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List of works by Linda J Van Eldik

"End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?

scientific article

"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).

scientific article published on 21 May 2016

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

scientific article

A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity

scientific article published in January 2004

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

scientific article published on 4 September 2007

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology

scientific article

APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

scientific article

Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38

scientific article published on 01 January 2004

Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia

scientific article published on January 2013

Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene

scientific article published on 01 January 2020

Alzheimer's Biomarkers are Correlated with Brain Connectivity in Older Adults Differentially during Resting and Task States.

scientific article published on 8 February 2016

Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies

scientific article

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation

scientific article

Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

scientific article published in November 2004

Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism ⬇️

scientific article published on May 12, 1998

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release ⬇️

scientific article published on March 2, 1998

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Analysis of the calcium-modulated proteins, S100 and calmodulin, and their target proteins during C6 glioma cell differentiation

scientific article

Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker

scientific article

Antisense approaches to the function of glial cell proteins

scientific article published on October 28, 1992

Antisense inhibition of glial S100 beta production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation

scientific journal article

ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function

scientific article published on January 2004

Apolipoprotein E Attenuates β‐Amyloid‐Induced Astrocyte Activation ⬇️

scientific article published on October 1, 1998

Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses

scientific article

Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures

scientific article published on 01 October 2000

Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing

scientific article

Association between male gender and cortical Lewy body pathology in large autopsy series

scientific article

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

scientific article published on 10 April 2015

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

scientific article published in 2023

Barriers to Alzheimer disease drug discovery and development in academia

scientific article

Barriers to drug discovery and development for Alzheimer disease.

scientific article

Beyond amyloid: Getting real about nonamyloid targets in Alzheimer's disease ⬇️

scientific article published on July 1, 2013

Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia

scientific article published on 01 January 2019

Brain arteriolosclerosis

scientific article published on 24 October 2020

Brain pathologies in extreme old age.

scientific article

Brain structure changes over time in normal and mildly impaired aged persons

scientific article published on 20 May 2020

Brainstem Imaging in Alzheimer's Disease: Potential for Biomarker Development

article

Calcium-binding proteins and the molecular basis of calcium action.

scientific article published on January 1982

Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine

scientific article

Calmodulin, calbindin-D28K and calretinin in rat and chicken pineal glands: Immunocytochemical and immunoblotting analysis

article

Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease

scientific article

Challenges and Considerations Related to Studying Dementia in Blacks/African Americans

scientific article published on 19 July 2017

Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain

scientific article published on 05 December 2013

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

scientific article published on April 2015

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation.

scientific article published on 28 July 2011

Comparative biochemistry of calmodulins and calmodulin-like proteins

scientific article published on 01 January 1980

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

scientific article published on 24 May 2013

Conditions for reproducible detection of calmodulin and S100 beta in immunoblots

scientific article published on 01 November 1984

Copper-dependent formation of disulfide-linked dimer of S100B protein

scientific article

Correction to "A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction"

scientific article published on 16 July 2020

Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells

scientific article

De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders

scientific article published on July 2006

Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models

scientific article

Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice

article

Delivering probes and clinical candidates to test precision medicine therapeutic hypotheses

scientific article published in 2021

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

scientific article

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

scientific article published on 17 October 2006

Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease

scientific article

Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation.

scientific article

Differential regulation of S100 beta and mRNAs coding for S100-like proteins (42A and 42C) during development and after lesion of rat sciatic nerve

scientific article

Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques

scientific article published on 01 January 2018

Diffuse brain injury induces acute post-traumatic sleep

scientific article published on 08 January 2014

Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge

scientific article published on 13 May 2016

Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound

scientific article published in January 2002

Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's

scientific article published on January 2003

Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses

scientific article published on August 2002

Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

scientific article published on 23 May 2015

Disulfide-linked S100 beta dimers and signal transduction

scientific article published on November 10, 1992

Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology ⬇️

scientific article published on July 25, 2012

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice

scientific article published on 14 April 2020

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

scientific article

Elucidation of a minimal immunoreactive site of vertebrate calmodulin

scientific article published on 01 December 1983

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.

