List of works - Wojciech Rode

A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase.

scientific article

Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification

scientific article published on 27 February 2006

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

scientific article published on 23 June 2020

Antitumor and anti-nematode activities of α-mangostin

scientific article published on 19 September 2019

Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme

scientific article published on September 2005

Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase

scientific article published on 13 December 2012

Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

scientific article

Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer

scientific article

Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.

scientific article published on 12 August 2017

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.

scientific article published on 21 April 2009

EGFP fluorescence as an indicator of cancer cells response to methotrexate.

scientific article published on 28 October 2006

Electron capture dissociation mass spectrometric analysis of lysine-phosphorylated peptides.

scientific article published on December 2010

Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells

scientific article published on 16 June 2011

Gold nanoparticle-enhanced target (AuNPET) as universal solution for laser desorption/ionization mass spectrometry analysis and imaging of low molecular weight compounds

scientific article published on 7 February 2015

Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.

scientific article published on 17 May 2016

Immunofluorescent localization of thymidylate synthase in the development of Trichinella spiralis and Caenorhabditis elegans.

scientific article published on 13 February 2012

Increased thymidine kinase activity in human thyroid toxic adenomas: effects of exposure to epidermal growth factor in vitro.

scientific article published in February 2004

Interactions of 2'-fluoro-substituted dUMP analogues with thymidylate synthase

scientific article published on 27 July 2007

Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase

scientific article published on 9 April 2010

Methotrexate-induced senescence in human adenocarcinoma cells is accompanied by induction of p21(waf1/cip1) expression and lack of polyploidy.

scientific article

Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations

scientific article published on 01 April 2019

Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme

N(4)-[B-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan)methyl]-2'-deoxycytidine as a potential boron delivery agent with respect to glioblastoma.

scientific article published on 7 September 2017

Novel monoisotopic 109AgNPET for laser desorption/ionization mass spectrometry.

scientific article

Nurse cell of Trichinella spp. as a model of long-term cell cycle arrest

scientific article

Oxidative stress and inhibition of nitric oxide generation underlie methotrexate-induced senescence in human colon cancer cells

scientific article

Phosphorylation of basic amino acid residues in proteins: important but easily missed.

scientific article

Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N(4)-hydroxy-dCMP.

scientific article

Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits

scientific article

Properties of phosphorylated thymidylate synthase

scientific journal article

Relative free energies of binding to thymidylate synthase of 2- and/or 4-thio and/or 5-fluoro analogues of dUMP.

scientific article published in October 2003

Segmental motions of rat thymidylate synthase leading to half-the-sites behaviour

scientific article published on 01 June 2010

Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging

scientific article published on 6 August 2015

Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.

scientific article published in January 2002

Synthesis and NMR properties of derivatives of 5,6-dihydroborauracil and 5,6-dihydroborathymine.

scientific article published on 18 July 2009

Synthesis and NMR properties of novel 5,6-dihydroborauracil derivatives.

scientific article published on 24 March 2009

Synthesis and NMR properties of the first boron analogues of uracil

scientific article published on 2 October 2009

Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid

scientific article

Synthesis, reactivity and biological activity of N(4)-boronated derivatives of 2'-deoxycytidine.

scientific article

The aromaticity of 5,6-dihydroborauracil, borauracil and benzoborauracil systems.

scientific article published on July 2010

The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR

scientific article published on 19 January 2007

The effect of Arg209 to Lys mutation in mouse thymidylate synthase

scientific article published in January 2002

The synthesis and NMR investigation on novel boron derivatives of stavudine

scientific article

Thiophosphorylation of free amino acids and enzyme protein by thiophosphoramidate ions

scientific article published on 26 November 2009

Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP

scientific article published on 11 September 2019

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence.

scientific article

Tyrosine nitration affects thymidylate synthase properties.

scientific article

Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp.

scientific article published on 02 September 2016

[Thymidylate synthase-catalyzed reaction mechanism].

scientific article published in January 2015

List of works by Wojciech Rode

A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase.

Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

Antitumor and anti-nematode activities of α-mangostin

Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme

Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase

Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer

Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.

EGFP fluorescence as an indicator of cancer cells response to methotrexate.

Electron capture dissociation mass spectrometric analysis of lysine-phosphorylated peptides.

Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells

Gold nanoparticle-enhanced target (AuNPET) as universal solution for laser desorption/ionization mass spectrometry analysis and imaging of low molecular weight compounds

Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.

Immunofluorescent localization of thymidylate synthase in the development of Trichinella spiralis and Caenorhabditis elegans.

Increased thymidine kinase activity in human thyroid toxic adenomas: effects of exposure to epidermal growth factor in vitro.

Interactions of 2'-fluoro-substituted dUMP analogues with thymidylate synthase

Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase

Methotrexate-induced senescence in human adenocarcinoma cells is accompanied by induction of p21(waf1/cip1) expression and lack of polyploidy.

Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations

Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme

N(4)-[B-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan)methyl]-2'-deoxycytidine as a potential boron delivery agent with respect to glioblastoma.

Novel monoisotopic 109AgNPET for laser desorption/ionization mass spectrometry.

Nurse cell of Trichinella spp. as a model of long-term cell cycle arrest

Oxidative stress and inhibition of nitric oxide generation underlie methotrexate-induced senescence in human colon cancer cells

Phosphorylation of basic amino acid residues in proteins: important but easily missed.

Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N(4)-hydroxy-dCMP.

Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits

Properties of phosphorylated thymidylate synthase

Relative free energies of binding to thymidylate synthase of 2- and/or 4-thio and/or 5-fluoro analogues of dUMP.

Segmental motions of rat thymidylate synthase leading to half-the-sites behaviour

Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging

Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.

Synthesis and NMR properties of derivatives of 5,6-dihydroborauracil and 5,6-dihydroborathymine.

Synthesis and NMR properties of novel 5,6-dihydroborauracil derivatives.

Synthesis and NMR properties of the first boron analogues of uracil

Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid

Synthesis, reactivity and biological activity of N(4)-boronated derivatives of 2'-deoxycytidine.

The aromaticity of 5,6-dihydroborauracil, borauracil and benzoborauracil systems.

The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR

The effect of Arg209 to Lys mutation in mouse thymidylate synthase

The synthesis and NMR investigation on novel boron derivatives of stavudine

Thiophosphorylation of free amino acids and enzyme protein by thiophosphoramidate ions

Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence.

Tyrosine nitration affects thymidylate synthase properties.

Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp.

[Thymidylate synthase-catalyzed reaction mechanism].