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List of works by Raffit Hassan

A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice

scientific article

A Recombinant Immunotoxin against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity ⬇️

scientific article published on November 6, 2012

A binding domain on mesothelin for CA125/MUC16

scientific article

A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake

scientific article

A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction

scientific article published on 6 December 2011

Chemotherapy and targeted therapies for unresectable malignant mesothelioma ⬇️

scientific article published on May 28, 2011

Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma

scientific article

Consensus report of the 2015 Weinman International Conference on Mesothelioma

journal article published in 2016

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

scholarly article

Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding

scientific article

DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma

scientific article

Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer

scientific article

Discovery of mesothelin and exploiting it as a target for immunotherapy

scientific article

Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity

scientific article published on 04 May 2016

Efficacy of anti‐insulin‐like growth factor I receptor monoclonal antibody cixutumumab in mesothelioma is highly correlated with insulin growth factor‐I receptor sites/cell ⬇️

scientific article published on April 24, 2012

Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti-PD-1 antibody in patients with mesothelioma and mouse tumor models

scientific article published on 01 July 2020

Farletuzumab in lung cancer ⬇️

scientific article published on January 26, 2013

High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis.

scientific article published on May 2015

Identification of novel human CTL epitopes and their agonist epitopes of mesothelin

scientific article

Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors

scholarly article

Immunotoxin treatment of cancer

scientific article

In Vivo Imaging of Human Malignant Mesothelioma Grown Orthotopically in the Peritoneal Cavity of Nude Mice ⬇️

scientific article published on March 1, 2011

Inhibition of mesothelin-CA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy

scientific article

Malignant mesothelioma and central nervous system metastases. Report of two cases, pooled analysis, and systematic review

scientific article

Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice

scientific article

Mesothelin Expression in Advanced Gastroesophageal Cancer Represents a Novel Target for Immunotherapy

scientific article published on 18 February 2016

Mesothelin Immunotherapy for Cancer: Ready for Prime Time?

scientific article

Mesothelin targeted cancer immunotherapy

scientific article

Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells

scientific article

Mesothelin-Targeted Agents in Clinical Trials and in Preclinical Development ⬇️

scientific article published on February 17, 2012

Mesothelin: a new target for immunotherapy

scientific article

Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma

scientific article published on 8 May 2015

New Insights into Understanding the Mechanisms, Pathogenesis, and Management of Malignant Mesotheliomas ⬇️

scientific article published on February 8, 2013

New Life for Immunotoxin Cancer Therapy

scientific article published on 13 October 2015

New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma

scientific article

Nonpleural mesotheliomas: mesothelioma of the peritoneum, tunica vaginalis, and pericardium

scientific article

Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts ⬇️

scientific article published on April 26, 2011

Phase 1 study of the immunotoxin LMB-100 in patients with mesothelioma and other solid tumors expressing mesothelin

scientific article published on 01 September 2020

Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers ⬇️

scientific article published on October 29, 2010

Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma

scientific article

Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin.

scientific article

Recombinant Immunotoxin with T-cell Epitope Mutations That Greatly Reduce Immunogenicity for Treatment of Mesothelin-Expressing Tumors

scientific article

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

scientific article

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

scientific article

Safety and biodistribution of 111In-amatuximab in patients with mesothelin expressing cancers using single photon emission computed tomography-computed tomography (SPECT-CT) imaging

scientific article published on February 2015

Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers ⬇️

scientific article published on April 1, 2012

The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy ⬇️

scientific article published on January 31, 2011

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