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List of works by Hector C Aguilar

A broad-spectrum antiviral targeting entry of enveloped viruses

scientific article

A catalytically and genetically optimized beta-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics

scientific article published on 31 July 2009

A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion

scientific article published in 2013

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice

scientific article

A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F)

scientific article published on 19 November 2008

A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade

scientific article

A stochastic assembly model for Nipah virus revealed by super-resolution microscopy

scientific article published in Nature Communications

Addicted to sugar: roles of glycans in the order Mononegavirales

scientific article published on 01 January 2019

An increase in glycoprotein concentration on extracellular virions dramatically alters vaccinia virus infectivity and pathogenesis without impacting immunogenicity

scientific article published on 28 December 2021

Antibodies to ovine herpesvirus 2 glycoproteins decrease virus infectivity and prevent malignant catarrhal fever in rabbits

scientific article published on 9 December 2014

A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

scientific article published on 28 March 2022

Broad-spectrum antiviral JL122 blocks infection and inhibits transmission of aquatic rhabdoviruses

Broad-spectrum antiviral JL122 blocks infection and inhibits transmission of aquatic rhabdoviruses

Contributions of herpes simplex virus 1 envelope proteins to entry by endocytosis

scientific article published on 09 October 2013

Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly

scientific article (publication date: December 2015)

Cysteines in the stalk of the nipah virus G glycoprotein are located in a distinct subdomain critical for fusion activation

scientific article

Cytoplasmic Motifs in the Nipah Virus Fusion Protein Modulate Virus Particle Assembly and Egress

scientific article published on March 2017

Detection of receptor-induced glycoprotein conformational changes on enveloped virions by using confocal micro-Raman spectroscopy.

scientific article published on 2 January 2013

Emerging paramyxoviruses: molecular mechanisms and antiviral strategies

scientific article published on 24 February 2011

Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation

scientific article published in 2010

EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus

scientific article

Expression of 9-O- and 7,9-O-Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses

scientific article published on 03 December 2019

Feline Morbillivirus, a New Paramyxovirus Possibly Associated with Feline Kidney Disease

scientific article published on 01 May 2020

Finding proteases that make cells go viral

scientific article published on 01 August 2020

Flow virometry as a tool to study viruses

scientific article published on 16 December 2017

Henipavirus Membrane Fusion and Viral Entry ⬇️

scientific article published on January 1, 2012

Individual N-glycans added at intervals along the stalk of the Nipah virus G protein prevent fusion but do not block the interaction with the homologous F protein

scientific article published on 2 January 2013

Inhibition of an Aquatic Rhabdovirus Demonstrates Promise of a Broad-Spectrum Antiviral for Use in Aquaculture

scientific article published on 30 November 2016

Interactions of human complement with virus particles containing the Nipah virus glycoproteins

scientific article published on 30 March 2011

Mildly Acidic pH Triggers an Irreversible Conformational Change in the Fusion Domain of Herpes Simplex Virus 1 Glycoprotein B and Inactivation of Viral Entry

scientific article published on 21 December 2016

Modified sialic acids on mucus and erythrocytes inhibit influenza A HA and NA functions

scientific article published on 12 February 2020

Molecular requirement for sterols in herpes simplex virus entry and infectivity

scientific article

Multiple Novel Functions of Henipavirus O-glycans: The First O-glycan Functions Identified in the Paramyxovirus Family

scientific article published on 11 February 2016

Multiple Strategies Reveal a Bidentate Interaction between the Nipah Virus Attachment and Fusion Glycoproteins

scientific article published on 21 September 2016

N-Glycans on the Nipah virus attachment glycoprotein modulate fusion and viral entry as they protect against antibody neutralization

scientific article

N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry

scientific article published on May 2006

Nipah Virus-Like Particle Egress Is Modulated by Cytoskeletal and Vesicular Trafficking Pathways: a Validated Particle Proteomics Analysis

scientific article published on 24 September 2019

Nipah and Hendra Virus Glycoproteins Induce Comparable Homologous but Distinct Heterologous Fusion Phenotypes

scientific article published on 14 June 2019

Nipah virion entry kinetics, composition, and conformational changes determined by enzymatic virus-like particles and new flow virometry tools

scientific article published on October 2014

Nipah virus attachment glycoprotein stalk C-terminal region links receptor binding to fusion triggering

scientific article

Novel Functions of Hendra Virus G N-Glycans and Comparisons to Nipah Virus

scientific article published on 6 May 2015

Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines

scientific article published on July 2005

Ovine Herpesvirus 2 Glycoproteins B, H, and L Are Sufficient for, and Viral Glycoprotein Ov8 Can Enhance, Cell-Cell Membrane Fusion.

scientific article published on 4 January 2017

Paramyxovirus Glycoproteins and the Membrane Fusion Process

scientific article published on 5 July 2016

Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling

scientific article published on 14 February 2007

Polyethylene glycol-mediated fusion of herpes simplex type 1 virions with the plasma membrane of cells that support endocytic entry

scientific article

Rho GTPase activity modulates paramyxovirus fusion protein-mediated cell–cell fusion

Roles of Cholesterol in Early and Late Steps of the Nipah Virus Membrane Fusion Cascade

scientific article published on 06 January 2021

SialoPen peptides are new cationic foldamers with remarkable cell permeability

scientific article published on 24 December 2020

Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage

scientific article published on 25 July 2007

The effects of modified sialic acids on mucus and erythrocytes on influenza A virus HA and NA functions

scientific article published on 10 October 2019

Third Helical Domain of the Nipah Virus Fusion Glycoprotein Modulates Both Early and Late Steps in the Membrane Fusion Cascade

scientific article published on 15 July 2020

Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytium formation in endothelial cells

scientific article

Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors

scientific article

Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus

scientific article

Unraveling a three-step spatiotemporal mechanism of triggering of receptor-induced Nipah virus fusion and cell entry.

scientific article

Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene

scientific article published on 17 July 2015

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