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List of works by David P Nicolau

1336. Assessment of the In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) Against Carbapenems-Resistant Acinetobacter baumannii (CR-ACBN) in the Neutropenic Murine Thigh Infection Model

1368. Assessment of the In Vivo Efficacy of Human-Simulated Epithelial Lining Fluid (ELF) Exposure of Meropenem/Nacubactam (MEM/NAC) Combination Against β-Lactamase-Producing Enterobacteriaceae in Neutropenic Lung Infection Model

1397. Comparative Efficacy of Human-Simulated Epithelial Lining Fluid (ELF) Exposures of Tedizolid (TZD) Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Neutropenic (I−) vs. Immunocompetent (I+) Murine Models of Pneumonia

1398. β-Lactam Probability of Target Attainment (PTA) and Penetration into Epithelial Lining Fluid (ELF) Based on Multiple Bronchoalveolar Lavage (BAL) Sampling Time Points in a Swine Pneumonia Model

1405. Efficacy of the Human-Simulated Regimen (HSR) of Cefepime (FEP)/VNRX-5133 Combination Against Serine β-Lactamase-Producing Gram-negative Bacteria in the Neutropenic Murine Thigh Infection Model

1533. Is Cation-Adjusted Mueller–Hinton Broth (CAMHB) Appropriate for Metallo-β-lactamase (MBL) Susceptibility Testing? Novel Insights in In Vitro–In Vivo Discordance Among MBL-Producing Enterobacteriaceae

1544. Efficacy of Human-Simulated Cefiderocol Exposure Against Gram-Negative Bacteria in an Iron-Overloaded Murine Thigh Infection Model

1550. PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models

1553. Human-Simulated Pharmacokinetic Profiles of Cefiderocol and Meropenem Are Conserved in Murine Models of Thigh Infection With or Without Iron Overload

2175. In vitro Potency of Ceftolozane/Tazobactam and Other Antipseudomonal β-Lactams Against P. aeruginosa

2176. Single β-Lactams v. Combination Regimens: Assessing the Probability that an Active Agent Would be Selected When Considering Empiric Therapy for P. aeruginosa

2388. Efficacy of Humanized Cefiderocol Exposures Over 72 Hours Against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model

415In Vitro Potency of Ceftolozane/Tazobactam against Pseudomonas aeruginosa Displaying Multidrug Resistance.

scientific article

675. Efficacy of Human-Simulated Bronchopulmonary Exposures of Cefepime and Zidebactam (WCK 5222) Against Multidrug-Resistant (MDR) Pseudomonas aeruginosa (PSA) in a Neutropenic Murine Pneumonia Model

scientific article published on 23 October 2019

682. In Vivo Pharmacodynamics of VNRX-7145 in the Neutropenic Murine Thigh Infection Model When Administered in Combination with Humanized Exposures of Twice Daily Ceftibuten (CTB) Against Serine β-Lactamase-Producing Enterobacteriaceae (SBL-EB)

685. An In Vitro Investigation of WCK 5222 (Cefepime/Zidebactam) and Currently Available Combination Antibiotic Regimens Against Enterobacteriaceae That Co-express Serine-β-Lactamase (SBL) and Metallo-β-Lactamase (MBL) Enzymes

725. WCK 5222 (Cefepime/Zidebactam): An In Vitro Assessment of Activity Compared with Current Dual-Antibiotic Options Against Multidrug-Resistant Pseudomonas aeruginosa

A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

scientific article published on 01 November 2017

A Simulated Application of the Hartford Hospital Aminoglycoside Dosing Nomogram for Plazomicin Dosing Interval Selection in Patients With Serious Infections Caused by Carbapenem-Resistant Enterobacterales

scientific article published on 24 June 2019

A pharmacodynamic strategy to optimize empirical antibiotic therapy for gram-negative bacteria in a Brazilian Intensive Care Unit

scientific article published on 01 April 2007

A pilot study to assess bacterial and toxin reduction in patients with Clostridium difficile infection given fidaxomicin or vancomycin.

scientific article published on 12 April 2016

A sensitive assay of amoxicillin in mouse serum and broncho-alveolar lavage fluid by liquid-liquid extraction and reversed-phase HPLC.

scientific article published in September 2005

Absence of association between use of ertapenem and change in antipseudomonal carbapenem susceptibility rates in 25 hospitals

scientific article published in May 2010

Acute Physiology and Chronic Health Evaluation II Score Is a Better Predictor of Mortality than IBMP-10 in Patients with Ventilator-Associated Pneumonia ⬇️

scientific article published on October 17, 2011

Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa

scientific article published on 17 June 2013

An exploratory analysis of the ability of a cefepime trough concentration greater than 22 mg/L to predict neurotoxicity

scientific article published on 17 December 2015

An exploratory study to evaluate Clostridium difficile polymerase chain reaction ribotypes and infection outcomes

scientific article published on 27 June 2016

Antibacterial Efficacy of Eravacycline In Vivo against Gram-Positive and Gram-Negative Organisms

scientific article published on 27 June 2016

Antibacterial activity of achievable epithelial lining fluid exposures of Amikacin Inhale with or without meropenem

scientific article

Antibacterial activity of ceftolozane/tazobactam alone and in combination with other antimicrobial agents against MDR Pseudomonas aeruginosa

scientific article published on 18 December 2017

Antibacterial effects of moxifloxacin and levofloxacin simulating epithelial lining fluid concentrations against community-acquired methicillin-resistant Staphylococcus aureus

scientific article

Antibiotic Tissue Penetration in Diabetic Foot Infections A Review of the Microdialysis Literature and Needs for Future Research

scientific article

Antimicrobial resistance: impact on clinical and economic outcomes and the need for new antimicrobials.

scientific article

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

scientific article

Application of Pharmacodynamic Profiling for the Selection of Optimal β-lactam Regimens in a Large University Hospital

scientific article

Application of the Hartford Hospital Nomogram for Plazomicin Dosing Interval Selection in Patients with Complicated Urinary Tract Infection

scientific article published on 23 September 2019

Assessing the Surrogate Susceptibility of Oxacillin and Cefoxitin for Commonly Utilized Parenteral Agents against Methicillin-Susceptible Staphylococcus aureus: Focus on Ceftriaxone Discordance between Predictive Susceptibility and in Vivo Exposures

scientific article

Assessing the in vitro activity of ceftazidime/avibactam and aztreonam among carbapenemase-producing Enterobacteriaceae: Defining the zone of hope

scientific article published on 22 July 2018

Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia

scientific article published in September 2011

Assessment of Clostridium difficile Burden in Patients Over Time With First Episode Infection Following Fidaxomicin or Vancomycin.

scientific article

Assessment of In Vivo Efficacy of Eravacycline against Enterobacteriaceae Exhibiting Various Resistance Mechanisms: A Dose-Ranging Study and PK/PD Analysis

scientific article published on 8 January 2018

Assessment of Meropenem and Vaborbactam Room Temperature and Refrigerated Stability in Polyvinyl Chloride Bags and Elastomeric Devices

scientific article published on 02 March 2020

Assessment of sustained efficacy and resistance emergence under human-simulated exposure of cefiderocol against <i>Acinetobacter baumannii</i> using <i>in vitro</i> chemostat and <i>in vivo</i> murine infection models

scientific article published on 03 May 2022

Assessment of the Efficacy of WCK 5222 (Cefepime-Zidebactam) against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Murine Lung Infection Model

scientific article published on 24 October 2018

Assessment of the In Vivo Activity of SPR741 in Combination with Azithromycin against Multidrug-Resistant Enterobacteriaceae Isolates in the Neutropenic Murine Thigh Infection Model.

scientific article published on 26 June 2018

Assessment of the In Vivo Efficacy of Plazomicin (PLZ) Alone or in Combination with Meropenem (MEM) or Tigecycline (TGC) against Enterobacteriaceae (EB) Isolates Exhibiting Various Resistance Mechanisms in an Immunocompetent (I+) Murine Septicemia M

scientific article

Assessment of the Physical Compatibility of Eravacycline and Common Parenteral Drugs During Simulated Y-site Administration

scientific article published on 07 September 2019

Assessment of the efficacy of telithromycin simulating human exposures against S. pneumoniae with ribosomal mutations in a murine pneumonia model

scientific article published in June 2005

Bactericidal In Vitro Activity of a Tissue-Achievable Concentration of Cefazolin against Methicillin-Resistant Staphylococcus aureus

scientific article published on 15 September 2020

Bactericidal activities of meropenem and ertapenem against extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a neutropenic mouse thigh model

scientific article published on 5 February 2007

Bactericidal effect and pharmacodynamics of cethromycin (ABT-773) in a murine pneumococcal pneumonia model

scientific article

Bactericidal effect of cethromycin (ABT-773) in an immunocompetent murine pneumococcal pneumonia model

scientific article

Bactericidal efficacy of ABI-0043, a novel rifamycin, in a murine pneumococcal pneumonia model

scientific article published on 01 December 2006

Bronchopulmonary disposition of intravenous voriconazole and anidulafungin given in combination to healthy adults

scientific article published on 21 September 2009

Bronchopulmonary disposition of micafungin in healthy adult volunteers

scientific article

Bronchopulmonary pharmacokinetic and pharmacodynamic profiles of levofloxacin 750 mg once daily in adults undergoing treatment for acute exacerbation of chronic bronchitis ⬇️

scientific article published on December 22, 2011

Carbapenem-Nonsusceptible Pseudomonas aeruginosa Isolates from Intensive Care Units in the United States: a Potential Role for New β-Lactam Combination Agents

scientific article published on 26 July 2019

Cefazolin prophylaxis in obese women undergoing cesarean delivery: a randomized controlled trial

scientific article published on May 2015

Cefepime pharmacodynamics in patients with extended spectrum beta-lactamase (ESBL) and non-ESBL infections.

scientific article

Ceftazidime/avibactam and Ceftolozane/tazobactam: Novel Therapy for Multidrug Resistant Gram Negative Infections in Children

scientific article published on 8 March 2018

Change in antipseudomonal carbapenem susceptibility in 25 hospitals across 9 years is not associated with the use of ertapenem ⬇️

scientific article published on April 1, 2011

Characterization of the penetration of garenoxacin into the breast milk of lactating women

scientific article published on 01 February 2004

Characterizing in vivo pharmacodynamics of carbapenems against Acinetobacter baumannii in a murine thigh infection model to support breakpoint determinations

scientific article published on 28 October 2013

Clinical and economic benefits of a meropenem dosage strategy based on pharmacodynamic concepts.

scientific article published in June 2004

Clinical comparison of ertapenem and cefepime for treatment of infections caused by AmpC beta-lactamase-producing Enterobacteriaceae

scientific article published on 29 September 2014

Clinical efficacy and pharmacoeconomics of a continuous-infusion piperacillin-tazobactam program in a large community teaching hospital

scientific article published on April 2002

Clinical implications of extended spectrum beta-lactamase (ESBL) producing Klebsiella species and Escherichia coli on cefepime effectiveness

scientific article

Clinical laboratory-based assay methodologies may underestimate and increase variability of vancomycin protein binding in hospitalized patients

scientific article

Clinical pharmacodynamics of antipseudomonal cephalosporins in patients with ventilator-associated pneumonia

scientific article published on 16 December 2013

Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa

scientific article

Clinical pharmacodynamics of meropenem in patients with lower respiratory tract infections

scientific article published on 16 February 2007

Clinical use comparison of a semiautomated PCR with fluorescent ribotyping for typing of Clostridium difficile

scientific article

Clostridium difficile infection--not just a burden anymore.

scientific article published on August 2009

Comparative Assessment of Tedizolid Pharmacokinetics and Tissue Penetration between Diabetic Patients with Wound Infections and Healthy Volunteers via In Vivo Microdialysis

scientific article published on 6 November 2017

Comparative Efficacies of Human Simulated Exposures of Telavancin and Vancomycin against Methicillin-Resistant Staphylococcus aureus with a Range of Vancomycin MICs in a Murine Pneumonia Model ⬇️

scientific article published on September 13, 2010

Comparative In Vitro and In Vivo Efficacies of Human Simulated Doses of Ceftazidime and Ceftazidime-Avibactam against Pseudomonas aeruginosa ⬇️

scientific article published on September 17, 2012

Comparative In Vivo Antibacterial Activity of Human-Simulated Exposures of Cefiderocol and Ceftazidime against Stenotrophomonas maltophilia in the Murine Thigh Model

scientific article published on 07 October 2019

Comparative In Vivo Efficacies of Epithelial Lining Fluid Exposures of Tedizolid, Linezolid, and Vancomycin for Methicillin-Resistant Staphylococcus aureus in a Mouse Pneumonia Model ⬇️

scientific article published on February 21, 2012

Comparative Pharmacokinetics, Pharmacodynamics, and Tolerability of Ertapenem 1 Gram/Day Administered as a Rapid 5‐Minute Infusion versus the Standard 30‐Minute Infusion in Healthy Adult Volunteers ⬇️

scientific article published on February 11, 2013

Comparative efficacy of human-simulated epithelial lining fluid exposures of tedizolid, linezolid and vancomycin in neutropenic and immunocompetent murine models of staphylococcal pneumonia

scientific article published on 01 April 2019

Comparative in vivo efficacy of meropenem, imipenem, and cefepime against Pseudomonas aeruginosa expressing MexA-MexB-OprM efflux pumps

scientific article published on 23 August 2006

Comparative pharmacodynamics for intravenous antibiotics against Gram-negative bacteria in Europe between 2002 and 2006: a report from the OPTAMA program

scientific article

Comparative pharmacokinetic and pharmacodynamic profile of piperacillin/tazobactam 3.375G Q4H and 4.5G Q6H.

scientific article

Comparison of 2002-2006 OPTAMA programs for US hospitals: focus on gram-negative resistance

scientific article published on 3 February 2009

Comparison of meropenem MICs and susceptibilities for carbapenemase-producing Klebsiella pneumoniae isolates by various testing methods

scientific article published on 19 May 2010

Comparison of pharmacodynamic target attainment between healthy subjects and patients for ceftazidime and meropenem

scientific article published in July 2005

Comparison of probability of target attainment calculated by Monte Carlo simulation with meropenem clinical and microbiological response for the treatment of complicated skin and skin structure infections

scientific article

Comparison of the activity of a human simulated, high-dose, prolonged infusion of meropenem against Klebsiella pneumoniae producing the KPC carbapenemase versus that against Pseudomonas aeruginosa in an in vitro pharmacodynamic model

scientific article published on 7 December 2009

Comparison of tigecycline penetration into the epithelial lining fluid of infected and uninfected murine lungs

scientific article

Correlation between vancomycin and daptomycin MIC values for methicillin-susceptible and methicillin-resistant Staphylococcus aureus by 3 testing methodologies ⬇️

scientific article published on November 1, 2010

Corrigendum to Physical Compatibility of Meropenem and Vaborbactam with Select Intravenous Drugs During Simulated Y-site Administration [Clinical Therapeutics 40 (2018) 261-269]

scientific article published on 16 October 2018

Cost analysis of continuous versus intermittent infusion of piperacillin-tazobactam: a time-motion study

scientific article

Cost effect of managing methicillin-resistant Staphylococcus aureus in a long-term care facility

scientific article

Cost-effective approaches to the treatment of community-acquired pneumonia in the era of resistance

scientific article

Cost-effectiveness of telavancin versus vancomycin for treatment of complicated skin and skin structure infections

scientific article published on December 2008

Defining Clinical Exposures of Cefepime for Gram-Negative Bloodstream Infections That Are Associated with Improved Survival.

scientific article published on 14 December 2015

Defining Extended Spectrum β-Lactamases: Implications of Minimum Inhibitory Concentration-Based Screening Versus Clavulanate Confirmation Testing

scientific article

Defining the impact of severity of illness on time above the MIC threshold for cefepime in Gram-negative bacteraemia: a 'Goldilocks' window

scientific article published on 28 June 2017

Defining the need for new antimicrobials: clinical and economic implications of resistance in the hospitalised patient

scientific article

Defining the potency of amikacin against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii derived from Chinese hospitals using CLSI and inhalation-based breakpoints.

scientific article

Demography and burden of care associated with patients readmitted for urinary tract infection

scientific article published on 23 May 2014

Derivation of meropenem dosage in patients receiving continuous veno-venous hemofiltration based on pharmacodynamic target attainment

scientific article published on 28 June 2005

Detection of Piperacillin-Tazobactam-Resistant/Pan-β-Lactam-Susceptible Escherichia coli with Current Automated Susceptibility Test Systems

scientific article published on 10 January 2017

Determination of Tissue Penetration and Pharmacokinetics of Linezolid in Patients with Diabetic Foot Infections Using In Vivo Microdialysis ⬇️

scientific article published on June 27, 2011

Determination of the in vivo pharmacodynamic profile of cefepime against extended-spectrum-beta-lactamase-producing Escherichia coli at various inocula

scientific article

Determination of the pharmacodynamic profile of daptomycin against Streptococcus pneumoniae isolates with varying susceptibility to penicillin in a murine thigh infection model

scientific article

Development and Application of a Pragmatic Algorithm to Guide Definitive Carbapenemase Testing to Identify Carbapenemase-Producing Pseudomonas aeruginosa

scientific article published on 27 October 2020

Development of Daptomycin Susceptibility Breakpoints for Enterococcus faecium and Revision of the Breakpoints for Other Enterococcal Species by the Clinical and Laboratory Standards Institute

scientific article published on 01 March 2020

Development of HPLC methods for the determination of vancomycin in human plasma, mouse serum and bronchoalveolar lavage fluid

scientific article published on 31 July 2012

Development of Neutropenic Murine Models of Iron Overload and Depletion To Study the Efficacy of Siderophore-Antibiotic Conjugates

scientific article published on 20 December 2019

Development of an HPLC Method for the Determination of Anidulafungin in Human Plasma and Saline ⬇️

scientific article published on 01 May 2011

Development of an HPLC Method for the Determination of Meropenem/Vaborbactam in Biological and Aqueous Matrixes

scientific article published on 20 July 2020

Development of an HPLC method for the determination of doripenem in human and mouse serum

scientific article published on 19 March 2007

Development of an HPLC-MS/MS method for the determination of ceftolozane/tazobactam in bronchoalveolar lavage fluid

scientific article published on 15 November 2018

Differential efficacy of clarithromycin in lung versus thigh infection models

scientific article

Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.

scientific article published on 22 June 2015

Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections

scientific article published on 18 June 2013

Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae ⬇️

scientific article published on March 21, 2011

EDTA-modified carbapenem inactivation method (eCIM) for detecting IMP Metallo-β-lactamase-producing Pseudomonas aeruginosa: an assessment of increasing EDTA concentrations

scientific article published on 20 July 2020

Early antibiotic discontinuation in patients with clinically suspected ventilator-associated pneumonia and negative quantitative bronchoscopy cultures

scientific article published in July 2013

Economic benefit of a meropenem dosage strategy based on pharmacodynamic concepts.

scientific article published in March 2003

Effect of Body Weight on Cefazolin and Vancomycin Trabecular Bone Concentrations in Patients Undergoing Total Joint Arthroplasty.

scientific article published on 23 September 2015

Effect of Clinically Meaningful Antibiotic Concentrations on Recovery of Escherichia coli and Klebsiella pneumoniae Isolates from Anaerobic Blood Culture Bottles with and without Antibiotic Binding Resins

scientific article published on 22 November 2019

Effects of Clinically Meaningful Concentrations of Antipseudomonal β-Lactams on Time to Detection and Organism Growth in Blood Culture Bottles

scientific article published on 11 October 2017

Effects of Urine Matrix and pH on the Potency of Delafloxacin and Ciprofloxacin against Urogenic Escherichia coli and Klebsiella pneumoniae

scientific article published on 29 January 2015

Efficacies of ceftazidime-avibactam and ceftazidime against Pseudomonas aeruginosa in a murine lung infection model

scientific article published on 16 December 2013

Efficacy and Safety of Eravacycline in Obese Patients: A Post Hoc Analysis of Pooled Data From the IGNITE1 and IGNITE4 Clinical Trials

scientific article published on 13 November 2020

Efficacy of Ceftaroline Fosamil in a Staphylococcal Murine Pneumonia Model ⬇️

scientific article published on September 17, 2012

Efficacy of Human Simulated Exposures of Ceftaroline Administered at 600 Milligrams Every 12 Hours against Phenotypically Diverse Staphylococcus aureus Isolates ⬇️

scientific article published on June 13, 2011

Efficacy of Human Simulated Exposures of Ceftaroline against Phenotypically Diverse Enterobacteriaceae Isolates ⬇️

scientific article published on February 13, 2012

Efficacy of Human-Simulated Epithelial Lining Fluid Exposure of Meropenem-Nacubactam Combination against Class A Serine β-Lactamase-Producing Enterobacteriaceae in the Neutropenic Murine Lung Infection Model

scientific article published on 27 March 2019

Efficacy of Humanized Cefiderocol Exposure Is Unaltered by Host Iron Overload in the Thigh Infection Model

scientific article published on 20 December 2019

Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model

scientific article published in 2019

Efficacy of Humanized Exposures of Cefiderocol (S-649266) against a Diverse Population of Gram-negative Bacteria in the Murine Thigh Infection Model

scientific article published on 28 August 2017

Efficacy of clarithromycin against Streptococcus pneumoniae expressing mef(A)-mediated resistance

scientific article published in May 2004

Efficacy of doripenem and ertapenem against KPC-2-producing and non-KPC-producing Klebsiella pneumoniae with similar MICs ⬇️

scientific article published on March 8, 2013

Efficacy of human-simulated bronchopulmonary exposures of cefepime, zidebactam and the combination (WCK 5222) against MDR Pseudomonas aeruginosa in a neutropenic murine pneumonia model

scientific article published on 01 January 2020

Efficacy of human-simulated exposures of meropenem/vaborbactam and meropenem against OXA-48 β-lactamase-producing Enterobacterales in the neutropenic murine thigh infection model

scientific article published on 26 October 2020

Efficacy of pulsatile amoxicillin and clarithromycin dosing alone and in combination in a murine pneumococcal pneumonia model

scientific article published on 15 July 2005

Elevated vancomycin minimum inhibitory concentrations among methicillin-resistant Staphylococcus aureus isolated from patients with ventilator-associated pneumonia at a Connecticut hospital.