scientific article published on 6 June 2009

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid

scientific article published in August 2005

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo

scientific article

Factors Associated with Unmet Needs among African-American Dementia Care Providers

scientific article published on 22 January 2016

First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers

scientific article published on 07 April 2020

Generation and behavior characterization of CaMKIIβ knockout mice

scientific article

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia

scientific article published on 19 May 2019

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Glia and Alzheimer's disease

scientific article

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

scientific article published in January 2006

Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches

scientific article published on January 2007

Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation

scientific article

Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation

scientific article published in September 1999

Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons

scientific article published on 12 March 2016

Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature

scientific article

Hippocampal sclerosis in advanced age: clinical and pathological features.

scientific article

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease

scientific article

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration

scientific article published on April 2006

Human brain S100 beta and S100 beta mRNA expression increases with age: pathogenic implications for Alzheimer's disease

scientific article published in May 1996

Identification of the binding site on S100B protein for the actin capping protein CapZ.

scientific article published on December 1997

Immunohistochemical localization of S100 beta in human nervous system tumors by using monoclonal antibodies with specificity for the S100 beta polypeptide

scientific article published in August 1986

Immunoreactive levels of myosin light-chain kinase in normal and virus-transformed chicken embryo fibroblasts.

scientific article published on October 1984

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production

scientific article published on April 2004

In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

scientific article published on September 1996

Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia

scientific article published in July 2004

Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected].

scientific article published on 3 July 2009

Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug

scientific article published on October 2008

Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.

scientific article published on 11 July 2014

Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100 beta

scientific article published on 01 September 1994

Interaction of calmodulin and other calcium-modulated proteins with gap junctions

scientific article published on 01 January 1987

Interaction of calmodulin and other calcium-modulated proteins with mammalian and arthropod junctional membrane proteins

scientific article published on 01 January 1985

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid

scientific article

Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation

scientific article

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

scientific article published in October 2006

Ion-binding properties of recombinant S100β and two derivatives with either an inactivated Ca2+ site II or a normalized Ca2+ site I ⬇️

scientific article published on 01 December 1997

Isolation of a protein from brain using calcium-dependent affinity-based adsorption chromatography on phenothiazine-Sepharose conjugates

scientific article published on 01 January 1980

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples

scientific article published on 4 January 2013

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.

scientific article

MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

scientific article published on 15 August 2008

MFG-E8 regulates microglial phagocytosis of apoptotic neurons

scientific article

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses

scientific article published on 12 February 2016

Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB.

scientific article published in September 2001

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

scientific article

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

scientific article published on 20 December 2011

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer's disease

scientific article published on 17 September 2020

Mild cognitive impairment: statistical models of transition using longitudinal clinical data

scientific article

Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures

scientific article

Multiple gene products are produced from a novel protein kinase transcription region.

scientific article published on October 1995

Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain

scientific article published on August 2004

Nascent Astrocyte Particles Differ from Lipoproteins in CSF ⬇️

scientific article published on May 1, 1998

Neurite extension and neuronal survival activities of recombinant S100 beta proteins that differ in the content and position of cysteine residues

scientific article

Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin

scientific article

Neuroinflammation: a potential therapeutic target

scientific article

Neurotrophic protein S100 beta stimulates glial cell proliferation

scientific article

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis ⬇️

scientific article published on 19 October 2020

Organization of the genetic locus for chicken myosin light chain kinase is complex: Multiple proteins are encoded and exhibit differential expression and localization ⬇️

scientific article published on September 1, 1998

Overexpression of the neurotrophic cytokine S100 beta in human temporal lobe epilepsy

scientific article published on July 1995

P1‐097: TRAUMATIC BRAIN INJURY IN A MOUSE MODEL OF ALZHEIMER'S DISEASE LEADS TO PERSISTENT GLIAL ACTIVATION, CHRONIC PROINFLAMMATORY PHENOTYPE, AND INCREASED COGNITIVE DEFICITS

scientific article published on 06 September 2014

Peripheral (deep) but not periventricular MRI white matter hyperintensities are increased in clinical vascular dementia compared to Alzheimer's disease

scientific article

Perturbation of the calmodulin system in transformed cells

scientific article published on January 1990

Preclinical AD Workgroup staging: pathological correlates and potential challenges.

scientific article published on 19 April 2011

Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition

scientific article

Preparation and use of iodinated calmodulin for studies of calmodulin-binding proteins

scientific article published on 01 January 1988

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults

scientific article published on 22 June 2020

Production and characterization of monoclonal antibodies with specificity for the S100 beta polypeptide of brain S100 fractions ⬇️

scientific article published on October 1, 1984

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

scientific article

Rapid separation and quantitation of 3',5'-cyclic nucleotides and 5'-nucleotides in phosphodiesterase reaction mixtures using high-performance liquid chromatography

scientific article published on 01 March 1980

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

Rarity of the Alzheimer disease-protective APP A673T variant in the United States

scientific article

Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes

scientific article published on 5 September 2002

Reproducible production and characterization of anti-calmodulin antisera

scientific article published on 01 January 1980

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.

scientific article

Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals

scientific article published on 6 January 2016

S100 beta and serotonin: a possible astrocytic-neuronal link to neuropathology of Alzheimer's disease

scientific article published on January 1, 1992

S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions

scientific article published in September 1994

S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway

scientific article published in October 1996

S100 beta protects hippocampal neurons from damage induced by glucose deprivation

scientific article published on 01 April 1995

S100 beta stimulates calcium fluxes in glial and neuronal cells ⬇️

scientific article published on May 15, 1992

S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes

scientific article published in February 1996

S100B proteins that lack one or both cysteine residues can induce inflammatory responses in astrocytes and microglia

scientific article

S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors

scientific article

S100β Increases Levels of β‐Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures ⬇️

scientific article published on October 1, 1998

S100β Induces Neuronal Cell Death Through Nitric Oxide Release from Astrocytes ⬇️

scientific article published on 01 December 1997

Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets

scientific article

Selective modulation of BV-2 microglial activation by prostaglandin E(2). Differential effects on endotoxin-stimulated cytokine induction

scientific article published on October 1999

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology.

scientific article published on 15 December 2016

Self-Reported Memory Complaints: A Comparison of Demented and Unimpaired Outcomes

scientific article published on March 2016

Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort

scientific article

Self-reported memory complaints: implications from a longitudinal cohort with autopsies

scientific article

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

scientific article published on 18 May 2018

Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands

scientific article published on 01 November 2001

Spinach calmodulin: isolation, characterization, and comparison with vertebrate calmodulins

scientific article published on 01 December 1980

Structure and enzymology of a death-associated protein kinase

scientific article

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

scientific article

TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase ⬇️

scientific article published on July 1, 1998

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

scientific article

Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

scientific article published on November 2012

Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

scientific article

Targeting innate immunity for neurodegenerative disorders of the central nervous system

scientific article

Targeting protein kinases in central nervous system disorders

scientific article

The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases

scientific article

The C-terminus and linker region of S100B exert dual control on protein-protein interactions with TRTK-12.

scientific article published in April 2002

The Effectiveness of Small-group Community-based Information Sessions on Clinical Trial Recruitment for Secondary Prevention of Alzheimer's Disease

scientific article published on 20 May 2016

The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain

scientific article published on January 2003

The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review

scientific article published on 11 January 2020

The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS ⬇️

scientific article published on September 24, 2010

The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target

scientific article

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

scientific article

The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.

scientific article published on April 2013

The roles of inflammation and immune mechanisms in Alzheimer's disease

scientific article published on 30 May 2016

The solution structure of the bovine S100B protein dimer in the calcium-free state

scientific article

Tissue distribution of rat S100 alpha and S100 beta and S100-binding proteins

scientific article published on 01 March 1987

Transcriptional regulation of the human S100 beta gene

scientific article published in June 1997

Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton

scientific article

University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology

scientific article

Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity

scientific article

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

scientific article

Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model

scientific article published in April 2005

White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.

scientific article

[Penetrating peptide inhibitor of the myosin light chain kinase suppresses hyperpermeability of vascular endothelium].

scientific article

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