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List of works by Edward J Goetzl

"Liquid Biopsy" of White Matter Hyperintensity in Functionally Normal Elders

scientific article published on 09 November 2018

A lymphocyte-generated fragment of vasoactive intestinal peptide with VPAC1 agonist activity and VPAC2 antagonist effects.

scientific article published on 15 May 2003

A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function

scientific article published on 9 August 2004

Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells

scientific article published in December 2002

Acute Insulin Resistance and Rapid Alterations in Neuronal Derived Blood Exosome Concentration After Branched Endovascular Aortic Aneurysm Repair

scientific article published on 19 December 2019

Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages

scientific article

Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease.

scientific article published on 5 May 2017

Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury

scientific article published on 03 January 2019

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

scientific article published on 10 June 2015

An IgM-kappa rat monoclonal antibody specific for the type 1 sphingosine 1-phosphate G protein-coupled receptor with antagonist and agonist activities

scientific article

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

scientific article published on 15 July 2019

Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate

scientific article

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology

article published in 2019

Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts

scientific article

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease

scientific article published on 10 August 2016

Changing paradigms in the immunologic science of allergy

scientific article published in February 2006

Changing paradigms in the immunological science of allergy

scientific article published on April 2007

Changing paradigms in the immunological science of allergy: 2008.

scientific article published on March 2008

Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia

article

Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.

scientific article published in May 2007

Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate

scientific article published in October 2002

Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile

scientific article published in March 2008

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease

scientific article published on 12 October 2017

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease

scientific article

Defective T Cell Chemotaxis to Sphingosine 1-Phosphate and Chemokine CCL21 in Idiopathic T Lymphocytopenia ⬇️

scientific article published on June 14, 2011

Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease

scientific article published on 20 June 2018

Differential signaling of T cell generation of IL-4 by wild-type and short-deletion variant of type 2 G protein-coupled receptor for vasoactive intestinal peptide (VPAC2)

scientific article

Distinct energy requirements for human memory CD4 T-cell homeostatic functions

scientific article

Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors

scientific article

Distinctive immunoregulatory effects of adenosine on T cells of older humans

scientific article published on 25 November 2011

Diverse mechanisms and consequences of immunoadoption of neuromediator systems

scientific article

Diverse pathways for nuclear signaling by G protein-coupled receptors and their ligands

scientific article published on 27 December 2006

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease

scientific article

Endothelial-derived plasma exosome proteins in Alzheimer's disease angiopathy

scientific article published on 10 March 2020

Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

scientific article

Functional splice variants of the type II G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide in mouse and human lymphocytes

scientific article

Gender specificity of altered human immune cytokine profiles in aging

scientific article

Growth Hormone-Releasing Hormone Administration in Mild Cognitive Impairment and Its Impact on Neuronal Exosome Biomarkers of Dementia

scientific article published on 01 January 2018

High complement levels in astrocyte-derived exosomes of Alzheimer's disease

scientific article published on 6 February 2018

Human CD4- 8- T cells are a distinctive immunoregulatory subset

scientific article

Human plasma platelet-derived exosomes: effects of aspirin

scientific article published on 12 February 2016

Hypothesis: VPAC G protein-coupled receptors for vasoactive intestinal peptide constitute a dynamic system for signaling T cells from plasma membrane and nuclear membrane complexes.

scientific article published on 28 August 2006

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

scientific article

Immunoeffector and immunoregulatory activities of vasoactive intestinal peptide

scientific article

Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes

scientific article published in February 2005

Immunoregulatory lysophospholipids: new stars in the mast cell constellation

scientific article published in May 2004

Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor

scientific article published on 21 January 2009

Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2).

scientific article

International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature

scientific article (publication date: June 2002)

Is aging a drug target?

scientific article published on 01 August 2011

Low neural exosomal levels of cellular survival factors in Alzheimer's disease

scientific article

Lysophospholipid growth factors and their G protein-coupled receptors in immunity, coronary artery disease, and cancer

scientific article published on 6 February 2002

Lysophospholipid mediators of immunity and neoplasia

scientific article

Lysophospholipid regulation of mononuclear phagocytes

scientific article

Lysophospholipids and their G protein-coupled receptors in biology and diseases

scientific article published on 01 August 2004

Lysophospholipids and their G protein-coupled receptors in inflammation and immunity

scientific article

Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1.

scientific article published on 7 July 2003

Multicellular hypothesis for the pathogenesis of Alzheimer's disease

scientific article published on 18 January 2017

Neural signaling opportunities for novel diagnostic approaches and therapies. Preface

Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy

article published in 2019

Neuron-Derived Plasma Exosome Proteins after Remote Traumatic Brain Injury

scientific article published on 11 October 2019

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

scientific article

Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1.

scientific article published on 30 March 2006

Novel window on early human neurodevelopment via fetal exosomes in maternal blood

scientific article published on 25 February 2016

Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines

scientific article published on 11 February 2008

Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells

scientific article published on 14 April 2004

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes.

scientific article

Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

scientific article published on 13 April 2016

Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile

scientific article published on 07 May 2016

Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide

scientific article

Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes

scientific article

Regulation of immunity by lysosphingolipids and their G protein-coupled receptors

scientific article

Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity

scientific article published on 12 March 2008

Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice

scientific article published in January 2003

Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

scientific article published in January 1998

Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia

scientific article published on 31 August 2007

Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction

scientific article published on 20 February 2009

Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system

scientific article

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

scientific article

Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes

scientific article published on 24 February 2004

Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity

scientific article published on April 2007

Sphingosine kinase activation mediates ischemic preconditioning in murine heart

scientific article published on 27 September 2004

Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice

scientific article published in June 2007

The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

scientific article

Transduction of Multiple Effects of Sphingosine 1-Phosphate (S1P) on T Cell Functions by the S1P1 G Protein-Coupled Receptor ⬇️

scientific article published on October 1, 2003

Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins

scientific article published on 08 January 2020

Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice

scientific article published in April 2007

Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines

scientific article

Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration

scientific article published on 26 July 2005

VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1) G protein-coupled receptor mediation of VIP enhancement of murine experimental colitis

scientific article

Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros

scientific article (publication date: 19 April 2002)

Vasoactive intestinal peptide-mediated Th17 differentiation: an expanding spectrum of vasoactive intestinal peptide effects in immunity and autoimmunity

scientific article

c-Maf and JunB mediation of Th2 differentiation induced by the type 2 G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide

scientific article

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