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List of works by Thomas C. Südhof

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter

scientific article

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

scientific article

A Neural Circuit for Memory Specificity and Generalization ⬇️

scientific article published on March 15, 2013

A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion Proteins ⬇️

scientific article published on August 14, 1998

A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.

scientific article (publication date: 2 June 1995)

A Synaptic Circuit Required for Acquisition but Not Recall of Social Transmission of Food Preference

scientific article published on 29 April 2020

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release

scientific article published on 01 August 2020

A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain ⬇️

scientific article published on September 18, 1998

A broken alpha -helix in folded alpha -Synuclein

scientific article

A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory

scientific article published on 22 October 2018

A complete genetic analysis of neuronal Rab3 function.

scientific article published in July 2004

A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis

scientific article

A conformational switch in syntaxin during exocytosis: role of munc18.

scientific article

A conformational switch in the Piccolo C2A domain regulated by alternative splicing

scientific article

A conversation with Thomas Südhof. Interview by Ushma S. Neill

scientific article

A dual-Ca2+-sensor model for neurotransmitter release in a central synapse

scientific article

A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones

scientific article

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

scientific article published in November 2006

A molecular machine for neurotransmitter release: synaptotagmin and beyond

scientific article

A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides

scientific article published on 24 February 2008

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice

scientific article

A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export

scientific article

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

scientific article

A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans

scientific article (publication date: 16 March 2001)

A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic

scientific article

A phospho-switch controls the dynamic association of synapsins with synaptic vesicles

scientific article (publication date: October 1999)

A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission

scientific article

A role for cAMP in long-term depression at hippocampal mossy fiber synapses

scientific article published in October 1998

A simple Ca2+-imaging approach to neural network analyses in cultured neurons

scientific article published on 16 December 2020

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding

scientific article (publication date: 15 December 1993)

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

scientific article published in January 1991

A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins

scientific article (publication date: 20 October 2005)

A stoichiometric complex of neurexins and dystroglycan in brain

scientific article

A synaptic vesicle membrane protein is conserved from mammals to Drosophila

scientific article

A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions

scientific article published in Science

A systematic approach to studying synaptic function in vertebrates

scientific article published on January 1995

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons

scientific article published on 30 September 2019

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

scientific article (publication date: 6 July 2001)

A trimeric protein complex functions as a synaptic chaperone machine.

scientific article

Ablation of All Synaptobrevin vSNAREs Blocks Evoked But Not Spontaneous Neurotransmitter Release at Neuromuscular Synapses

scientific article published on 03 June 2019

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

scientific article

Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10

scientific article

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2

scientific article

Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts

scientific article

Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery

scientific article

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis

scientific journal article

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

scientific journal article

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

scientific article

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses

scientific article published on 17 April 2019

Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism

scientific article published on 01 May 2020

An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus ⬇️

scientific article published on June 3, 2011

An interview with Randy Schekman and Thomas Südhof

scientific article published in January 2014

An interview with the Kavli prize winners. Interview by Claudia Wiedemann.

scientific article

An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release

scientific article

Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice

scientific journal article

Analysis of conditional heterozygous STXBP1 mutations in human neurons

scientific article

Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II

scientific journal article

Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus

scientific article published on May 2017

Annexin VI is required for budding of clathrin-coated pits

scientific article published on July 24, 1992

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

scientific article published on 18 January 2017

Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis

scientific article

Are neuronal SNARE proteins Ca2+ sensors?

scientific article published on 01 March 2005

Assembly of SNARE core complexes prior to neurotransmitter release sets the readily releasable pool of synaptic vesicles

scientific article published on 01 September 2000

Assignment of the 1H, 15N and 13C resonances of the calcium-free and calcium-bound forms of the first C2-domain of synaptotagmin I

scientific article published on 01 October 1997

Association of Rab3A with synaptic vesicles at late stages of the secretory pathway

scientific article published on November 1991

Association of neuronal calcium channels with modular adaptor proteins

scientific article (publication date: 27 August 1999)

Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1

scientific article

Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling ⬇️

scientific article published on April 11, 2013

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons

scientific article

Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors

scientific article

Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses

scientific article published on 03 May 2018

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function ⬇️

scientific article published on August 16, 2011

Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release

scientific article

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

scientific journal article

Binding Properties of Neuroligin 1 and Neurexin 1β Reveal Function as Heterophilic Cell Adhesion Molecules ⬇️

scientific article (publication date: 10 October 1997)

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage

scientific article

Binding of neuroligins to PSD-95

scientific article (publication date: 5 September 1997)

Binding of synaptotagmin to the alpha-latrotoxin receptor implicates both in synaptic vesicle exocytosis

scientific article published in September 1991

Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C

scientific article published on 01 July 1996

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

scientific article published in Nature

Building Bridges through Science.

scientific article published in November 2017

Building bridges between neuroscientific evidence and policy

scientific article

C-Terminal Complexin Sequence Is Selectively Required for Clamping and Priming But Not for Ca2+Triggering of Synaptic Exocytosis ⬇️

scientific article published on February 22, 2012

C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1.

scientific article published on 23 November 2004

C-terminal domain of mammalian complexin-1 localizes to highly curved membranes

scientific article

C2-domains, Structure and Function of a Universal Ca2+-binding Domain ⬇️

scientific article (publication date: 26 June 1998)

CAPS in search of a lost function

scientific article

CASK Functions as a Mg2+-independent neurexin kinase

scientific article

CASK and protein 4.1 support F-actin nucleation on neurexins

scientific article

CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein

scientific article

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

scientific article

CSPalpha-deficiency causes massive and rapid photoreceptor degeneration

scientific article

CSPα knockout causes neurodegeneration by impairing SNAP-25 function ⬇️

scientific article published on December 20, 2011

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity ⬇️

scientific article published on December 12, 2010

Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins

scientific article

Ca(2+)-dependent conformational change in synaptotagmin I

scientific article published on 01 November 1994

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain? ⬇️

scientific article published on July 15, 1998

Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin

scientific article

Calcium Control of Neurotransmitter Release ⬇️

scientific article published on January 1, 2012

Calcium regulation of neurotransmitter release: reliably unreliable? ⬇️

scientific article published on August 1, 1997

Calcium-promoted resonance energy transfer between fluorescently labeled proteins during aggregation of chromaffin granule membranes

scientific article published on December 1982

Calelectrin in human blood cells

scientific article published on 01 May 1983

Calelectrin self-aggregates and promotes membrane aggregation in the presence of calcium

scientific article

Calelectrin, a Calcium-Dependent Membrane-Binding Protein Associated with Secretory Granules inTorpedoCholinergic Electromotor Nerve Endings and Rat Adrenal Medulla ⬇️

scientific article published on 01 July 1983

Calelectrins are a ubiquitous family of Ca2+-binding proteins purified by Ca2+-dependent hydrophobic affinity chromatography by a mechanism distinct from that of calmodulin ⬇️

scientific article published on August 30, 1984

Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.

scientific article published on March 2010

Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons

scientific article

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins

scientific article

Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development ⬇️

scientific article published on October 16, 2012

Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand

scientific article

Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing

scientific article

Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons

scientific article published in March 1995

Cassette of eight exons shared by genes for LDL receptor and EGF precursor

scientific article

Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs

article published in the Proceedings of the National Academy of Sciences of the United States of America

Cell Biology and Pathophysiology of α-Synuclein

scientific article published on 20 January 2017

Cell biology of Ca2+-triggered exocytosis

scientific article

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

scientific article

Cellugyrin, a Novel Ubiquitous Form of Synaptogyrin That Is Phosphorylated by pp60c- ⬇️

scientific article published on January 30, 1998

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

scientific article

Cellular distribution of three mammalian Ca2+-binding proteins related to Torpedo calelectrin ⬇️

scientific article published on December 1, 1984

Cerebellins are differentially expressed in selective subsets of neurons throughout the brain

scientific article published on 16 July 2017

Cerebellins meet neurexins (Commentary on Matsuda & Yuzaki) ⬇️

scientific article published on 01 April 2011

Characteristics and determinants of osmotic lysis in chromaffin granules

scientific article published on 01 May 1983

Characterization of calelectrin, a Ca2+-binding protein isolated from the electric organ of Torpedo marmorata

scientific article published on 01 April 1985

Characterization of rabphilin phosphorylation using phospho-specific antibodies ⬇️

scientific article published on November 1, 2001

Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with Neurexin-1β ⬇️

scientific article (publication date: 12 December 2003)

Characterization of tissue-specific transcription by the human synapsin I gene promoter ⬇️

scientific article published on April 15, 1991

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

scientific article (publication date: 12 March 2004)

Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes.

scientific article published on September 1993

Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin

scientific journal article

Climate change and the integrity of science

scientific article

Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle

scientific article

Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids

scientific article published on 19 February 2006

Co-expression in vertebrate tissues and cell lines of multiple inositol 1,4,5-trisphosphate (InsP3) receptors with distinct affinities for InsP3

scientific article published on 01 November 1994

Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis

scientific article published on October 1991

Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations

scientific article

Common circuit defect of excitatory-inhibitory balance in mouse models of autism

scientific article

Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins ⬇️

scientific article published on January 23, 2013

Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix

scientific article

Complexin controls the force transfer from SNARE complexes to membranes in fusion

scientific article

Complexins regulate a late step in Ca2+-dependent neurotransmitter release

scientific article

Complexins: cytosolic proteins that regulate SNAP receptor function

scientific article

Comprehensive qPCR profiling of gene expression in single neuronal cells

scientific article

Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins

scientific article published in May 2017

Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism

scientific article published on 24 May 2016

Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation

scientific article published on 21 March 2016

Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.

