List of works - Alasdair M Gilfillan

5-hydroxytryptamine induces mast cell adhesion and migration

scientific article published on 01 November 2006

A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses

scientific article

A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells

scientific article published on 02 May 2013

Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33.

scientific article published on 8 August 2015

Activation and function of the mTORC1 pathway in mast cells

scientific article published on April 2008

Activation of human mast cells through the high affinity IgG receptor

scientific article published in September 2002

Adaptive and innate immune reactions regulating mast cell activation: from receptor-mediated signaling to responses

scientific article published on August 2006

Amplification mechanisms for the enhancement of antigen-mediated mast cell activation

scientific article published on January 2009

Assay of mast cell mediators

scientific article published on 01 January 2015

Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit

scientific article published on 21 September 2005

Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells

scientific article

CD72 negatively regulates KIT-mediated responses in human mast cells

scientific article

CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells

scientific journal article

Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line

scientific article published on February 2008

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions

scientific article published on 11 January 2012

Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation ⬇️

scientific article published on May 1, 2003

Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation

scientific article published on 09 October 2007

Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival

scientific article published on May 2006

Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses

scientific article published on 01 July 2007

Defective eosinophil hematopoiesis ex vivo in inbred Rocky Mountain White (IRW) mice

scientific article published on 30 August 2011

Determination of protein phosphorylation in Fc epsilon RI-activated human mast cells by immunoblot analysis requires protein extraction under denaturing conditions

scientific article

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation

scientific article

Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: “All or nothing” enhancement of antigen-dependent mediator release ⬇️

scientific article published on July 20, 2011

Endosomal trafficking of the ligated FcvarepsilonRI receptor.

scientific article

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

scientific article

Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production

scientific article published on 29 December 2014

Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria ⬇️

scientific article published on September 8, 2011

Fcgamma receptors on mast cells: activatory and inhibitory regulation of mediator release

scientific article published on 10 March 2004

Flow cytometry-based monitoring of mast cell activation.

scientific article published on January 2015

G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation

scientific article

Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood.

scientific article

Generation, isolation, and maintenance of rodent mast cells and mast cell lines

scientific article

Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells

scientific article

Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis

scientific article published on 28 October 2011

IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.

scientific article published on 17 December 2012

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.

scientific article published on 07 January 2016

Identification of Fyn-binding proteins in MC/9 mast cells using mass spectrometry ⬇️

scientific article published on October 10, 2003

IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells

scientific article published on May 2009

IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses

scientific journal article

Integrated signalling pathways for mast-cell activation

scientific article

KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells

scientific article published on 04 June 2013

Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells

scientific article

Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells

scientific journal article

Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production ⬇️

scientific article published on March 13, 2013

Mast Cell Biology: Introduction and Overview ⬇️

scientific article published on January 1, 2011

Mastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype

scientific article

Measuring Mast Cell Mediator Release ⬇️

scientific article published on November 1, 2010

Mechanisms of mast cell signaling in anaphylaxis

scientific article published on October 2009

Molecular regulation of mast cell activation

scientific article

NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation

scientific article (publication date: July 2004)

Nitric oxide inhibits IgE-dependent cytokine production and Fos and Jun activation in mast cells

scientific article

Ntal/Lab/Lat2.

scientific article published on 28 October 2006

Prevention of F-actin assembly switches the response to SCF from chemotaxis to degranulation in human mast cells

scientific article

Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release ⬇️

scientific article published on October 27, 2010

Providing the TORC for cell cycle progression in neoplastic mast cells

scientific article published on 15 January 2012

RGS13 controls g protein-coupled receptor-evoked responses of human mast cells

scientific article published on December 2008

Regulation of Mast Cell Responses in Health and Disease ⬇️

scientific article published on January 1, 2011

Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation

scientific article

Roles of adaptor molecules in mast cell activation

scientific article

Stem cell factor programs the mast cell activation phenotype

scientific article

Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release

scientific article published on 22 January 2008

TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release

scientific article

Targeting kit activation: a potential therapeutic approach in the treatment of allergic inflammation

scientific article published on March 2007

The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling

scientific article

The adaptor 3BP2 is required for early and late events in FcεRI signaling in human mast cells

scientific article published on 15 August 2012

The high-affinity immunoglobulin-E receptor (FcepsilonRI) is endocytosed by an AP-2/clathrin-independent, dynamin-dependent mechanism

scientific article published on June 2006

The multiple roles of phosphoinositide 3-kinase in mast cell biology

scientific article published on 03 September 2008

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

scientific article published on December 2008

The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase

scientific article published on 16 September 2003

The tyrosine kinase network regulating mast cell activation

scientific article published on March 2009

Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined

scientific article published on 28 January 2013

mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells

scientific article published on 3 November 2011

List of works by Alasdair M Gilfillan

5-hydroxytryptamine induces mast cell adhesion and migration

A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses

A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells

Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33.

Activation and function of the mTORC1 pathway in mast cells

Activation of human mast cells through the high affinity IgG receptor

Adaptive and innate immune reactions regulating mast cell activation: from receptor-mediated signaling to responses

Amplification mechanisms for the enhancement of antigen-mediated mast cell activation

Assay of mast cell mediators

Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit

Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells

CD72 negatively regulates KIT-mediated responses in human mast cells

CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells

Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions

Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation ⬇️

Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation

Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival

Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses

Defective eosinophil hematopoiesis ex vivo in inbred Rocky Mountain White (IRW) mice

Determination of protein phosphorylation in Fc epsilon RI-activated human mast cells by immunoblot analysis requires protein extraction under denaturing conditions

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation

Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: “All or nothing” enhancement of antigen-dependent mediator release ⬇️

Endosomal trafficking of the ligated FcvarepsilonRI receptor.

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production

Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria ⬇️

Fcgamma receptors on mast cells: activatory and inhibitory regulation of mediator release

Flow cytometry-based monitoring of mast cell activation.

G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation

Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood.

Generation, isolation, and maintenance of rodent mast cells and mast cell lines

Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells

Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis

IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.

Identification of Fyn-binding proteins in MC/9 mast cells using mass spectrometry ⬇️

IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells

IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses

Integrated signalling pathways for mast-cell activation

KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells

Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells

Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells

Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production ⬇️

Mast Cell Biology: Introduction and Overview ⬇️

Mastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype

Measuring Mast Cell Mediator Release ⬇️

Mechanisms of mast cell signaling in anaphylaxis

Molecular regulation of mast cell activation

NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation

Nitric oxide inhibits IgE-dependent cytokine production and Fos and Jun activation in mast cells

Ntal/Lab/Lat2.

Prevention of F-actin assembly switches the response to SCF from chemotaxis to degranulation in human mast cells

Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release ⬇️

Providing the TORC for cell cycle progression in neoplastic mast cells

RGS13 controls g protein-coupled receptor-evoked responses of human mast cells

Regulation of Mast Cell Responses in Health and Disease ⬇️

Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation

Roles of adaptor molecules in mast cell activation

Stem cell factor programs the mast cell activation phenotype

Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release

TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release

Targeting kit activation: a potential therapeutic approach in the treatment of allergic inflammation

The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling

The adaptor 3BP2 is required for early and late events in FcεRI signaling in human mast cells

The high-affinity immunoglobulin-E receptor (FcepsilonRI) is endocytosed by an AP-2/clathrin-independent, dynamin-dependent mechanism

The multiple roles of phosphoinositide 3-kinase in mast cell biology

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase

The tyrosine kinase network regulating mast cell activation

Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined

mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells