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List of works by Tsvee Lapidot

A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells

scientific article published on 24 July 2008

Age-dependent modulation of vascular niches for haematopoietic stem cells

scientific article published on 13 April 2016

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

scientific journal article

Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells

scientific article

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging ⬇️

scientific article published on January 12, 2011

Biology of normal and acute myeloid leukemia stem cells

scientific article

Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system

scientific article published on 31 March 2009

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma

scientific article published on 14 September 2020

CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow

scientific article

CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice

scientific article

CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules

scientific article published on 8 September 2008

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.

scientific article

CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice

scientific article published on April 2004

Caspase-8 serves both apoptotic and nonapoptotic roles

scientific journal article

Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling

scientific article published on 09 September 2007

Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells

scientific article published on 18 September 2005

Chronic B Cell Deficiency from Birth Prevents Age-Related Alterations in the B Lineage ⬇️

scientific article published on September 1, 2011

Corrigendum: Age-dependent modulation of vascular niches for haematopoietic stem cells

scientific article published in Nature

Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis

scientific article published on 20 July 2016

Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

scientific article published on 01 April 2016

Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells

scientific article

Cycling G1 CD34+/CD38+ cells potentiate the motility and engraftment of quiescent G0 CD34+/CD38-/low severe combined immunodeficiency repopulating cells

scientific article published on 01 April 2005

Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

scientific article published in October 2018

Daily light and darkness onset and circadian rhythms metabolically synchronize hematopoietic stem cell differentiation and maintenance: The role of bone marrow norepinephrine, tumor necrosis factor, and melatonin cycles

scientific article published on 05 September 2019

Daily light-and-darkness onset regulates mouse hematopoietic stem cells:

scholarly article published 26 February 2019

Distinct bone marrow blood vessels differentially regulate haematopoiesis.

scientific article published on 13 April 2016

Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation

scientific article

Dynamic Cross Talk between S1P and CXCL12 Regulates Hematopoietic Stem Cells Migration, Development and Bone Remodeling

scientific article published on 23 September 2013

Egress and Mobilization of Hematopoietic Stem and Progenitor Cells: A Dynamic Multi-facet Process

scientific article published on 10 May 2013

Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients.

scientific article published on March 2005

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

scientific article published on 28 June 2010

Ex vivo expansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution.

scientific article published in March 2003

FGF signaling facilitates postinjury recovery of mouse hematopoietic system.

scientific article

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation

scientific article

Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal.

scientific article published on May 2013

Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells

scientific article published on 01 November 2006

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.

scientific article published on 17 June 2002

GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement

scientific article

GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement

HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver

scientific article published on July 2003

Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammation

scientific article published on 01 July 2005

Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment

scientific article

How do stem cells find their way home?

scientific article

Human CD34(+)CXCR4(-) sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation

scientific article published on 01 October 2002

Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1.

scientific article

Insights into the mechanism of enhanced mobilization of hematopoietic progenitor cells and release of CXCL12 by a combination of AMD3100 and aminoglycoside–polyarginine conjugates ⬇️

scientific article published on October 4, 2011

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

scientific article published on 15 July 2020

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization

scientific article published on 9 February 2009

MT1-MMP and RECK: opposite and essential roles in hematopoietic stem and progenitor cell retention and migration

scientific article published on 13 August 2011

Mobilization of Hematopoietic Stem and Progenitor Cells

Mobilizing the older patient with myeloma

scientific article

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

scientific article

Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice

scientific article published on 07 June 2005

Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice

scientific article published on August 2006

NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity

scientific article

Neural regulation of bone, marrow, and the microenvironment

scientific article published on June 1, 2011

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

scientific article published on 21 May 2006

Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation

scientific article published on 24 December 2003

PAR1 Expression Predicts Clinical G-CSF CD34+ HSPC Mobilization and Repopulation Potential in Transplanted Patients

scientific article published on 20 August 2019

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

scientific article published on 12 October 2015

Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis

scientific article published on 01 January 2011

Quantifying Hematopoietic Stem and Progenitor Cell Mobilization

scientific article published on 01 January 2012

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

scientific article

Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment

scientific article published on 26 June 2014

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals

scientific article

Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling

scientific article published on March 2016

Regulatory Cross Talks of Bone Cells, Hematopoietic Stem Cells and the Nervous System Maintain Hematopoiesis ⬇️

scientific article published on June 1, 2012

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release

scientific article published on 25 January 2012

SDF-1 keeps HSC quiescent at home ⬇️

scientific article published on January 13, 2011

Stem cell mobilization.

scientific article published on January 2003

Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment

scientific article

Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells.

scientific article

Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

scientific article published on 20 January 2015

TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules

scientific article published on 01 January 2002

The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells

scientific article published on 25 March 2012

The Endosteum Region Keeps Human Leukemic Stem Cells Alive

scientific article published on 01 November 2007

The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche

scientific article

The brain-bone-blood triad: traffic lights for stem-cell homing and mobilization

scientific article published on January 2010

The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization

scientific article published on January 2007

Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling

scientific article published on 20 November 2003

Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing

scientific article published in September 2006

Vascular Procr+ stem cells: Finding new branches while looking for the roots

scientific article published on 2 August 2016

cAMP-induced PKCzeta activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors

scientific article

p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts

scientific article published on November 2006

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