List of works - Joel Habener

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

scientific article

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

scientific journal article

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

scientific article

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes

scientific article published in March 2001

The glucagon-like peptides

scientific article

Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA

scientific journal article

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

scientific article published on 01 October 1997

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas

scientific article published on February 1987

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line

scientific article

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas

scientific article published in May 2000

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

scientific article published on January 1993

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

scientific journal article

Minireview: transcriptional regulation in pancreatic development

scientific article

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor

scientific article published in July 1996

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines

scientific article

Cyclic AMP response element binding proteins: a cornucopia of transcription factors

scientific article published on August 1990

Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat

scientific article published on July 1986

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

scientific article

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells

scientific article

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing

scientific article published on 01 September 1986

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

scientific article

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements

scientific article

Leptin receptors expressed on pancreatic beta-cells

scientific article

Cyclic AMP signaling and gene regulation

scientific article published on January 1, 1998

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

scientific article

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene

scientific article published on March 1994

Cyclic adenosine 3',5'-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins

scientific article published on June 1993

The adipoinsular axis: effects of leptin on pancreatic beta-cells

scientific article

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

scientific article published in May 2002

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration

scientific article published on 01 March 1999

The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects

scientific article

cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

scientific article

Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects

scientific article published on February 1, 1992

No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo

scientific article published in March 2004

Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis

scientific article published on 01 January 2001

Phosphorylation of the cAMP Response Element Binding Protein CREB by cAMP-Dependent Protein Kinase A and Glycogen Synthase Kinase-3 Alters DNA-Binding Affinity, Conformation, and Increases Net Charge

scientific article published on March 17, 1998

Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins

scientific article

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells

scientific article published on January 1, 1992

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem

scientific article

CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins

scientific article

Hedgehog signaling regulation of insulin production by pancreatic beta-cells

scientific journal article

Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4.

scientific article

Transcription Factors C/EBPα, C/EBPβ, and CHOP (Gadd153) Expressed During the Differentiation Program of Keratinocytes In Vitro and In Vivo

scientific article published on March 1, 1998

Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats

scientific article

Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells

scientific article published in August 2002

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein

scientific article published on July 1, 1998

Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus

scientific article

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

scientific article

Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept

scientific article published on October 1, 1992

Cloning and characterization of cDNAs encoding human gastrin-releasing peptide

scientific article published on September 1, 1984

List of works by Joel Habener

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes

The glucagon-like peptides

Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

Minireview: transcriptional regulation in pancreatic development

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines

Cyclic AMP response element binding proteins: a cornucopia of transcription factors

Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements

Leptin receptors expressed on pancreatic beta-cells

Cyclic AMP signaling and gene regulation

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene

Cyclic adenosine 3',5'-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins

The adipoinsular axis: effects of leptin on pancreatic beta-cells

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration

The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects

cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects

No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo

Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis

Phosphorylation of the cAMP Response Element Binding Protein CREB by cAMP-Dependent Protein Kinase A and Glycogen Synthase Kinase-3 Alters DNA-Binding Affinity, Conformation, and Increases Net Charge

Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem

CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins

Hedgehog signaling regulation of insulin production by pancreatic beta-cells

Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4.

Transcription Factors C/EBPα, C/EBPβ, and CHOP (Gadd153) Expressed During the Differentiation Program of Keratinocytes In Vitro and In Vivo

Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats

Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein

Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept

Cloning and characterization of cDNAs encoding human gastrin-releasing peptide