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List of works by Heather Eng

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol

scientific article published on 07 September 2018

A Physiologically Based in Silico Tool to Assess the Risk of Drug-Related Crystalluria

scientific article published on 13 March 2020

A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS

scientific article published on 08 March 2018

Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)

scientific article published on 02 August 2018

Alfuzosin delays cardiac repolarization by a novel mechanism

scientific article published on 6 November 2007

An estimate of the number of hepatocyte donors required to provide reasonable estimates of human hepatic clearance from in vitro experiments

scientific article published on 01 April 2007

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

scholarly article

Classification and Regression Tree (CART) analysis to predict influenza in primary care patients

scientific article

Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

scientific article published on 07 March 2017

Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivat

scientific article published on 2 April 2021

Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor

scientific article published on 7 May 2013

Determination of Eligibility for Influenza Research: A Clinical Informatics Approach

scientific article published on 10 June 2019

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), etc.

scientific article

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

scientific article published on 28 October 2015

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators.

scientific article published on 18 October 2017

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

scientific article published on 13 September 2020

Disposition of PF-07321332 (Nirmatrelvir), an Orally Bioavailable Inhibitor of SARS-CoV-2 3CL Protease, across Animals and Humans

scientific article published on 13 February 2022

Electronic source materials in clinical research: acceptability and validity of symptom self-rating in major depressive disorder

scientific article published on 2 February 2007

Estimation of the Effect of OAT2-Mediated Active Uptake on Meloxicam Exposure in the Human Liver

scientific article published on 03 January 2020

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

scientific article

Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement

scientific article

In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF-00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor

scientific article

In vitro metabolism of the glucagon-like peptide-1 (GLP-1)-derived metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in mouse and human hepatocytes

scientific article published on 20 September 2013

Influenza Vaccine Intention After a Medically Attended Acute Respiratory Infection

scientific article published on 13 July 2018

Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia / Cholestasis

scientific article published on 27 September 2016

Intention to receive influenza vaccine after an acute respiratory illness

scientific article

In Vitro-In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein-Cannulated Monkey.

scientific article published on 17 December 2016

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

scientific article published on 26 October 2017

Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1

scientific article published on 12 March 2019

Mechanistic Insights on Clearance and Inhibition Discordance between Liver Microsomes and Hepatocytes When Clearance in Liver Microsomes Is Higher than in Hepatocytes

scientific article published on 11 September 2020

Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.

scientific article published on 20 August 2014

Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D).

scientific article published in May 2004

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).

scientific article

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

scientific article published on October 2012

Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey

scientific article published on 28 January 2021

Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma

scientific article

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides.

scientific article published on 5 June 2015

Pharmacokinetics and metabolism studies on the glucagon-like peptide-1 (GLP-1)-derived metabolite GLP-1(9-36)amide in male Beagle dogs

scientific article published on 4 March 2014

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

scientific article published on 18 October 2021

Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs

scientific article published on 28 September 2020

Proposed Clinical Indicators for Efficient Screening and Testing for COVID-19 Infection from Classification and Regression Trees (CART) Analysis

scientific article published on 15 May 2020

Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor

scientific article

Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides

scientific article published on 20 November 2014

Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes

scientific article published on 14 April 2016

Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes

scientific article published on 29 July 2021

Statistical methods for analysis of time-dependent inhibition of cytochrome p450 enzymes

scientific article published on 31 August 2012

The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy

scientific article published on 17 February 2016

Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast

scientific article published on 20 September 2016

Undesired versus designed enzymatic cleavage of linkers for liver targeting

scientific article published on 8 January 2014

Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes.

scientific article published on 6 June 2016

Use of influenza antiviral medications among outpatients at high risk for influenza-associated complications during the 2013-2014 influenza season

scientific article

Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor

scientific article published in June 2010

Viral infections in outpatients with medically attended acute respiratory illness during the 2012-2013 influenza season

scientific article

Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project

scientific article published on January 2004

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