List of works - Toshio Shimizu

A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors

scientific article published on 30 March 2016

A phase 1 study of niraparib in Japanese patients with advanced solid tumors ⬇️

scholarly article

A phase I/Ib study of trametinib (GSK1120212) alone and in combination with gemcitabine in Japanese patients with advanced solid tumors

scientific article published on 12 August 2015

An early clinical trial of Salirasib, an oral RAS inhibitor, in Japanese patients with relapsed/refractory solid tumors.

scientific article published on 10 July 2018

Correlation between the expression of folate receptor alpha (FRα) and clinicopathological features in patients with lung adenocarcinoma

scientific article published on 11 May 2020

Dose exploration results from Phase 1 study of cemiplimab, a human monoclonal programmed death (PD)-1 antibody, in Japanese patients with advanced malignancies

scientific article published on 04 November 2020

Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors

scientific article published on 20 October 2010

First-in-human phase I study of E7090, a novel selective fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors

scientific article published on 01 February 2020

Global trends in the distribution of cancer types among patients in oncology phase I trials, 1991-2015

scientific article published on 07 August 2018

Improved survival among patients enrolled in oncology phase 1 trials in recent decades

scientific article published on 19 November 2019

Infection risk with PI3K-AKT-mTOR pathway inhibitors and immune checkpoint inhibitors in patients with advanced solid tumours in phase I clinical trials

scientific article published on 01 April 2020

Oxaliplatin/fluorouracil/leucovorin (FOLFOX4 and modified FOLFOX6) in patients with refractory or advanced colorectal cancer: post-approval Japanese population experience

scientific article published on 27 June 2007

Phase 1 study of new formulation of patritumab (U3-1287) Process 2, a fully human anti-HER3 monoclonal antibody in combination with erlotinib in Japanese patients with advanced non-small cell lung cancer

scientific article published on 31 January 2017

Phase 1 study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced solid tumors

scientific article published on 22 March 2016

Phase 1 study of the investigational, oral angiogenesis inhibitor motesanib in Japanese patients with advanced solid tumors.

scientific article published on 28 January 2010

Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone (BMS-247550), an epothilone B analog, in Japanese patients with refractory solid tumors

scientific article published on 27 June 2007

Phase I clinical and pharmacokinetic study of the glucose-conjugated cytotoxic agent D-19575 (glufosfamide) in patients with solid tumors.

scientific article published in January 2010

Phase I safety and pharmacokinetic study of YM155, a potent selective survivin inhibitor, in combination with erlotinib in patients with EGFR TKI refractory advanced non-small cell lung cancer

scientific article published on 08 July 2020

Phase I study of the indoleamine 2,3-dioxygenase 1 inhibitor navoximod (GDC-0919) as monotherapy and in combination with the PD-L1 inhibitor atezolizumab in Japanese patients with advanced solid tumours

scientific article published on 24 May 2019

Successful human epidermal growth receptor 2-targeted therapy beyond disease progression for extramammary Paget's disease

scientific article published on 9 February 2016

The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer ⬇️

scientific article published on January 19, 2012

The safety and tolerability of epacadostat alone and in combination with pembrolizumab in patients with advanced solid tumors: results from a first-in-Japanese phase I study (KEYNOTE-434)

scientific article published on 20 June 2020

List of works by Toshio Shimizu