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List of works by Rolf W Sparidans

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).

scientific article published on 8 September 2015

Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699).

scientific article

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation

scientific article published on 26 January 2010

Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease.

scientific article published on 23 March 2013

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

scientific article

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma

scientific article published on 22 July 2015

Dendrimer-based macromolecular conjugate for the kidney-directed delivery of a multitargeted sunitinib analogue

scientific article

Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics ⬇️

scientific article published on January 31, 2011

Extrahepatic metabolism of ibrutinib

scientific article published on 04 July 2020

Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters

scientific article published on 19 January 2010

In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug

scientific article published on August 2004

In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug

scientific article published on February 2007

In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction

scientific article published on October 2005

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

scientific article published on 14 September 2009

Isocratic ion-exchange chromatographic assay for the nucleotide gemcitabine triphosphate in human white blood cells

scientific article published in November 2002

Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde

scientific article

Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma

scientific article

Liquid chromatographic assay for the protease inhibitor atazanavir in plasma

scientific article published in January 2006

Liquid chromatographic assay with fluorescence detection to determine ajmaline in serum from patients with suspected Brugada syndrome

scientific article published on 25 June 2010

Liquid chromatography-tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis

scientific article published on 19 June 2010

Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates ⬇️

scientific article published on August 21, 2010

Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma

scientific article published on 12 September 2013

Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma

scientific article published on 30 October 2009

Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma

scientific article

Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma

scientific article

Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction

scientific article published on 21 January 2016

Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH4 with biomarker potential in human plasma and serum

scientific article

Melphalan antitumor efficacy and hepatotoxicity: the effect of variable infusion duration in the hepatic artery

scientific article published on 20 February 2003

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

scientific article published on 21 April 2005

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes

scientific article published on 21 December 2007

Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

scientific article

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin

scientific article published on 14 January 2008

P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.

scientific article published on 11 April 2014

Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol

scientific article

Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies ⬇️

scientific article published on August 2, 2011

Population pharmacokinetics of itraconazole in Thai HIV-1-infected persons

scientific article published on April 2003

Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry

scientific article published on 26 July 2008

Randomized phase I clinical and pharmacologic study of weekly versus twice-weekly dose-intensive cisplatin and gemcitabine in patients with advanced non-small cell lung cancer ⬇️

scientific article published on September 1, 2003

Recent developments in the chromatographic bioanalysis of approved kinase inhibitor drugs in oncology.

scientific article

Reduced liver uptake of arterially infused melphalan during retrograde rat liver perfusion with unaffected liver tumor uptake

scientific article published on November 2002

Selective high-performance liquid chromatographic assay for itraconazole and hydroxyitraconazole in plasma from human immunodeficiency virus-infected patients

scientific article published in February 2002

Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples

scientific article published in July 2010

Simple high‐performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue ⬇️

scientific article published on October 1, 2003

Specific Investigation of Sample Handling Effects on Protease Activities and Absolute Serum Concentrations of Various Putative Peptidome Cancer Biomarkers ⬇️

scientific article published on September 30, 2010

Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells ⬇️

scientific article published on January 31, 2012

The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

scientific article published in January 2015

Validation of a quantitative assay for human neutrophil peptide-1, -2, and -3 in human plasma and serum by liquid chromatography coupled to tandem mass spectrometry

scientific article published on 15 March 2010

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