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List of works by Carlos Caldas

112 Luminal-like oestrogen receptor-positive breast cancer: identification of prognostic biological subclasses

3D deformable registration of longitudinal abdominopelvic CT images using unsupervised deep learning

scientific article published on 08 July 2021

6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial

scientific article published on 06 June 2019

A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes

scientific article

A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia

scientific article published on 2 June 2010

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

scientific article

A Ki67/BCL2 index based on immunohistochemistry is highly prognostic in ER-positive breast cancer

scientific article published on 26 September 2011

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

scientific article published on 01 December 2018

A Recurrent Chromosome Breakpoint in Breast Cancer at theNRG1/Neuregulin 1/HeregulinGene

article

A central review of histopathology reports after breast cancer neoadjuvant chemotherapy in the neo-tango trial

scientific article published on 8 January 2013

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation

scientific article

A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer ⬇️

scientific article

A consensus prognostic gene expression classifier for ER positive breast cancer

scientific article published on 31 October 2006

A gene-expression signature to predict survival in breast cancer across independent data sets.

scientific article

A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus

scientific journal article

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

scientific article published on June 2016

A key genomic subtype associated with lymphovascular invasion in invasive breast cancer

scientific article published on 22 May 2019

A metadata approach for clinical data management in translational genomics studies in breast cancer.

scientific article

A metadata-aware application for remote scoring and exchange of tissue microarray images

scientific article

A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities

scientific article

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

scientific article published on 16 January 2020

A new genome-driven integrated classification of breast cancer and its implications

scientific article published on 8 February 2013

A population-based validation of the prognostic model PREDICT for early breast cancer

scientific article published on 02 March 2011

A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients

scientific article (publication date: 2013)

A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma

scientific article published on 01 August 2003

A quantum leap in our knowledge of breast cancer mutations

scientific article published on January 2006

A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer

scientific article published on 28 August 2008

A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples

scientific article

A sparse regulatory network of copy-number driven expression reveals putative breast cancer oncogenes

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer

scientific article

A variational Bayesian mixture modelling framework for cluster analysis of gene-expression data

scientific article

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer

scientific article

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

scientific article published on 06 January 2020

Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours

scientific article

Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition

scientific article published on May 2006

Absence of rearrangements in the BRCA2 gene in human cancers.

scientific article published on January 2001

Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer

scholarly article

Abstract B02: Co-clinical trial of olaparib in breast and ovarian patient-derived tumor xenografts (PDX) enables the identification of response biomarkers

Addition of gemcitabine to paclitaxel, epirubicin, and cyclophosphamide adjuvant chemotherapy for women with early-stage breast cancer (tAnGo): final 10-year follow-up of an open-label, randomised, phase 3 trial.

scientific article published on 4 May 2017

Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials

scientific article

Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

scientific article published in 2020

Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer

scientific article

Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant

scientific article published on 08 June 2022

Allelotype of pancreatic adenocarcinoma

scientific article published on 01 May 1994

Allelotype of pancreatic adenocarcinoma using xenograft enrichment

scientific article published on 01 October 1995

Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line

scientific article

Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy

scientific article

An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer

scientific article published on January 2007

An investigation of the factors effecting high-risk individuals' decision-making about prophylactic total gastrectomy and surveillance for hereditary diffuse gastric cancer (HDGC).

scientific article published on 2 June 2016

Analysis of circulating tumor DNA to monitor metastatic breast cancer

scientific article (publication date: 28 March 2013)

Analysis of the region of the 5' end of the MLL gene involved in genomic duplication events.

scientific article published in April 1999

Array comparative genomic hybridization copy number profiling: a new tool for translational research in solid malignancies

scientific article published on April 2008

Association Between Levels of Hormones and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus

scientific article published on 19 November 2019

Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients

scientific article published on 9 June 2014

Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort.

scientific article published on 7 March 2018

Astronomical algorithms for automated analysis of tissue protein expression in breast cancer

scientific article published on 17 January 2013

Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer

scientific article

Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

scientific article published on 01 March 2020

Author Correction: Caring for patients with cancer in the COVID-19 era

scientific article published on 03 June 2020

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article published on 01 February 2019

