List of works - Philip J Kranzusch

A Broad-Spectrum Inhibitor of CRISPR-Cas9.

scientific article

A bacterial Argonaute with noncanonical guide RNA specificity

scientific article published on 30 March 2016

A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)

scientific article published on 13 July 2020

African origin of the malaria parasite Plasmodium vivax

scientific article

Analysis of human cGAS activity and structure

scientific article published on 02 May 2019

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling

scientific article

Architecture and regulation of negative-strand viral enzymatic machinery

scientific article

Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex

scientific article published on 21 November 2011

Assembly of a functional Machupo virus polymerase complex

scientific article

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

scientific article published on 20 February 2019

CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

scientific article published on 04 June 2020

Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

scientific article

Conserved strategies for pathogen evasion of cGAS-STING immunity

scientific article published on 15 April 2020

Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.

scientific article

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

scientific article

Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry

scientific article

Foreign DNA capture during CRISPR-Cas adaptive immunity

scientific article

Foreign DNA capture during CRISPR–Cas adaptive immunity

scientific article published in Nature

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin

scientific article

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

scientific article published on 01 April 2019

Molecular architecture of the vesicular stomatitis virus RNA polymerase.

scientific article

Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas

scientific article

Origin of the human malaria parasite Plasmodium falciparum in gorillas

scientific article

Origin of the human malaria parasite Plasmodium falciparum in gorillas.

scientific article

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity

scientific article published on 08 April 2022

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

scientific article published on 28 February 2019

Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling

scientific article published on 01 May 2019

Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates

scientific article published on 31 January 2019

Ribose 2'-O Methylation of the Vesicular Stomatitis Virus mRNA Cap Precedes and Facilitates Subsequent Guanine-N-7 Methylation by the Large Polymerase Protein

scientific article

STING cyclic dinucleotide sensing originated in bacteria

scientific article published on 02 September 2020

Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity

scientific article published on 10 January 2020

Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration

scientific article published on 09 April 2019

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

scientific article

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance

scientific article published on 01 July 2018

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity

scientific article

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict

scientific article published on 16 November 2020

The polymerase of negative-stranded RNA viruses

scientific article

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling

scientific article published on 06 February 2019

cGAS Conducts Micronuclei DNA Surveillance

scientific article published on 4 September 2017

cGAS and CD-NTase enzymes: structure, mechanism, and evolution

scientific article published on 06 October 2019

cGAS dimerization entangles DNA recognition

scientific article

cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila

scientific article published on 14 July 2021

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

scientific journal article

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

scientific journal article

List of works by Philip J Kranzusch

A Broad-Spectrum Inhibitor of CRISPR-Cas9.

A bacterial Argonaute with noncanonical guide RNA specificity

A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)

African origin of the malaria parasite Plasmodium vivax

Analysis of human cGAS activity and structure

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling

Architecture and regulation of negative-strand viral enzymatic machinery

Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex

Assembly of a functional Machupo virus polymerase complex

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

Conserved strategies for pathogen evasion of cGAS-STING immunity

Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry

Foreign DNA capture during CRISPR-Cas adaptive immunity

Foreign DNA capture during CRISPR–Cas adaptive immunity

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

Molecular architecture of the vesicular stomatitis virus RNA polymerase.

Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas

Origin of the human malaria parasite Plasmodium falciparum in gorillas

Origin of the human malaria parasite Plasmodium falciparum in gorillas.

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling

Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates

Ribose 2'-O Methylation of the Vesicular Stomatitis Virus mRNA Cap Precedes and Facilitates Subsequent Guanine-N-7 Methylation by the Large Polymerase Protein

STING cyclic dinucleotide sensing originated in bacteria

Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity

Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict

The polymerase of negative-stranded RNA viruses

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling

cGAS Conducts Micronuclei DNA Surveillance

cGAS and CD-NTase enzymes: structure, mechanism, and evolution

cGAS dimerization entangles DNA recognition

cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation