List of works - Norie Murayama

A Case of Delayed Emergence After Propofol Anesthesia: Genetic Analysis

scientific article published on 5 October 2016

A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin.

scientific article published on September 2010

A rapid multiplex PCR assay that can reliably discriminate the cytochrome P450 2D6 whole-gene deletion allele from 2D6*10 alleles

article

Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).

scientific article

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.

scientific article

Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing

scientific article published on May 2016

Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

scientific article

Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA

scientific article published on 01 January 2018

Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition ⬇️

scientific article published on March 13, 2013

Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.

scientific article

Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

scientific article published on 23 June 2010

Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects

scientific article published in January 2009

CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey

scientific article published on 9 November 2010

CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques

scientific article published on 15 July 2014

CYP2C76 deficiency is embryonic lethal in cynomolgus macaques: The potential role of CYP2C76 in early embryogenesis

scientific article published on 27 October 2016

CYP2C76 non-synonymous variants in cynomolgus and rhesus macaques.

scientific article

CYP2D44 polymorphisms in cynomolgus and rhesus macaques.

scientific article

CYP2G2, pseudogenized in human, is expressed in nasal mucosa of cynomolgus monkey and encodes a functional drug-metabolizing enzyme.

scientific article published on 28 December 2010

CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes

scientific article published on January 2013

Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque.

scientific article published on 19 June 2013

Chimeric Mice with Humanized Liver as a Model for Testing Organophosphate and Carbamate Pesticide Exposure.

scientific article published on 13 December 2017

Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5

scientific article published on 01 January 2019

Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation

scientific article published on 01 January 2014

Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition.

scientific article published on June 2011

Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans

scientific article published on January 2010

Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5.

scientific article published on January 2008

Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition

Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants

scientific article (publication date: April 2011)

Complex mechanism underlying transcriptional control of the haplotyped flavin-containing monooxygenase 3 (FMO3) gene in Japanese: different regulation between mutations in 5'-upstream distal region and common element in proximal region

scientific article

Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase

scientific article published on 06 May 2015

Corrigendum to "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9" [Drug Metab Pharmacokinet 30 (2015) 130-132].

scientific article

Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.

scientific article published on 25 May 2010

Cytochrome P450 1A1, 2C9, 2C19, and 3A4 polymorphisms account for inter-individual variability of toxicological drug metabolism in cynomolgus macaques

scientific article published on 19 November 2018

Cytochrome P450 2A6 Phenotyping Using Dietary Caffeine Salivary Metabolite Ratios and Genotyping Using Blood on Storage Cards in Non-smoking Japanese Volunteers

scientific article published on 14 November 2016

Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone.

scientific article

Cytochrome P450-dependent drug oxidation activities in commercially available hepatocytes derived from human induced pluripotent stem cells cultured for 3 weeks

scientific article published on 01 January 2018

Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies

scientific article published in January 2009

Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity

scientific article published on 14 January 2020

Different Mechanisms for Inhibition of Human Cytochromes P450 1A1, 1A2, and 1B1 by Polycyclic Aromatic Inhibitors

scientific article published on 10 February 2007

Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

scientific article published on 31 December 2019

Drug Metabolism and Toxicity in Chimeric Mice with Humanized Liver

article

Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation

scientific article

Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5

scientific article

Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.

scientific article

Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients

scientific article published on 02 December 2014

Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase

scientific article

Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems

scientific article published in December 2009

Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450

scientific article published on 19 February 2014

Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase

scientific article published on 15 October 2014

Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells

scientific article published on 29 December 2015

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

article

Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques

scientific article published on 02 March 2019

Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques

scientific article published on 06 December 2018

Genetic Variants of Glutathione S-Transferase GSTT1 and GSTT2 in Cynomolgus Macaques: Identification of GSTT Substrates and Functionally Relevant Alleles

scientific article published on 13 September 2018

Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.

scientific article published on 19 October 2014

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

scientific article published on 12 November 2009

Genetic variants of N-acetyltransferases 1 and 2 (NAT1 and NAT2) in cynomolgus and rhesus macaques

scientific article published on 24 April 2020

Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig

scientific article published on 21 May 2014

Heterotropic cooperativity in oxidation mediated by cytochrome p450.

scientific article published on June 2008

Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays

scientific article

Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.

scientific article published on 20 March 2015

Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling

scientific article published on September 2010

Human liver enzymes responsible for metabolic elimination of tyramine; a vasopressor agent from daily food

scientific article

Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate

scientific article published on June 2010

Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data

scientific article published on 01 January 2019

Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.

scientific article

Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

scientific article published on 10 July 2014

Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.

scientific article published on 21 March 2015

Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors

scientific article published on 18 November 2015

Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

scientific article

Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys

scientific article

Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.

scientific article

In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans.

scientific article published on 18 December 2015

In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants

scientific article published on 05 April 2018

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

scientific article

In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans

scientific article published on 21 September 2018

In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

scientific article published on 28 September 2018

Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5.

scientific article published on 8 February 2016

Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3.

scientific article published on 8 February 2016

Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol with regard to CYP2B6 and UGT1A9 genotype and patient age.

scientific article published on 23 August 2011

Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity

scientific article published in January 2017

Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors

scientific article published on January 2009

Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes

scientific article published on 28 February 2020

Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence from In Vivo Canine Models.

scientific article published on 22 November 2014

Intravenous and oral administrations of DD2 [7-Amino-2-(sulfanylmethyl)heptanoic acid] produce thrombolysis through inhibition of plasma TAFIa in rats with tissue factor-induced microthrombosis

scientific article published on 12 July 2012

Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan

scientific article published on 24 March 2015

Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6.

