Search filters

List of works by Nagio Takigawa

A Randomized Phase II Study of a Combination of Docetaxel and S-1 versus Docetaxel Monotherapy in Patients with Non-small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy: Results of Okayama Lung Cancer Study Group (OLCSG) Trial 0

A case of advanced non-small-cell lung cancer who responded slowly to gefitinib monotherapy after long-term disease stabilization

scientific article

A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene

scientific article published on 28 August 2014

A phase I and pharmacological study of amrubicin and topotecan in patients of small-cell lung cancer with relapsed or extensive-disease small-cell lung cancer

scientific article

A phase I study of 3-day topotecan and cisplatin in elderly patients with small-cell lung cancer

scientific article

A phase I study of S-1 with concurrent thoracic radiotherapy in elderly patients with localized advanced non-small cell lung cancer

scientific article

A phase I study of combination S-1 plus cisplatin chemotherapy with concurrent thoracic radiation for locally advanced non-small cell lung cancer

scientific article

A phase II study of S-1 chemotherapy with concurrent thoracic radiotherapy in elderly patients with locally advanced non-small-cell lung cancer: the Okayama Lung Cancer Study Group Trial 0801.

scientific article

A phase II study of amrubicin and topotecan combination therapy in patients with relapsed or extensive-disease small-cell lung cancer: Okayama Lung Cancer Study Group Trial 0401.

scientific article published on 18 February 2011

A phase II study of cisplatin plus S-1 with concurrent thoracic radiotherapy for locally advanced non-small-cell lung cancer: the Okayama Lung Cancer Study Group Trial 0501.

scientific article published on 8 November 2014

A phase II study of topotecan and cisplatin with sequential thoracic radiotherapy in elderly patients with small-cell lung cancer: Okayama Lung Cancer Study Group 0102.

scientific article

A phase II trial of carboplatin plus S-1 for elderly patients with advanced non-small-cell lung cancer with wild-type epidermal growth factor receptor: The Okayama Lung Cancer Study Group Trial 1202.

scientific article published on 12 August 2017

A phase II trial of erlotinib monotherapy in pretreated patients with advanced non-small cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705.

scientific article published in January 2010

A phase III randomized trial comparing vindesine and cisplatin with or without ifosfamide in patients with advanced non-small-cell lung cancer: long-term follow-up results and analysis of prognostic factors

scientific article

A relapse of small-cell lung cancer ten years after concomitant chemoradiotherapy followed by high-dose chemotherapy with autologous peripheral blood stem cell transfusion

scientific article

A survey of Japanese thoracic oncologists' perception of diagnostic and treatment strategies for EGFR mutant or EML4-ALK fusion non-small cell lung cancer

scientific article published in December 2014

Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma

scientific article published on 13 January 2012

Aberrant promoter hypermethylation in serum DNA from patients with silicosis

scientific article published on 16 July 2008

Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.

scientific article published on 29 March 2013

Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation

scientific article published on March 2007

Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model

scientific article published on 26 February 2013

Association between poor performance status and risk for toxicity during erlotinib monotherapy in Japanese patients with non-small cell lung cancer: Okayama Lung Cancer Study Group experience

scientific article published on 22 April 2010

Association of the benefit from gefitinib monotherapy with smoking status in Japanese patients with non-small-cell lung cancer

scientific article published on 15 May 2008

Benefits and Adverse Events Among Elderly Patients Receiving Concurrent Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer: Analysis of the Okayama Lung Cancer Study Group Trial 0007

article

Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice

scientific article published on 18 August 2009

Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation

scientific article

Clinical and pharmacokinetic study of docetaxel in elderly non-small-cell lung cancer patients

scientific article published on 4 May 2004

Clinical factors affecting acquired resistance to gefitinib in previously treated Japanese patients with advanced nonsmall cell lung cancer

scientific article published in October 2006

Clinical outcome in patients with leptomeningeal metastasis from non-small cell lung cancer: Okayama Lung Cancer Study Group

scientific article published on 7 April 2012

Clinical significance of epidermal growth factor receptor gene mutations on treatment outcome after first-line cytotoxic chemotherapy in Japanese patients with non-small cell lung cancer

scientific article published in July 2007

Coinfection with Mycoplasma pneumoniae and Chlamydophila pneumoniae in a middle-aged adult

scientific article published on October 2007

Comparison of chemosensitivity tests: clonogenic assay versus MTT assay

scientific article published in June 2002

Comparison of the incidence and pattern of interstitial lung disease during erlotinib and gefitinib treatment in Japanese Patients with non-small cell lung cancer: the Okayama Lung Cancer Study Group experience

scientific article published in February 2010

Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer

scientific article published on 31 January 2009

Cytotoxicity of activated natural killer cells and expression of adhesion molecules in small-cell lung cancer

scientific article

Daily low-dose cisplatin and concurrent thoracic irradiation for poor-risk patients with unresectable non-small-cell lung cancer

scientific article published in October 2002

Desire for information and involvement in treatment decisions: lung cancer patients' preferences and their physicians' perceptions: results from Okayama Lung Cancer Study Group Trial 0705.

scientific article published in October 2010

Detection of the EGFR mutation in exhaled breath condensate from a heavy smoker with squamous cell carcinoma of the lung

scientific article published in September 2011

Determinants of cisplatin and irinotecan activities in human lung adenocarcinoma cells: evidence of cisplatin accumulation and topoisomerase I activity

scientific article published on July 2005

Development of a skin rash within the first week and the therapeutic effect in afatinib monotherapy for EGFR-mutant non-small cell lung cancer (NSCLC): Okayama Lung Cancer Study Group experience

scientific article published on 31 March 2016

Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors

scientific article

Discomfort during bronchoscopy performed after endobronchial intubation with fentanyl and midazolam: a prospective study

scientific article published on 23 February 2017

Do Elderly Lung Cancer Patients Aged ≥75 Years Benefit from Immune Checkpoint Inhibitors?

scientific article published on 21 July 2020

Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model

scientific article published on 24 July 2015

Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model

scientific article published on 29 October 2013

Effect of Vandetanib on Lung Tumorigenesis in Transgenic Mice Carrying an Activating Egfr Gene Mutation

scientific article published on August 2016

Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice

scientific article

Effects of (-)-epigallocatechin-3-gallate on EGFR- or Fusion Gene-driven Lung Cancer Cells

scientific article

Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo

scientific article

Efficacy of a lumbo-peritoneal shunt for meningeal carcinomatosis refractory to gefitinib treatment.

scientific article published in July 2009

Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line

scientific article published on August 2007

Endobronchial ultrasound-guided transbronchial biopsy with or without a guide sheath for diagnosis of lung cancer

scientific article published on 13 November 2014

Endobronchial ultrasound-guided transbronchial needle aspiration of hilar and mediastinal lymph nodes detected on 18F-fluorodeoxyglucose positron emission tomography/computed tomography

scientific article published on 22 March 2016

Establishment of a 7-ethyl-10-hydroxy-camptothecin-resistant small cell lung cancer cell line.

scientific article published on November 2004

Establishment of pemetrexed-resistant non-small cell lung cancer cell lines

scientific article published on 24 June 2011

Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors

scientific article published on 25 April 2014

Factor associated with failure to administer subsequent treatment after progression in the first-line chemotherapy in EGFR-mutant non-small cell lung cancer: Okayama Lung Cancer Study Group experience

scientific article published on 16 March 2014

Fractionated administration of irinotecan and cisplatin for treatment of extensive-disease small-cell lung cancer: a phase II study.

scientific article published in January 2003

Gefitinib Combined With Standard Chemoradiotherapy in EGFR-Mutant Locally Advanced Non-Small-Cell Lung Cancer: The LOGIK0902/OLCSG0905 Intergroup Study Protocol

scientific article published on 18 August 2015

Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation.

scientific article published on February 2007

Impact of HER2 gene and protein status on the treatment outcome of cisplatin-based chemoradiotherapy for locally advanced non-small cell lung cancer

scientific article published in May 2008

Impact of body surface area on survival in EGFR-mutant non-small cell lung cancer patients treated with gefitinib monotherapy: observational study of the Okayama Lung Cancer Study Group 0703.

scientific article

Impact of physical size on gefitinib efficacy in patients with non-small cell lung cancer harboring EGFR mutations

scientific article published in July 2013

Influence of altering administration sequence of docetaxel, gemcitabine and cisplatin in patients with advanced non-small cell lung cancer

scientific article

Influence of the timing of tumor regression after the initiation of chemoradiotherapy on prognosis in patients with limited-disease small-cell lung cancer achieving objective response

scientific article published on 31 July 2012

JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation

scientific article

Large cell neuroendocrine carcinoma of the mediastinum

scientific article published on July 2010

Liposomal delivery of MicroRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells

scientific article published on 28 June 2011

Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model

scientific article published on 25 October 2013

Magnitude of the benefit of progression-free survival as a potential surrogate marker in phase 3 trials assessing targeted agents in molecularly selected patients with advanced non-small cell lung cancer: systematic review

scientific article published on 16 March 2015

Non-Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases

scientific article published on 30 December 2015

Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.

scientific article published on 07 December 2013

Obstructive jaundice at the initial presentation in small-cell lung cancer.

scientific article

Paradoxical Clinical Effects of Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitors for Acute Myelogenous Leukemia

Phase I study of irinotecan and amrubicin in patients with advanced non-small-cell lung cancer.

scientific article

Phase I/II study of altered schedule of cisplatin and etoposide administration and concurrent accelerated hyperfractionated thoracic radiotherapy for limited-stage small-cell lung cancer

scientific article

Phase II Study of the EGFR-TKI Rechallenge With Afatinib in Patients With Advanced NSCLC Harboring Sensitive EGFR Mutation Without T790M: Okayama Lung Cancer Study Group Trial OLCSG 1403.

scientific article published on 9 July 2016

Phase II trial of gefitinib in combination with bevacizumab as first-line therapy for advanced non-small cell lung cancer with activating EGFR gene mutations: the Okayama Lung Cancer Study Group Trial 1001.

scientific article published in March 2015

Phase III trial comparing docetaxel and cisplatin combination chemotherapy with mitomycin, vindesine, and cisplatin combination chemotherapy with concurrent thoracic radiotherapy in locally advanced non-small-cell lung cancer: OLCSG 0007.

scientific article published on 7 June 2010

Potential influence of being overweight on the development of hepatic dysfunction in Japanese patients with EGFR-mutated non-small cell lung cancer undergoing gefitinib monotherapy: the Okayama Lung Cancer Study Group experience

scientific article published on 2 September 2016

Presentation of Garcin syndrome due to lung cancer

scientific article

Prognostic significance of mutant p53 protein, P-glycoprotein and glutathione S-transferase-pi in patients with unresectable non-small cell lung cancer.

scientific article published in May 2003

Progression-free survival and overall survival in phase III trials of molecular-targeted agents in advanced non-small-cell lung cancer

scientific article

Protocol Design for the Bench to Bed Trial in Alectinib-Refractory Non-Small-Cell Lung Cancer Patients Harboring the EML4-ALK Fusion Gene (ALRIGHT/OLCSG1405).

scientific article published on 2 June 2016

Rapid on-site evaluation with BIOEVALUATOR(®) during endobronchial ultrasound-guided transbronchial needle aspiration for diagnosing pulmonary and mediastinal diseases

scientific article published on January 2014

Reappraisal of short-term low-volume hydration in cisplatin-based chemotherapy: results of a prospective feasibility study in advanced lung cancer in the Okayama Lung Cancer Study Group Trial 1002.

scientific article published on 29 September 2013

Reappraisal of short-term low-volume hydration in cisplatin-based chemotherapy; hoping for it as a public domain

scientific article published on 28 April 2015

Recent improvement in the survival of patients with advanced nonsmall cell lung cancer enrolled in phase III trials of first-line, systemic chemotherapy

scientific article published on March 2007

Relationship between epidermal growth factor receptor gene mutations and the severity of adverse events by gefitinib in patients with advanced non-small cell lung cancer

scientific article published on 28 February 2006

Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine

scientific article

Role of early serial change in serum carcinoembryonic antigen levels as a predictive marker for radiological response to gefitinib in Japanese patients with non-small cell lung cancer

scientific article published in May 2007

Role of survival post-progression in phase III trials of systemic chemotherapy in advanced non-small-cell lung cancer: a systematic review

scientific article

STAT3 expression in activating EGFR-driven adenocarcinoma of the lung

scientific article published on January 2012

Safety and discomfort during bronchoscopy performed under sedation with fentanyl and midazolam: a prospective study

scientific article published on 5 July 2016

Second primary cancer in survivors of locally advanced non-small cell lung cancer treated with concurrent chemoradiation followed by surgery

scientific article published on 2 February 2018

Severe interstitial pneumonia induced by paclitaxel in a patient with adenocarcinoma of the lung.

scientific article published on October 2006

Sex difference in the influence of smoking status on the responsiveness to gefitinib monotherapy in adenocarcinoma of the lung: Okayama Lung Cancer Study Group experience

scientific article

Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer

scientific article published on 15 January 2014

Subpopulation of small-cell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy

scientific article

Super scan using positron emission tomography in lung cancer patients

scientific article published in November 2007

Synchronous pulmonary MALT lymphoma and pulmonary adenocarcinoma after metachronous gastric MALT lymphoma and gastric adenocarcinoma

scientific article published in November 2008

Synergistic effect of olaparib with combination of cisplatin on PTEN-deficient lung cancer cells

scientific article

The combination effect of amrubicin with cisplatin or irinotecan for small-cell lung cancer cells.

scientific article published on April 2006

Time to progression as a surrogate marker for overall survival in patients with advanced non-small cell lung cancer

scientific article published on March 2009

Treatment-related death in patients with small-cell lung cancer in phase III trials over the last two decades

scientific article

Triple combination chemotherapy with cisplatin, docetaxel, and irinotecan for advanced non-small cell lung cancer: a phase I/II trial.

scientific article published on January 2007

Triplet chemotherapy with cisplatin, docetaxel, and irinotecan for patients with recurrent or refractory non-small cell lung cancer

scientific article published on February 2010

Twenty-seven years of phase III trials for patients with extensive disease small-cell lung cancer: disappointing results

scientific article

Utility of immune checkpoint inhibitors in non-small-cell lung cancer patients with poor performance status

scientific article published on 29 July 2020

Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency

scientific article

Variant angina pectoris associated with FOLFOX4 therapy

scientific article

Paulina is supported by:

About Paulina

Help