Search filters

List of works by Salem Chouaib

A dose escalation phase 1 study of radiotherapy (RT) in combination with anti-cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody ipilimumab in patients (pts) with metastatic melanoma

scientific article published on 20 May 2017

A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor ⬇️

scientific article

A polyepitope DNA vaccine targeted to Her-2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge

scientific article

A three-dimensional tumor cell defect in activating autologous CTLs is associated with inefficient antigen presentation correlated with heat shock protein-70 down-regulation.

scientific article published in July 2003

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells

scientific article published on 01 February 2020

AXL Targeting Overcomes Human Lung Cancer Cell Resistance to NK- and CTL-Mediated Cytotoxicity

scientific article published on 05 September 2019

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

scientific article published on 17 January 2017

Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity

scientific article published on 13 August 2018

Activation of cytotoxic T-cell receptor gammadelta T lymphocytes in response to specific stimulation in myelodysplastic syndromes

scientific article published on 11 February 2008

Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis

scientific article

Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

scientific article published in March 2018

Altered IFNgamma signaling and preserved susceptibility to activated natural killer cell-mediated lysis of BCR/ABL targets.

scientific article

Analysis of the mechanisms of human cytotoxic T lymphocyte response inhibition by NO.

scientific article published in October 2002

Analysis of the natural killer mediated immune response in metastatic renal cell carcinoma patients

scientific article published in April 2004

Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

scientific article

Antitumor cytotoxic T-lymphocyte response in human lung carcinoma: identification of a tumor-associated antigen.

scientific article

Attenuation of soft-tissue sarcomas resistance to the cytotoxic action of TNF-α by restoring p53 function

scientific article (publication date: 2012)

Autophagic degradation of GZMB/granzyme B: a new mechanism of hypoxic tumor cell escape from natural killer cell-mediated lysis

scientific article

BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC).

scientific article published on 21 September 2017

Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression.

scientific article

Breast cancer in Tunisia: association of body mass index with histopathological aspects of tumors.

scientific article

CD158 receptor controls cytotoxic T-lymphocyte susceptibility to tumor-mediated activation-induced cell death by interfering with Fas signaling.

scientific article published in November 2003

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT.

scientific article published on 15 February 2018

Chemokine receptors expression and migration potential of tumor-infiltrating and peripheral-expanded Vgamma9Vdelta2 T cells from renal cell carcinoma patients

scientific article published in April 2008

Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors.

scientific article

Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress

scientific article

Cross-talk between Smad and p38 MAPK signalling in transforming growth factor beta signal transduction in human glioblastoma cells.

scientific article published on 29 January 2007

Crosstalk between CTC, Immune System and Hypoxic Tumor Microenvironment

scientific article

Cutting Edge: NANOG Activates Autophagy under Hypoxic Stress by Binding to BNIP3L Promoter.

scientific article published on 16 January 2017

Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1.

scientific article published on 13 November 2013

Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells

scientific article published on 10 August 2015

Cytokeratin 18 expression pattern correlates with renal cell carcinoma progression: relationship with Snail

scientific article published on May 2010

Cytotoxic T cells - stroma interactions

scientific article published on February 2011

Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution.

scientific article

Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules

scientific article published on 6 March 2003

Differentiation Therapy: Targeting Human Renal Cancer Stem Cells with Interleukin 15

scientific article published on 31 October 2011

EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction ⬇️

scientific article published on April 23, 2013

Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells, extracellular matrix and immune killer cells

scientific article published on January 2010

Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction

scientific article (publication date: 15 October 2002)

Enhanced cytotoxic activity of ex vivo-differentiated human natural killer cells in the presence of HOXB4

scientific article published on 01 June 2014

EphA2 as target of anticancer immunotherapy: identification of HLA-A*0201-restricted epitopes.

scientific article published on December 2003

Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis.

scientific article published on 22 February 2013

Erratum: anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

scientific article published in March 2015

Expression of CD94 by -differentiated NK cells correlates with the and acquisition of cytotoxic features

scientific article published on 18 July 2017

Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells

scientific article

Fas Ligand Deficiency Impairs Tumor Immunity by Promoting an Accumulation of Monocytic Myeloid-Derived Suppressor Cells

scientific article published on 10 September 2015

Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma

scientific article (publication date: 16 October 2003)

Gap junction communication between autologous endothelial and tumor cells induce cross-recognition and elimination by specific CTL.

scientific article

Generation of CTL recognizing an HLA-A*0201-restricted epitope shared by MAGE-A1, -A2, -A3, -A4, -A6, -A10, and -A12 tumor antigens: implication in a broad-spectrum tumor immunotherapy

scientific article published on 01 July 2002

Generation of a novel regulatory NK cell subset from peripheral blood CD34+ progenitors promoted by membrane-bound IL-15

scientific article

Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival

scientific article published on 01 September 2005

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

scientific article

Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis.

scientific article

Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells

scientific article published on 13 September 2007

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapy

scientific article

HIF-2α/ITPR1 axis: A new saboteur of NK-mediated lysis

scientific article

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy.

scientific article published on February 2004

Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet

scientific article

Human CD5 protects circulating tumor antigen-specific CTL from tumor-mediated activation-induced cell death

scientific article published on June 2007

Human NK cells lyse organ-specific endothelial cells: analysis of adhesion and cytotoxic mechanisms

scientific article

Human Renal Normal, Tumoral, and Cancer Stem Cells Express Membrane-Bound Interleukin-15 Isoforms Displaying Different Functions.

scientific article

Human mesenchymal stem cells derived from induced pluripotent stem cells down-regulate NK-cell cytolytic machinery ⬇️

scientific article published on July 29, 2011

Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours

scientific article published in Nature Communications

Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition

scientific article

Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape ⬇️

scientific article published on February 23, 2012

Hypoxia increases mutational load of breast cancer cells through frameshift mutations

scientific article published on 16 April 2020

Hypoxia-dependent inhibition of tumor cell susceptibility to CTL-mediated lysis involves NANOG induction in target cells

scientific article published on 12 September 2011

Hypoxia-driven intratumor heterogeneity and immune evasion

scientific article published on 23 July 2020

Hypoxia-induced autophagy: a new player in cancer immunotherapy?

scientific article published in April 2012

Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells

scientific article published on 7 September 2012

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

scientific article

Hypoxic Stress-Induced Tumor and Immune Plasticity, Suppression, and Impact on Tumor Heterogeneity

scientific article published on 24 November 2017

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

scientific article

ICAM-1 has a critical role in the regulation of metastatic melanoma tumor susceptibility to CTL lysis by interfering with PI3K/AKT pathway

scientific article

ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy

scientific article published on 8 October 2014

Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure

scholarly article

Impact of Metabolism on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment

scientific article published on 13 March 2017

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges

scientific article published on 14 September 2019

Improving the outcome of leukemia by natural killer cell-based immunotherapeutic strategies

scientific article

In situ sensory adaptation of tumor-infiltrating T lymphocytes to peptide-MHC levels elicits strong antitumor reactivity

scientific article

Independent association of PD-L1 expression with noninactivated VHL clear cell renal cell carcinoma-A finding with therapeutic potential

scientific article

Inducible Hsp70 as target of anticancer immunotherapy: Identification of HLA-A*0201-restricted epitopes

scientific article published on March 2004

Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide

scientific article published on 01 March 2007

Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapy

scientific article published on 09 January 2020

Interleukin-15 is a major regulator of the cell-microenvironment interactions in human renal cancer

scientific article published on 01 May 2011

Interleukin-15 is a major regulator of the cell-microenvironment interactions in human renal homeostasis.

scientific article published on 13 September 2012

Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway.

scientific article

Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention

scientific article

Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function

scientific article

Isolation and characterization of renal cancer stem cells from patient-derived xenografts

scientific article

Leukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression

scientific article published on March 2002

Mechanisms of Cytotoxic Lymphocyte-Mediated Apoptosis and Relationship with the Tumor Suppressor p53.

scientific article

Melanoma-associated fibroblasts decrease tumor cell susceptibility to NK cell-mediated killing through matrix-metalloproteinases secretion

scientific article

Membrane-Bound Interleukin (IL)-15 on Renal Tumor Cells Rescues Natural Killer Cells from IL-2 Starvation-Induced Apoptosis

scientific article published on 01 June 2007

Membrane-bound IL-15 stimulation on peripheral blood natural kiler progenitors leads to the generation of an adherent subset co-expressing dendritic cells and natural kiler functional markers ⬇️

scientific article published on January 17, 2011

Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

scientific article published on 23 June 2005

Microenvironmental hypoxia orchestrating the cell stroma cross talk, tumor progression and antitumor response

scientific article published on January 2011

Mutant alpha-actinin-4 promotes tumorigenicity and regulates cell motility of a human lung carcinoma

scientific article

NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors

scientific article published on November 2005

New insights into the role of EMT in tumor immune escape.

scientific article

Off-target effects of plasmid-transcribed shRNAs on NFκB signaling pathway and cell survival of human melanoma cells.

scientific article published on 30 October 2013

Opposite effects of estrogen receptors alpha and beta on MCF-7 sensitivity to the cytotoxic action of TNF and p53 activity

scientific article

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

scientific article

Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment.

scientific article published on 14 May 2018

Phosphostim-activated gamma delta T cells kill autologous metastatic renal cell carcinoma.

scientific article published on February 2005

Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway

scientific article

Potentiation of a tumor cell susceptibility to autologous CTL killing by restoration of wild-type p53 function.

scientific article published on June 2003

Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway

scholarly article

Prevention of autoimmunity and control of recall response to exogenous antigen by Fas death receptor ligand expression on T cells

scientific article published on 13 November 2008

Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death

scientific article published on January 2004

Recent Advances in Lung Cancer Immunotherapy: Input of T-Cell Epitopes Associated With Impaired Peptide Processing

scientific article published on 03 July 2019

Regulation of gap junctions in melanoma and their impact on Melan-A/MART-1-specific CD8⁺ T lymphocyte emergence

scientific article published on 7 June 2013

Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status

scientific article published on 17 December 2015

Resistance of tumor cells to cytolytic T lymphocytes involves Rho-GTPases and focal adhesion kinase activation.

scientific article published on 8 September 2008

Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity

scientific article published on 06 October 2018

Role of p53 in the sensitization of tumor cells to apoptotic cell death

scientific article published on 01 May 2002

STEAP, a prostate tumor antigen, is a target of human CD8+ T cells

scientific article published on 19 April 2006

Search for novel STAT3-dependent genes reveals SERPINA3 as a new STAT3 target that regulates invasion of human melanoma cells

scientific article published on 05 July 2019

Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death

scientific article published on November 2007

Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFα- and NK cytotoxicity ⬇️

scientific article published on November 10, 2012

Synaptic release of CCL5 storage vesicles triggers CXCR4 surface expression promoting CTL migration in response to CXCL12.

scientific article published on 10 October 2014

TLR ligands stimulation protects MSC from NK killing

scientific article published on 01 January 2014

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity.

scientific article published on 25 April 2018

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

scientific article published on 16 October 2017

Targeting hypoxia at the forefront of anticancer immune responses

scientific article published on December 2014

The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

scientific article

The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray.

scientific article published on July 2011

The actin filament cross-linker L-plastin confers resistance to TNF-alpha in MCF-7 breast cancer cells in a phosphorylation-dependent manner

scientific article published on 03 October 2009

The anti-angiogenic activity of IL-12 is increased in iNOS−/− mice and involves NK cells

scientific article published on 11 April 2010

The autophagy sensor ITPR1 protects renal carcinoma cells from NK-mediated killing

scientific article published on 25 February 2015

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

scientific article

The decreased susceptibility of Bcr/Abl targets to NK cell-mediated lysis in response to imatinib mesylate involves modulation of NKG2D ligands, GM1 expression, and synapse formation

scientific article published on January 2006

The decreased susceptibility of metastatic melanoma cells to killing involves an alteration of CTL reactivity.

scientific article published on July 2006

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200.

scientific article published on 23 January 2017

The multifaceted role of autophagy in tumor evasion from immune surveillance

scientific article published on 20 February 2016

The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy

scientific article published on 20 September 2019

Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3.

scientific article published on 30 October 2017

Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies

scientific article published in 2021

Tumor Hypoxia: A Key Determinant of Microenvironment Hostility and a Major Checkpoint during the Antitumor Response

scientific article published on 01 January 2018

Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization

scientific article

Tumor plasticity interferes with anti-tumor immunity

scientific article

Tumor resistance to specific lysis: a major hurdle for successful immunotherapy of cancer

scientific article

Tumor-Associated Macrophages (TAMs) Form an Interconnected Cellular Supportive Network in Anaplastic Thyroid Carcinoma ⬇️

scientific article published on July 21, 2011

Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210.

scientific article published on 23 July 2015

Tumor-infiltrating CD4+ T lymphocytes express APO2 ligand (APO2L)/TRAIL upon specific stimulation with autologous lung carcinoma cells: role of IFN-alpha on APO2L/TRAIL expression and -mediated cytotoxicity

scientific article published on 01 July 2002

Tumor/cytotoxic effector cross-talk in the control of tumor susceptibility to lysis

scientific article published in August 2003

Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4+ T cells

scientific article

Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells

scientific article

Wild-type p53 induced sensitization of mutant p53 TNF-resistant cells: role of caspase-8 and mitochondria

scientific article published in March 2002

[Immune response and cancer]

scientific article published on 01 January 2008

[Immunotherapy of cancer: promise and reality]

scientific article published on 01 August 2006

[Tumor hypoxia: a key player in the regulation of stromal and anti-tumor responses]

scientific article published on 01 April 2014

c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis

scientific article

hSMG-1 is a granzyme B-associated stress-responsive protein kinase

scientific article published on 8 February 2011

miR-181a modulates acute myeloid leukemia susceptibility to natural killer cells

scientific article

miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function.

scientific article

p53 potentiation of tumor cell susceptibility to CTL involves Fas and mitochondrial pathways.

scientific article

Paulina is supported by:

About Paulina

Help