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List of works by Michael A Caligiuri

A CS1-NKG2D bispecific antibody collectively activates cytolytic immune cells against multiple myeloma.

scientific article

A Comprehensive Program for the Enhancement of Accrual to Clinical Trials

scientific article published on 20 January 2016

A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation

scientific article published on 17 November 2005

A NotI-EcoRV promoter library for studies of genetic and epigenetic alterations in mouse models of human malignancies

scientific article

A Phase I Trial of the Anti-KIR Antibody IPH2101 and Lenalidomide in Patients with Relapsed/Refractory Multiple Myeloma.

scientific article

A Phase I/II Trial of Cetuximab in Combination with Interleukin-12 Administered to Patients with Unresectable Primary or Recurrent Head and Neck Squamous Cell Carcinoma

scientific article published on 29 May 2019

A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets

scientific article published on 10 May 2016

A Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma via Toll-Like Receptor-Mediated NF-κB and STAT3 Signaling Pathways

scientific article published on 18 July 2018

A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells

scientific article published in March 2005

A novel Raji-Burkitt's lymphoma model for preclinical and mechanistic evaluation of CD52-targeted immunotherapeutic agents

scientific article published on January 2008

A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.

scientific article

A novel regimen for relapsed/refractory adult acute myeloid leukemia using a KMT2A partial tandem duplication targeted therapy: results of phase 1 study NCI 8485.

scientific article published on 22 March 2018

A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma ⬇️

scientific article published on November 22, 2012

A phase 2 study of rituximab in combination with recombinant interleukin-2 for rituximab-refractory indolent non-Hodgkin's lymphoma

scientific article published on 01 December 2006

A phase I study of ultra low dose interleukin-2 and stem cell factor in patients with HIV infection or HIV and cancer

scientific article

A phase I trial of escalating doses of trastuzumab combined with daily subcutaneous interleukin 2: report of cancer and leukemia group B 9661.

scientific article published on December 2002

A phase II trial of trastuzumab in combination with low-dose interleukin-2 (IL-2) in patients (PTS) with metastatic breast cancer (MBC) who have previously failed trastuzumab

scientific article

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

scientific article

A sheep in wolf's clothing

scientific article published on 01 February 2011

AIDS-associated malignancies

scientific article

AIDS-associated malignancies

scientific article published on 01 January 2003

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

scientific article

Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation ⬇️

scientific article published on November 13, 2012

Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes

scholarly article

Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations

scientific article published on 01 April 2005

Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells.

scientific article

Administration of two macrophage-derived interferon-gamma-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-gamma

scientific article published on 01 March 2002

Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia

scientific article

Amendments: Publisher Correction: An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma

scientific article published on 01 January 2019

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

scientific article published on 07 August 2013

Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies.

scientific article published on 14 October 2004

Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients

scientific article published on 01 April 2006

Autologous immune strategies to reduce the risk of leukemic relapse: consideration for IL-15.

scientific article

Axl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell development ⬇️

scientific article published on 08 July 2013

BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study

scientific article published on 15 May 2003

BAALC, a novel marker of human hematopoietic progenitor cells*1 ⬇️

scientific article published on November 1, 2003

BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy.

scientific article published on 9 November 2016

BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

scientific article

BCR/ABL activates mdm2 mRNA translation via the La antigen

scientific article published on February 2003

Biology and clinical impact of human natural killer cells

scientific article

Bortezomib Treatment Sensitizes Oncolytic HSV-1-Treated Tumors to NK Cell Immunotherapy

scientific article

Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia

scientific article

Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects

scientific article

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells.

scientific article published on 9 July 2015

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody

scientific article

CD94 defines phenotypically and functionally distinct mouse NK cell subsets

scientific article

CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets

scientific article

Cancer T cell therapy expands

scientific article published on 01 March 2003

Cancer and leukemia group B leukemia correlative science committee: major accomplishments and future directions

scientific article

Cellular localization and function of Fas ligand (CD95L) in tumors

scientific article published on 01 March 2002

Cellular pathways in the development of human and murine innate lymphoid cells

scientific article published on 19 December 2018

Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia

scientific article

Characterization of leukemia-associated Rho guanine nucleotide exchange factor (LARG) expression during murine development

scientific article published on 26 September 2003

Chronic lymphocytosis of functionally immature natural killer cells

scientific article published on 2 July 2007

Circulating myeloid-derived suppressor cells increase in patients undergoing neo-adjuvant chemotherapy for breast cancer

scientific article published on 7 July 2017

Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia ⬇️

scientific article published on May 7, 2012

Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients

scientific article published on 06 May 2013

Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma

scientific article published on 3 January 2008

Combination immunotherapy of B-cell non-Hodgkin's lymphoma with rituximab and interleukin-2: a preclinical and phase I study

scientific article published on 01 September 2004

Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties

scientific article published on 15 February 2013

Complete and durable responses in Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder with Zidovudine, Ganciclovir, Rituximab and Dexamethasone.

scientific article published on 9 April 2018

Complex role of NK cells in regulation of oncolytic virus-bortezomib therapy

scientific article published on 23 April 2018

Comprehensive cytogenetic and molecular genetic characterization of the TI-1 acute myeloid leukemia cell line reveals cross-contamination with K-562 cell line

scientific article published in March 2002

Convection-enhanced delivery of boronated epidermal growth factor for molecular targeting of EGF receptor-positive gliomas.

scientific article published in November 2002

Cooperative group tissue banks as research resources: the cancer and leukemia group B tissue repositories

scientific article published on 01 May 2002

Core binding factor (CBF) acute myeloid leukemia: is molecular monitoring by RT-PCR useful clinically?

scientific article

Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses

scholarly article

DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication

scientific article published on 19 June 2008

Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells ⬇️

scientific article published on December 11, 2011

Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts

scientific article published on 24 March 2016

Differential effects of IL-2 and IL-21 on expansion of the CD4+ CD25+ Foxp3+ T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic lymphocytic leukemia

scientific article

Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation.

scientific article

Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome

scientific article

Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia

scientific article

Donor-derived IL-15 is critical for acute allogeneic graft-versus-host disease

scientific article published on 16 September 2004

Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Gr

scientific article published in November 2004

Durable hematologic complete response and suppression of HTLV-1 viral load following alemtuzumab in zidovudine/IFN-{alpha}-refractory adult T-cell leukemia

scientific article published on 2 August 2005

EBV kidney allograft infection: possible relationship with a peri-graft localization of PTLD

scientific article published on 01 January 2004

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells

scientific article

Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector.

scientific article published on 8 December 2004

Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells

scientific article published on 11 March 2004

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

scientific article published on 4 April 2016

Epigenetic and Posttranscriptional Regulation of CD16 Expression during Human NK Cell Development

scientific article published on 11 December 2017

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway

scientific article published on 6 December 2012

Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score

scientific article published on 30 December 2013

Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease

scientific article published on October 2013

Evidence for a stepwise program of extrathymic T cell development within the human tonsil ⬇️

scientific article published on March 1, 2012

Evidence for discrete stages of human natural killer cell differentiation in vivo

scientific article

Experimental treatment of Epstein-Barr virus-associated primary central nervous system lymphoma.

scientific article

Expression and prognostic impact of lncRNAs in acute myeloid leukemia

scientific article

Extracellular Matrix Protein CCN1 Limits Oncolytic Efficacy in Glioma ⬇️

scientific article published on January 26, 2012

FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

scientific article

FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia

scientific article

Failed adoptive immunotherapy with tumor-specific T cells: reversal with low-dose interleukin 15 but not low-dose interleukin 2.

scientific article published in November 2004

Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study

scientific article

FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways

scientific article published on 16 March 2006

Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by Ex Vivo Expanded Autologous NK Cells.

scientific article published on 17 April 2018

GAS6 expression identifies high-risk adult AML patients: potential implications for therapy

scientific article

Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia

scientific article

Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

scientific article

Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity

scientific article published on 09 February 2015

High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation

scientific article published on 2 May 2007

Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells

scientific article

Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function

scientific article published on 29 August 2018

Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies.

scientific article published on 21 July 2005

Human natural killer cell development in secondary lymphoid tissues

scientific article

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

IFN-gamma gene polymorphisms associate with development of EBV+ lymphoproliferative disease in hu PBL-SCID mice

scientific article

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease.

scientific article published on 23 June 2005

IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB.

scientific article

IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

scientific article published on 8 January 2008

IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect

scientific article

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes ⬇️

scientific article published on July 25, 2013

Ibrutinib treatment improves T cell number and function in CLL patients

scientific article published on 17 July 2017

Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study

scientific article published on 4 February 2013

Identification of medium-sized copy number alterations in whole-genome sequencing

scientific article

Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis

scientific article

Immature NK cells, capable of producing IL-22, are present in human uterine mucosa

scientific article published on 27 August 2010

Immunologic approaches to acute leukemia in the elderly

scientific article

Immunotherapeutic approaches for hematologic malignancies

scientific article

In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline

scientific article published on 10 June 2013

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

scientific article published on 05 July 2002

In vivo role of Flt3 ligand and dendritic cells in NK cell homeostasis

scientific article

Increased Levels of Plasma Epstein Barr Virus DNA Identify a Poor-Risk Subset of Patients With Advanced Stage Cutaneous T-Cell Lymphoma

scientific article

Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study

scientific article published on 2 May 2006

Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target

scientific article published on 15 January 2013

Innate or adaptive immunity? The example of natural killer cells

scientific article (publication date: 7 January 2011)

Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.

scientific article published on June 2010

Interleukin-2, interleukin-15, and their roles in human natural killer cells

scientific article

IκBζ augments IL-12– and IL-18–mediated IFN-γ production in human NK cells ⬇️

scientific article published on January 11, 2011

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia

scientific article published on 25 October 2012

Location and cellular stages of natural killer cell development

scientific article published on 19 September 2013

Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study

scientific article published on 6 March 2007

Loss of C/EBP alpha and favorable prognosis of acute myeloid leukemias: a biological paradox

scientific article published on 15 January 2004

Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia

scientific article published on 9 August 2011

Low-dose interleukin-2 immunotherapy does not improve outcome of patients age 60 years and older with acute myeloid leukemia in first complete remission: Cancer and Leukemia Group B Study 9720.

scientific article

LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis

scientific article

MICA-Expressing Monocytes Enhance Natural Killer Cell Fc Receptor-Mediated Antitumor Functions

scientific article published on 19 July 2017

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

scientific article published on 16 January 2015

Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity

scientific article published on April 2007

Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

scientific article published on 15 July 2016

MicroRNA expression in cytogenetically normal acute myeloid leukemia

scientific article

MicroRNA-29b mediates altered innate immune development in acute leukemia

scientific article published on 24 October 2016

MicroRNAs activate natural killer cells through Toll-like receptor signaling ⬇️

scientific article published on April 11, 2013

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias ⬇️

scientific article published on June 6, 2012

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

scientific article

Modeling Human Natural Killer Cell Development in the Era of Innate Lymphoid Cells

scientific article published on 27 March 2017

Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells

scientific article published on 9 January 2018

Molecular Basis for the Recognition of Herpes Simplex Virus Type 1 Infection by Human Natural Killer Cells

scientific article published on 12 February 2018

Molecular pathways: interleukin-15 signaling in health and in cancer

scientific article published on April 2014

Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment

scientific article published on 15 February 2016

NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines

scientific article published on 10 February 2016

NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors

scientific article published on 25 November 2012

NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human ⬇️

scientific article published on April 1, 2011

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect

scientific article

New directions in natural killer cell-based immunotherapy of human cancer

scientific article

Nitric Oxide Production by Myeloid Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function

scientific article published on 23 January 2018

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

scientific article published on 2 May 2007

Obesity, Inflammation, and Cancer

scientific article

Oncolytic HSV-Infected Glioma Cells Activate NOTCH in Adjacent Tumor Cells Sensitizing Tumors to Gamma Secretase Inhibition

scientific article published on 05 March 2020

Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells ⬇️

scientific article published on February 19, 2013

Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study

scientific article

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

scientific article published on 03 September 2013

PRDM1/Blimp-1 Controls Effector Cytokine Production in Human NK Cells ⬇️

scientific article published on October 13, 2010

Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes

scientific article published on 23 August 2018

Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia.

scientific article published on 30 May 2007

Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia

scientific article published on 22 August 2002

Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

scientific article published on 10 August 2006

Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720.

scientific article published in August 2002

Postremission therapy with low-dose interleukin 2 with or without intermediate pulse dose interleukin 2 therapy is well tolerated in elderly patients with acute myeloid leukemia: Cancer and Leukemia Group B study 9420.

scientific article

Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia ⬇️

scientific article published on June 7, 2012

Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias

scientific article published on 22 August 2013

Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.

