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List of works by Jong K Yun

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

scientific article published on 27 August 2014

AP-1 binding transcriptionally regulates human neutral ceramidase

scientific article

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

scientific article

Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)

scientific article published on 23 August 2020

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

scientific article published on 23 February 2012

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

scientific journal article

Development of SKI-349, a Dual-Targeted Inhibitor of Sphingosine Kinase and Microtubule Polymerization

scientific article published on 28 July 2020

Development of a sphingosine kinase 1 specific small-molecule inhibitor

scientific article published on November 2010

Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics

scientific article published on 5 May 2011

Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery

scientific article published on December 2008

Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus

scientific article

Gβ2 and Gβ4 participate in the opioid and adrenergic receptor‐mediated Ca2+ channel modulation in rat sympathetic neurons ⬇️

scientific article published on June 18, 2012

Inflammatory mediators are perpetuated in macrophages resistant to apoptosis induced by hypoxia ⬇️

scientific article published on December 9, 1997

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression

scientific article published on 16 September 2011

Network model of survival signaling in large granular lymphocyte leukemia

scholarly article

Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation

scientific article

SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

scientific article published on July 2017

Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

scientific article published on 27 August 2010

Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism

scientific article published on 12 July 2007

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

scientific article

Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells

scientific article published on 03 April 2007

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

scientific article published on 24 September 2009

Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

scientific article published in May 2008

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

scientific article

Sphingosine kinase: a key to solving the 'French Paradox'?

scientific article published on July 2012

Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

scientific article published on 12 June 2010

Targeting sphingosine kinase-1 to inhibit melanoma.

scientific article published on March 2012

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

scientific article

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

scientific article published on 18 March 2015

Transcriptional regulation of the human neutral ceramidase gene

scientific article

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