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List of works by Alec J Hirsch

A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection

scientific article

A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

scientific article

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

scientific article published on 14 January 2020

Analysis of Serum Anti-Zika Virus Antibodies by Focus Reduction Neutralization Test

scientific article published on 01 January 2020

Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions.

scientific article published on 27 April 2018

Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

scientific article published on 5 April 2017

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

scientific article published on 01 November 2019

Flaviviruses are sensitive to inhibition of thymidine synthesis pathways

scientific article published on 03 July 2013

High-content assay to identify inhibitors of dengue virus infection

scientific article

Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12. ⬇️

scientific article published on August 2004

Immune response to the West Nile virus in aged non-human primates

scientific article

Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors

scientific article

Inhibition of Dengue Virus Infections in Cell Cultures and in AG129 Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence ⬇️

scientific article published on July 27, 2011

Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling

scientific article

Isolation and Detection of Zika Virus-Infected Rhesus Macaques Lymph Node Cells and Splenocytes

scientific article published on 01 January 2020

Key role of T cell defects in age-related vulnerability to West Nile virus

scientific article (publication date: 23 November 2009)

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

scholarly article by Dawn M Dudley et al published August 2018 in Nature Medicine

Risk of Zika microcephaly correlates with features of maternal antibodies

scientific article published on 14 August 2019

Sultam Thiourea Inhibition of West Nile Virus

scientific article

The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection

scientific article published on 14 February 2020

The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles

scientific article (publication date: September 2005)

The use of RNAi-based screens to identify host proteins involved in viral replication

scientific article

West Nile Virus Capsid Degradation of Claudin Proteins Disrupts Epithelial Barrier Function

scientific article published in June 2009

West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of v 3 Integrin

scientific article (publication date: June 2008)

West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP Induction and Apoptosis

scientific article (publication date: October 2007)

Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques

scientific article published on 01 April 2020

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

scientific article (publication date: 9 March 2017)

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.

scientific article published on 17 January 2018

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