scientific article

Emerging Pseudomonas aeruginosa resistance: implications in clinical practice.

scientific article published on January 2004

Empiric therapy for secondary peritonitis: a pharmacodynamic analysis of cefepime, ceftazidime, ceftriaxone, imipenem, levofloxacin, piperacillin/tazobactam, and tigecycline using Monte Carlo simulation

scientific article published on 01 May 2007

Empiric treatment of multidrug-resistant Burkholderia cepacia lung exacerbation in a patient with cystic fibrosis: application of pharmacodynamic concepts to meropenem therapy

scientific article published in November 2004

Epidemiology and economics of adult patients hospitalized with urinary tract infections

scientific article published on 16 December 2015

Eravacycline Pharmacokinetics and Challenges in Defining Humanized Exposure In Vivo

scientific article published on 27 June 2016

Erratum for Asempa et al., "In Vitro Activity of Imipenem-Relebactam Alone or in Combination with Amikacin or Colistin against Pseudomonas aeruginosa"

scientific article published on 21 April 2020

Evaluating empiric treatment options for secondary peritonitis using pharmacodynamic profiling

scientific article published on April 2007

Evaluation of Plazomicin, Tigecycline, and Meropenem Pharmacodynamic Exposure against Carbapenem-Resistant Enterobacteriaceae in Patients with Bloodstream Infection or Hospital-Acquired/Ventilator-Associated Pneumonia from the CARE Study (ACHN-490-0

scientific article published on 28 June 2019

Evaluation of a Phenotypic Algorithm to Direct Carbapenemase Testing in <i>Pseudomonas aeruginosa</i>: Validation in a Multicenter German Cohort

scientific article published on 08 January 2021

Evaluation of a disease state management guideline for urinary tract infection

scientific article

Evaluation of bacterial kill when modelling the bronchopulmonary pharmacokinetic profile of moxifloxacin and levofloxacin against parC-containing isolates of Streptococcus pneumoniae

scientific article published on 19 July 2006

Evaluation of linezolid pharmacokinetics in critically-ill obese patients with severe skin and soft tissue infections

scientific article published on 30 November 2020

Evaluation of telithromycin against Streptococcus pneumoniae with ribosomal mutations utilizing in vitro time-kill methodology

scientific article

Evaluation of the Xpert Carba-R NxG Assay for Detection of Carbapenemase Genes in a Global Challenge Set of Pseudomonas aeruginosa

scientific article published on 28 October 2020

Evaluation of the in vitro activity of WCK 5222 (cefepime/zidebactam) and currently available combination therapies against single- and double-carbapenemase producing Enterobacteriaceae: Expanding the zone of hope

scientific article published on 20 December 2019

Expression of the MexXY-OprM efflux system in Pseudomonas aeruginosa with discordant cefepime/ceftazidime susceptibility profiles ⬇️

scientific article published on November 23, 2008

Extended interval aminoglycoside dosing: from concept to clinic

scientific article

Extended-spectrum beta-lactamases (ESBL).

scientific article

Feasibility of routine synergy testing using antibiotic gradient diffusion strips in the clinical laboratory

scientific article published on 01 August 2018

Fluoroquinolone use is not associated with the change in imipenem susceptibility of Pseudomonas aeruginosa in 25 hospitals ⬇️

scientific article published on March 22, 2011

Hospital costs and outcomes among intravenous antifungal therapies for patients with invasive aspergillosis in the United States

scientific article

Human Simulated Studies of Aztreonam and Aztreonam-Avibactam To Evaluate Activity against Challenging Gram-Negative Organisms, Including Metallo-β-Lactamase Producers ⬇️

scientific article published on 06 May 2013

Humanized Exposures of a β-Lactam-β-Lactamase Inhibitor, Tazobactam, versus Non-β-Lactam-β-Lactamase Inhibitor, Avibactam, with or without Colistin, against Acinetobacter baumannii in Murine Thigh and Lung Infection Models

scientific article published on 13 March 2018

Humanized tissue pharmacodynamics of cefazolin against commonly isolated pathogens in skin and skin structure infections

scientific article published on 14 May 2014

Identifying exposure targets for treatment of staphylococcal pneumonia with ceftobiprole

scientific article published on 18 May 2009

Imipenem/Cilastatin/Relebactam Alone and in Combination against Pseudomonas aeruginosa in the In Vitro Pharmacodynamic Model

scientific article published on 02 November 2020

Impact of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species on clinical outcomes and hospital costs: a matched cohort study

scientific article

Impact of extended-spectrum β-lactamase-producing organisms on clinical and economic outcomes in patients with urinary tract infection

scientific article published on 24 January 2014

Impact of pharmacodynamics on dosing of macrolides, azalides, and ketolides

scientific article published on September 2003

Impact of revised cefepime CLSI breakpoints on Escherichia coli and Klebsiella pneumoniae susceptibility and potential impact if applied to Pseudomonas aeruginosa

scientific article published on 18 February 2015

Impact of superinfection on hospital length of stay and costs in patients with ventilator-associated pneumonia

scientific article published on 06 February 2009

Impact of vancomycin faecal concentrations on clinical and microbiological outcomes in Clostridium difficile infection.

scientific article published on 30 May 2015

Impact of various conditions on the efficacy of dual carbapenem therapy against KPC-producing Klebsiella pneumoniae

scientific article

In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae

scientific article published on 18 August 2015

In Vitro Activity of Imipenem-Relebactam Alone or in Combination with Amikacin or Colistin against Pseudomonas aeruginosa

scientific article published on 23 August 2019

In Vitro Activity of Novel Gyrase Inhibitors against a Highly Resistant Population of Pseudomonas aeruginosa ⬇️

scientific article published on 09 April 2013

In Vitro Comparison of Ceftolozane-Tazobactam to Traditional Beta-Lactams and Ceftolozane-Tazobactam as an Alternative to Combination Antimicrobial Therapy for Pseudomonas aeruginosa

scientific article

In Vitro Evaluation of Novel Compounds against Selected Resistant Pseudomonas aeruginosa Isolates ⬇️

scientific article published on December 27, 2011

In Vitro Pharmacodynamics of Human Simulated Exposures of Telavancin against Methicillin-Susceptible and -Resistant Staphylococcus aureus with and without Prior Vancomycin Exposure.

scientific article

In Vitro Pharmacodynamics of Simulated Pulmonary Exposures of Tigecycline Alone and in Combination against Klebsiella pneumoniae Isolates Producing a KPC Carbapenemase ⬇️

scientific article published on January 31, 2011

In Vitro Pharmacodynamics of Vancomycin and Cefazolin Alone and in Combination against Methicillin-Resistant Staphylococcus aureus ⬇️

scientific article published on October 17, 2011

In Vitro Pharmacodynamics of a Novel Ceftibuten-Clavulanate Combination Antibiotic against Enterobacteriaceae

scientific article published on 24 June 2019

In Vivo Activity of Humanized Exposures of Piperacillin-Tazobactam (TZP) against TZP-Resistant/Pan-β-Lactam-Susceptible (TZP-R/PBL-S) Escherichia coli in a Murine Pneumonia Model

scientific article published in 2016

In Vivo Efficacy of Humanized Exposures of Cefiderocol Compared with Cefepime (FEP) and Meropenem (MEM) against Gram-negative Bacteria in a Murine Thigh Model.

