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List of works by Gerhard Moldenhauer

A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression

scientific article

A novel method for measuring cellular antibody uptake using imaging flow cytometry reveals distinct uptake rates for two different monoclonal antibodies targeting L1.

scientific article published on 9 May 2015

A photosensitizer delivered by bispecific antibody redirected T lymphocytes enhances cytotoxicity against EpCAM-expressing carcinoma cells upon light irradiation.

scientific article

A standardized staining protocol for L1CAM on formalin-fixed, paraffin-embedded tissues using automated platforms

scientific article published on 25 June 2014

A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins

scientific article published on 01 June 2007

AID expression identifies interfollicular large B cells as putative precursors of mature B-cell malignancies.

scientific article published on 3 November 2005

Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases

scientific article published on 09 October 2014

Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT.

scientific article

CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non-small cell lung cancer patients

scientific article

CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer

scientific article published on 30 September 2011

CD24 controls Src/STAT3 activity in human tumors.

scientific article

Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter

scientific article published on 20 November 2008

Clever-1/Stabilin-1 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation

scientific article published on 01 December 2009

Combined treatment of L1CAM antibodies and cytostatic drugs improve the therapeutic response of pancreatic and ovarian carcinoma ⬇️

scientific article published on December 27, 2011

Combining forces to hit cancer stem cells: TRAIL-lymphocytes and EpCAMxCD3 bispecific antibody show efficacy against pancreatic cancer

scientific article

Cytokine-induced killer cells against autologous CLL: direct cytotoxic effects and induction of immune accessory molecules by interferon-gamma

scientific article published on September 2006

Cytokine-induced killer cells targeted by the novel bispecific antibody CD19xCD5 (HD37xT5.16) efficiently lyse B-lymphoma cells

scientific article

Detection of circulating tumor-associated antigen depends on the domains recognized by the monoclonal antibodies used: N-terminal trimmed EpCAM-levels are much higher than untrimmed forms.

scientific article published on 22 February 2012

Dickkopf-3, a tissue-derived modulator of local T-cell responses

scientific article published on 24 February 2015

Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance ⬇️

scientific article published on January 17, 2012

Dietary polyphenol quercetin targets pancreatic cancer stem cells ⬇️

scientific article published on September 1, 2010

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

scientific article published on 25 June 2013

Effect of domain order on the activity of bacterially produced bispecific single-chain Fv antibodies.

scientific article

Effect of tetravalent bispecific CD19xCD3 recombinant antibody construct and CD28 costimulation on lysis of malignant B cells from patients with chronic lymphocytic leukemia by autologous T cells

scientific article published on 01 November 2004

Efficient carcinoma cell killing by activated polymorphonuclear neutrophils targeted with an Ep-CAMxCD64 (HEA125x197) bispecific antibody

scientific article published on 08 October 2002

Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment

scientific article published on 01 January 2006

Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinoma ⬇️

scientific article published on 01 October 2010

Endocytosis of advanced glycation end-products in bovine choriocapillaris endothelial cells

scientific article published on 01 October 2009

Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets?

scientific article published in March 2010

Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy

scientific article published on 21 June 2006

Functional analysis of bispecific antibody (EpCAMxCD3)-mediated T-lymphocyte and cancer cell interaction by single-cell force spectroscopy

scientific article published on May 2011

Generation of “LYmph Node Derived Antibody Libraries” (LYNDAL) for selecting fully human antibody fragments with therapeutic potential

scientific article

High-density Peptide Arrays Help to Identify Linear Immunogenic B-cell Epitopes in Individuals Naturally Exposed to Malaria Infection

scientific article published on 10 January 2019

Humoral response to catumaxomab correlates with clinical outcome: results of the pivotal phase II/III study in patients with malignant ascites

scientific article

Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential ⬇️

scientific article published on September 26, 2012

Immunosuppressive properties of anti-CD3 single-chain Fv and diabody

scientific article published in February 2004

Immunotherapy of B-cell non-Hodgkin lymphoma by targeting the chemokine receptor CXCR5 in a preclinical mouse model

scientific article published on 29 April 2014

In vitro characterization of (177)Lu-radiolabelled chimeric anti-CD20 monoclonal antibody and a preliminary dosimetry study

scientific article published on 7 April 2009

Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma

scientific article published on September 2002

L1 cell adhesion molecule as a potential therapeutic target in murine models of endometriosis using a monoclonal antibody approach

scientific article

Lack of CD24 expression in mice reduces the number of leukocytes in the colon

scientific article published on 20 June 2014

Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas

scientific article

Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage.

scientific article published on 20 May 2011

Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.

scientific article published on 29 April 2014

Molecular and clinical dissection of CD24 antibody specificity by a comprehensive comparative analysis

scientific article published on 29 March 2010

Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent ⬇️

scientific article published on November 17, 2011

Neurofibromin specific antibody differentiates malignant peripheral nerve sheath tumors (MPNST) from other spindle cell neoplasms

scientific article published on 25 January 2014

New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting ⬇️

scientific article published on January 6, 2012

Quality of recombinant protein determines the amount of autoreactivity detected against the tumor-associated epithelial cell adhesion molecule antigen: low frequency of antibodies against the natural protein.

scientific article

Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity.

scientific article published on 2 April 2015

Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate ⬇️

scientific article published on October 12, 2010

Synergistic antitumor effect of bispecific CD19 x CD3 and CD19 x CD16 diabodies in a preclinical model of non-Hodgkin's lymphoma

scientific article published on July 2002

Systematic comparison of surface coatings for protein microarrays

scholarly article by Birgit Guilleaume published in December 2005

Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma

scientific article

Targeting of cancer stem cell marker EpCAM by bispecific antibody EpCAMxCD3 inhibits pancreatic carcinoma

scientific article

The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7

scientific article

Therapeutic Potential of Amanitin-Conjugated Anti-Epithelial Cell Adhesion Molecule Monoclonal Antibody Against Pancreatic Carcinoma ⬇️

scientific article published on March 27, 2012

Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma.

scientific article published on 9 March 2010

Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis

scientific article published on 21 January 2016

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