scientific article published in March 2016

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration

scientific article

Conditional knockout of Nlgn2 in the adult medial prefrontal cortex (mPFC) induces delayed loss of inhibitory synapses

scientific article

Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments

scientific article published on 31 March 2015

Conformational switch of syntaxin-1 controls synaptic vesicle fusion

scientific article

Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.

scientific article published on April 1994

Continuous and Discrete Neuron Types of the Adult Murine Striatum

scientific article published on 05 December 2019

Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins

scientific article

Core structure, internal osmotic pressure and irreversible structural changes of chromaffin granules during osmometer behaviour

scientific article published on January 1982

Correction: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones

scientific article published on 13 March 2017

Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution

scientific article

Crystal structure of the RIM2 C2A-domain at 1.4 A resolution

scientific article

Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing

scientific article

Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings

scientific article

Cysteine string protein-alpha is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse

scientific article published in June 2008

DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion

scientific article (publication date: March 1997)

Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes

scientific article

Definition of a molecular pathway mediating α-synuclein neurotoxicity

scientific article

Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes ⬇️

scientific article published on October 27, 2010

Deletion of CASK in mice is lethal and impairs synaptic function

scientific article

Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum

scientific article published in 2022

Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons

scientific article published on 21 May 2018

Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease

scientific article

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation

scientific article published in May 2007

Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism

scientific article published on 01 September 2020

Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held

scientific article

Developmentally Regulated Alternative Splicing in a Novel Synaptojanin ⬇️

scientific article published on January 23, 1998

Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation.

scientific article published on January 2006

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

scientific article published on 22 July 2019

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

scientific article

Differential distributions of novel synaptotagmins: comparison to synapsins

scientific article published on 01 November 1995

Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission

scientific article

Differential expression and regulation of multiple dynamins

scientific article

Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification

scientific journal article

Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity

scientific article published on 30 May 2019

Direct conversion of fibroblasts to functional neurons by defined factors

scientific article

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

scientific article

Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071

scientific article (publication date: 2 April 1999)

Direct lineage conversion of terminally differentiated hepatocytes to functional neurons

scientific article

Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation

scientific article

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation

scientific article published on 24 March 2004

Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism

scientific article

Distinct Ca(2+)-dependent properties of the first and second C2-domains of synaptotagmin I.

scientific article published in January 1996

Distinct Ca2+ and Sr2+ binding properties of synaptotagmins. Definition of candidate Ca2+ sensors for the fast and slow components of neurotransmitter release

scientific article published on October 1995

Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses

scientific article

Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission

scientific article

Distribution of synaptic markers in the retina: implications for synaptic vesicle traffic in ribbon synapses

scientific article published on 01 January 1994

Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses

scientific article

Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis

scientific article

Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism

scientific article

Domain structure of a mammalian myosin I beta

scientific article

Domain structure of synaptotagmin (p65)

scientific article published on January 1991

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

scientific article

Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus

scientific article

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

scientific article

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

scientific article published in Nature

Dynamin I is a Ca(2+)-sensitive phospholipid-binding protein with very high affinity for protein kinase C

scientific article published on 01 August 1994

Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor ⬇️

scientific article published on 07 July 2020

E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains

scientific article

EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?

scientific article (publication date: 25 June 1999)

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

scientific article published on 6 March 2017

ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses

scientific article

Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca2+ channels

scientific article published on 5 September 2017

Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.

scientific article

Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α

Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha

scientific article

Erratum: CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity

scholarly article published in Nature Cell Biology

Essential functions of synapsins I and II in synaptic vesicle regulation

scientific journal article

Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I

scientific article (publication date: November 1999)

Evidence for SNARE zippering during Ca2+-triggered exocytosis in PC12 cells ⬇️

scientific article published on November 1, 2003

Evidence for a divalent cation dependent catecholamine storage complex in chromaffin granules

scientific article published on 01 October 1983

Evolution of CASK into a Mg2+-sensitive kinase

scientific article

Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents

scientific article published on 03 February 2020

Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties

scientific article

Evolutionary conservation and structural determinants of the calelectrins (annexins).

scientific article published on December 1990

Evolutionary conservation of complexins: from choanoflagellates to mice

scientific article published on 3 September 2015

Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+

scientific article

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release

scientific article published on 18 September 2017

Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons

scientific article

Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors

scientific article

Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction

scientific article

Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels.

scientific article published in April 2005

Fatty acylation of synaptotagmin in PC12 cells and synaptosomes.

scientific article

First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins

scientific article published in December 1987

FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice

scientific article published on 11 July 2016

Function of Rab3 GDP-GTP exchange

scientific article published on April 1997

Functional analysis of conserved structural elements in yeast syntaxin Vam3p

scientific article

Functional properties of multiple synaptotagmins in brain

scientific article (publication date: December 1994)

Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins

scientific article published in October 2006

Generation of induced neuronal cells by the single reprogramming factor ASCL1

scientific article

Generation of pure GABAergic neurons by transcription factor programming

scientific article published on 15 May 2017

Genetic Analysis of α-Latrotoxin Receptors Reveals Functional Interdependence of CIRL/Latrophilin 1 and Neurexin 1α ⬇️

scientific article published on December 6, 2001

Genetic ablation of all cerebellins reveals synapse organizer functions in multiple regions throughout the brain

scientific article published on 24 April 2018

Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family

scientific journal article

Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release

scientific article

Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis

scientific article

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis

scientific article

Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation

scientific article

Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle

scientific article

Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins

scientific article (publication date: February 2003)

Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins☆☆Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF548738 and AF548739.

scientific article (publication date: February 2003)

GluD1 is a signal transduction device disguised as an ionotropic receptor

scientific article published on 16 June 2021

Harness the power of endogenous neural stem cells by biomaterials to treat spinal cord injury

scientific article published on 01 November 2015

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons

scientific article

High Affinity Binding of α-Latrotoxin to Recombinant Neurexin Iα ⬇️

scientific article published on October 13, 1995

High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex

scientific article

High-level expression of the 32.5-kilodalton calelectrin in ductal epithelia as revealed by immunocytochemistry

scientific article published in January 1986

Histogenesis and differentiation potential of central neurocytomas

scientific article published in April 1991

Homo- and heterodimerization of synapsins

scientific article

How Tlg2p/syntaxin 16 'snares' Vps45

scientific article

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs

scientific article published in August 2016

How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release

scientific article published on 29 February 2016

Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins

scientific article

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1.

scientific article published on 12 August 2015

Human endomembrane H+ pump strongly resembles the ATP-synthetase of Archaebacteria

scientific article

IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning

scientific article

Identification, expression, and crystallization of the protease‐resistant conserved domain of synapsin I ⬇️

scientific article published on October 1, 1997

Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice

scientific article

Impaired learning in mice with abnormal short-lived plasticity

scientific article

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction

scientific article

Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2

scientific article

Induced neuronal cells: how to make and define a neuron

scientific article

Induction of human neuronal cells by defined transcription factors

scientific article

Inositol 1,4,5-trisphosphate receptor causes formation of ER cisternal stacks in transfected fibroblasts and in cerebellar Purkinje cells

scientific article published on February 1994

Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron

scientific article

Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines

scientific article

Interaction of synaptotagmin with the cytoplasmic domains of neurexins

scientific article published in February 1993

Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

scientific article

Isolation of mammalian calelectrins: a new class of ubiquitous calcium(2+)-regulated proteins ⬇️

scientific article published on March 13, 1984

LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses

scientific article published on 27 January 2020

LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation

scientific article

LTP requires a unique postsynaptic SNARE fusion machinery

scientific article

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

scientific article published on 01 February 2019

Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum

scientific article published on 23 March 2020

Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicing

scientific article

Leucine-Rich Repeat Transmembrane Proteins Are Essential for Maintenance of Long-Term Potentiation ⬇️

scientific article published on August 7, 2013

Lipid and protein interactions in ca-promoted aggregation and fusion of chromaffin granule membranes

scientific article

Lipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter release

scientific article

Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway

scientific article published on 01 December 1994

Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion

scientific journal article

Long-term potentiation in mice lacking synapsins

scientific article

MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development ⬇️

scientific article published on December 17, 2012

Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins

scientific article

Mammary gland Ca2+-binding (-dependent) proteins: identification as calelectrins and calpactin I/p36.

scientific article published in June 1988

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

scientific article published on 8 April 2022

Mapping of synapsin II (SYN2) genes to human chromosome 3p and mouse chromosome 6 band F ⬇️

scientific article published on 01 January 1995

Mechanics of membrane fusion

scientific article published on 01 October 1998

Mechanism of Ca2+ inhibition of inositol 1,4,5-trisphosphate (InsP3) binding to the cerebellar InsP3 receptor ⬇️

scientific article published on April 15, 1992

Mechanism of Phospholipid Binding by the C2A-Domain of Synaptotagmin I ⬇️

scientific article published on 01 September 1998

Mechanism of action of rab3A in mossy fiber LTP.

scientific article

Membrane fusion

scientific article (publication date: 21 February 2003)

Membrane fusion and exocytosis

scientific article (publication date: 1999)

Membrane fusion as a team effort

scientific article

Membrane fusion machinery: insights from synaptic proteins

scientific journal article

Membrane fusion: grappling with SNARE and SM proteins

scientific article

Membrane-tethered monomeric neurexin LNS-domain triggers synapse formation

scientific article

Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits

scientific article

Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity

scientific article published on June 2014

Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2

scientific article

Mints as adaptors. Direct binding to neurexins and recruitment of munc18

scientific article (publication date: 22 December 2000)

Mints, Munc18-interacting Proteins in Synaptic Vesicle Exocytosis ⬇️

scientific article published on December 12, 1997

Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network

scientific article published on 09 January 2017

Molecular Neuroscience in the 21st Century: A Personal Perspective

scientific article published in November 2017

Molecular approaches to synaptic vesicle exocytosis.

scientific article

Molecular determinants of regulated exocytosis

scientific journal article

Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation

scientific article published on 21 November 2006

Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

scientific article

Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release

scientific article

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

scientific article

Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release

scientific article published on July 1998

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

scientific article

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

scientific article

Munc18-1 binds directly to the neuronal SNARE complex

scientific article

Munc18-1 promotes large dense-core vesicle docking

scientific journal article

Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation

scientific article

Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains

scientific article

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

scientific article

N-glycosylation is essential for vesicular targeting of synaptotagmin 1.

scientific article published on January 2004

NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern

scientific article (publication date: 2002)

NMR analysis of the structure of synaptobrevin and of its interaction with syntaxin

scientific journal article

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

scientific article

Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action

scientific journal article

Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms

scientific article

Neurexins

scientific article published on 01 January 1992

Neurexins are functional alpha-latrotoxin receptors

scientific article published on 01 March 1999

Neurexins cluster Ca2+ channels within the presynaptic active zone

scientific article published on 05 March 2020

Neurexins physically and functionally interact with GABA(A) receptors

scientific article

Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin

scientific article

Neurexins: three genes and 1001 products

scientific article

Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit

scientific article

Neurexophilins form a conserved family of neuropeptide-like glycoproteins

scientific article

Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses

scientific article

Neuroligin 1: a splice site-specific ligand for beta-neurexins

scientific article (publication date: 5 May 1995)

Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways

scientific article published on 11 March 2019

Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior

scientific article

Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation

scientific article

Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons

scientific article

Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons

scientific article published on 27 June 2019

Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons

scientific article published on August 2016

Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses

scientific article

Neuroligins and neurexins link synaptic function to cognitive disease

scientific article

Neuroligins determine synapse maturation and function

scientific journal article

Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons

scientific article

Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses

scientific article published on 01 October 2019

Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion

scientific article

Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation

scientific article

Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex

scientific article

Neurotransmitter release: the last millisecond in the life of a synaptic vesicle

scientific article

Newly Synthesized Phosphatidylinositol Phosphates Are Required for Synaptic Norepinephrine but Not Glutamate or γ-Aminobutyric Acid (GABA) Release ⬇️

scientific article published on August 21, 1998

Nicastrin functions as a gamma-secretase-substrate receptor

scientific article published in August 2005

Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions

scientific article (publication date: November 2000)

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

scientific article

Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking

scientific article

Persistent transcriptional programmes are associated with remote memory

scientific article published on 11 November 2020

Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1.

scientific article published on 4 April 2006

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

scientific journal article

Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin

scientific article (publication date: 29 March 1996)

Phosphorylation of RIM1α by PKA Triggers Presynaptic Long-Term Potentiation at Cerebellar Parallel Fiber Synapses ⬇️

scientific article published on October 3, 2003

Phosphorylation of dynamin I and synaptic-vesicle recycling

scientific article published on August 1994

Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro.

scientific article published on March 1995

Phosphorylation of synaptotagmin I by casein kinase II.

scientific article published in March 1993

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

scientific article

Polypeptide composition of the alpha-latrotoxin receptor. High affinity binding protein consists of a family of related high molecular weight polypeptides complexed to a low molecular weight protein.

scientific article published in January 1993

Postsynaptic Membrane Fusion and Long-Term Potentiation ⬇️

scientific article published on January 16, 1998

Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins

scientific article

Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly

scientific article

Postsynaptic complexin controls AMPA receptor exocytosis during LTP

scientific article

Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP.

