 28 May 2013

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol

scientific article

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.

scientific article published on 8 August 2017

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension

scientific article published on 03 December 2010

Diaphragm adaptations in patients with COPD.

scientific article published on 24 January 2008

Diaphragm dysfunction in chronic obstructive pulmonary disease.

scientific article published on 22 April 2005

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.

scientific article published in April 2014

Diaphragm muscle fiber dysfunction in chronic obstructive pulmonary disease: toward a pathophysiological concept

scientific article published on 5 April 2007

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

scientific article published on May 2015

Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats

scientific article published on 20 April 2007

Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction

scientific article published on 07 September 2012

Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development

scientific article

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

scientific article

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

scientific article published on 12 January 2018

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.

scientific article published on 28 April 2015

Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.

scientific article

Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency

scientific article

Gene expression profile in the diaphragm following contractile inactivity during thoracic surgery.

scientific article

Hypoxia-induced skeletal muscle fiber dysfunction: role for reactive nitrogen species

scientific article

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer

scientific article published on 07 May 2020

K7del is a common TPM2 gene mutation associated with nemaline myopathy and raised myofibre calcium sensitivity

scientific article

KBTBD13 is an actin-binding protein that modulates muscle kinetics

scientific article published on 01 February 2020

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

scientific article published on 24 September 2014

Lifting the Nebula: Novel Insights into Skeletal Muscle Contractility ⬇️

scientific article published on October 1, 2010

Muscle fiber dysfunction contributes to weakness in inclusion body myositis

scientific article published on 07 March 2019

Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype.

scientific article

Muscle weakness in TPM3-myopathy is due to reduced Ca2+-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres

scientific article

Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy

scientific article published on 25 October 2016

Mutation-specific effects on thin filament length in thin filament myopathy

scientific article published on 13 April 2016

Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost

scientific article published on 07 September 2009

Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy

scientific article

Nebulin, a major player in muscle health and disease

scientific article

New insights into the structural roles of nebulin in skeletal muscle

scientific article

Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles.

scientific article

Novel mutations in NEB cause abnormal nebulin expression and markedly impaired muscle force generation in severe nemaline myopathy

scientific article

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

scientific journal article

Preserved single muscle fiber specific force in facioscapulohumeral muscular dystrophy

scientific article published on 21 January 2020

Proteasome inhibition improves diaphragm function in an animal model for COPD.

scientific article published in April 2011

Proteasome inhibition improves diaphragm function in congestive heart failure rats

scientific article

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension

scientific article

Recessive MYH7-related myopathy in two families

scientific article published on 12 April 2019

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension.

scientific article published on 17 May 2016

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension: Relative Contribution of Fibrosis and Myofibril Stiffness.

scientific article published on July 2016

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

scientific article published on 20 September 2013

Role of Titin in Skeletal Muscle Function and Disease ⬇️

scientific article published on January 1, 2010

Sarcomere Dysfunction in Nemaline Myopathy

scientific article

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy

scientific article

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

scientific article published on 23 April 2008

Selective Diaphragm Muscle Weakness After Contractile Inactivity During Thoracic Surgery

scientific article published on 01 December 2011

The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization

scientific article published on 27 February 2012

Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency

scientific article published on 04 April 2009

Titin and diaphragm dysfunction in chronic obstructive pulmonary disease

scientific article published on 09 December 2005

Titin and diaphragm dysfunction in mechanically ventilated rats

scientific article published on 11 February 2012

Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading? ⬇️

scientific article published on November 12, 2010

Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome

scientific article published on 05 January 2012

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

scientific article

Tuning passive mechanics through differential splicing of titin during skeletal muscle development

scientific article published on October 2009

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation

scientific article

List of works by Coen A C Ottenheijm

A bright light on myosin to study skeletal muscle relaxation

A two-faced cysteine residue modulates skeletal muscle contraction. Focus on "S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers

Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease

Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice

Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathy

Altered contractility of skeletal muscle in mice deficient in titin's M-band region

Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2).

Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy.

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension

Diaphragm adaptations in patients with COPD.

Diaphragm dysfunction in chronic obstructive pulmonary disease.

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.

Diaphragm muscle fiber dysfunction in chronic obstructive pulmonary disease: toward a pathophysiological concept

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats

Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction

Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.

Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.

Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency

Gene expression profile in the diaphragm following contractile inactivity during thoracic surgery.

Hypoxia-induced skeletal muscle fiber dysfunction: role for reactive nitrogen species

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer

K7del is a common TPM2 gene mutation associated with nemaline myopathy and raised myofibre calcium sensitivity

KBTBD13 is an actin-binding protein that modulates muscle kinetics

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

Lifting the Nebula: Novel Insights into Skeletal Muscle Contractility ⬇️

Muscle fiber dysfunction contributes to weakness in inclusion body myositis

Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype.

Muscle weakness in TPM3-myopathy is due to reduced Ca2+-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres

Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy

Mutation-specific effects on thin filament length in thin filament myopathy

Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost

Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy

Nebulin, a major player in muscle health and disease

New insights into the structural roles of nebulin in skeletal muscle

Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles.

Novel mutations in NEB cause abnormal nebulin expression and markedly impaired muscle force generation in severe nemaline myopathy

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

Preserved single muscle fiber specific force in facioscapulohumeral muscular dystrophy

Proteasome inhibition improves diaphragm function in an animal model for COPD.

Proteasome inhibition improves diaphragm function in congestive heart failure rats

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension

Recessive MYH7-related myopathy in two families

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension.

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension: Relative Contribution of Fibrosis and Myofibril Stiffness.

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

Role of Titin in Skeletal Muscle Function and Disease ⬇️

Sarcomere Dysfunction in Nemaline Myopathy

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

Selective Diaphragm Muscle Weakness After Contractile Inactivity During Thoracic Surgery

The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization

Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency

Titin and diaphragm dysfunction in chronic obstructive pulmonary disease

Titin and diaphragm dysfunction in mechanically ventilated rats

Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading? ⬇️

Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

Tuning passive mechanics through differential splicing of titin during skeletal muscle development

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation