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List of works by Steven A Belinsky

1,3-butadiene: cancer, mutations, and adducts. Part I: Carcinogenicity of 1,2,3,4-diepoxybutane.

scientific article

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers

scientific article

17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway

scientific article published in January 2006

5-Azacytidine inhaled dry powder formulation profoundly improves pharmacokinetics and efficacy for lung cancer therapy through genome reprogramming

scientific article published on 27 February 2020

A Phase I Protocol of Hydralazine and Valproic Acid in Advanced, Previously Treated Solid Cancers

scientific article published on 17 April 2014

A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk

scientific article

A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells

scientific article published on 12 February 2007

A microassay for measuring cytosine DNA methyltransferase activity during tumor progression

scientific article published on 01 December 1995

A phase I study of 5-azacytidine and erlotinib in advanced solid tumor malignancies

scientific article published on 08 September 2011

A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania

scientific article published on June 2016

ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status

scientific article

Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens

scientific article published on February 2002

Aberrant methylation of gene promoters in cancer---concepts, misconcepts, and promise

scientific article published on 01 September 2000

Aberrant methylation of p16 INK4a is an early event in lung cancer and a potential biomarker for early diagnosis ⬇️

scientific article published on September 29, 1998

Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens

scientific article published on June 2004

Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers

scientific article published in April 2002

Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers.

scientific article published in August 2003

Abstract 3554: Gene and miRNA expression networks specific to never smoker lung adenocarcinoma

article

Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

scientific article published in March 1986

Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis

scientific article

Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells

scientific article published on May 2008

Alterations in the K-ras and p53 genes in rat lung tumors ⬇️

scientific article published on June 1, 1997

Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors

scientific article published on February 1994

Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.

scientific article

Animal models of beryllium-induced lung disease

scientific article

Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers

scientific article published in August 2008

Carbon content in airway macrophages and genomic instability in Chinese carbon black packers

scientific article published on 19 February 2020

Carcinogen exposure differentially modulates RAR-beta promoter hypermethylation, an early and frequent event in mouse lung carcinogenesis

scientific article published on 4 December 2003

Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells

scientific article

Carcinogenic Responses of Transgenic Heterozygous p53 Knockout Mice to Inhaled 239PuO2 or Metallic Beryllium ⬇️

scientific article published on July 1, 1998

Carcinogenicity of inhaled butadiene diepoxide in female B6C3F1 mice and Sprague-Dawley rats

scientific article published on 01 November 1999

Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

scientific article published on 01 February 1987

Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells

scientific article published on 01 November 1988

Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats

scientific article published on 22 June 2004

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer ⬇️

scientific article published on November 9, 2011

Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model ⬇️

scientific article published on January 11, 2011

Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers

scientific article published on 11 July 2018

Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers

scientific article

Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions

scientific article

Cytotoxicity and Genotoxicity of E-Cigarette Generated Aerosols Containing Diverse Flavoring Products and Nicotine in Oral Epithelial Cell Lines

scientific article published on 23 November 2020

DNA adducts as a dosimeter for risk estimation

scientific article

DNA methylation biomarkers to assess therapy and chemoprevention for non-small cell lung cancer

scientific article published on August 2008

DNA methylation markers and early recurrence in stage I lung cancer

scientific article

DNA-PKc deficiency drives pre-malignant transformation by reducing DNA repair capacity in concert with reprogramming the epigenome in human bronchial epithelial cells

scientific article published on 27 April 2019

Deep sequencing of the microRNA transcriptome in current, former, and never smokers with lung adenocarcinoma

Defining a Gene Promoter Methylation Signature in Sputum for Lung Cancer Risk Assessment ⬇️

scientific article published on April 17, 2012

Deletion and differential expression of p16INK4a in mouse lung tumors

scientific article published on 01 January 1997

Detection of trisomy 7 in nonmalignant bronchial epithelium from lung cancer patients and individuals at risk for lung cancer ⬇️

journal article published in 1996

Dietary nutrient intake, ethnicity, and epigenetic silencing of lung cancer genes detected in sputum in New Mexican smokers.

scientific article published on 8 November 2017

Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico.

scientific article

Difference in airflow obstruction between Hispanic and non-Hispanic White female smokers.

scientific article published on October 2008

Differences in microRNA expression in breast cancer between women of African and European ancestry ⬇️

scientific article published on 01 March 2019

Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers ⬇️

scientific article published on April 4, 2012

Discovery of common SNPs in the miR-205/200 family-regulated epithelial to mesenchymal transition pathway and their association with risk for non-small cell lung cancer ⬇️

scientific article published on January 1, 2011

Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

scientific article published on June 1990

Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation

scientific article published on April 2008

Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer

scientific article published on December 2009

EMT and Stem Cell–Like Properties Associated with miR-205 and miR-200 Epigenetic Silencing Are Early Manifestations during Carcinogen-Induced Transformation of Human Lung Epithelial Cells ⬇️

scientific article published on April 15, 2011

Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum.

scientific article published on 11 October 2016

Effect of chronic ethanol diet on the replication, alkylation, and repair of DNA from hepatocytes and nonparenchymal cells following dimethylnitrosamine administration

scientific article published in January 1982

Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression ⬇️

scientific article published on August 1, 1998

Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer

scientific article published on 27 December 2019

Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer

scientific article published in August 2015

Epigenetic change (GATA-4 gene methylation) is associated with health status in chronic obstructive pulmonary disease

scientific article published on 27 June 2014

Epigenetics is alive and growing

scientific article published in February 2002

Expanded genetic landscape of chronic obstructive pulmonary disease reveals heterogeneous cell type and phenotype associations

scholarly article published 26 June 2018

Factors regulating activation and DNA alkylation by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and nitrosodimethylamine in rat lung and isolated lung cells, and the relationship to carcinogenicity ⬇️

scientific article published on 01 August 1988

Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse

scientific article

Frequency of trisomy 20 in nonmalignant bronchial epithelium from lung cancer patients and cancer-free former uranium miners and smokers

scientific article published on 01 November 1998

Frequent aberrant methylation of p16INK4a in primary rat lung tumors

scientific article published on March 1997

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer

scientific article

GATA2 is epigenetically repressed in human and mouse lung tumors and is not requisite for survival of KRAS mutant lung cancer

scientific article

Gene Methylation Biomarkers in Sputum and Plasma as Predictors for Lung Cancer Recurrence.

scientific article published on 13 September 2017

Gene Promoter Hypermethylation Detected in Sputum Predicts FEV1 Decline and All-cause Mortality in Smokers

scientific article published on 13 February 2018

Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors

scientific article published on 22 July 2008

Gene methylation biomarkers in sputum as a classifier for lung cancer risk.

scientific article published on 15 July 2017

Gene promoter hypermethylation in mouse lung tumors

scientific article published on 01 April 2006

Gene promoter methylation in plasma and sputum increases with lung cancer risk

scientific article published in September 2005

Gene-promoter hypermethylation as a biomarker in lung cancer

scientific article published in September 2004

Genetic changes in lung cancer: Potential biomarkers for early detection and prevention ⬇️

scientific article published on December 1, 1997

Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study

scientific article published on 2 December 2011

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

scientific article published on 25 February 2019

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

scientific article

Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau

scientific article published on 25 January 2013

Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers

scientific article

Genotypes in matrix metalloproteinase 9 are a risk factor for COPD.

scientific article published on January 2006

Genotypes in matrix metalloproteinase 9 are risk factors for chronic obstructive pulmonary disease.

scientific article

Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum

scientific article published in April 2002

HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer ⬇️

scientific article published on March 31, 2012

Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers

scientific article

Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer

scientific article published on 01 June 2006

Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer

scientific article published on March 2004

Identification of novel epigenetic abnormalities as sputum biomarkers for lung cancer risk among smokers and COPD patients

scientific article published on 25 May 2020

Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung

scientific article published on 16 July 2015

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

scientific article published on October 1999

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer

scientific article published on April 1996

Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion

scientific article published on 09 January 2014

Individuals at high risk for lung cancer have airway epithelial cells with chromosome aberrations frequently found in lung tumor cells

scientific article published on 01 January 1998

Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model

scientific article published on 01 November 2018

Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer

scientific article published on 26 July 2019

Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer ⬇️

scientific article published on November 1, 2003

Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non-small-cell lung cancer cells

scientific article published on 06 March 2019

Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways

scientific article published on 8 June 2005

Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black

scientific article

Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis

scientific article published on 9 July 2015

Low-Dose Gamma-Radiation Inhibits Benzo[a]pyrene-Induced Lung Adenoma Development in A/J Mice ⬇️

scientific article published on November 22, 2012

Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen ⬇️

scientific article published on May 2, 2012

Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness

scientific article published on 01 June 2019

MS-qFRET: a quantum dot-based method for analysis of DNA methylation

scientific article published on 14 May 2009

MUC1 Contributes to BPDE-Induced Human Bronchial Epithelial Cell Transformation through Facilitating EGFR Activation ⬇️

scientific article published on March 22, 2012

MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer

scientific article

Metabolism of nitrofluoranthenes by rat lung subcellular fractions

scientific article published in June 1993

Methylated Genes in Sputum Among Older Smokers With Asthma.