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells

scientific article

BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

scientific article

BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received.

scientific article published on 28 September 2010

BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer

scientific article published on 13 August 2019

BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines

scientific article

BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential

scientific article

Basic cancer research is essential for the success of personalised medicine

scientific article

Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic Index

scientific article published on 01 April 2006

Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue

scientific article published on 08 May 2012

Body mass index and breast cancer survival: a Mendelian randomization analysis

scientific article published in December 2017

Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters

scientific article

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

scientific article published on 26 September 2016

Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression

scientific article

CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

scientific article published on 17 February 2017

CYP2D6 gene variants and their association with breast cancer susceptibility

scientific article

CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen

scientific article

Calling sample mix-ups in cancer population studies

scientific article

Calpastatin is associated with lymphovascular invasion in breast cancer

scientific article published on 4 May 2011

Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century

scientific article published on 18 September 2018

Cancer Core Europe: A translational research infrastructure for a European mission on cancer

Cancer Core Europe: a consortium to address the cancer care-cancer research continuum challenge

scientific article published on 25 September 2014

Cancer Treatment in the Genomic Era

scientific article published on 22 March 2019

Cancer genes and molecular oncology in the clinic.

scientific article published on May 1997

Cancer genetics of epigenetic genes

scientific article published on April 2007

Cancer sequencing unravels clonal evolution ⬇️

scientific article published on 07 May 2012

Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance

scientific article published on 23 November 2011

Caring for patients with cancer in the COVID-19 era

scientific article published on 16 April 2020

Cell-free circulating tumour DNA as a liquid biopsy in breast cancer

scientific article

Central pathology review with two-stage quality assurance for pathological response after neoadjuvant chemotherapy in the ARTemis Trial

scientific article published on 26 May 2017

Characterisation of PALB2 tumours through whole-exome and whole-transcriptomic analyses

scientific article published on 23 April 2021

Characterisation of microRNA expression in post-natal mouse mammary gland development

scientific article

Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance

scientific article published on 24 May 2019

Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity

scientific article published on 18 June 2019

Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping

scientific article published on October 2005

Chromosome translocations in breast cancer

scientific article published on 13 May 2008

Circulating Tumor DNA to Monitor Metastatic Breast Cancer ⬇️

scientific article published on July 4, 2013

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

scientific article

Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy

scientific article published in Nature Communications

Co-amplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event.

scientific article published on May 2007

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

scientific article

Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer.

scientific article

Common germ-line polymorphism of C1QA and breast cancer survival

scientific article

Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer

scientific article

Common germline polymorphisms associated with breast cancer-specific survival

scientific article published on 22 April 2015

Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer

scientific article published in December 2009

Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias

scientific article published on 01 February 1995

Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines

scientific article published on January 2006

Comparative genomic hybridization using DNA from laser capture microdissected tissue.

scientific article published in January 2005

Comparative study of endoscopic surveillance in hereditary diffuse gastric cancer according to CDH1 mutation status

scientific article published on 5 July 2017

Comparison of methods for handling missing data on immunohistochemical markers in survival analysis of breast cancer

scientific article

Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts

scientific article published on 5 January 2018

Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer.

scientific article published on 16 February 2016

Confirmation of frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukaemia

scientific article published on 01 December 1997

Consensus on precision medicine for metastatic cancers: a report from the MAP conference.

scientific article published on 3 May 2016

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.

scientific article published on 9 December 2015

Copynumber: Efficient algorithms for single- and multi-track copy number segmentation

scientific article

Correction: PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer.

scientific article published in March 2010

Correlation between clinical symptoms and peripheral immune response in HAM/TSP.

scientific article published on 25 November 2015

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on May 2016

Corrigendum: p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.

