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List of works by Hiroshi Kobayashi

A Case of Early-Stage Ovarian Carcinoid Tumor Metastasized to the Liver ⬇️

scientific article published on December 26, 2012

A Classification Proposal for Adenomyosis Based on Magnetic Resonance Imaging

scientific article published on 11 March 2020

A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-beta 1 signaling cascade

scientific article published on 20 December 2002

A Relationship Between Endometriosis and Obstetric Complications

scientific article published on 06 January 2020

A case of intravenous leiomyomatosis with high levels of hyaluronan

scientific article published in April 2010

A case of recurrent endometrial cancer metastasis successfully treated with zoledronic Acid

scientific article published on June 1, 2011

A diagnostic challenge of seromucinous borderline tumor: A case report

scientific article published on 01 May 2019

A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-beta and subsequently suppresses TGF-beta signalings

scientific article

A neonate with umbilical arteriovenous malformation showing hemorrhagic shock from massive umbilical hemorrhage

scientific article published on 27 April 2009

A novel peptide blocking cancer cell invasion by structure-based drug design

scientific article

A potential link of oxidative stress and cell cycle regulation for development of endometriosis.

scientific article published on 17 May 2012

A soybean Kunitz trypsin inhibitor reduces tumor necrosis factor-alpha production in ultraviolet-exposed primary human keratinocytes

scientific article published in October 2005

A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation

scientific article published on January 2004

Addition of aprepitant to standard therapy for prevention of nausea and vomiting among patients with cervical cancer undergoing concurrent chemoradiotherapy

scientific article published on 19 August 2015

Aging impairs the protective effect of magnesium supplementation on hypertension in spontaneously hypertensive rats

scientific article published in September 2007

Analysis of Risk Factors for Lymphatic Metastasis in Endometrial Carcinoma and Utility of Three-Dimensional Magnetic Resonance Imaging in Gynecology.

scientific article published on 26 June 2018

Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain

scientific article published on 08 May 2010

Antiangiogenic-Induced Hypertension: The Molecular Basis of Signaling Network ⬇️

scientific article published on 03 January 2012

Anticytokine therapy in preterm labor: current knowledge and future perspectives

scientific article published on 15 December 2010

Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling.

scientific article

Bikunin plus paclitaxel markedly reduces tumor burden and ascites in mouse model of ovarian cancer

scientific article

Bikunin suppresses expression of pro-inflammatory cytokines induced by lipopolysaccharide in neutrophils

scientific article published on 01 January 2007

Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophages

scientific article

CA-125 cut-off value as a predictor for complete interval debulking surgery after neoadjuvant chemotherapy in patients with advanced ovarian cancer ⬇️

scientific article published on April 5, 2013

CD44 stimulation by fragmented hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells

scientific article published on August 2002

CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells

scientific article published on December 2002

Candidate synthetic lethality partners to PARP inhibitors in the treatment of ovarian clear cell cancer

scientific article published on 27 September 2017

Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma.

scientific article published on 05 January 2017

Checkpoint kinase 1 inhibitors as targeted molecular agents for clear cell carcinoma of the ovary

scientific article published on 26 May 2015

Chemokine and Free Fatty Acid Levels in Insulin-Resistant State of Successful Pregnancy: A Preliminary Observation ⬇️

scientific article published on February 9, 2012

Clear Cell Adenocarcinoma Arising from Endometriosis in the Groin: Wide Resection and Reconstruction with a Fascia Lata Tensor Muscle Skin Flap.

scientific article published in April 2018

Clear cell carcinoma of the ovary: potential pathogenic mechanisms (Review).

scientific article published on May 2010

Clinical Significance of Tissue Factor Pathway Inhibitor 2, a Serum Biomarker Candidate for Ovarian Clear Cell Carcinoma

scientific article

Clinical significance of M2 macrophages expressing heme oxygenase-1 in malignant transformation of ovarian endometrioma

scientific article published on 12 December 2018

Clinicopathologic features of ovarian cancer in patients with ovarian endometrioma

scientific article published on October 2008

Combination of B‐Lynch brace suture and uterine artery embolization for atonic bleeding after cesarean section in a patient with placenta previa accreta ⬇️

scientific article published on 05 December 2011

Comparison of Neoadjuvant Intraarterial Chemotherapy Versus Concurrent Chemoradiotherapy in Patients With Stage IIIB Uterine Cervical Cancer

scientific article published in December 2013

Comparison of redox parameters in ovarian endometrioma and its malignant transformation

scientific article published on 31 July 2018

Comparison of the Different Definition Criteria for the Diagnosis of Amniotic Fluid Embolism

scientific article published in July 2017

Complement, fetal antigen, and shaking rigors in parturients

scientific article published on 01 January 2006

Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary

scientific article published on 20 June 2018

Cut-off value of D-dimer for prediction of deep venous thrombosis before treatment in ovarian cancer ⬇️

scientific article published on April 3, 2012

Cyst fluid hemoglobin species in endometriosis and its malignant transformation: The role of metallobiology

scientific article published on 29 March 2016

Cyst fluid iron-related compounds as useful markers to distinguish malignant transformation from benign endometriotic cysts

scientific article published in January 2015

Dietary supplementation of soybean kunitz trypsin inhibitor reduces lipopolysaccharide-induced lethality in mouse model

scientific article published on May 2005

Discrimination of malignant transformation from benign endometriosis using a near-infrared approach

scientific article published on 19 January 2018

Enhanced spontaneous metastasis in bikunin-deficient mice

scientific article published on 01 May 2006

Epigenetic dysregulation of endometriosis susceptibility genes (Review).

scientific article published on 16 April 2015

Evaluation of the relation between patient characteristics and the state of chemotherapy-induced nausea and vomiting in patients with gynecologic cancer receiving paclitaxel and carboplatin

scientific article published on 02 November 2013

Evaluation of the vessels of the cardinal ligament by transrectal ultrasonography with color Doppler imaging ⬇️

scientific article published on 06 June 2011

Evaluation of vaginal fluid squamous cell carcinoma antigen test in diagnosis of premature rupture of membranes.

scientific article published on 19 April 2016

Expression profiles of genes involved in poor prognosis of epithelial ovarian carcinoma: a review

scientific article published on August 2009

Factors that Differentiate between Endometriosis-associated Ovarian Cancer and Benign Ovarian Endometriosis with Mural Nodules

scientific article published on 21 August 2017

Fatal factors of clinical manifestations and laboratory testing in patients with amniotic fluid embolism

scientific article published on 24 April 2010

Fetal programming theory: implication for the understanding of endometriosis

scientific article published on 27 December 2013

Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells

scientific article published in March 2003

GSK-3β mediates the effects of HNF-1β overexpression in ovarian clear cell carcinoma

scientific article published on 21 September 2020

Genes Downregulated in Endometriosis Are Located Near the Known Imprinting Genes.

scientific article

Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells

scientific article published on 3 November 2003

Giant abdominal tumor of the ovary

scientific article published on February 2008

Hepatocyte growth factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial cancer cells.

scientific article published on January 2008

Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis

scientific article published on 11 October 2012

Hereditary breast and ovarian cancer susceptibility genes (review).

scientific article published on 19 June 2013

High-Quality Transmission of Cardiotocogram and Fetal Information Using a 5G System: Pilot Experiment

scientific article published on 08 September 2020

Hypoxia promotes extravillous trophoblast cell invasion through the hypoxia-inducible factor urokinase-type plasminogen activator receptor pathway.

scientific article published in 2022

Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)

scientific article

Immunohistochemical expression of CD44v9 and 8-OHdG in ovarian endometrioma and the benign endometriotic lesions adjacent to clear cell carcinoma

scientific article published on 14 August 2019

Increase of high molecular weight adiponectin in hypertensive pregnancy was correlated with brain-type natriuretic peptide stimulation on adipocyte

scientific article published on 26 July 2011

Inflammatory pattern recognition receptors and their ligands: factors contributing to the pathogenesis of preeclampsia ⬇️

scientific article published on 06 March 2011

Inhibition of cell death and induction of G2 arrest accumulation in human ovarian clear cells by HNF-1β transcription factor: chemosensitivity is regulated by checkpoint kinase CHK1.

scientific article

Integrating modern approaches to pathogenetic concepts of malignant transformation of endometriosis

scientific article published on 21 December 2018

Intravascular Large B-Cell Lymphoma Coexisting with an Ovarian Carcinoma.

scientific article published on January 2016

Involvement of Receptor for Advanced Glycation Endproducts in Hypertensive Disorders of Pregnancy ⬇️

scientific article published on 01 November 2019

Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia

scientific article published on 31 May 2015

Iron-dependent oxidative stress as a pathogenesis for preterm birth

scientific article published on October 2008

Late onset of pulmonary embolism caused by lymphocyst following pelvic lymphadenectomy

scientific article published in October 2007

Link protein as an enhancer of cumulus cell-oocyte complex expansion

scientific article published in October 2002

Long-Term Follow-Up after Surgical Management for Atypical Endometriosis: A Series of Nine Cases