scientific article published on 4 October 2017

In Vivo Efficacy of Meropenem with a Novel Non-β-Lactam-β-Lactamase Inhibitor, Nacubactam, against Gram-Negative Organisms Exhibiting Various Resistance Mechanisms in a Murine Complicated Urinary Tract Infection Model

scientific article published on 27 August 2018

In Vivo Efficacy of Plazomicin Alone or in Combination with Meropenem or Tigecycline against Enterobacteriaceae Isolates Exhibiting Various Resistance Mechanisms in an Immunocompetent Murine Septicemia Model.

scientific article

In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Multidrug-Resistant Pseudomonas aeruginosa in the Neutropenic Murine Thigh Infection Model

scientific article published on 24 June 2019

In Vivo Efficacy of a Human-Simulated Regimen of Ceftaroline Combined with NXL104 against Extended-Spectrum-β-Lactamase (ESBL)-Producing and Non-ESBL-Producing Enterobacteriaceae ⬇️

scientific article published on April 25, 2011

In Vivo Pharmacodynamic Profile of Ceftibuten-Clavulanate Combination against Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in the Murine Thigh Infection Model

scientific article published on 24 June 2019

In vitro Activity of Ceftolozane/Tazobactam Alone or with an Aminoglycoside Against Multi-Drug-Resistant Pseudomonas aeruginosa from Pediatric Cystic Fibrosis Patients

scientific article published on 9 December 2016

In vitro activity and pharmacodynamics of commonly used antibiotics against adult systemic isolates of Escherichia coli and Pseudomonas aeruginosa at Forty US Hospitals.

scientific article

In vitro activity of ampicillin and ceftriaxone against ampicillin-susceptible Enterococcus faecium

scientific article published on 01 August 2019

In vitro activity of human-simulated epithelial lining fluid exposures of ceftaroline, ceftriaxone, and vancomycin against methicillin-susceptible and -resistant Staphylococcus aureus

scientific article published on 6 October 2014

In vitro investigation of synergy among fosfomycin and parenteral antimicrobials against carbapenemase-producing Enterobacteriaceae

scientific article published on 25 May 2019

In vitro microdialysis membrane efficiency of broad-spectrum antibiotics in combination and alone

scientific article published on 5 June 2014

In vitro pharmacodynamics of human simulated exposures of ceftaroline and daptomycin against MRSA, hVISA, and VISA with and without prior vancomycin exposure

scientific article published on 11 November 2013

In vitro pharmacodynamics of human-simulated exposures of ampicillin/sulbactam, doripenem and tigecycline alone and in combination against multidrug-resistant Acinetobacter baumannii

scientific article published on 24 May 2013

In vitro pharmacodynamics of polymyxin B and tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii

scientific article published on 25 November 2013

In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance

scientific article published on 16 November 2009

In vitro potency of amikacin and comparators against E. coli, K. pneumoniae and P. aeruginosa respiratory and blood isolates

scientific article published on 17 June 2016

In vitro potency of antipseudomonal β-lactams against blood and respiratory isolates of P. aeruginosa collected from US hospitals

scientific article published on 01 May 2019

In vitro synergy of ceftolozane/tazobactam in combination with fosfomycin or aztreonam against MDR Pseudomonas aeruginosa

scientific article published on 02 April 2020

In vivo activities of simulated human doses of cefepime and cefepime-AAI101 against multidrug-resistant Gram-negative Enterobacteriaceae

scientific article

In vivo activity of human-simulated regimens of imipenem alone and in combination with relebactam against Pseudomonas aeruginosa in the murine thigh infection model

scientific article published on 09 May 2020

In vivo comparison of CXA-101 (FR264205) with and without tazobactam versus piperacillin-tazobactam using human simulated exposures against phenotypically diverse gram-negative organisms ⬇️

scientific article published on 7 November 2011

In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa

scientific article published on October 2009

In vivo efficacy of humanized ceftaroline fosamil-avibactam exposures in a polymicrobial infection model

scientific article published on 16 September 2013

In vivo efficacy of humanized exposures of Ceftazidime-Avibactam in comparison with Ceftazidime against contemporary Enterobacteriaceae isolates

scientific article

In vivo efficacy of simulated human dosing regimens of prolonged-infusion doripenem against carbapenemase- producing Klebsiella pneumoniae

scientific article

In vivo microdialysis study of the penetration of daptomycin into soft tissues in diabetic versus healthy volunteers

scientific article published on 08 September 2008

In vivo pharmacodynamic profile of tigecycline against phenotypically diverse Escherichia coli and Klebsiella pneumoniae isolates

scientific article published on 13 April 2009

In vivo pharmacodynamic profiling of doripenem against Pseudomonas aeruginosa by simulating human exposures

scientific article published on 5 May 2008

In vivo pharmacodynamics of new-generation β-lactamase inhibitor taniborbactam (formerly VNRX-5133) in combination with cefepime against serine-β-lactamase-producing Gram-negative bacteria

scientific article published on 30 August 2020

Inappropriate Antibiotic Use Due to Decreased Compliance with a Ventilator‐Associated Pneumonia Computerized Clinical Pathway: Implications for Continuing Education and Prospective Feedback ⬇️

scientific article published on August 1, 2012

Increased 3-gram cefazolin dosing for cesarean delivery prophylaxis in obese women

scientific article

Influence of automated screening and confirmation of extended-spectrum beta-lactamase-producing members of the Enterobacteriaceae on prescribing of antibiotics

scientific article

Influence of sex on the pharmacokinetic interaction of fleroxacin and ciprofloxacin with caffeine

scientific article published in January 2003

Intra-abdominal infections: considerations for the use of the carbapenems

scientific article published on February 2007

Investigational drugs for the treatment of infections caused by multidrug-resistant Gram-negative bacteria

scientific article published on 3 April 2018

Is One Sample Enough? β-Lactam Target Attainment and Penetration into Epithelial Lining Fluid Based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model

scientific article published on 29 January 2019

Is all free time above the minimum inhibitory concentration the same: implications for beta-lactam in vivo modelling

scientific article published on 16 January 2007

Isolation and quantitation of Clostridium difficile in aqueous and fecal matter using two types of selective media

scientific article published on 27 June 2015

KPC Presence in Pseudomonas aeruginosa Has Minimal Impact on the In Vivo Efficacy of Carbapenem Therapy ⬇️

scientific article published on December 17, 2012

Lack of Correlation between Bristol Stool Scale and Quantitative Bacterial Load in Clostridium difficile Infection

scientific article published on 26 February 2015

Length of stay and hospital costs associated with a pharmacodynamic-based clinical pathway for empiric antibiotic choice for ventilator-associated pneumonia

scientific article published on May 2010

Linezolid penetration into wound tissue of two diabetic patients before and after hyperbaric oxygen therapy

scientific article published on 01 January 2011

Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill patients with pneumonia

scientific article published on 24 March 2020

Macrolide resistance in Streptococcus pneumoniae: mechanisms, patterns, and clinical implications of resistance.

scientific article

Making the most of surveillance studies: summary of the OPTAMA Program

scientific article published in December 2005

Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections

scientific article

Meropenem time above the MIC exposure is predictive of response in cystic fibrosis children with acute pulmonary exacerbations

scientific article published on 24 February 2018

Meropenem-nacubactam activity against AmpC-overproducing and KPC-expressing Pseudomonas aeruginosa in a neutropenic murine lung infection model

scientific article published on 06 November 2019

Metallo-β-lactamase resistance in Enterobacteriaceae is an artefact of currently utilized antimicrobial susceptibility testing methods

scientific article published on 01 April 2020

Microbiological activity of ceftolozane/tazobactam, ceftazidime, meropenem, and piperacillin/tazobactam against Pseudomonas aeruginosa isolated from children with cystic fibrosis

scientific article published on May 2015

Monte Carlo Simulation Methodologies for β-Lactam/β-Lactamase Inhibitor Combinations: Effect on Probability of Target Attainment Assessments

scientific article published on 18 August 2019

Multicenter Evaluation of Ceftazidime-Avibactam and Ceftolozane-Tazobactam Inhibitory Activity against Meropenem-Nonsusceptible Pseudomonas aeruginosa from Blood, Respiratory Tract, and Wounds.

scientific article published on 24 July 2017

Multidrug-Resistant Pseudomonas aeruginosa Infection in a Child with Cystic Fibrosis.

scientific article published on 23 September 2016

Nebulized Amikacin and Fosfomycin for Severe Pseudomonas aeruginosa Pneumonia: An Experimental Study

scientific article published on 01 June 2019

Newer developments in the treatment of Gram-positive infections

scientific article published on December 2009

Novel Pharmacotherapy for the Treatment of Hospital-Acquired and Ventilator-Associated Pneumonia Caused by Resistant Gram-Negative Bacteria

scientific article published on 7 February 2018

Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationship

scientific article published on 9 August 2008

Optimal cefepime and meropenem dosing for ventilator-associated pneumonia patients with reduced renal function: an update to our clinical pathway

scientific article published in March 2010

Optimal dosing of piperacillin-tazobactam for the treatment of Pseudomonas aeruginosa infections: prolonged or continuous infusion?

scientific article published in November 2007

Optimising antibiotic dosing regimens based on pharmacodynamic target attainment against Pseudomonas aeruginosa collected in Hungarian hospitals

scientific article published on 01 November 2006

Optimising dosing strategies of antibacterials utilising pharmacodynamic principles: impact on the development of resistance

scientific article published on January 2006

Optimizing Antibiotic Administration for Pneumonia

scientific article published on 01 December 2018

Optimizing Antibiotic Dosing Strategies for the Treatment of Gram-negative Infections in the Era of Resistance

scientific article published on 17 December 2015

Optimizing antibiotic pharmacodynamics in hospital-acquired and ventilator-acquired bacterial pneumonia

scientific article published on July 12, 2011

Optimizing antimicrobial pharmacodynamics: dosage strategies for meropenem

scientific article published in August 2004

Optimizing pharmacodynamic target attainment using the MYSTIC antibiogram: data collected in North America in 2002.

scientific article

Patient preferences for treatment of acute bacterial skin and skin structure infections in the emergency department

Pharmacodynamic Approaches to Optimizing Beta-Lactam Therapy ⬇️

scientific article published on January 1, 2011

Pharmacodynamic Profile of GSK2140944 against Methicillin-Resistant Staphylococcus aureus in a Murine Lung Infection Model

scientific article published on 8 June 2015

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

scientific article

Pharmacodynamic and pharmacokinetic profiling of delafloxacin in a murine lung model against community-acquired respiratory tract pathogens.

scientific article published on 29 September 2016

Pharmacodynamic assessment of clarithromycin in a murine model of pneumococcal pneumonia

scientific article

Pharmacodynamic assessment of ertapenem (MK-0826) against Streptococcus pneumoniae in a murine neutropenic thigh infection model

scientific article

Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains

scientific article published on 14 April 2008

Pharmacodynamic considerations for the selection of oral cephalosporins in the treatment of rhinosinusitis

scientific article

Pharmacodynamic evaluation of i.v. antimicrobials against Pseudomonas aeruginosa samples collected from U.S. hospitals

scientific article

Pharmacodynamic evaluation of meropenem and cefotaxime for pediatric meningitis: a report from the OPTAMA program

scientific article published on 01 January 2006

Pharmacodynamic evaluation of tigecycline against Acinetobacter baumannii in a murine pneumonia model

scientific article published on 11 March 2009

Pharmacodynamic modeling of beta-lactam antibiotics for the empiric treatment of secondary peritonitis: a report from the OPTAMA program

scientific article

Pharmacodynamic modeling of imipenem-cilastatin, meropenem, and piperacillin-tazobactam for empiric therapy of skin and soft tissue infections: a report from the OPTAMA Program

scientific article published in January 2005

Pharmacodynamic modeling of intravenous antibiotics against gram-negative bacteria collected in the United States

scientific article published in April 2010

Pharmacodynamic performance of tigecycline versus common intravenous antibiotics for the empiric treatment of complicated skin and skin structure infections

scientific article published in February 2008

Pharmacodynamic profile of commonly utilised parenteral therapies against meticillin-susceptible and meticillin-resistant Staphylococcus aureus collected from US hospitals

scientific article published on 24 June 2014

Pharmacodynamic profile of daptomycin against Enterococcus species and methicillin-resistant Staphylococcus aureus in a murine thigh infection model

scientific article published on 13 August 2003

Pharmacodynamic profile of telithromycin against macrolide- and fluoroquinolone-resistant Streptococcus pneumoniae in a neutropenic mouse thigh model

scientific article

Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model

scientific article published on 08 September 2009

Pharmacodynamic profiling of doripenem, imipenem and meropenem against prevalent Gram-negative organisms in the Asia-Pacific region ⬇️

scientific article published on November 3, 2012

Pharmacodynamic profiling of modithromycin: assessment in a pneumococcal murine pneumonia model

scientific article

Pharmacodynamic study of beta-lactams alone and in combination with beta-lactamase inhibitors against Pseudomonas aeruginosa possessing an inducible beta-lactamase

scientific article

Pharmacodynamic target attainment of oral beta-lactams for the empiric treatment of acute otitis media in children

scientific article published in January 2008

Pharmacodynamic target attainment of seven antimicrobials against Gram-negative bacteria collected from China in 2003 and 2004.

scientific article published on 23 July 2007

Pharmacodynamic target attainment of six beta-lactams and two fluoroquinolones against Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella species collected from United States intensive care units in 2004.

scientific article published in March 2007

Pharmacodynamic-based clinical pathway for empiric antibiotic choice in patients with ventilator-associated pneumonia.

scientific article published on 7 May 2009

Pharmacodynamics of Daptomycin against Enterococcus faecium and Enterococcus faecalis in the Murine Thigh Infection Model.

scientific article

Pharmacodynamics of a Novel Des-F(6)-Quinolone, BMS-284756, against Streptococcus pneumoniae in the Thigh Infection Model ⬇️

scientific article published on May 1, 2003

Pharmacodynamics of antimicrobials for the empirical treatment of nosocomial pneumonia: a report from the OPTAMA Program

scientific article

Pharmacodynamics of antimicrobials: treatment optimisation

scientific article published on October 2005

Pharmacodynamics of meropenem and imipenem against Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa

scientific article published in January 2004

Pharmacodynamics of moxifloxacin and levofloxacin at simulated epithelial lining fluid drug concentrations against Streptococcus pneumoniae

scientific article published on April 2004

Pharmacodynamics of tigecycline against phenotypically diverse Staphylococcus aureus isolates in a murine thigh model

scientific article published on 29 December 2008

Pharmacoeconomic analysis of amphotericin B lipid complex versus liposomal amphotericin B in the treatment of fungal infections

scientific article published in January 2004

Pharmacoeconomics of a pharmacist-managed program for automatically converting levofloxacin route from i.v. to oral

scientific article published in November 2002

Pharmacoeconomics of continuous versus intermittent infusion of piperacillin-tazobactam for the treatment of complicated intraabdominal infection

scientific article published on 01 April 2006

Pharmacokinetic Profile of Meropenem, Administered at 500 Milligrams Every 8 Hours, in Plasma and Cantharidin-Induced Skin Blister Fluid ⬇️

scientific article published on May 1, 2003

Pharmacokinetic and Pharmacodynamic Analysis of Ceftazidime/Avibactam in Critically Ill Patients

scientific article published on 23 October 2018

Pharmacokinetic and Pharmacodynamic Evaluation of P-873 versus Klebsiella pneumoniae in a Neutropenic Murine Thigh Infection Model ⬇️

scientific article published on January 28, 2013

Pharmacokinetic and pharmacodynamic evaluation of two dosing regimens for piperacillin-tazobactam

scientific article published on May 2002

Pharmacokinetic profile of tigecycline in serum and skin blister fluid of healthy subjects after multiple intravenous administrations

scientific article

Pharmacokinetic properties and stability of continuous-infusion meropenem in adults with cystic fibrosis

scientific article

Pharmacokinetics and Monte Carlo Simulations of Doripenem in Patients with Febrile Neutropenia ⬇️

scientific article published on September 25, 2012

Pharmacokinetics and Pulmonary Disposition of Tedizolid and Linezolid in a Murine Pneumonia Model under Variable Conditions ⬇️

scientific article published on March 19, 2012

Pharmacokinetics and Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients with Lower Limb Infections and Healthy Adult Volunteers

scientific article published on 11 September 2017

Pharmacokinetics of ABT-773, a new semi-synthetic ketolide in neutropenic lung-infected mice: a population approach

scientific article published in January 2002

Pharmacokinetics of Cefazolin and Vancomycin in Infants Undergoing Open-Heart Surgery With Cardiopulmonary Bypass

scientific article published on 01 May 2019

Pharmacokinetics of Intravenous Linezolid in Moderately to Morbidly Obese Adults ⬇️

scientific article published on December 17, 2012

Pharmacokinetics of Intravenous and Oral Linezolid in Adults with Cystic Fibrosis ⬇️

scientific article published on April 25, 2011

Pharmacokinetics of Telavancin in Adult Patients with Cystic Fibrosis during Acute Pulmonary Exacerbation

scientific article published on 20 December 2019

Pharmacokinetics of clarithromycin extended-release (ER) tablets in patients with AIDS.

scientific article published in September 2005

Pharmacokinetics of dalbavancin in plasma and skin blister fluid

scientific article published on 12 July 2007

Pharmacokinetics of doripenem in infected patients treated within and outside the intensive care unit

scientific article

Pharmacokinetics of meropenem 0.5 and 2 g every 8 hours as a 3-hour infusion

scientific article published in August 2003

Pharmacokinetics-pharmacodynamics of β-lactamase inhibitors: are we missing the target?

scientific article published on 30 July 2019

Phase I, open-label, safety and pharmacokinetic study to assess bronchopulmonary disposition of intravenous eravacycline in healthy men and women

scientific article

Physical Compatibility of Meropenem and Vaborbactam With Select Intravenous Drugs During Simulated Y-site Administration

scientific article published on 28 December 2017

Physical compatibility of ceftolozane-tazobactam with selected i.v. drugs during simulated Y-site administration.

scientific article published on 22 December 2016

Physical compatibility of isavuconazonium sulfate with select i.v. drugs during simulated Y-site administration.

scientific article published on 22 December 2016

Physical compatibility of plazomicin with select i.v. drugs during simulated Y-site administration

scientific article published on 12 June 2018

Physical compatibility of telavancin hydrochloride with select i.v. drugs during simulated Y-site administration ⬇️

scientific article published on 01 December 2011

Plasma and Cerebrospinal Fluid Therapeutic Drug Monitoring of Ceftolozane and Tazobactam During Treatment of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Meningitis

scientific article published on 12 November 2020

Polymyxins: older antibiotics for a new threat.

scientific article

Poor outcomes of empiric ceftriaxone ± azithromycin for community-acquired pneumonia caused by methicillin-susceptible Staphylococcus aureus

scientific article published on 3 November 2015

Population Pharmacokinetics and Safety of Ceftolozane-Tazobactam in Adult Cystic Fibrosis Patients Admitted with Acute Pulmonary Exacerbation

scientific article published on 22 August 2016

Population Pharmacokinetics of Cefazolin in Serum and Adipose Tissue From Overweight and Obese Women Undergoing Cesarean Delivery

scientific article published on 7 December 2016

Population Pharmacokinetics of Cefazolin in Serum and Tissue for Patients with Complicated Skin and Soft Tissue Infections (cSSTI).

scientific article

Population pharmacokinetic analysis and dosing regimen optimization of meropenem in adult patients

scientific article published on 01 October 2006

Population pharmacokinetics and pharmacodynamics of meropenem in pediatric patients

scientific article published in January 2006

Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection

scientific article published on 7 July 2005

Population pharmacokinetics of gentamicin in hospitalized patients receiving once-daily dosing

scientific article

Population pharmacokinetics of meropenem administered as a prolonged infusion in children with cystic fibrosis

scientific article

Potentiation of antibacterial activity of the MB-1 siderophore-monobactam conjugate using an efflux pump inhibitor

scientific article published on 20 January 2015

Precision medicine for the diagnosis and treatment of carbapenem-resistant Enterobacterales: time to think from a different perspective

scientific article published on 05 May 2020

Predicting doripenem susceptibility based on meropenem and imipenem interpretation for Pseudomonas aeruginosa ⬇️

scientific article published on December 29, 2011

Presence of infection influences the epithelial lining fluid penetration of oral levofloxacin in adult patients

scientific article

Prevalence of extended spectrum beta-lactamase producing Escherichia coli and Klebsiella isolates in a large community teaching hospital in Connecticut

scientific article

Prevalence of in vitro synergistic antibiotic interaction between fosfomycin and nonsusceptible antimicrobials in carbapenem-resistant Pseudomonas aeruginosa

scientific article published on 03 May 2019

Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children

scientific article

Probability of pharmacodynamic target attainment with standard and prolonged-infusion antibiotic regimens for empiric therapy in adults with hospital-acquired pneumonia

scientific article published in November 2009

Production and resolution of cantharidin-induced inflammatory blisters

scientific article published in July 2003

Prolonging β-lactam infusion: a review of the rationale and evidence, and guidance for implementation

scientific article

Pseudomonas aeruginosa is not just in the intensive care unit any more: implications for empirical therapy

scientific article published in April 2012

Pulmonary Disposition of Tedizolid following Administration of Once-Daily Oral 200-Milligram Tedizolid Phosphate in Healthy Adult Volunteers ⬇️

scientific article published on February 13, 2012

Quantitation of tigecycline, a novel glycylcycline [corrected] by liquid chromatography

scientific article published in November 2004

Questioning the paradigm: monotherapy vs combination antimicrobial therapy for treatment of Pseudomonas aeruginosa.

scientific article

Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection

scientific article

Recovery of Gram-Negative Bacteria from Aerobic Blood Culture Bottles Containing Antibiotic Binding Resins after Exposure to β-Lactam and Fluoroquinolone Concentrations

scientific article published on 24 September 2019

Reevaluation of current susceptibility breakpoints for Gram-negative rods based on pharmacodynamic assessment.

scientific article published on 9 March 2007

Resource utilization of adults admitted to a large urban hospital with community-acquired pneumonia caused by Streptococcus pneumoniae

scientific article

Review of dalbavancin, a novel semisynthetic lipoglycopeptide

scientific article published on May 2007

Risk factors and outcomes associated with isolation of meropenem high-level-resistant Pseudomonas aeruginosa

scientific article

Role of pharmacodynamics in designing dosage regimens for beta-lactams

scientific article

SHORT-TERM EFFECTS OF APPROPRIATE EMPIRICAL ANTIMICROBIAL TREATMENT WITH CEFTOLOZANE/TAZOBACTAM IN A SWINE MODEL OF NOSOCOMIAL PNEUMONIA

scientific article published on 09 November 2020

Selection of Prophylactic Antimicrobial Agent May Affect Incidence of Infection in Small Bowel and Colorectal Surgery ⬇️

scientific article published on December 5, 2011

Serum bactericidal activities of high-dose daptomycin with and without coadministration of gentamicin against isolates of Staphylococcus aureus and Enterococcus species

scientific article

Simplifying Piperacillin/Tazobactam Dosing: Pharmacodynamics of Utilizing Only 4.5 or 3.375 g Doses for Patients With Normal and Impaired Renal Function

scientific article published on 21 December 2016

Simulation of antibiotic pharmacodynamic exposure for the empiric treatment of nosocomial bloodstream infections: a report from the OPTAMA program

scientific article

Simultaneous analysis of piperacillin and tazobactam in rabbits: application to pharmacokinetic study

scientific article

Simultaneous determination of ticarcillin and clavulanate in rabbit serum and tissue cage fluid by liquid chromatography

scientific article published in September 2003

Single β-lactams versus combinations as empiric therapy for infections with Pseudomonas aeruginosa: assessing the in vitro susceptibility

scientific article published on 09 October 2019

Stability of doripenem in polyvinyl chloride bags and elastomeric pumps ⬇️

scientific article published on September 15, 2010

Stability of doripenem, imipenem and meropenem at elevated room temperatures

scientific article published on 10 August 2010

Stability of ertapenem 100 mg/mL in polypropylene syringes stored at 25, 4, and -20 °C.

scientific article published on September 2014

Steady-state intrapulmonary concentrations of moxifloxacin, levofloxacin, and azithromycin in older adults

scientific article published on March 2004

Subcutaneous cefazolin to reduce surgical site infections in a porcine model.

scientific article

Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy

scientific article published on 19 March 2014

Supporting the ceftaroline fosamil/avibactam Enterobacteriaceae breakpoint determination using humanised in vivo exposures in a thigh model

scientific article published on 16 September 2014

Surgical site infections: does inadequate antibiotic therapy affect patient outcomes?

scientific article

Susceptibility Profile of Ceftolozane/Tazobactam and Other Parenteral Antimicrobials Against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa From US Hospitals

scientific article published on 15 June 2015

Synergistic Activity of Exebacase (CF-301) in Addition to Daptomycin against Staphylococcus aureus in a Neutropenic Murine Thigh Infection Model

scientific article published on 21 February 2020

Tackling empirical antibiotic therapy for ventilator-associated pneumonia in your ICU: guidance for implementing the guidelines

scientific article published on 06 February 2009

Telavancin: a novel lipoglycopeptide for serious gram-positive infections

scientific article published on March 2007

The Effect of Clinical Concentrations of Meropenem (MEM), Ceftolozane/tazobactam (C/T), and Ceftazidime/avaibactam (CZA) on Time to Detection (TTD) and Growth of Pseudomonas aeruginosa (PSA) in bioMerieux BacT/ALERT®FA Plus Blood Culture (BC) Bottle

scientific article published on 4 October 2017

The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey.

scientific article published on August 2017

The OPTAMA programme: utilizing MYSTIC (2002) to predict critical pharmacodynamic target attainment against nosocomial pathogens in Europe

scientific article published in December 2004

The Zinc Conundrum: Meropenem activity against NDM-harboring Enterobacteriaceae

scientific article published on 23 November 2020

The authors reply

The clinical and economic benefits of administering piperacillin-tazobactam by continuous infusion

scientific article

The current state of multidrug-resistant gram-negative bacilli in North America

scientific article published on February 2008

The efficacy and safety of antibiotic combination therapy for infections caused by Gram-positive and Gram-negative organisms ⬇️

scientific article published on February 18, 2012

The paradoxical in vivo activity of β-lactams against metallo-β-lactamase-producing Enterobacterales is not restricted to carbapenems

scientific article published on 12 November 2020

Tigecycline Displays In Vivo Bactericidal Activity against Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae after 72-Hour Exposure Period ⬇️

scientific article published on October 31, 2012

Tigecycline Penetration into Skin and Soft Tissue ⬇️

scientific article published on 02 December 2011

Tissue Penetration and Pharmacokinetics of Tigecycline in Diabetic Patients with Chronic Wound Infections Described by Using In Vivo Microdialysis ⬇️

scientific article published on October 4, 2010

Tissue penetration and exposure of cefepime in patients with diabetic foot infections.

scientific article

Tissue penetration of telavancin after intravenous administration in healthy subjects

scientific article

Tissue pharmacokinetics of cefazolin in patients with lower limb infections

scientific article published on 16 September 2013

To add or not to add polysorbate 80: impact on colistin MICs for clinical strains of Enterobacteriaceae and Pseudomonas aeruginosa and quality controls

scientific article published on 10 September 2014

Transitions of care in the management of acute bacterial skin and skin structure infections: a paradigm shift

scientific article published on June 2016

Translational Efficacy of Humanized Exposures of Cefepime, Ertapenem, and Levofloxacin against Extended-Spectrum-β-Lactamase-Producing Escherichia coli in a Murine Model of Complicated Urinary Tract Infection

scientific article published on 28 August 2017

Treatment of Clostridium difficile-associated disease (CDAD).

scientific article

Treatment of Serratia marcescens meningitis with prolonged infusion of meropenem

scientific article published in May 2007

Unexpected in vivo activity of ceftazidime alone and in combination with avibactam against New Delhi metallo-β-lactamase-producing Enterobacteriaceae in a murine thigh infection model

scientific article

Update on daptomycin: the first approved lipopeptide antibiotic

scientific article published on July 2006

Use of Monte Carlo Simulation to Design an Optimized Pharmacodynamic Dosing Strategy for Meropenem ⬇️

scientific article published on October 1, 2003

Use of Monte Carlo simulation to assess the pharmacodynamics of beta-lactams against Pseudomonas aeruginosa infections in children: a report from the OPTAMA program

scientific article published in November 2005

Use of Oritavancin in Moderate-to-Severe ABSSSI Patients Requiring IV Antibiotics: A U.S. Payer Budget Impact Analysis

scientific article published on June 2016

Utilization of extended-spectrum beta-lactamase (ESBL) detection systems in microbiology laboratories: survey of Connecticut hospitals from 1998-2002.

scientific article published in March 2003

Validation of the Infectious Diseases Society of America/American Thoracic Society criteria to predict severe community-acquired pneumonia caused by Streptococcus pneumoniae

scientific article published in October 2009

Vancomycin Tissue Pharmacokinetics in Patients with Lower-Limb Infections via In Vivo Microdialysis.

scientific article

Vancomycin serum concentrations do not adequately predict tissue exposure in diabetic patients with mild to moderate limb infections

scientific article published on 22 March 2015

Variability in Zinc Concentration among Mueller-Hinton Broth Brands: Impact on Antimicrobial Susceptibility Testing of Metallo-β-lactamase-producing Enterobacteriaceae

scientific article published on 30 September 2020

When "S" does not mean success: the importance of choice of antibiotic and dose on clinical and economic outcomes of severe infection

scientific article

parE mutations in Streptococcus pneumoniae may reduce bactericidal activity of respiratory fluoroquinolones

scientific article published on 03 January 2007

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