scientific article published on 6 September 2017

Cross-platform array comparative genomic hybridization meta-analysis separates hematopoietic and mesenchymal from epithelial tumors

scientific article published on 28 August 2006

Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer

scientific article

Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

article

DNA copy number motifs are strong and independent predictors of survival in breast cancer

scientific article published on 02 April 2020

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

scientific article published on 13 September 2021

DNA polymerase β deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts

scientific article published on 10 January 2014

DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study

scientific article published on 19 July 2008

Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity

scientific article published on 7 July 2017

Decline in Antigenicity of Tumor Markers by Storage Time Using Pathology Sections Cut From Tissue Microarrays

scientific article published on 05 June 2015

Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures

scientific article published on 15 December 2020

Degenerate oligonucleotide primed-polymerase chain reaction-based array comparative genomic hybridization for extensive amplicon profiling of breast cancers : a new approach for the molecular analysis of paraffin-embedded cancer tissue

scientific article

Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia

scientific article published on 01 July 1994

Detection of the KIT D816V mutation in peripheral blood of systemic mastocytosis: diagnostic implications

scientific article published on 12 June 2015

Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants ⬇️

scientific article published on 13 December 2017

Diagnosis and classification of mastocytosis in non-specialized versus reference centres: a Spanish Network on Mastocytosis (REMA) study on 122 patients.

scientific article published on 12 October 2015

Differential expression of selected histone modifier genes in human solid cancers

scientific article published on 25 April 2006

Differential gene expression in the murine gastric fundus lacking interstitial cells of Cajal

scientific article

Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal

scientific article

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

scientific article

Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells

scientific article published on 3 February 2009

Disease-free and overall survival at 3.5 years for neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin and cyclophosphamide, for women with HER2 negative early breast cancer: ARTemis Trial

scientific article published on 27 April 2017

Does massively parallel transcriptome analysis signify the end of cancer histopathology as we know it?

scientific article

Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner.

scientific article

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

scientific article

DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer

scientific article published on 22 December 2012

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups

scientific article published on 13 March 2019

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

scientific article published on 26 November 2014

Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.

scientific article

Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer

scientific article published on 11 August 2009

E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma

article

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

scientific article

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

scientific article (publication date: 26 November 2003)

EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis

scientific article published on 25 June 2019

ESR1 gene amplification in breast cancer: a common phenomenon?

scientific article published on July 2008

EZH2 Is Overexpressed in -like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy

scientific article published on 29 April 2019

Early Gastric Cancer in Young, Asymptomatic Carriers of Germ-Line E-Cadherin Mutations

scientific article published on 01 June 2001

Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers

scientific article

Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients

scientific article published on 28 August 2018

Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort

scientific article published on 28 May 2008

Effects of the addition of gemcitabine, and paclitaxel-first sequencing, in neoadjuvant sequential epirubicin, cyclophosphamide, and paclitaxel for women with high-risk early breast cancer (Neo-tAnGo): an open-label, 2×2 factorial randomised phase 3

scientific article

Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): an open-label, randomised, phase 3 trial

scientific article published on 11 May 2015

Elucidating the altered transcriptional programs in breast cancer using independent component analysis

scientific article

Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor

scientific article published on 9 February 2013

Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

scientific article published on 9 February 2017

Erratum: Corrigendum: Progesterone receptor modulates ERα action in breast cancer

scientific article published in Nature

Erratum: Corrigendum: Signatures of mutational processes in human cancer

scientific article published in Nature

Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

scientific article published on 6 June 2016

Evidence for a role of FGF-2 and FGF receptors in the proliferation of non-small cell lung cancer cells

scientific article

Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer

scientific article published on 27 January 2005

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

scientific article

Excellent translational research in oncology: A journey towards novel and more effective anti-cancer therapies

scientific article

Exon scrambling of MLL transcripts occur commonly and mimic partial genomic duplication of the gene

scientific article

Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins

scientific article

Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling

scientific article

Expression of androgen receptor splice variants in clinical breast cancers.

scientific article published on 7 November 2015

Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer

scientific article

Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast

scientific article

Facilitating a culture of responsible and effective sharing of cancer genome data

scientific article

Familial gastric cancer: overview and guidelines for management

scientific article

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation

scientific article published on 27 September 2019

Finding common regions of alteration in copy number data

scientific article

Fine scale mapping of the breast cancer 16q12 locus

scientific article

Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia

scientific article published on 01 September 1996

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

scientific article

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on 11 May 2015

From genomic landscapes to personalized cancer management—is there a roadmap? ⬇️

scientific article published on October 1, 2010

Further evidence to support bimodality of oestrogen receptor expression in breast cancer

scientific article

G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells

scientific article published on 25 June 2013

Genetic alterations in the PI3K/AKT pathway and baseline AKT activity define AKT inhibitor sensitivity in breast cancer patient-derived xenografts

scientific article published on 27 March 2020

Genetic heterogeneity in breast cancer: the road to personalized medicine? ⬇️

scientific article published on June 18, 2013

Genetic predisposition to gastro-oesophageal cancer

scientific article

Genetic screening for hereditary diffuse gastric cancer

scientific article

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells

scientific article

Genetics: How to validate a breast cancer prognostic signature

scientific article published on November 1, 2010

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

scientific article published on July 2016

Genome-driven integrated classification of breast cancer validated in over 7,500 samples

scientific article

Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis ⬇️

scientific article

Genome-wide association study of germline variants and breast cancer-specific mortality

scientific article published on 21 February 2019

Genomic analysis of the 8p11-12 amplicon in familial breast cancer

article

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

scientific article

Genomic architecture characterizes tumor progression paths and fate in breast cancer patients

scientific article published on June 2010

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer

scientific article

Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines

scientific article published on 31 January 2006

Germline CDH1 deletions in hereditary diffuse gastric cancer families

scientific article published on 24 January 2009

Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria

scientific article

Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study.

scientific article

Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma

scientific article published on 2 August 2016

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma

scientific article published in November 2002

Hepcidin-Dependent Regulation of Erythropoiesis during Anemia in a Teleost Fish, Dicentrarchus labrax

scientific article

Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond

scientific article published on April 2015

Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research

scientific article

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis

scientific article published on 24 April 2018

High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer

scientific article

High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation

scientific article published on 24 April 2006

High-resolution array CGH clarifies events occurring on 8p in carcinogenesis

scientific article

High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53.

scientific article published in May 2008

High-resolution magic angle spinning 1H NMR spectroscopy and reverse transcription-PCR analysis of apoptosis in a rat glioma

scientific article published in March 2006

High-risk individuals' perceptions of reproductive genetic testing for CDH1 mutations

scientific article published on 15 February 2017

Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk

article

Human and mouse oligonucleotide-based array CGH.

scientific article

Hyperpolarized 13C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer

scientific article published on 31 July 2020

IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy

scientific article

Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays

scientific article

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands

scientific article published in March 2003

Identification of novel genetic markers of breast cancer survival

scientific article published on 18 April 2015

Imaging breast cancer using hyperpolarized carbon-13 MRI

scientific article published on 21 January 2020

Impact of somatic and germline mutations on the outcome of systemic mastocytosis

scientific article published on 01 November 2018

Impaired transforming growth factor beta signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation

scientific article published on 20 December 2005

Imprinted Chromatin around DIRAS3 Regulates Alternative Splicing of GNG12-AS1, a Long Noncoding RNA ⬇️

scientific article published on July 18, 2013

Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules

scientific article

Improving breast cancer survival analysis through competition-based multidimensional modeling

scientific article

In Reply:

Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families

scientific article

Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer

scientific article

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

scientific article

Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma

scientific article

Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study

scientific article

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

scientific article

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

scientific article published on 29 March 2017

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus ⬇️

scientific article published on 15 March 2018

Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma

scientific article published on 01 October 2001

International network of cancer genome projects

scientific article

Interrogating open issues in cancer medicine with patient-derived xenografts

scientific article published on 15 September 2017

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

Intersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers

scientific article

Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment

scientific article published on 07 May 2021

Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer

scientific article

Isolation and characterization of a pufferfish MLL (mixed lineage leukemia)-like gene (fMll) reveals evolutionary conservation in vertebrate genes related to Drosophila trithorax

scientific article published in June 1998

It's PRIMETIME. Postoperative Avoidance of Radiotherapy: Biomarker Selection of Women at Very Low Risk of Local Recurrence

scientific article published on 22 June 2016

JARID1B is a luminal lineage-driving oncogene in breast cancer

scientific article

K-ras mutation and pancreatic adenocarcinoma

scientific article

KIT D816V-mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progression.

