List of works by Devorah Crown

A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model

scientific article

Anthrax edema factor toxicity is strongly mediated by the N-end rule

scientific article

Anthrax edema toxin impairs clearance in mice

scientific article published on 21 November 2011

Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages

scientific journal article

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice

scientific article

Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy

scientific article

Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain

scientific article

Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes

scientific article published on 13 December 2013

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

scientific article

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

scientific article

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

scientific article published on 18 February 2014

Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

scientific article

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors

scientific article

Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1β release is a neutrophil and PAD4-dependent event

scientific article published on 18 May 2020

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii

scientific article

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment

scientific article

Key tissue targets responsible for anthrax-toxin-induced lethality

scientific article

Lipoprotein biosynthesis by prolipoprotein diacylglyceryl transferase is required for efficient spore germination and full virulence of Bacillus anthracis

scientific article published on 22 November 2011

Mouse monoclonal antibodies to anthrax edema factor protect against infection

scientific article published on 12 September 2011

MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function

scientific article

Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody

scientific article published on 15 June 2009

Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding

scientific article published on 27 July 2009

Role of N-terminal amino acids in the potency of anthrax lethal factor

scientific article

Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection

scientific article published on 17 June 2013

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1

scientific article

The Bacillus cereus Hbl and Nhe tripartite enterotoxin components assemble sequentially on the surface of target cells and are not interchangeable

scientific article

The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).

scientific article

Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity

scientific article published on 8 January 2018

Transcriptional analysis of the three Nlrp1 paralogs in mice

scientific article

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