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List of works by Ovanes G Mekenyan

2D-3D migration of large chemical inventories with conformational multiplication. Application of the genetic algorithm

scientific article published in March 2005

A Stepwise Approach for Defining the Applicability Domain of SAR and QSAR Models

A Stepwise Approach for Defining the Applicability Domain of SAR and QSAR Models

scientific article published on 01 July 2005

A category approach to predicting the hemolytic effects of ethylene glycol alkyl ethers in repeated-dose toxicity ⬇️

scientific article published on January 1, 2012

A category approach to predicting the repeated-dose hepatotoxicity of allyl esters ⬇️

scientific article published on December 12, 2012

A comparative survey of chemistry-driven in silico methods to identify hazardous substances under REACH.

scientific article published on 21 May 2013

A critical evaluation of the 2011 ECHA reports on compliance with the REACH and CLP regulations and on the use of alternatives to testing on animals for compliance with the REACH regulation.

scientific article published on October 2011

A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity?

scientific article published on 16 March 2015

A mechanistic approach to modeling respiratory sensitization

scientific article published on 6 February 2014

A systematic approach to simulating metabolism in computational toxicology. I. The TIMES heuristic modelling framework

scientific article published in January 2004

Accessing and using chemical databases

scientific article

Conformational coverage by a genetic algorithm: saturation of conformational space

scientific article published on 28 April 2007

Development of a Decision Tree for Mitochondrial Dysfunction: Uncoupling of Oxidative Phosphorylation

scientific article published on 25 July 2018

Development of a mechanistic SAR model for the detection of phototoxic chemicals and use in an integrated testing strategy ⬇️

scientific article published on October 12, 2010

Dynamic QSAR techniques: applications in drug design and toxicology

scientific article

Identification of the structural requirements for mutagenicity by incorporating molecular flexibility and metabolic activation of chemicals I: TA100 model

scientific article published in June 2004

Identifying the structural requirements for chromosomal aberration by incorporating molecular flexibility and metabolic activation of chemicals

scientific article published on 4 December 2007

Improvement of quantitative structure-activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project

scientific article published on 01 March 2019

Integrated approach to testing and assessment for predicting rodent genotoxic carcinogenicity

scientific article

Interspecies quantitative structure-activity relationship model for aldehydes: aquatic toxicity

scientific article published in February 2004

Investigating the relationship between in vitro-in vivo genotoxicity: derivation of mechanistic QSAR models for in vivo liver genotoxicity and in vivo bone marrow micronucleus formation which encompass metabolism

scientific article

Mechanistic relationship between biodegradation and bioaccumulation. Practical outcomes

scientific article published on 19 June 2019

MetaPath: an electronic knowledge base for collating, exchanging and analyzing case studies of xenobiotic metabolism.

scientific article published on 07 March 2012

Potency and characterization of estrogen-receptor agonists in United Kingdom estuarine sediments

scientific article published in February 2004

Quantitative structure-activity relationship modeling of dermatomyositis activity of drug chemicals

scientific article published in January 2006

Quantitative structure-activity relationship models for prediction of estrogen receptor binding affinity of structurally diverse chemicals

scientific article

Representation of chemical information in OASIS centralized 3D database for existing chemicals

scientific article published in November 2006

Rule interpreter: a chemical language for structure-based screening

Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates

scientific article published in July 2005

TIMES-SS—A Mechanistic Evaluation of an External Validation Study Using Reaction Chemistry Principles

scientific article published on 23 August 2007

TIMES-SS—A promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity

article

The OECD QSAR Toolbox Starts Its Second Decade

scientific article published on 01 January 2018

The SOLUTIONS project: challenges and responses for present and future emerging pollutants in land and water resources management

scientific article

The adverse outcome pathway for skin sensitisation: Moving closer to replacing animal testing

scientific article

The implementation of RAAF in the OECD QSAR Toolbox

scientific article published on 07 April 2019

Towards AOP application--implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization

scientific article

UVCB substances II: Development of an endpoint-nonspecific procedure for selection of computationally generated representative constituents

scientific article published on 18 February 2019

UVCB substances: methodology for structural description and application to fate and hazard assessment

scientific article published on 06 June 2015

Use of genotoxicity information in the development of integrated testing strategies (ITS) for skin sensitization

scientific article published on 16 September 2010

Validation of the performance of TIMES genotoxicity models with EFSA pesticide data

scientific article published on 01 March 2019

What determines skin sensitization potency–myths, maybes and realities. Part 1. The 500 molecular weight cut‐off ⬇️

scientific article published on August 25, 2012

Workgroup report: review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances

scientific article published on 30 October 2006

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