List of works - Dongyan Zhang

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

scientific article published on 26 August 2020

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

scientific article

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

scientific journal article

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

scientific article

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

scientific article published on 28 March 2019

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.

scientific article published in March 2018

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance

scientific article published on 04 July 2019

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

scientific article

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

scientific article published on 31 May 2016

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

scientific article published on 01 March 2019

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

scientific article published on 9 January 2013

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

scientific article

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice

scientific article

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

scholarly article

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

scientific article

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

scholarly article by Andreas L. Birkenfeld et al published October 2011 in Cell Metabolism

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

scientific article

Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference

scientific article published on 06 October 2020

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice

scientific article published on 19 December 2018

Enzyme-free synthesis of natural phospholipids in water

scientific article published on 12 October 2020

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis

scientific article published on 28 April 2015

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

scientific article published on 04 March 2020

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

scientific article

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

scientific article

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

scientific article published on 5 February 2015

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21.

scientific article

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

scientific article

Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

scientific article published on 01 November 2019

Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats

scientific article published on 23 August 2011

Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents

scientific article published on 12 July 2016

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats

scientific article published on 25 September 2007

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

scientific article

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

scientific article

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

scientific article

Light-activated tetrazines enable precision live-cell bioorthogonal chemistry

scientific article published in 2022

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

scientific article

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

scientific article

Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice

scientific article published on 09 September 2020

Metabolic control analysis of hepatic glycogen synthesis in vivo

scientific article published on 18 March 2020

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

scientific article

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

scientific article

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

scientific article published on 11 April 2014

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.

scientific article published in November 2008

OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

scientific article published on 29 June 2020

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

scientific article published on 17 March 2020

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

scholarly article

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

scientific article

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein

scientific article published on December 2009

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

scientific journal article

Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency

scientific article published on May 2010

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

scientific article published on 16 February 2006

Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler

scientific article

Reversing a model of Parkinson's disease with in situ converted nigral neurons

scientific article published on 24 June 2020

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

scientific article

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

scientific article published on 25 January 2013

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

scientific article published on 09 July 2013

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

scientific article published on 7 December 2015

Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol - PKCε - insulin receptorT1160 phosphorylation

scientific article published on 07 January 2021

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

scientific journal article

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

scientific article

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

scientific article

Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance

scientific article

Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes

scientific article

XBP1s Is an Anti-lipogenic Protein

scientific article

List of works by Dongyan Zhang

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice

Enzyme-free synthesis of natural phospholipids in water

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21.

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats

Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

Light-activated tetrazines enable precision live-cell bioorthogonal chemistry

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice

Metabolic control analysis of hepatic glycogen synthesis in vivo

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.

OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler

Reversing a model of Parkinson's disease with in situ converted nigral neurons

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol - PKCε - insulin receptorT1160 phosphorylation

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance

Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes

XBP1s Is an Anti-lipogenic Protein