scientific article

Methylation in benign prostate and risk of disease progression in men subsequently diagnosed with prostate cancer

scientific article

Methylation of the RARB Gene Increases Prostate Cancer Risk in Black Americans ⬇️

scientific article published on January 30, 2013

Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure

scientific article published on 01 August 1996

MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis

scientific article published on 24 October 2013

Mining the epigenome for methylated genes in lung cancer

scientific article published on December 2008

Molecular and physiologic evidence for 5'CpG island methylation of the endothelin B receptor gene in lung cancer

scientific article published on 01 March 2002

Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to the tobacco specific nitrosamine 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia

scientific article

Molecular dosimetry of O6-methylguanine formation and cell toxicity in lung and nasal mucosa by 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone

scientific article published on 01 January 1987

Molecular identification of individuals at high risk for lung cancer ⬇️

scientific article published on 01 January 1997

Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop

scientific article published on 4 May 2017

Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers

scientific article published in April 2005

Multivitamins, folate, and green vegetables protect against gene promoter methylation in the aerodigestive tract of smokers

scientific article

Native American ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from New Mexico

scientific article

Nested multigene MSP/DHPLC method for analyzing promoter hypermethylation status in clinical samples

scientific article published in January 2006

New Mexican Hispanic smokers have lower odds of chronic obstructive pulmonary disease and less decline in lung function than non-Hispanic whites.

scientific article published on 8 September 2011

Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells ⬇️

scientific article published on June 5, 1998

Perspective: cell differentiation theory may advance early detection of and therapy for lung cancer

scientific article published on 01 January 2001

Pharmacokinetic Profile of Inhaled Submicron Particle Paclitaxel (NanoPac) in a Rodent Model

scholarly article by James Verco et al published 25 October 2018 in Journal of Aerosol Medicine and Pulmonary Drug Delivery

Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma.

scientific article published on 23 January 2004

Predicting lung cancer by detecting aberrant promoter methylation in sputum

scientific article published on 01 November 2000

Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort

scientific article published on 01 March 2006

Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression.

scientific article published in August 2003

Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25.

scientific article

Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I: Neoplastic and nonneoplastic lung lesions.

scientific article

Radiation-induced lung adenocarcinoma is associated with increased frequency of genes inactivated by promoter hypermethylation

scientific article published on 01 October 2007

Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer

scientific article published on 11 June 2009

Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners

scientific article published on 15 September 2015

Randomized phase III study of thoracic radiation in combination with paclitaxel and carboplatin with or without thalidomide in patients with stage III non-small-cell lung cancer: the ECOG 3598 study

scientific article published on 23 January 2012

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

scientific article

Rapid lung function decline in smokers is a risk factor for COPD and is attenuated by angiotensin-converting enzyme inhibitor use

scientific article published on April 2014

Reduced DNA-dependent protein kinase activity is associated with lung cancer

scientific article published in May 2001

Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines

scientific article published on 01 October 1989

Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine

scientific article published in March 1991

Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines

scientific article

Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse

scientific article published on 01 June 1992

Rosiglitazone prevents the progression of preinvasive lung cancer in a murine model

scientific article published on December 2009

SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome

scientific article published on 5 April 2014

SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle.

scientific article

Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers

scientific article

Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer

scientific article published on February 2008

Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer

scientific article

Smoke Chemistry, In vitro Cytotoxicity, and Genotoxicity Demonstrates Enhanced Toxicity of Cigarillos Compared to Cigarettes

scientific article published on 06 October 2020

Softwares and methods for estimating genetic ancestry in human populations ⬇️

scientific article published on January 5, 2013

TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade

scientific article published on 18 October 2016

The A/G Allele of Rs16906252 Predicts for MGMT Methylation and Is Selectively Silenced in Premalignant Lesions from Smokers and in Lung Adenocarcinomas ⬇️

scientific article published on February 25, 2011

The A/J mouse lung as a model for developing new chemointervention strategies

scientific article published on 01 January 1993

The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung

scientific article

The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence

scientific article

Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo

scientific article published in May 2004

Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo

scientific article (publication date: 15 January 2004)

Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI's EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and Tools

scientific article published on 01 May 2007

Transcriptional regulation of basal cyclooxygenase-2 expression in murine lung tumor-derived cell lines by CCAAT/enhancer-binding protein and activating transcription factor/cAMP response element-binding protein

scientific article published on August 2002

Unmasking the lung cancer epigenome

scientific article

Vasorin/ATIA Promotes Cigarette Smoke-Induced Transformation of Human Bronchial Epithelial Cells by Suppressing Autophagy-Mediated Apoptosis

scientific article published on 21 November 2019

Voltage and e-liquid composition affect nicotine deposition within the oral cavity and carbonyl formation

scientific article published on 25 June 2020

Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility

scientific article

Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.

scientific article

miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis

scientific article published on 14 June 2016

p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer

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