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List of works by Michael Ristow

A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism

scientific article published on 19 May 2016

A Mitochondrially Encoded Hormone Ameliorates Obesity and Insulin Resistance

scientific article published on 01 March 2015

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

scientific article published on 21 November 2008

A cell-based high-throughput assay system reveals modulation of oxidative and nonoxidative glucose metabolism due to commonly used organic solvents

scientific article published on January 2008

A radical opposition in body weight control ⬇️

scientific article published on August 1, 2013

Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men

scientific article (publication date: March 2006)

Activation of mitochondrial energy metabolism protects against cardiac failure

scientific article

Adiponectin Oligomers in Human Serum during Acute and Chronic Exercise: Relation to Lipid Metabolism and Insulin Sensitivity

scientific article published on 28 November 2006

Adiponectin and protection against type 2 diabetes mellitus

scientific article

Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome.

scientific article published in December 2004

Ageing with elegans: a research proposal to map healthspan pathways

scientific article published on 4 April 2016

Alterations of pancreatic beta-cell mass and islet number due to Ins2-controlled expression of Cre recombinase: RIP-Cre revisited; part 2.

scientific article published in May 2007

An association between NIDDM and a GAA trinucleotide repeat polymorphism in the X25/frataxin (Friedreich's ataxia) gene

article

Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans

scientific article

Antioxidant supplements in exercise: worse than useless?

scientific article published on 01 February 2012

Antioxidants prevent health-promoting effects of physical exercise in humans

scientific article

Author Correction: Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

scientific article published on 21 July 2020

Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes

scientific article published in April 2004

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

scientific article

Chemical Inhibition of Citrate Metabolism Alters Glucose Metabolism in Mice

scientific article published on 01 August 2006

Comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry (GC × GC-TOF) for high resolution metabolomics: biomarker discovery on spleen tissue extracts of obese NZO compared to lean C57BL/6 mice

article

Consuming fructose-sweetened beverages increases body adiposity in mice.

scientific article published in July 2005

Crystal structure of human frataxin

scientific article

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

scientific article published on 08 April 2014

Deficiency in ROS-sensing nuclear factor erythroid 2-like 2 causes altered glucose and lipid homeostasis following exercise training

scientific article published on 27 November 2019

Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice

scientific article published on 27 May 2008

Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance

scientific article

Deficiency of phosphofructo-1-kinase/muscle subtype in humans is associated with impairment of insulin secretory oscillations.

scientific article published on August 1999

Dietary Carbohydrates Impair Healthspan and Promote Mortality

scientific article published in October 2017

Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans

scientific article

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?

scientific article

Elevation of blood glucose following anaesthetic treatment in C57BL/6 mice.

scientific article published in January 2004

Endogenous metabolites promote stress resistance through induction of mitohormesis

scientific article published on 23 April 2020

Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection

scientific article published in 2022

Extending life span by increasing oxidative stress

scientific article (publication date: 15 July 2011)

Extension of life span by impaired glucose metabolism in Caenorhabditis elegans is accompanied by structural rearrangements of the transcriptomic network

scientific article

Frataxin activates mitochondrial energy conversion and oxidative phosphorylation

scientific article

Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells.

scientific article

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass

scientific article

Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass

article published in 2003

Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro

scientific article published on April 2002

Gender-Specific Effects of Health and Lifestyle Markers on Individual BrainAGE

article

Gender-specific impact of personal health parameters on individual brain aging in cognitively unimpaired elderly subjects

scientific article

Ghrelin is not suppressed in hyperglycemic clamps by gastric inhibitory polypeptide and arginine.

scientific article

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

scientific article

Glukosestoffwechsel und Tumorwachstum

Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan

scientific article published on 10 January 2022

Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans

scientific article published in September 2000

High activity enables life on a high-sugar diet: blood glucose regulation in nectar-feeding bats

scientific article published on 13 April 2011

High baseline vitamin C levels do not prevent a positive outcome of a lifestyle intervention: response to Thamer et al.

scientific article published in January 2010

High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytes

scientific article

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

scientific article

Impact of cereal fibre on glucose-regulating factors

scientific article published on 20 September 2005

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

scientific article published on April 2012

Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia

scientific article published on 10 January 2007

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

scientific article published on 3 March 2018

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan

scientific article published on 22 May 2017

Improved glucose metabolism in mice lacking alpha-tocopherol transfer protein

scientific article published on 19 September 2007

Improvement of HbA(1c) and stable weight loss 2 years after an outpatient treatment and teaching program for patients with type 2 diabetes without insulin therapy based on urine glucose self-monitoring

scientific article published on 13 March 2012

In silico evidence for gluconeogenesis from fatty acids in humans

scientific article published in July 2011

Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited

scientific article

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

scientific article published on March 2003

Ingestion of single guide RNAs induces gene overexpression and extends lifespan in Caenorhabditis elegans via CRISPR activation

scientific article published in 2022

Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth

scientific article

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes

scientific article

Insulin resistance and impaired insulin secretion due to phosphofructo-1-kinase-deficiency in humans

scientific article

Insulin-regulated transcription factors: molecular link between insulin resistance and cardiovascular risk factors

scientific article published on 01 May 2001

Interview with Michael Ristow ⬇️

scientific article published on January 1, 2012

L-Theanine extends lifespan of adult Caenorhabditis elegans

scientific article

Lifespan effects of mitochondrial mutations

scientific article published in December 2016

Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner

scientific article published on April 2013

Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro.

scientific article

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan.

scientific article published on 24 February 2016

Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species

scientific article

Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease.

scientific article published in December 2001

Low-dose lithium uptake promotes longevity in humans and metazoans

scientific article

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.

scientific article published on 12 April 2018

Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan

scientific article published on 13 July 2019

Maternally inherited differences within mitochondrial Complex I control murine healthspan

article published in 2018

MicroRNA-29a in Adult Muscle Stem Cells Controls Skeletal Muscle Regeneration During Injury and Exercise Downstream of Fibroblast Growth Factor-2.

scientific article published on 5 January 2016

Mitochondria and metabolic homeostasis

scientific article published on 28 March 2013

Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri

scientific article published on 27 June 2011

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

scientific article published on 06 May 2013

Mitochondrial impairment of human muscle in Friedreich ataxia in vivo

scientific article published on 01 August 2000

Mitohormesis in exercise training

scientific article

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).

scientific article

Mitohormesis: non-linear signaling responses to metabolic ROS formation

article

Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice

scientific article published in February 2005

Muscle phosphofructokinase deficiency in two generations

scientific article published on 01 September 1996

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

scientific article

Neurodegenerative disorders associated with diabetes mellitus

scientific article published on 3 June 2004

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

scientific article published on 14 February 2013

New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains.

scientific article

Non-linear impact of glutathione depletion on C. elegans life span and stress resistance

scientific article published on 06 December 2016

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice.

scientific article published on 20 April 2016

Obesity Research and the Physiology of Energy Homeostasis

Obesity associated with a mutation in a genetic regulator of adipocyte differentiation

scientific article

Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice

scientific article published on 10 March 2010

Oxidative Phosphorylation and Cancer: The Ongoing Warburg Hypothesis

Oxidative metabolism in cancer growth

scientific article (publication date: July 2006)

Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

scientific article published on 29 April 2020

Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system

scientific article published on April 2014

Perspektiven des medizinisch-kademischen Nachwuchses in Deutschland

Physical activity does not influence the effect of antioxidant supplementation at nutritional doses on the incidence of impaired fasting glucose: a 7.5 year post-hoc analysis from the SU.VI.MAX study

scientific article published on 27 July 2010

Predictors of abnormal glucose metabolism in women with polycystic ovary syndrome.

scientific article published in February 2006

Prevalence of injection-meal interval usage and its association with variables of metabolic control in patients with Type 1 and Type 2 diabetes

scientific article published in February 2011

Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress

scientific article published on 06 August 2010

Prävention von Krankheiten und Steigerung der Lebenserwartung durch Kalorienrestriktion

Publisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.

scientific article published on 31 May 2019

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

scientific article

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance

scientific article published in September 2007

Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A

scientific article published on 04 February 2020

Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity

scientific journal article

Restricted geographical extension of the association of a glucagon receptor gene mutation (Gly40Ser) with non-insulin-dependent diabetes mellitus

article

Serum vaspin concentrations are decreased after exercise-induced oxidative stress.

scientific article published on 20 October 2010

Small-molecule targeting of the mitochondrial compartment with an endogenously cleaved reversible tag.

scientific article

Specific alterations of carbohydrate metabolism are associated with hepatocarcinogenesis in mitochondrially impaired mice

scientific article published on 03 November 2011

Statistical methods for comparing comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry results: Metabolomic analysis of mouse tissue extracts

article

Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice

scientific journal article

Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice

Telomerase deficiency impairs glucose metabolism and insulin secretion

scientific article

The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals

scientific article

The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity.

scientific article published in August 2002

The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans

scientific article published on 24 January 2011

The polycystic ovary syndrome per se is not associated with increased chronic inflammation

scientific article published in April 2004

The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins

scientific article published in August 2002

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

scientific article published on 30 January 2018

Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping

scientific article

Warburg and his Legacy

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