scientific article published on June 2006

Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells

scientific article published on 24 June 2009

Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells.

scientific article

Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia

scientific article published on 04 May 2017

Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia

scientific article published on 22 May 2017

Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8.

scientific article

Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study

scientific article

Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

scientific article published in February 2004

Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study

scientific article published on 22 September 2008

Purification of human NK cell developmental intermediates from lymph nodes and tonsils

scientific article published in January 2010

RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures

scientific article

Rapid Column-Free Enrichment of Mononuclear Cells from Solid Tissues

scientific article published on 30 July 2015

Recombinant interleukin-2 in patients aged younger than 60 years with acute myeloid leukemia in first complete remission: results from Cancer and Leukemia Group B 19808

scientific article

Regulation of acute graft-versus-host disease by microRNA-155.

scientific article

Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation

scientific journal article

Rituximab: converging mechanisms of action in non-Hodgkin's lymphoma?

scientific article published on 01 December 2003

Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance

scientific article published on 4 June 2014

SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity

scientific article published on 15 October 2018

SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients

scientific article published on March 2008

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome

scientific article published on 03 March 2014

STAT-1-mediated repression of monocyte interleukin-10 gene expression in vivo

scientific article published on 01 March 2006

Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for risk-adapted therapy

scientific article

Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder.

scientific article

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

scientific article published on 16 March 2013

Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia

scientific article

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis

scholarly article

Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12.

scientific article

Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22

scientific article

Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells

scientific article published on 05 December 2008

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

scientific article

Successful treatment of posttransplantation lymphoproliferative disorder (PTLD) following renal allografting is associated with sustained CD8(+) T-cell restoration

scientific article published in October 2002

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

TGF-beta 1 suppresses [correction of supresses] myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunit.

scientific article published on May 2003

TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells

scientific article

TGFβ Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response

scientific article

TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia

scientific article published on 27 March 2009

Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia

scientific article published on 14 March 2013

Targeted immunotherapy for acute myeloid leukemia ⬇️

scientific article published on November 11, 2011

Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical

scientific article

Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator

scientific article published on 25 July 2016

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

scientific article

The Broad Spectrum of Human Natural Killer Cell Diversity

scientific article published in November 2017

The Epstein-Barr Virus Lytic Protein BZLF1 as a Candidate Target Antigen for Vaccine Development

scientific article published on 3 March 2015

The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells

scientific article

The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment

scientific article published on 31 March 2015

The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy

scientific article published on 17 March 2005

The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele

scientific article published on 10 July 2008

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

scientific article

The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells.

scientific article

The PP2A inhibitor SET regulates natural killer cell IFN-gamma production

scientific article

The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells

scientific article

The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry

scientific article published in August 2006

The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon

scientific article published on 8 February 2012

The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia

scientific article published on 12 January 2009

The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis

scientific article

The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells

scientific article published on 13 March 2018

The natural product phyllanthusmin C enhances IFN-γ production by human NK cells through upregulation of TLR-mediated NF-κB signaling

scientific article

The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells.

scientific article published on 19 June 2014

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

scientific article published on November 2005

Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity

scientific article published on 6 June 2006

Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function

scientific article

Transcriptional control of human T-BET expression: the role of Sp1.

scientific article published on September 2007

Tumor growth decreases NK and B cells as well as common lymphoid progenitor

scientific article

Tumor growth impedes natural-killer-cell maturation in the bone marrow.

scientific article published on 23 March 2006

Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells

scientific article published on 21 August 2003

Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy ⬇️

scientific article published on April 1, 2013

Understanding the molecular basis of imatinib mesylate therapy in chronic myelogenous leukemia and the related mechanisms of resistance. Commentary re: A. N. Mohamed et al., The effect of imatinib mesylate on patients with Philadelphia chromosome-po

scientific article

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.

scientific article published on 17 January 2012

Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV

scientific article published on 9 September 2014

Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study

scientific article

inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations

scientific article published on 16 November 2012

miR-155 regulates IFN-γ production in natural killer cells

scientific article published on 29 February 2012

miR-3151 Interplays With its Host Gene BAALC and Independently Impacts on Outcome of Older Patients With Cytogenetically Normal Acute Myeloid Leukemia by Direct Deregulation of TP53

article

miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia

scientific article

miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts

scientific article

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