List of works - Gregory D. Plowman

227 POSTER Anti-angiogenic effects of PI3K/Akt/mTOR pathway inhibitors

A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments ⬇️

scientific article published on July 24, 2012

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin

scientific article

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers ⬇️

scientific article published on June 1, 1998

A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester

scientific article (publication date: 17 October 1997)

Activation of ErbB4 by the Bifunctional Epidermal Growth Factor Family Hormone Epiregulin Is Regulated by ErbB2 ⬇️

scientific article published on May 1, 1998

Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells

scientific article

Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation

scientific article published on 01 June 1996

Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus

scientific article

Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer

scientific article published on 01 August 1993

Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7

scientific article

Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans

scientific article published on April 1994

Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models

scientific article published on October 2010

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

scientific article published on 23 May 2010

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.

scientific article

Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

scientific article published on 17 September 2019

Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene

article

Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity

scientific article published on 27 July 2020

Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth

scientific article

Blocking neuropilin-2 function inhibits tumor cell metastasis

scientific article

CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor

scientific article

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells ⬇️

scientific article published on May 19, 2011

Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form

scientific article published on July 1998

Cellular and viral ligands that interact with the EGF receptor

scientific article published on August 1990

Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity

scientific article published on 01 April 2020

Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor

scientific article

Characterization of a recombinant vaccinia virus expressing human melanoma-associated antigen p97.

scientific article

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

scientific article

Chromosomal sublocalization of the human p97 melanoma antigen

scientific article

Chronic DLL4 blockade induces vascular neoplasms

scientific article published in Nature

Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains

scientific journal article

Cloning and sequence analysis of simian transforming growth factor-beta cDNA.

scientific article

Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions

scientific article published in March 1997

Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family

scientific article published on January 1, 1992

Differential expression of epidermal growth factor-related proteins in human colorectal tumors ⬇️

scientific article published on September 1, 1991

ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine

scientific article published on 19 November 2019

Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins

scientific article

Evolution of protein kinase signaling from yeast to man

scientific article (publication date: October 2002)

Expression of amphiregulin, cripto-1, and heregulin-alpha in human breast-cancer cells

scientific article

Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the "window" of implantation.

scientific article published in October 1997

Expression of the c-erbB-3 protein in normal human adult and fetal tissues

scientific article (publication date: July 1992)

Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Implication for tumor biology and clinical behavior.

scientific article published on October 1994

HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein

scientific article published on March 1995

Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells

scientific article published on October 1992

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

scientific journal article

Identification of a new Pyk2 target protein with Arf-GAP activity

scientific article

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions

scientific article

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein

scientific article

Identification of an enhancer involved in the melanoma-specific expression of the tumor antigen melanotransferrin gene ⬇️

scientific article published on June 11, 1992

Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1

scientific article published on 01 May 1995

Informatics issues in large-scale sequence analysis: elucidating the protein kinases of C. elegans

scientific article published on October 2000

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

scientific article published on December 2006

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers

scientific article

Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells

scientific article

Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro

scientific article published on April 1995

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

scientific article

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene

scientific article

Molecular cloning of a novel bone-forming compound: osteoinductive factor

scientific article

Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations.

scientific article published on 13 June 2017

Neuregulins signaling via a glial erbB-2-erbB-4 receptor complex contribute to the neuroendocrine control of mammalian sexual development

scientific article published in November 1999

Neuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinal cancer cell lines

scientific article (publication date: 2011)

Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.

scientific article

Overcoming the gridlock in discovery research

scientific article published on 01 May 2004

Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells

scientific article published on 15 September 2009

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence

scientific article

Production and characterization of a polyclonal antibody to the c-erbB-3 protein: examination of c-erbB-3 protein expression in adenocarcinomas

scientific article published on November 1992

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

scientific article

Purification of Messenger RNA by Polysome Isolation with Monoclonal Antibodies

Purification of amphiregulin from serum-free conditioned medium of 12-O-tetradecanoylphorbol 13-acetate-treated cell lines

scientific article published on January 1, 1991

Recombinant vaccinia virus vaccine against the human melanoma antigen p97 for use in immunotherapy

scientific article

Regulation of amphiregulin mRNA by TGF-beta in the human lung adenocarcinoma cell line A549

scientific article published on January 1, 1992

Structure and function of human amphiregulin: a member of the epidermal growth factor family

scientific article

Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene

scientific article

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome

scientific article published on 22 February 2004

Target discovery in the postgenomic era.

scientific article published on 31 October 2003

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.

scientific article published on 4 June 2018

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

scientific article

The Heparin-Binding Domain of Amphiregulin Necessitates the Precursor Pro-Region for Growth Factor Secretion

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity

scientific article

The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin

scientific article

The discovery and validation of new drug targets in cancer

scientific article published on 01 December 1998

The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4

scientific journal article

The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth

scientific article

The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion

scientific article published on March 1994

The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor

scientific article

The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms

scientific article

The protein kinases of budding yeast: six score and more

scientific article

Transforming growth factor beta 1 supports autonomous growth of human papillomavirus-immortalized cervical keratinocytes under conditions promoting squamous differentiation

scientific article published on 01 June 1996

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype ⬇️

scientific article published on November 1, 1997

Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung

scientific article

cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta

scientific article published on September 1, 1992

List of works by Gregory D. Plowman

227 POSTER Anti-angiogenic effects of PI3K/Akt/mTOR pathway inhibitors

A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments ⬇️

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers ⬇️

A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester

Activation of ErbB4 by the Bifunctional Epidermal Growth Factor Family Hormone Epiregulin Is Regulated by ErbB2 ⬇️

Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells

Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation

Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus

Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer

Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7

Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans

Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.

Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene

Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity

Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth

Blocking neuropilin-2 function inhibits tumor cell metastasis

CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells ⬇️

Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form

Cellular and viral ligands that interact with the EGF receptor

Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity

Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor

Characterization of a recombinant vaccinia virus expressing human melanoma-associated antigen p97.

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

Chromosomal sublocalization of the human p97 melanoma antigen

Chronic DLL4 blockade induces vascular neoplasms

Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains

Cloning and sequence analysis of simian transforming growth factor-beta cDNA.

Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions

Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family

Differential expression of epidermal growth factor-related proteins in human colorectal tumors ⬇️

ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine

Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins

Evolution of protein kinase signaling from yeast to man

Expression of amphiregulin, cripto-1, and heregulin-alpha in human breast-cancer cells

Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the "window" of implantation.

Expression of the c-erbB-3 protein in normal human adult and fetal tissues

Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Implication for tumor biology and clinical behavior.

HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein

Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

Identification of a new Pyk2 target protein with Arf-GAP activity

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein

Identification of an enhancer involved in the melanoma-specific expression of the tumor antigen melanotransferrin gene ⬇️

Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1

Informatics issues in large-scale sequence analysis: elucidating the protein kinases of C. elegans

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers

Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells

Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene

Molecular cloning of a novel bone-forming compound: osteoinductive factor

Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations.

Neuregulins signaling via a glial erbB-2-erbB-4 receptor complex contribute to the neuroendocrine control of mammalian sexual development

Neuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinal cancer cell lines

Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.

Overcoming the gridlock in discovery research

Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence

Production and characterization of a polyclonal antibody to the c-erbB-3 protein: examination of c-erbB-3 protein expression in adenocarcinomas

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

Purification of Messenger RNA by Polysome Isolation with Monoclonal Antibodies

Purification of amphiregulin from serum-free conditioned medium of 12-O-tetradecanoylphorbol 13-acetate-treated cell lines

Recombinant vaccinia virus vaccine against the human melanoma antigen p97 for use in immunotherapy

Regulation of amphiregulin mRNA by TGF-beta in the human lung adenocarcinoma cell line A549

Structure and function of human amphiregulin: a member of the epidermal growth factor family

Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome

Target discovery in the postgenomic era.

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

The Heparin-Binding Domain of Amphiregulin Necessitates the Precursor Pro-Region for Growth Factor Secretion