Magnetic resonance imaging findings for discriminating clear cell carcinoma and endometrioid carcinoma of the ovary

scientific article published on 25 February 2019

Magnetic resonance relaxometry improves the accuracy of conventional MRI in the diagnosis of endometriosis-associated ovarian cancer: A case report

scientific article published on 01 July 2019

Malignant Transformation from Endometriosis to Atypical Endometriosis and Finally to Endometrioid Adenocarcinoma within 10 Years

scientific article published on 21 September 2013

Massive ovarian edema in pregnancy after ovulation induction using clomiphene citrate

scientific article published on 3 October 2007

Mechanism of pain generation for endometriosis-associated pelvic pain

scientific article published on 12 October 2013

Mechanisms Underlying Adenomyosis-Related Fibrogenesis

scientific article published on 05 September 2019

Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis

scientific article published on 16 November 2018

Modulation of estrogenic action in clear cell carcinoma of the ovary (Review) ⬇️

scientific article published on October 24, 2011

Molecular genetics and epidemiology of epithelial ovarian cancer (Review) ⬇️

scientific article published on September 12, 2011

Molecular mechanisms linking endometriosis under oxidative stress with ovarian tumorigenesis and therapeutic modalities

scientific article published on 25 April 2012

Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review).

scientific article published on August 2009

Molecular structure and function analysis of bikunin on down-regulation of tumor necrosis factor-alpha expression in activated neutrophils

scientific article published on 28 January 2008

New insights into pattern recognition receptors and their ligands in gynecologic pathologies ⬇️

scientific article published on December 15, 2010

New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal

scientific article published on 16 August 2010

New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor

scientific article published on 10 August 2013

Nonhormonal Treatment for Endometriosis Focusing on Redox Imbalance

scientific article published on 04 January 2021

Ovarian endometrioma--risks factors of ovarian cancer development

scientific article published on 26 December 2007

Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro

scientific article published on January 2005

Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation

scientific article (publication date: 2015)

Oxytocin hypersensitivity in pregnant P-LAP deficient mice

scientific article published on 26 February 2009

PP029. Genetic change of adipose tissue related to inflammation in preeclampsia: Findings under novel culture method

scientific article

Pathogenesis and malignant transformation of adenomyosis (review).

scientific article published on 13 December 2012

Pathogenesis of endometriosis: the role of initial infection and subsequent sterile inflammation (Review).

scientific article published on 24 October 2013

Peripheral RAGE (Receptor for Advanced Glycation Endproducts)-ligands in normal pregnancy and preeclampsia: novel markers of inflammatory response ⬇️

scientific article published on March 3, 2012

Peritoneal disseminated recurrence and lung metastasis after surgery for stage IA uterine papillary serous carcinoma of the endometrium: a case report

scientific article published on 12 January 2008

Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium.

scientific article published on 18 December 2017

Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: possible relation to preeclampsia and preterm delivery ⬇️

scientific article published on July 29, 2009

Plasma bikunin as a favorable prognostic factor in ovarian cancer

scientific article published on 01 March 2005

Posttreatment cut-off levels of squamous cell carcinoma antigen as a prognostic factor in patients with locally advanced cervical cancer treated with radiotherapy

scientific article published on 02 October 2013

Potential signaling pathways as therapeutic targets for overcoming chemoresistance in mucinous ovarian cancer

scientific article published on 17 January 2018

Predictor of mortality in patients with amniotic fluid embolism

scientific article published on 10 December 2013

Preliminary evidence of a paternal-maternal genetic conflict on the placenta: Link between imprinting disorder and multi-generational hypertensive disorders

scientific article published on 23 February 2019

Prevalence of ovarian cancer among women with a CA125 level of 35 U/ml or less

scientific article published on 23 October 2007

Redox-Active Iron-Induced Oxidative Stress in the Pathogenesis of Clear Cell Carcinoma of the Ovary ⬇️

scientific article published on October 1, 2011

Reduced bikunin gene expression as a factor of poor prognosis in ovarian carcinoma

scientific article

Relationship between adenomyosis and endometriosis; Different phenotypes of a single disease?

scientific article published on 23 August 2020

Reproductive failure in mice lacking inter-alpha-trypsin inhibitor (ITI)--ITI target genes in mouse ovary identified by microarray analysis

scientific article published in October 2004

Risk factors for wound complications after surgery for gynecologic malignancies

scientific article published in October 2013

Risk of carcinoma in women with ovarian endometrioma ⬇️

scientific article published on January 1, 2011

Role of Oxidative Stress in Epigenetic Modification in Endometriosis

scientific article

Satisfaction of a new telephone consultation service for prenatal and postnatal health care

scientific article published on 06 May 2019

Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer

scientific article published on 20 May 2019

Sequential molecular changes and dynamic oxidative stress in high-grade serous ovarian carcinogenesis

scientific article

Sequential screening to predict symptomatic pulmonary thromboembolism after gynecologic surgery in Nara, Japan

scientific article published in October 2015

Shared Molecular Features Linking Endometriosis and Obstetric Complications

scientific article published on 06 January 2020

Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells ⬇️

scientific article published on June 15, 2011

Skeletal muscle metastasis as a first site of recurrence of cervical cancer: A case report and review of the literature

scientific article published on 01 May 2020

Squamous cell carcinoma antigen as a novel candidate marker for amniotic fluid embolism.

scientific article published on 11 September 2017

Subtype I (intrinsic) adenomyosis is an independent risk factor for dienogest-related serious unpredictable bleeding in patients with symptomatic adenomyosis

scientific article published on 27 November 2019

Successful laparoscopic management of a primary omental pregnancy: case report and review of literature

scientific article

Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model

scientific article published on November 2004

Suppression of lipopolysaccharide-induced cytokine production of gingival fibroblasts by a soybean, Kunitz trypsin inhibitor

scientific article published on 01 December 2005

Suppression of urokinase expression and invasion by a soybean Kunitz trypsin inhibitor are mediated through inhibition of Src-dependent signaling pathways

scientific article published on 7 July 2005

Suppression of urokinase receptor expression by thalidomide is associated with inhibition of nuclear factor kappaB activation and subsequently suppressed ovarian cancer dissemination

scientific article published on November 2005

Targeted molecular therapies for ovarian cancer: An update and future perspectives (Review) ⬇️

scientific article published on May 25, 2012

Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation

scientific article

The HNF-1β-USP28-Claspin pathway upregulates DNA damage-induced Chk1 activation in ovarian clear cell carcinoma

scientific article published on 3 April 2018

The Usefulness of Photodynamic Eye for Sentinel Lymph Node Identification in Patients with Cervical Cancer ⬇️

scientific article published on November 1, 2010

The biology of uterine sarcomas: A review and update

scientific article published on 20 May 2013

The conceptual advances of carcinogenic sequence model in high-grade serous ovarian cancer

scientific article

The dichotomy in the histogenesis of endometriosis-associated ovarian cancer: clear cell-type versus endometrioid-type adenocarcinoma

scientific article published on 01 July 2012

The role of components of the chromatin modification machinery in carcinogenesis of clear cell carcinoma of the ovary (Review) ⬇️

scientific article published on May 16, 2011

The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary

scientific article published on April 2009

The role of iron in the pathogenesis of endometriosis

scientific article published on January 2009

Theoretical model of treatment strategies for clear cell carcinoma of the ovary: focus on perspectives

scientific article published on 08 August 2009

Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer

scientific article published in February 2004

Thymidine phosphorylase expression in tumor-infiltrating macrophages may be correlated with poor prognosis in uterine endometrial cancer

scientific article published in November 2002

Toward an understanding of the pathophysiology of clear cell carcinoma of the ovary (Review).

scientific article published on 28 August 2013

Towards an understanding of the molecular mechanism of endometriosis: unbalancing epithelial-stromal genetic conflict.

scientific article published on 03 September 2013

Transforming Growth Factor-β1 Produced by Ovarian Cancer Cell Line HRA Stimulates Attachment and Invasion through an Up-regulation of Plasminogen Activator Inhibitor Type-1 in Human Peritoneal Mesothelial Cells ⬇️

scientific article published on May 12, 2003

Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells

scientific article published in October 2004

Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells

scientific article published on 15 December 2003

Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis

scientific article

Two cases of pregnant women with ovarian endometrioma mimicking a malignant ovarian tumor

scientific article published on 01 October 2008

Upregulation of bikunin in tumor-infiltrating macrophages as a factor of favorable prognosis in ovarian cancer

scientific article published on 01 September 2004

Uterine adenomatoid tumor associated with lymph node lesions: a case report

scientific article published on 14 February 2020

Uterine carcinosarcoma including angiosarcoma: A short case report

scientific article published on 4 September 2016

Uterine endometrial carcinoma with DNA mismatch repair deficiency: magnetic resonance imaging findings and clinical features

scientific article published on 04 May 2018

Vaginal delivery after placental abruption and intrauterine fetal death, including failed cases

scientific article published on 02 April 2014

Vaginal fluid pH and buffer capacity for predicting false preterm labor in Japanese women

scientific article

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