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List of works by Zhen-Yong Keck

A Point Mutation Leading to Hepatitis C Virus Escape from Neutralization by a Monoclonal Antibody to a Conserved Conformational Epitope

scientific article

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

scientific article published on 23 October 2017

Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.

scientific article

Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus

scientific article

An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

scientific article published on 24 July 2020

An anti-H5N1 influenza virus FcDART antibody is a highly efficacious therapeutic agent and prophylactic against H5N1 influenza virus infection

scientific article

Analysis of a Highly Flexible Conformational Immunogenic Domain A in Hepatitis C Virus E2

scientific article

Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus

scientific article published on 6 January 2016

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

scientific article published on 4 May 2016

Antibody-Dependent Enhancement of Hepatitis C Virus Infection

scientific article (publication date: March 2008)

Antigenicity and Immunogenicity of Differentially Glycosylated Hepatitis C Virus E2 Envelope Proteins Expressed in Mammalian and Insect Cells

scientific article published on 21 March 2019

Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a.

scientific article published on 2 October 2014

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

scientific article published on 17 May 2019

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein

scientific article

CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells

scientific journal article

Crystal Structure of a Bivalent Antibody Fab Fragment

scientific article published on 18 November 2020

Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies

scientific article (publication date: June 2008)

Designing a B Cell-Based Vaccine against a Highly Variable Hepatitis C Virus

scientific article published in January 2017

Global mapping of antibody recognition of the hepatitis C virus E2 glycoprotein: Implications for vaccine design

scientific article published on 26 October 2016

Hepatitis C Virus (HCV)-Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design.

scientific article published on 21 June 2018

Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions

scientific article

Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes.

scientific article

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

scientific article

Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate

scientific article

Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity

scientific article

Immunogenic and Functional Organization of Hepatitis C Virus (HCV) Glycoprotein E2 on Infectious HCV Virions

scientific article

In vitro selection of a neutralization-resistant hepatitis C virus escape mutant

scientific article

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection

scientific article published on 30 December 2018

Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection

scientific article published on 21 June 2019

Isolation of HCV Neutralizing Antibodies by Yeast Display

Learning from a clinical cohort for HCV vaccine development

scientific article published on 13 April 2019

Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein.

scientific article

Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations

scientific article

Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus Infectivity

scientific article (publication date: June 2009)

Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies

scientific article published on 10 April 2012

Neutralizing antibody response to hepatitis C virus

scientific article

Non-random escape pathways from a broadly neutralizing human monoclonal antibody map to a highly conserved region on the hepatitis C virus E2 glycoprotein encompassing amino acids 412-423

scientific article

Preclinical Evaluation of Two Neutralizing Human Monoclonal Antibodies against Hepatitis C Virus (HCV): a Potential Treatment To Prevent HCV Reinfection in Liver Transplant Patients

scientific article (publication date: March 2006)

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

scientific article

Structural basis for penetration of the glycan shield of hepatitis C virus E2 glycoprotein by a broadly neutralizing human antibody

scientific article

Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization

scientific article published on 17 April 2020

Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization

scientific article published on 02 September 2020

The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope Protein

scientific article

Toward a Hepatitis C Virus Vaccine: the Structural Basis of Hepatitis C Virus Neutralization by AP33, a Broadly Neutralizing Antibody

scientific article

Viral evasion and challenges of hepatitis C virus vaccine development

scientific article published on 19 September 2016

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