scientific article

Presenilins are essential for regulating neurotransmitter release

scientific article

Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses

scientific article published on 16 December 2016

Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking

scientific article

Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes

scientific article published on 30 March 2020

Propagation of prions causing synucleinopathies in cultured cells

scientific article

Properties of native brain α-synuclein

scientific article

Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration ⬇️

scientific article published on August 15, 2012

Proteins of synaptic vesicles involved in exocytosis and membrane recycling

scientific article

Proteolysis of SNAP-25 by types E and A botulinal neurotoxins

scientific journal article

Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport

scientific article published on 16 August 2004

Purification and expression of gCap39. An intracellular and secreted Ca2(+)-dependent actin-binding protein enriched in mononuclear phagocytes

scientific article

Purification of calelectrins

scientific article published on 01 January 1987

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product

scientific article

Push-and-pull regulation of the fusion pore by synaptotagmin-7

scientific article

Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor

scientific article

QnAs with Thomas C. Südhof. Interview by Prashant Nair

scientific article published on 20 September 2010

RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion

scientific article published on January 1998

RIBEYE, a Component of Synaptic Ribbons

scientific article (publication date: December 2000)

RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function

scientific article (publication date: December 2000)

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13 ⬇️

scientific article published on January 27, 2011

RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone

scientific article

RIM function in short- and long-term synaptic plasticity

scientific article

RIM genes differentially contribute to organizing presynaptic release sites ⬇️

scientific article published on July 2, 2012

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction

scientific article

RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release

scientific article published in September 2015

RIM-binding proteins recruit BK-channels to presynaptic release sites adjacent to voltage-gated Ca-channels

scholarly article by Alessandra Sclip published in August 2018

RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse

scientific article

RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions

scientific article

RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia

scientific article

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone

scientific article (publication date: 17 January 2002)

RIM1alpha is required for presynaptic long-term potentiation

scientific journal article

RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning

scientific article

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys ⬇️

scientific article published on July 15, 1992

Rab proteins in regulated exocytosis

scientific article published on April 1994

Rab3 Proteins Involved in Vesicle Biogenesis and Priming in Embryonic Mouse Chromaffin Cells

scientific article published on 03 September 2010

Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras

scientific article

Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.

scientific article published in January 2006

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus ⬇️

scientific article published on August 7, 1997

Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning

scientific article

Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis

scientific article published on April 1994

Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules

scientific article

Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release

scientific article

Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion

scientific article

Rapid single-step induction of functional neurons from human pluripotent stem cells

scientific article

Rat homologues of yeast sec7p

scientific article published on October 1, 1997

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release

scientific article

Region-Specific Phosphorylation of Rabphilin in Mossy Fiber Nerve Terminals of the Hippocampus ⬇️

scientific article published on January 15, 1998

Region-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-) phenotypes

scientific article

Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms

scientific article (publication date: September 2002)

Relative properties and localizations of synaptic vesicle protein isoforms: the case of the synaptophysins

scientific article published on 01 November 1993

Reproducibility: Experimental mismatch in neural circuits

scientific article published on 9 December 2015

Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms

scientific article

Retinoic acid receptor RARα-dependent synaptic signaling mediates homeostatic synaptic plasticity at the inhibitory synapses of mouse visual cortex

scientific article published on 24 October 2018

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion ⬇️

scientific article published on August 7, 1997

Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

scientific article published in January 2003

Role of calcium in neurotransmitter release evoked by alpha-latrotoxin or hypertonic sucrose

scientific article published on 01 January 2000

Role of electrostatic and hydrophobic interactions in Ca(2+)-dependent phospholipid binding by the C(2)A-domain from synaptotagmin I.

scientific article published in February 2002

Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons

scientific article published on June 1991

SCAMP1 function in endocytosis

scientific article (publication date: 28 April 2000)

SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice ⬇️

scientific article published on November 2, 2001

SPARCL1 promotes excitatory but not inhibitory synapse formation and function independent of neurexins and neuroligins

scientific article published on 24 September 2020

SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis

scientific article

SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release

scientific journal article

SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family

scientific article published in January 1999

SVOP, an Evolutionarily Conserved Synaptic Vesicle Protein, Suggests Novel Transport Functions of Synaptic Vesicles ⬇️

scientific article published on November 15, 1998

Selective capability of SynCAM and neuroligin for functional synapse assembly

scientific article published on 01 January 2005

Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions

scientific article (publication date: 30 June 2000)

Short-term synaptic plasticity is altered in mice lacking synapsin I.

scientific article

Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms

scientific article

Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons

scientific article published on 16 August 2016

Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif

scientific journal article

Snares and Munc18 in synaptic vesicle fusion

scientific article (publication date: August 2002)

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

scientific article

Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide

scientific journal article

Solution structure of the Vam7p PX domain

scientific article

Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

scientific article

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment

scientific article published on 03 June 2019

Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins

scientific article (publication date: 21 March 2000)

Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions

scientific article

Stable expression of truncated inositol 1,4,5-trisphosphate receptor subunits in 3T3 fibroblasts. Coordinate signaling changes and differential suppression of cell growth and transformation.