scientific article published on 13 March 2013

Metabolism of P450 Probe Substrates by Cynomolgus Monkey CYP2C76

scientific article published on 14 July 2011

Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.

scientific article published on October 2010

Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort

article

Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque

scholarly article by Yasuhiro Uno et al published 25 October 2018 in Chemical Research in Toxicology

Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques

scientific article published on 23 June 2018

Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque

scientific article published on 14 May 2019

Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets

scientific article published on 10 December 2019

Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation

scientific article published on 03 October 2012

Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline

scientific article published on 16 May 2013

Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey

scientific article

Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.

scientific article published on 21 July 2017

Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes

scientific article published on 02 February 2015

Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes

scientific article published on 17 April 2019

Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets.

scientific article published on 15 September 2016

Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome

scientific article published on September 2009

Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13

scientific article published on 6 August 2015

Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

scientific article published on 5 February 2013

Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.

scientific article published in July 2014

Potential impact of cytochrome P450 3A5 in human liver on drug interactions with triazoles

scientific article published on June 2010

Preference for O-demethylation reactions in the oxidation of 2´-, 3´-, and 4´-methoxyflavones by human cytochrome P450 enzymes

scientific article published on 21 April 2020

Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing

scientific article (publication date: 2014)

Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol

scientific article published on 8 August 2006

Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6

scientific article published on 14 June 2019

Regioselective hydroxylation of steroid hormones by human cytochromes P450.

scientific article

Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study

scientific article published on July 2009

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.

scientific article published on 19 March 2007

Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl

scientific article published on 13 September 2016

Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances

scientific article published on 8 September 2015

Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs

scientific article

Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes

scientific article published on 28 September 2018

Sorafenib and sunitinib, two anticancer drugs, inhibit CYP3A4-mediated and activate CY3A5-mediated midazolam 1'-hydroxylation

scientific article

Species Difference between Cynomolgus Monkeys and Humans on Cytochromes P450 2D and 3A-Dependent Drug Oxidation Activities in Liver Microsomes

article

Spectral Modification and Catalytic Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by Four Chemopreventive Organoselenium Compounds ⬇️

scientific article published on July 20, 2011

Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate

scientific article published on 05 February 2019

Stereoselectivity of human cytochrome p450 in metabolic and inhibitory activities

scientific article published on July 2011

Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6.

scientific article published on 3 May 2016

Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives

scientific article published on December 2010

Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates

scientific article published on 18 June 2018

Systematic characterization of glutathione S-transferases in common marmosets

scientific article published on 04 February 2020

Systematic identification and characterization of glutathione S-transferases in cynomolgus macaque.

scientific article published on July 2013

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor

scientific article published on 5 February 2014

Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation.

scientific article

Voriconazole metabolism, toxicity, and the effect of cytochrome P450 2C19 genotype

scientific article

List of works by Norie Murayama

A Case of Delayed Emergence After Propofol Anesthesia: Genetic Analysis

A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin.

A rapid multiplex PCR assay that can reliably discriminate the cytochrome P450 2D6 whole-gene deletion allele from 2D6*10 alleles

Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.

Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing

Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA

Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition ⬇️

Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.

Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects

CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey

CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques

CYP2C76 deficiency is embryonic lethal in cynomolgus macaques: The potential role of CYP2C76 in early embryogenesis

CYP2C76 non-synonymous variants in cynomolgus and rhesus macaques.

CYP2D44 polymorphisms in cynomolgus and rhesus macaques.

CYP2G2, pseudogenized in human, is expressed in nasal mucosa of cynomolgus monkey and encodes a functional drug-metabolizing enzyme.

CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes

Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque.

Chimeric Mice with Humanized Liver as a Model for Testing Organophosphate and Carbamate Pesticide Exposure.

Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5

Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation

Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition.

Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans

Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5.

Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition

Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants

Complex mechanism underlying transcriptional control of the haplotyped flavin-containing monooxygenase 3 (FMO3) gene in Japanese: different regulation between mutations in 5'-upstream distal region and common element in proximal region

Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase

Corrigendum to "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9" [Drug Metab Pharmacokinet 30 (2015) 130-132].

Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.

Cytochrome P450 1A1, 2C9, 2C19, and 3A4 polymorphisms account for inter-individual variability of toxicological drug metabolism in cynomolgus macaques

Cytochrome P450 2A6 Phenotyping Using Dietary Caffeine Salivary Metabolite Ratios and Genotyping Using Blood on Storage Cards in Non-smoking Japanese Volunteers

Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone.

Cytochrome P450-dependent drug oxidation activities in commercially available hepatocytes derived from human induced pluripotent stem cells cultured for 3 weeks

Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies

Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity

Different Mechanisms for Inhibition of Human Cytochromes P450 1A1, 1A2, and 1B1 by Polycyclic Aromatic Inhibitors

Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

Drug Metabolism and Toxicity in Chimeric Mice with Humanized Liver

Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation

Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5

Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.

Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients

Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase

Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems

Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450

Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase

Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques

Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques

Genetic Variants of Glutathione S-Transferase GSTT1 and GSTT2 in Cynomolgus Macaques: Identification of GSTT Substrates and Functionally Relevant Alleles

Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

Genetic variants of N-acetyltransferases 1 and 2 (NAT1 and NAT2) in cynomolgus and rhesus macaques

Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig

Heterotropic cooperativity in oxidation mediated by cytochrome p450.

Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays

Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.

Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling

Human liver enzymes responsible for metabolic elimination of tyramine; a vasopressor agent from daily food

Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate

Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data

Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.

Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.

Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors

Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys

Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.

In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans.

In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans

In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5.

Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3.