List of works - Mercedes Rincón

A framework for the role of acute inflammation in tumor progression

scientific article published on 19 April 2015

A switch from white to brown fat increases energy expenditure in cancer-associated cachexia

scientific article published on 17 July 2014

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

scientific article published on September 1994

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

scientific journal article

Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells

scholarly article

Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells

scientific article published on 20 May 2005

Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice

scientific article published in May 2002

Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint

scientific article

Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus.

scientific article published in June 2000

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis

scientific article

Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells

scientific article

Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo

scientific article

Acute inflammation induced by the biopsy of mouse mammary tumors promotes the development of metastasis

scientific article

Animal models of asthma

scientific article published on 26 June 2009

Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice

scientific article published on January 2007

Aspergillus fumigatus Generates an Enhanced Th2-Biased Immune Response in Mice with Defective Cystic Fibrosis Transmembrane Conductance Regulator

article

Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression.

scientific article published on June 2008

Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice

scientific article

Borrelia burgdorferi–Infected, Interleukin‐6–Deficient Mice Have Decreased Th2 Responses and Increased Lyme Arthritis

article

CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation.

scientific article

Choreography of MAGUKs during T cell activation

scientific article published on 01 February 2007

Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?

scientific article

Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity

scientific article

Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15

scientific article

Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells

scientific article published on June 2008

Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2

scientific article published on 01 August 2000

Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer

scientific article published on May 2016

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

scientific article published in October 1998

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

scientific article

ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo

scientific article

Effects of acute and chronic low density lipoprotein exposure on neutrophil function.

scientific article published on 17 October 2012

Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function

scientific article

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

scientific article published on 23 May 2016

Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo

scientific article

Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells

scientific article published on 3 June 2011

Genetic analysis of the influence of neuroantigen-complete Freund's adjuvant emulsion structures on the sexual dimorphism and susceptibility to experimental allergic encephalomyelitis

scientific article published on October 2003

Glycolysis Induces MCJ Expression That Links T Cell Proliferation With Caspase-3 Activity and Death

Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice

scientific article

Human breast cancer biopsies induce eosinophil recruitment and enhance adjacent cancer cell proliferation

scientific article published on June 2016

IL-6 is required for airway mucus production induced by inhaled fungal allergens

scientific article

IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.

scientific article published on 26 September 2016

IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program

scientific article

Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

scientific article

Impaired NFAT transcriptional activity in antigen-stimulated CD8 T cells linked to defective phosphorylation of NFAT transactivation domain.

scientific article

Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response

scientific article published on 29 January 2016

Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation

scientific article

Induction of hepatitis by JNK-mediated expression of TNF-alpha

scientific article published on January 2009

Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos

scientific article

Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo

scientific article published on May 2004

Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide

scientific article published on 01 May 2000

Inhibition of NFAT specifically in T cells prevents allergic pulmonary inflammation

scientific article published in March 2004

Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway ⬇️

scientific article published on May 15, 1998

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

scientific article

Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis

scientific article published on 7 March 2013

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations

scientific journal article

Macrophage p38 mitogen-activated protein kinase activity regulates invariant natural killer T-cell responses during Borrelia burgdorferi infection

scientific article

Metabolic dysfunction: mediator of the link between obesity and asthma?

scientific article published on 06 June 2016

Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression

scientific article published on 5 February 2007

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

scientific article

Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function

scientific article published on 14 May 2015

Mitochondrial Stat3, the Need for Design Thinking

scientific article

Molecular basis of T-cell differentiation

scientific article

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

scientific article published on 01 November 2000

Non-classical p38 map kinase functions: cell cycle checkpoints and survival

scientific article published on 19 December 2008

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway ⬇️

scientific article published on November 28, 1997

Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation

scientific article published on 12 September 2005

Nuclear localization of p38 MAPK in response to DNA damage

scientific journal article

Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury

scientific article

PKCtheta is required for the activation of human T lymphocytes induced by CD43 engagement.

scientific article

Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

scientific article published on May 2008

Polymorphisms in the CD1d promoter that regulate CD1d gene expression are associated with impaired NKT cell development

scientific article published on 4 December 2013

Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3.

scientific article published on 2 February 2006

Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages.

scientific article published on 7 April 2004

Regulation of CD4+ T cell differentiation.

scientific article published on January 1995

Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation

scientific article

Regulation of oxidative stress by methylation-controlled J protein controls macrophage responses to inflammatory insults

scientific article

Regulation of p38 MAP kinase in CD4+ lymphocytes by infliximab therapy in patients with rheumatoid arthritis.