scientific article published on July 1994

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1

scientific article published on 01 March 1988

Stimulus-dependent dynamic homo- and heteromultimerization of synaptobrevin/VAMP and synaptophysin

scientific article published in November 2004

Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse

scientific article

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

scientific article

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

scholarly article by Yue C. Lu published in February 2016

Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans

scientific journal article

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7

scientific article

Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch

scientific article

Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4

scientific journal article

Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry

scientific article published in February 2004

Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion.

scientific article published in June 2006

Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2

scientific article

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing

scientific article (publication date: June 2002)

Structure and evolution of neurexophilin

scientific article

Structure and expression of the rat inositol 1,4,5-trisphosphate receptor

scientific article published on July 1990

Structure of a novel InsP3 receptor

scientific article

Structure of synaptogyrin (p29) defines novel synaptic vesicle protein

scientific journal article

Structure of the 116-kDa polypeptide of the clathrin-coated vesicle/synaptic vesicle proton pump

scientific article

Structure of the Janus-faced C2B domain of rabphilin

scientific article

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold ⬇️

scientific article published on March 24, 1995

Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes

scientific article

Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1

article

Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2

scientific article

Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily

scientific article

Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing

scientific article published on 30 September 2019

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions

scientific article

Structures, alternative splicing, and neurexin binding of multiple neuroligins

scientific article

SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning

scientific article

SynCAM, a synaptic adhesion molecule that drives synapse assembly

scientific article

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

scientific article published on 03 June 2019

Synapses and Alzheimer's disease

scientific article

Synapsin I is structurally similar to ATP-utilizing enzymes ⬇️

scientific article published on February 16, 1998

Synapsin II. Mapping of a domain in the NH2-terminal region which binds to small synaptic vesicles.

scientific article

Synapsin III, a novel synapsin with an unusual regulation by Ca2+

scientific journal article

Synapsins I and II Are ATP-binding Proteins with Differential Ca2+ Regulation ⬇️

scientific article published on January 16, 1998

Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway

scientific article

Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins

scientific article

Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression

scientific article

Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits

scientific article published in November 2017

Synaptic assembly of the brain in the absence of neurotransmitter secretion

scientific article

Synaptic cell adhesion

scientific article

Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site

scientific article published on 01 February 1995

Synaptic function of nicastrin in hippocampal neurons

scientific article

Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters

scientific article published on 01 July 2019

Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning

scientific article published on 19 February 2019

Synaptic targeting domains of synapsin I revealed by transgenic expression in photoreceptor cells

scientific article

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

scientific journal article

Synaptic vesicle exocytosis

scientific article

Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

scientific article (publication date: 25 November 1993)

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly

scientific article

Synaptic vesicle proteins in exocytosis: what do we know?

scientific article

Synaptic vesicle traffic: rush hour in the nerve terminal

scientific article

Synaptic vesicles and exocytosis

scientific article

Synaptic vesicles.

scientific article

Synaptic vesicles: an organelle comes of age

scientific article published on 01 November 2006

Synaptobrevin is essential for fast synaptic-vesicle endocytosis

scientific article published on 10 October 2004

Synaptogyrins regulate Ca2+-dependent exocytosis in PC12 cells

scientific article

Synaptophysin is targeted to similar microvesicles in CHO and PC12 cells

scientific article

Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release

scientific article

Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse

scientific article

Synaptotagmin 13: structure and expression of a novel synaptotagmin

scientific article published in January 2001

Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling

scientific article

Synaptotagmin I functions as a calcium regulator of release probability

scientific article (publication date: March 2001)

Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling

scientific article

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

scientific journal article

Synaptotagmin II. A novel differentially distributed form of synaptotagmin

scientific journal article

Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis

scientific journal article

Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells

scientific article published on 01 July 2002

Synaptotagmin regulation of coated pit assembly

scientific article published on October 2000

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles

scientific article

Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells

scientific article

Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release

scientific article

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

scientific article

Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons

scientific article

Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity

scientific article published on 26 February 2019

Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP

scientific article

Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release

scientific article

Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses

scientific article

Synaptotagmin-7 Is Essential for Ca2+-Triggered Delayed Asynchronous Release But Not for Ca2+-Dependent Vesicle Priming in Retinal Ribbon Synapses

scientific article

Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas

scientific article

Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells

scientific article

Synaptotagmin-7-Mediated Asynchronous Release Boosts High-Fidelity Synchronous Transmission at a Central Synapse

scientific article published in May 2017

Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch

scientific article

Synaptotagmin: a calcium sensor on the synaptic vesicle surface

scientific article

Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles

scientific article published on 01 September 1993

Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities

scientific article

Synaptotagmins: C2-domain proteins that regulate membrane traffic

scientific article published on September 1996

Synaptotagmins: Why So Many? ⬇️

scientific article published on December 5, 2001

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

scientific article

Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities

scientific article

Temperature-induced lysis of chromaffin granules provides evidence against the two-pool hypothesis of catecholamine storage

