List of works - Sara W. Leung

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons

scientific article published on 09 July 2020

A budding yeast model for human disease mutations in the <i>EXOSC2</i> cap subunit of the RNA exosome complex

scientific article published on 23 June 2021

A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length

scientific article published on 26 March 2014

Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex

scientific article

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

scientific article published on 24 November 2020

Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness

scientific article published on 05 June 2020

Dissection of the karyopherin alpha nuclear localization signal (NLS)-binding groove: functional requirements for NLS binding

scientific article published on 13 August 2003

Enteropathogenic Escherichia coli Tir is an SH2/3 ligand that recruits and activates tyrosine kinases required for pedestal formation

scientific article

Functional Analysis of the Hydrophobic Patch on Nuclear Transport Factor 2 Involved in Interactions with the Nuclear Porein Vivo

scientific article published in Journal of Biological Chemistry

Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast

scientific article published on 24 October 2016

Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis.

scientific article

Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans

scientific journal article

Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.

scientific article published on 7 March 2018

Recognition of polyadenosine RNA by the zinc finger domain of nuclear poly(A) RNA-binding protein 2 (Nab2) is required for correct mRNA 3'-end formation.

scientific article published on 16 June 2010

Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein

scientific article

Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats

scientific article

The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons

scientific article published on August 2017

The RNA Exosome and Human Disease

scientific article published on 01 January 2020

The RNA exosome and RNA exosome-linked disease.

scientific article published in November 2017

The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops

preprint

The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice.

scientific article published on 29 June 2017

The mating response cascade does not modulate changes in the steady-state level of target mRNAs through control of mRNA stability.

scientific article published in May 2009

List of works by Sara W. Leung

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons

A budding yeast model for human disease mutations in the <i>EXOSC2</i> cap subunit of the RNA exosome complex

A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length

Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness

Dissection of the karyopherin alpha nuclear localization signal (NLS)-binding groove: functional requirements for NLS binding

Enteropathogenic Escherichia coli Tir is an SH2/3 ligand that recruits and activates tyrosine kinases required for pedestal formation

Functional Analysis of the Hydrophobic Patch on Nuclear Transport Factor 2 Involved in Interactions with the Nuclear Porein Vivo

Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast

Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis.

Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans

Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.

Recognition of polyadenosine RNA by the zinc finger domain of nuclear poly(A) RNA-binding protein 2 (Nab2) is required for correct mRNA 3'-end formation.

Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein

Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats

The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons

The RNA Exosome and Human Disease

The RNA exosome and RNA exosome-linked disease.

The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops

The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice.

The mating response cascade does not modulate changes in the steady-state level of target mRNAs through control of mRNA stability.