scientific article published on 30 November 2015

Ki67 expression in invasive breast cancer: the use of tissue microarrays compared with whole tissue sections

scientific article

Landscape of G-quadruplex DNA structural regions in breast cancer

scientific article published on 03 August 2020

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

scientific article published on 31 March 2021

Liquid biopsies come of age: towards implementation of circulating tumour DNA.

scientific article published on 24 February 2017

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

scientific article

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

scientific article

Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.

scientific article published on 28 October 2014

Lymphocyte density determined by computational pathology validated as a predictor of response to neoadjuvant chemotherapy in breast cancer: secondary analysis of the ARTemis trial

scientific article published on 19 May 2017

MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.

scientific article published on 24 May 2018

MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines

scientific article (publication date: 23 December 1999)

MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours.

scientific article published on 08 March 2016

Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts

scientific article (publication date: August 2015)

Master regulators of FGFR2 signalling and breast cancer risk

scientific article published on January 2013

Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer

scientific article

Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer

scientific article

Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer

scientific article published on 14 September 2020

Metabolic consequences of p300 gene deletion in human colon cancer cells

scientific article published on August 2006

Metabolic imaging with hyperpolarized [1-<sup>13</sup>C] pyruvate in patient-derived preclinical mouse models of breast cancer

scientific article published on 17 June 2021

Micro-RNAs and breast cancer

scientific article published on 28 April 2010

MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype

scientific article

MicroRNA: implications for cancer

scientific article

Microarray segmentation methods significantly influence data precision

scientific article published on 17 March 2004

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening

scientific article

Modeling Breast Cancer Intertumor and Intratumor Heterogeneity Using Xenografts

scientific article published on 01 January 2016

Molecular characteristics of screen-detected vs symptomatic breast cancers and their impact on survival

scientific article published on 22 September 2009

Molecular classification and molecular forecasting of breast cancer: ready for clinical application?

scientific article

Molecular classification of breast carcinomas using tissue microarrays

scientific article

Molecular classification of solid tumours: towards pathway-driven therapeutics

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Molecular cytogenetic analysis of breast cancer cell lines

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Molecular genetic profiles of colitis-associated neoplasms

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Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis

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Molecular mechanisms of hepcidin regulation in sea bass (Dicentrarchus labrax).

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Molecular profiling of breast cancer: portraits but not physiognomy

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Molecular staging of cancer: is it time? ⬇️

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Multi-omic machine learning predictor of breast cancer therapy response

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Multidisciplinary decisions in breast cancer: does the patient receive what the team has recommended?

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Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

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Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

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Mutations truncating the EP300 acetylase in human cancers

NRG1 fusions in breast cancer

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NRG1 is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene

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Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression

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Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA

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No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study

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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

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Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.

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Novel human, mouse and xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum

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Nuclear CSPP1 expression defined subtypes of basal-like breast cancer

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Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors

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Nucleosome mapping in plasma DNA predicts cancer gene expression

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Of mice and men: patient-derived xenografts in cancer medicine.

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Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas

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One-stop diagnostic breast clinics: how often are breast cancers missed?

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Optimal Amounts of Fluorescent Dye Improve Expression Microarray Results in Tumor Specimens

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Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

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PACK: Profile Analysis using Clustering and Kurtosis to find molecular classifiers in cancer

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PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes

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PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer

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PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

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PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes

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POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients

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PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2.

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PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer

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Paclitaxel (Taxol) therapy in ovarian carcinoma

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PathGrid: a service-orientated architecture for microscopy image analysis

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PathTracer: High-sensitivity detection of differential pathway activity in tumours

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Pathology findings and validation of gastric and esophageal cancer cases in a European cohort (EPIC/EUR-GAST)

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Pathway-based personalized analysis of breast cancer expression data

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Patient-derived xenograft models: an emerging platform for translational cancer research

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Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study

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Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium

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Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer

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Pharmacogenetics of cancer chemotherapy

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Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland

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Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium ⬇️

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Predicting treatment resistance and relapse through circulating DNA.

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Predictive cancer genomics--what do we need?

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Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601).

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Progesterone receptor modulates ERα action in breast cancer

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Prognosis by breast cancer subtypes in patients treated with adjuvant chemotherapy in a clinical trial

Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the NEAT/BR9601 trial

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Prognostic Value of MammaPrint® in Invasive Lobular Breast Cancer

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Prognostic and predictive value of PDL1 expression in breast cancer

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Prognostic gene network modules in breast cancer hold promise

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Proliferation markers and survival in early breast cancer: a systematic review and meta-analysis of 85 studies in 32,825 patients

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Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

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Prophylactic total gastrectomy for familial gastric cancer

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Publisher Correction: Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy.

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Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

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RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer.

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RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype.

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Regulation of p53 tetramerization and nuclear export by ARC

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Reliable gene expression profiling of formalin-fixed paraffin-embedded breast cancer tissue (FFPE) using cDNA-mediated annealing, extension, selection, and ligation whole-genome (DASL WG) assay

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Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel--response

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Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel

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Report on the first meeting of the International Collaborative Group on Hereditary Gastric Cancer

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Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer

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Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms

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SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors.

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SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis

SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis.

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Saccharomyces cerevisiae-like 1 (SEC14L1) is a prognostic factor in breast cancer associated with lymphovascular invasion

Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping

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Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred

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Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma

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Shallow whole genome sequencing for robust copy number profiling of formalin-fixed paraffin-embedded breast cancers.

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Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells ⬇️

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Signatures of mutational processes in human cancer

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Six versus 12 months' adjuvant trastuzumab in patients with HER2-positive early breast cancer: the PERSEPHONE non-inferiority RCT

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Sizing up miRNAs as cancer genes

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Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

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Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis

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Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

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Stratification and therapeutic potential of PML in metastatic breast cancer

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Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes

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Subtype-specific micro-RNA expression signatures in breast cancer progression

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Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies

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Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal

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Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

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Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer

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Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression

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T-cell bispecific antibodies in node-positive breast cancer: novel therapeutic avenue for MHC class I loss variants

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TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer

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TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome

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TOX3 mutations in breast cancer

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TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance

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Taking the responsibility in dementia care: A concept analysis about facticity

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Tamoxifen: the drug that came in from the cold

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Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy

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Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT.

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The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.

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The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31.

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The C/EBPδ protein is stabilized by estrogen receptor α activity, inhibits SNAI2 expression and associates with good prognosis in breast cancer.

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The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

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The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer.

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The Implications of Clonal Genome Evolution for Cancer Medicine ⬇️

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The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene

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The Psychosocial Impact of Undergoing Prophylactic Total Gastrectomy (PTG) to Manage the Risk of Hereditary Diffuse Gastric Cancer (HDGC).

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The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study ⬇️

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The breast cancer genome--a key for better oncology

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The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.

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The breast cancer somatic 'muta-ome': tackling the complexity

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The circular RNome of primary breast cancer

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The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper

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The clonal and mutational evolution spectrum of primary triple-negative breast cancers

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The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups ⬇️

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The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study

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The importance of platform annotation in interpreting microarray data

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The landscape of cancer genes and mutational processes in breast cancer

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The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape

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The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences

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The pitfalls of platform comparison: DNA copy number array technologies assessed

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The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer.

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The shaping and functional consequences of the microRNA landscape in breast cancer

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The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

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The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers

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Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer

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Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.

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Toward understanding and exploiting tumor heterogeneity

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Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features

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Translational genomics in breast cancer ⬇️

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Triple negative breast cancers: clinical and prognostic implications.

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Tumor diversity and the trade-off between universal cancer tasks

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Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells

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Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.

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Vascular endothelial growth factor as an angiogenesis biomarker for the progression of autosomal dominant polycystic kidney disease

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Video Q&amp;A: molecular profiling of breast cancer ⬇️

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Weibull regression with Bayesian variable selection to identify prognostic tumour markers of breast cancer survival

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ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML

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ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium

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ctDNA monitoring using patient-specific sequencing and integration of variant reads

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eEF2K--a new target in breast cancers with combined inactivation of p53 and PTEN

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miR-342-5p as a Potential Regulator of HER2 Breast Cancer Cell Growth

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p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

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p300 is required for orderly G1/S transition in human cancer cells

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p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels

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p300/CBP and cancer

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p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions

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αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer

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