scientific article published on May 1983

Testing the SNARE/SM protein model of membrane fusion

scientific article

Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis

scientific journal article

The C2B domain of synaptotagmin I is a Ca2+-binding module

scientific article

The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family

scientific journal article

The LDL receptor gene: a mosaic of exons shared with different proteins

scientific article

The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein

scientific article

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged? ⬇️

scientific article published on January 1, 2012

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

The Neurobiology of Opioid Addiction and the Potential for Prevention Strategies

scientific article published on 01 May 2018

The Presynaptic Active Zone ⬇️

scientific article published on July 12, 2012

The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins

scientific journal article

The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons

scientific article

The appendage domain of alpha-adaptin is a high affinity binding site for dynamin

scientific article published on 01 April 1995

The cDNA and derived amino acid sequences for rat and human synaptophysin

scientific article

The calelectrins: new and ubiquitous Ca2+-regulated proteins with a possible role in cytotic processes ⬇️

scientific article published on 01 December 1984

The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins ⬇️

scientific article published on January 24, 2011

The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice

scientific journal article

The chromaffin granule as a model for membrane fusion: implications for exocytosis

scientific article published on 01 January 1983

The conditional KO approach: Cre/Lox technology in human neurons

scientific article

The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding

scientific journal article

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling

scientific article published on 01 August 2018

The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor

scientific article

The making of neurexins

scientific article

The molecular machinery of neurotransmitter release (Nobel lecture).

scientific article

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones

scientific journal article

The multisubunit structure of synaptophysin. Relationship between disulfide bonding and homo-oligomerization

scientific article published on May 1990

The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo

scientific article

The presynaptic active zone protein RIM1alpha is critical for normal learning and memory

scientific article

The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis

scientific article published on 16 August 2017

The relation of protein binding to function: what is the significance of munc18 and synaptotagmin binding to syntaxin 1, and where are the corresponding binding sites?

scientific article published in June 2000

The role of Rab3A in neurotransmitter release

scientific article

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

scientific journal article

The structure of cytochrome b561, a secretory vesicle-specific electron transport protein

scientific article

The structure of the human synapsin I gene and protein

scientific article

The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing

scientific article

The subcellular localizations of atypical synaptotagmins III and VI. Synaptotagmin III is enriched in synapses and synaptic plasma membranes but not in synaptic vesicles

scientific article published in June 1999

The synaptic vesicle cycle

scientific article

The synaptic vesicle cycle revisited

scientific article

The synaptic vesicle cycle: a cascade of protein-protein interactions

scientific article (publication date: 22 June 1995)

The synaptic vesicle protein CSP alpha prevents presynaptic degeneration.

scientific article

The top loops of the C(2) domains from synaptotagmin and phospholipase A(2) control functional specificity

scientific article published on 10 July 2001

Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene

scientific article published on 01 August 1987

Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A ⬇️

scientific article published on September 18, 1998

Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein

scientific article published on 01 August 2004

Three-dimensional structure of the complexin/SNARE complex

scientific article

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

scientific article

Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability

scientific journal article

Towards an Understanding of Synapse Formation

scientific article published on 01 October 2018

Transdifferentiation of human adult peripheral blood T cells into neurons

scientific article published on 04 June 2018

Transmembrane topography and evolutionary conservation of synaptophysin.

scientific article published in January 1989

Transsynaptic cerebellin 4–neogenin 1 signaling mediates LTP in the mouse dentate gyrus

scientific article published in 2022

Truth in Science Publishing: A Personal Perspective

scientific article

Two distinct domains in hsc70 are essential for the interaction with the synaptic vesicle cysteine string protein

scientific article published on 01 June 1999

Two novel annexins from Drosophila melanogaster. Cloning, characterization, and differential expression in development.

scientific article published on July 1990

Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice

scientific article

Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ

scientific article

Understanding synapses: past, present, and future

scientific article

Unexpected Ca2+-binding properties of synaptotagmin 9

scientific article

Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties

scientific article published on 08 June 2017

Unusually rapid evolution of Neuroligin-4 in mice

scientific article

Vacuolar proton pumps

scientific article

Vam3p structure reveals conserved and divergent properties of syntaxins

scientific article

[The molecular machinery of neurotransmitter secretion]

scientific article published on 26 June 2015

alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins

scientific article (publication date: 2001)

alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis

scientific article published in December 1998

alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal

scientific article

alpha-latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membrane

scientific article

beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC

scientific article

cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map.

scientific article published on 28 January 2007

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase

scientific journal article

gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein

scientific article

lnsP3 receptor turnaround

scientific article published in Nature

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles

scientific article

rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence

scientific article published on July 1991

v-SNAREs control exocytosis of vesicles from priming to fusion

scientific article

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

scientific article

β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling

scientific article

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