scientific article published in August 2005

Reprogramming the signalling requirement for AP‐1 (activator protein‐1) activation during differentiation of precursor CD4+ T‐cells into effector Th1 and Th2 cells ⬇️

scientific article published on February 1, 1997

Requirement for transcription factor NFAT in interleukin-2 expression

scientific article

Requirement of transcription factor NFAT in developing atrial myocardium

scientific journal article

Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases ⬇️

scientific article published on October 25, 2012

Role of the CCAAT/enhancer-binding protein NFATc2 transcription factor cascade in the induction of secretory phospholipase A2

scientific article published on 24 February 2006

Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation

scientific article published in June 2002

Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells

scientific article published on January 2014

Signal transduction by MAP kinases in T lymphocytes

scientific article

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

scientific article published on 03 July 2020

Sonoporation as an Approach for siRNA delivery into T cells

scientific article published on 17 September 2019

Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos

scientific article

Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products

scientific article published on March 2009

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

scientific article

The effects of IL-6 on CD4 T cell responses

scientific article published on 08 October 2008

The emerging role of p38 mitogen-activated protein kinase in multiple sclerosis and its models.

scientific article published on 29 July 2013

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells

scientific article published on 12 January 2009

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.

scientific article

The regulation of CD4 T cell differentiation

scientific article published on 01 September 1998

The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury.

scientific article published on February 2014

The two faces of IL-6 on Th1/Th2 differentiation

scientific article

Therapeutic Efficacy of IL-17A Neutralization with Corticosteroid Treatment in a Model of Antigen-Driven Mixed Granulocytic Asthma

scientific article published on 12 August 2020

Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells

scientific article published on March 1997

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

scientific article

Translational control of NKT cell cytokine production by p38 MAPK.

scientific article published on 2 March 2011

c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages.

scientific article

c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation

scientific article published on April 2002

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

scientific article published on 16 August 2019

p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells.

scientific article

List of works by Mercedes Rincón

A framework for the role of acute inflammation in tumor progression

A switch from white to brown fat increases energy expenditure in cancer-associated cachexia

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells

Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells

Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice

Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint

Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus.

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis

Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells

Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo

Acute inflammation induced by the biopsy of mouse mammary tumors promotes the development of metastasis

Animal models of asthma

Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice

Aspergillus fumigatus Generates an Enhanced Th2-Biased Immune Response in Mice with Defective Cystic Fibrosis Transmembrane Conductance Regulator

Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression.

Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice

Borrelia burgdorferi–Infected, Interleukin‐6–Deficient Mice Have Decreased Th2 Responses and Increased Lyme Arthritis

CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation.

Choreography of MAGUKs during T cell activation

Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?

Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity

Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15

Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells

Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2

Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo

Effects of acute and chronic low density lipoprotein exposure on neutrophil function.

Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo

Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells

Genetic analysis of the influence of neuroantigen-complete Freund's adjuvant emulsion structures on the sexual dimorphism and susceptibility to experimental allergic encephalomyelitis

Glycolysis Induces MCJ Expression That Links T Cell Proliferation With Caspase-3 Activity and Death

Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice

Human breast cancer biopsies induce eosinophil recruitment and enhance adjacent cancer cell proliferation

IL-6 is required for airway mucus production induced by inhaled fungal allergens

IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.

IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program

Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

Impaired NFAT transcriptional activity in antigen-stimulated CD8 T cells linked to defective phosphorylation of NFAT transactivation domain.

Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response

Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation

Induction of hepatitis by JNK-mediated expression of TNF-alpha

Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos

Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo

Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide

Inhibition of NFAT specifically in T cells prevents allergic pulmonary inflammation

Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway ⬇️

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations

Macrophage p38 mitogen-activated protein kinase activity regulates invariant natural killer T-cell responses during Borrelia burgdorferi infection

Metabolic dysfunction: mediator of the link between obesity and asthma?

Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function

Mitochondrial Stat3, the Need for Design Thinking

Molecular basis of T-cell differentiation

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

Non-classical p38 map kinase functions: cell cycle checkpoints and survival

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway ⬇️

Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation

Nuclear localization of p38 MAPK in response to DNA damage

Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury

PKCtheta is required for the activation of human T lymphocytes induced by CD43 engagement.

Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

Polymorphisms in the CD1d promoter that regulate CD1d gene expression are associated with impaired NKT cell development

Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3.

Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages.

Regulation of CD4+ T cell differentiation.

Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation

Regulation of oxidative stress by methylation-controlled J protein controls macrophage responses to inflammatory insults

Regulation of p38 MAP kinase in CD4+ lymphocytes by infliximab therapy in patients with rheumatoid arthritis.

Reprogramming the signalling requirement for AP‐1 (activator protein‐1) activation during differentiation of precursor CD4+ T‐cells into effector Th1 and Th2 cells ⬇️

Requirement for transcription factor NFAT in interleukin-2 expression