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List of works by Alexandra M Mowday

Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

scientific article

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

scientific article published on 12 July 2013

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

scientific article

Discovery and development of imaging-capable bacterial nitroreductases and their cytotoxic prodrugs for Clostridium sporogenes based gene therapy ⬇️

2015 doctoral thesis by Alexandra Mowday at University of Auckland

Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy

scientific article published on 20 August 2019

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.

scientific article published on 20 February 2017

Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

scientific article published in February 2022

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.

scientific article

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

scientific article published on October 2015

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy

scientific article published on 10 June 2013

Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy

scientific article

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

scientific article published on 26 November 2021

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

scientific article published on 8 October 2021

Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954.

scientific article

Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

scientific article published in 2021

Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide

scientific article published on 15 June 2020

Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours

scientific article published on 8 February 2021

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