List of works - Olivier Boutaud

11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide

scientific article published on July 2003

Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation

scientific article

Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

scientific article

Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase

scientific article published on 27 December 2007

Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs

scientific article published on 15 January 2010

Bid maintains mitochondrial cristae structure and protects against cardiac disease in an integrative genomics study

scientific article published on 03 October 2018

Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain

scientific article

Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine

scientific article

Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin

scientific article published on November 2009

Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis

scientific article

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice

scientific article published on 13 May 2016

Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro

scientific article (publication date: June 2002)

Cyclooxygenase-dependent lipid-modification of brain proteins

scientific article

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

scientific article

Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies

scientific article

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

scientific article

Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function

scientific article

First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

Functional characterization of mutations in inherited human cPLA₂ deficiency

scientific journal article

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus

scientific article published on 08 November 2018

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator

scientific article

Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension

scientific article published on 27 May 2020

Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione

scientific article published on September 2002

In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate

scientific article published on 22 September 2018

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

scientific article

Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

scientific article published in February 2003

Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

scientific article published in January 2003

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

scientific article published on 23 August 2016

Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions

scientific article published on 16 October 2019

Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.

scientific article published on 11 April 2014

Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation

scientific article published on 11 March 2003

Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry

scientific article published on 01 January 2007

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure ⬇️

scientific article published on October 27, 2010

Meet Our Editorial Board Member

Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers

scientific article

Modification of proteins by isoketal-containing oxidized phospholipids

scientific article

New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

scientific article

On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry

scientific article

PGE2 decreases reactivity of human platelets by activating EP2 and EP4

scientific article

PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42

scientific article

Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth

scientific article

Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity

scientific article published on 30 June 2005

Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers

scientific article

Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis

scientific article

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation

scientific article published on 9 December 2011

Protein modification by adenine propenal

scientific article

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.

scientific article

Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

scientific article

Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues

scientific article published on August 2013

Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells

scientific article

Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation

scientific article published in 2018

Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial

scientific article published on 06 January 2020

Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes

scientific article published on January 2010

Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome

scientific article

Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

scientific article published on April 2014

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension

scientific article published on 04 January 2019

Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2

scientific article published in 2018

Tristetrapolin Binds to the COX-2 mRNA 3’ Untranslated Region in Cancer Cells ⬇️

scientific article published on 01 January 2003

Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site

scientific article (publication date: 18 April 2003)

Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease

scientific article

List of works by Olivier Boutaud

11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide

Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation

Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase

Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs

Bid maintains mitochondrial cristae structure and protects against cardiac disease in an integrative genomics study

Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain

Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine

Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin

Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice

Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro

Cyclooxygenase-dependent lipid-modification of brain proteins

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function

First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

Functional characterization of mutations in inherited human cPLA₂ deficiency

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator

Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension

Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione

In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions

Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.

Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation

Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure ⬇️

Meet Our Editorial Board Member

Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers

Modification of proteins by isoketal-containing oxidized phospholipids

New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry

PGE2 decreases reactivity of human platelets by activating EP2 and EP4

PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42

Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth

Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity

Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers

Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation

Protein modification by adenine propenal

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.

Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues

Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells

Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation

Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial

Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes

Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome

Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension

Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2

Tristetrapolin Binds to the COX-2 mRNA 3’ Untranslated Region in Cancer Cells ⬇️

Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site

Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease